CA2689588C - Promoterless cassettes for expression of alphavirus structural proteins - Google Patents
Promoterless cassettes for expression of alphavirus structural proteins Download PDFInfo
- Publication number
- CA2689588C CA2689588C CA2689588A CA2689588A CA2689588C CA 2689588 C CA2689588 C CA 2689588C CA 2689588 A CA2689588 A CA 2689588A CA 2689588 A CA2689588 A CA 2689588A CA 2689588 C CA2689588 C CA 2689588C
- Authority
- CA
- Canada
- Prior art keywords
- alphavirus
- rna
- helper
- rna molecule
- replicon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93663707P | 2007-06-21 | 2007-06-21 | |
| US60/936,637 | 2007-06-21 | ||
| PCT/US2008/007701 WO2008156829A2 (en) | 2007-06-21 | 2008-06-20 | Promoterless cassettes for expression of alphavirus structural proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2689588A1 CA2689588A1 (en) | 2008-12-24 |
| CA2689588C true CA2689588C (en) | 2016-08-23 |
Family
ID=40156867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2689588A Active CA2689588C (en) | 2007-06-21 | 2008-06-20 | Promoterless cassettes for expression of alphavirus structural proteins |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7850977B2 (enExample) |
| EP (2) | EP2947149B1 (enExample) |
| JP (3) | JP5602624B2 (enExample) |
| CN (1) | CN101802199B (enExample) |
| AU (1) | AU2008266807B2 (enExample) |
| CA (1) | CA2689588C (enExample) |
| DK (2) | DK2947149T3 (enExample) |
| ES (2) | ES2588906T3 (enExample) |
| IL (1) | IL202720A (enExample) |
| NZ (1) | NZ582495A (enExample) |
| PL (2) | PL2947149T3 (enExample) |
| WO (1) | WO2008156829A2 (enExample) |
| ZA (1) | ZA200909080B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ582495A (en) * | 2007-06-21 | 2012-05-25 | Alphavax Inc | Promoterless cassettes for expression of alphavirus structural proteins |
| WO2010065414A1 (en) | 2008-12-01 | 2010-06-10 | Alphavax, Inc. | Use of micrornas to control virus helper nucleic acids |
| ES2540958T3 (es) | 2009-04-08 | 2015-07-15 | Alphavax, Inc. | Partículas de replicón de alfavirus que expresan TRP2 |
| JP5940064B2 (ja) | 2010-07-06 | 2016-06-29 | ノバルティス アーゲー | 低用量のｒｎａを用いた大型哺乳動物の免疫化 |
| HUE047796T2 (hu) | 2010-07-06 | 2020-05-28 | Glaxosmithkline Biologicals Sa | RNS bevitele több immunútvonal bekapcsolására |
| RS54489B1 (sr) | 2010-07-06 | 2016-06-30 | Glaxosmithkline Biologicals Sa | Lipozomi sa lipidima koji imaju poboljšanu pka vrednost za oslobađanje rnk |
| SMT202200311T1 (it) | 2010-08-31 | 2022-09-14 | Glaxosmithkline Biologicals Sa | Liposomi pegilati per somministrare rna codificante un immunogene |
| EP3520813B1 (en) | 2010-10-11 | 2023-04-19 | GlaxoSmithKline Biologicals S.A. | Antigen delivery platforms |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| EP3854413A1 (en) | 2011-07-06 | 2021-07-28 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
| BE1023557B1 (fr) | 2014-02-10 | 2017-05-03 | Univercells Sa | Systeme, appareil et procede pour la production de biomolecules |
| PL3350333T3 (pl) | 2015-09-17 | 2022-03-07 | Modernatx, Inc. | Polinukleotydy zawierające region stabilizujący ogon |
| WO2017123652A1 (en) | 2016-01-11 | 2017-07-20 | Verndari, Inc. | Microneedle compositions and methods of using same |
| WO2017162265A1 (en) * | 2016-03-21 | 2017-09-28 | Biontech Rna Pharmaceuticals Gmbh | Trans-replicating rna |
| WO2017162266A1 (en) * | 2016-03-21 | 2017-09-28 | Biontech Rna Pharmaceuticals Gmbh | Rna replicon for versatile and efficient gene expression |
| US10538786B2 (en) | 2016-04-13 | 2020-01-21 | Janssen Pharmaceuticals, Inc. | Recombinant arterivirus replicon systems and uses thereof |
| US12385034B2 (en) | 2016-06-24 | 2025-08-12 | Modernatx, Inc. | Methods and apparatus for filtration |
| EP3526332B1 (en) | 2016-10-17 | 2024-06-26 | Janssen Pharmaceuticals, Inc. | Recombinant virus replicon systems and uses thereof |
| CA3045650A1 (en) * | 2016-12-05 | 2018-06-14 | Janssen Pharmaceuticals, Inc. | Compositions and methods for enhancing gene expression |
| MX2019013259A (es) | 2017-05-08 | 2020-01-13 | Gritstone Oncology Inc | Vectores de neoantigeno de alfavirus. |
| EP3681993A1 (en) * | 2017-09-13 | 2020-07-22 | BioNTech RNA Pharmaceuticals GmbH | Rna replicon for reprogramming somatic cells |
| AU2018333530B2 (en) * | 2017-09-13 | 2024-05-30 | Biontech Cell & Gene Therapies Gmbh | RNA replicon for expressing a T cell receptor or an artificial T cell receptor |
| JP7731670B2 (ja) | 2017-11-06 | 2025-09-01 | インターベット インターナショナル ベー． フェー． | ネコ白血病ウイルスワクチン |
| US11167027B2 (en) | 2017-11-06 | 2021-11-09 | Intervet Inc. | Multivalent feline vaccine |
| BR112020008958A2 (pt) | 2017-11-06 | 2021-05-11 | Intervet International B.V. | vacina contra calicivírus felino |
| WO2019110213A1 (en) | 2017-12-08 | 2019-06-13 | Intervet International B.V. | Feline calicivirus vaccine |
| WO2019115090A1 (en) | 2017-12-15 | 2019-06-20 | Intervet International B.V. | Multivalent feline vaccine |
| JP7472019B2 (ja) | 2017-11-06 | 2024-04-22 | インターベット インターナショナル ベー． フェー． | 狂犬病ウイルスワクチン |
| JP7825939B2 (ja) | 2017-12-04 | 2026-03-09 | インターベット インターナショナル ベー． フェー． | イヌライム病ワクチン |
| EP3720488A1 (en) | 2017-12-04 | 2020-10-14 | Intervet International B.V. | Vaccination with replicon particles and oil adjuvant |
| JP7346417B2 (ja) | 2017-12-18 | 2023-09-19 | インターベット インターナショナル ベー． フェー． | ブタインフルエンザａウイルスワクチン |
| US11021692B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Hepatitis B virus (HBV) vaccines and uses thereof |
| EA202091517A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и устройство для доставки вакцин против вируса гепатита b (hbv) |
| US11020476B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV) |
| WO2019124441A1 (en) | 2017-12-20 | 2019-06-27 | Vlp Therapeutics, Llc | Alphavirus replicon particle |
| BR112020014525A2 (pt) | 2018-01-19 | 2020-12-08 | Janssen Pharmaceuticals, Inc. | Induzir e intensificar respostas imunes utilizando sistemas de replicon recombinantes |
| US12331076B2 (en) | 2018-10-08 | 2025-06-17 | Janssen Pharmaceuticals, Inc. | Alphavirus-based replicons for administration of biotherapeutics |
| CN113194989B (zh) | 2018-12-20 | 2024-01-30 | 英特维特国际股份有限公司 | 初免-强化免疫接种方案 |
| JP7457733B2 (ja) | 2019-05-30 | 2024-03-28 | グリットストーン バイオ インコーポレイテッド | 改変アデノウイルス |
| JP2023517644A (ja) | 2020-03-09 | 2023-04-26 | アークトゥラス・セラピューティクス・インコーポレイテッド | コロナウイルスワクチン組成物及び方法 |
| EP4135847A4 (en) | 2020-04-17 | 2024-05-15 | VLP Therapeutics, Inc. | Coronavirus vaccine |
| CA3174651A1 (en) | 2020-04-30 | 2021-11-04 | Vlp Therapeutics, Inc. | Cytokine immunotherapy |
| WO2021228731A1 (en) | 2020-05-11 | 2021-11-18 | Intervet International B.V. | Feline severe acute respiratory syndrome coronavirus 2 vaccine |
| JP2023530135A (ja) | 2020-06-19 | 2023-07-13 | インターベット インターナショナル ベー． フェー． | 特定のウイルス系統の抗原をエンコードする核酸構築物を含むブタインフルエンザａウイルスワクチン |
| BR112022024932A2 (pt) * | 2020-06-19 | 2022-12-27 | Intervet Int Bv | Vacina contra vírus da influenza a suína compreendendo um constructo de ácido nucleico que possui uma ordem específica de genes |
| WO2021255225A1 (en) | 2020-06-19 | 2021-12-23 | Intervet International B.V. | Swine influenza a virus vaccine comprising a nucleic acid construct comprising first, second and third nucleic acid sequences encoding distinct neuraminidase antigens of the virus |
| US20230277649A1 (en) | 2020-06-19 | 2023-09-07 | Intervet Inc. | Swine influenza a virus vaccine comprising two distinct rna replicon particles |
| EP4192496A4 (en) | 2020-08-06 | 2025-01-01 | Gritstone bio, Inc. | MULTIEPITOP VACCINE CASSETTES |
| WO2022049276A1 (en) | 2020-09-07 | 2022-03-10 | Intervet International B.V. | Ha stem vaccine for ha antibody-positive targets |
| JP2023549787A (ja) | 2020-11-12 | 2023-11-29 | インターベット インターナショナル ベー． フェー． | キメラコロナウイルススパイクタンパク質をコードする組換えベクターおよびその使用 |
| US20250281597A1 (en) | 2021-10-25 | 2025-09-11 | Intervet Inc. | A vaccine for the protection of piglets against swine influenza a virus infection |
| EP4696782A1 (en) | 2024-08-14 | 2026-02-18 | Starvax One B.V. | Improved split rna replicons |
| WO2026037537A1 (en) | 2024-08-16 | 2026-02-19 | Intervet International B.V. | Canine influenza virus vaccine |
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| DK2183368T3 (en) | 2016-09-05 |
| ZA200909080B (en) | 2010-09-29 |
| PL2183368T3 (pl) | 2016-12-30 |
| JP2010530245A (ja) | 2010-09-09 |
| HK1217216A1 (en) | 2016-12-30 |
| EP2947149B1 (en) | 2018-02-28 |
| EP2183368A4 (en) | 2011-04-13 |
| JP2016198114A (ja) | 2016-12-01 |
| US20100183665A1 (en) | 2010-07-22 |
| AU2008266807B2 (en) | 2012-08-16 |
| EP2183368A2 (en) | 2010-05-12 |
| JP5995926B2 (ja) | 2016-09-21 |
| CA2689588A1 (en) | 2008-12-24 |
| US8460913B2 (en) | 2013-06-11 |
| JP5602624B2 (ja) | 2014-10-08 |
| PL2947149T3 (pl) | 2018-09-28 |
| AU2008266807A1 (en) | 2008-12-24 |
| IL202720A0 (en) | 2011-08-01 |
| JP2014230544A (ja) | 2014-12-11 |
| WO2008156829A2 (en) | 2008-12-24 |
| CN101802199B (zh) | 2012-08-22 |
| EP2183368B1 (en) | 2016-08-10 |
| NZ582495A (en) | 2012-05-25 |
| ES2588906T3 (es) | 2016-11-07 |
| ES2670813T3 (es) | 2018-06-01 |
| CN101802199A (zh) | 2010-08-11 |
| US7850977B2 (en) | 2010-12-14 |
| IL202720A (en) | 2013-10-31 |
| DK2947149T3 (en) | 2018-06-06 |
| WO2008156829A3 (en) | 2009-03-12 |
| EP2947149A1 (en) | 2015-11-25 |
| US20090075384A1 (en) | 2009-03-19 |
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