AU2009213147A1 - Modified RNAi polynucleotides and uses thereof - Google Patents

Modified RNAi polynucleotides and uses thereof Download PDF

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Publication number
AU2009213147A1
AU2009213147A1 AU2009213147A AU2009213147A AU2009213147A1 AU 2009213147 A1 AU2009213147 A1 AU 2009213147A1 AU 2009213147 A AU2009213147 A AU 2009213147A AU 2009213147 A AU2009213147 A AU 2009213147A AU 2009213147 A1 AU2009213147 A1 AU 2009213147A1
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Australia
Prior art keywords
dsrna
antisense
sense
nucleotides
strand
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Abandoned
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AU2009213147A
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Inventor
Joanne Kamens
Anastasia Khvorova
Pamela A. Pavco
William Salomon
Tod M. Woolf
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Phio Pharmaceuticals Corp
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RXi Pharmaceuticals Corp
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Publication of AU2009213147A1 publication Critical patent/AU2009213147A1/en
Abandoned legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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AU2009213147A 2008-02-11 2009-02-11 Modified RNAi polynucleotides and uses thereof Abandoned AU2009213147A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6533508P 2008-02-11 2008-02-11
US61/065,335 2008-02-11
PCT/US2009/000852 WO2009102427A2 (en) 2008-02-11 2009-02-11 Modified rnai polynucleotides and uses thereof

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AU2009213147A1 true AU2009213147A1 (en) 2009-08-20

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AU2009213147A Abandoned AU2009213147A1 (en) 2008-02-11 2009-02-11 Modified RNAi polynucleotides and uses thereof

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US (2) US10131904B2 (enExample)
EP (2) EP3643782A1 (enExample)
JP (3) JP5697993B2 (enExample)
CN (2) CN102016036B (enExample)
AU (1) AU2009213147A1 (enExample)
CA (1) CA2715289C (enExample)
IL (1) IL207548A0 (enExample)
WO (1) WO2009102427A2 (enExample)

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