CA2715289C - Modified rnai polynucleotides and uses thereof - Google Patents

Modified rnai polynucleotides and uses thereof Download PDF

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Publication number
CA2715289C
CA2715289C CA2715289A CA2715289A CA2715289C CA 2715289 C CA2715289 C CA 2715289C CA 2715289 A CA2715289 A CA 2715289A CA 2715289 A CA2715289 A CA 2715289A CA 2715289 C CA2715289 C CA 2715289C
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sense
anfisense
nucleotides
dsrna
strand
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French (fr)
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CA2715289A1 (en
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Pamela A. Pavco
Joanne Kamens
Tod M. Woolf
William Salomon
Anastasia Khvorova
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Phio Pharmaceuticals Corp
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Phio Pharmaceuticals Corp
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2320/00—Applications; Uses
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    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects

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CA2715289A 2008-02-11 2009-02-11 Modified rnai polynucleotides and uses thereof Active CA2715289C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6533508P 2008-02-11 2008-02-11
US61/065,335 2008-02-11
PCT/US2009/000852 WO2009102427A2 (en) 2008-02-11 2009-02-11 Modified rnai polynucleotides and uses thereof

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CA2715289A1 CA2715289A1 (en) 2009-08-20
CA2715289C true CA2715289C (en) 2019-12-24

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CA2715289A Active CA2715289C (en) 2008-02-11 2009-02-11 Modified rnai polynucleotides and uses thereof

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US (2) US10131904B2 (enExample)
EP (2) EP3643782A1 (enExample)
JP (3) JP5697993B2 (enExample)
CN (2) CN102016036B (enExample)
AU (1) AU2009213147A1 (enExample)
CA (1) CA2715289C (enExample)
IL (1) IL207548A0 (enExample)
WO (1) WO2009102427A2 (enExample)

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