CA2537498C - Cartouche a dose unitaire et inhalateur a poudre seche - Google Patents
Cartouche a dose unitaire et inhalateur a poudre seche Download PDFInfo
- Publication number
- CA2537498C CA2537498C CA002537498A CA2537498A CA2537498C CA 2537498 C CA2537498 C CA 2537498C CA 002537498 A CA002537498 A CA 002537498A CA 2537498 A CA2537498 A CA 2537498A CA 2537498 C CA2537498 C CA 2537498C
- Authority
- CA
- Canada
- Prior art keywords
- cartridge
- air
- inhaler
- medicament
- mouthpiece
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940112141 dry powder inhaler Drugs 0.000 title claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 55
- 239000000843 powder Substances 0.000 claims description 22
- 229920003023 plastic Polymers 0.000 claims description 7
- 238000009434 installation Methods 0.000 claims description 6
- 230000013011 mating Effects 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 239000002245 particle Substances 0.000 abstract description 58
- 229940079593 drug Drugs 0.000 abstract description 12
- 238000007865 diluting Methods 0.000 abstract 1
- 238000012383 pulmonary drug delivery Methods 0.000 abstract 1
- 239000003570 air Substances 0.000 description 76
- 210000004072 lung Anatomy 0.000 description 8
- 230000007246 mechanism Effects 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 239000004033 plastic Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 4
- 238000005054 agglomeration Methods 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 210000003128 head Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 210000003800 pharynx Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 description 1
- 229920005123 Celcon® Polymers 0.000 description 1
- 229920004943 Delrin® Polymers 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001870 copolymer plastic Polymers 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000011031 topaz Substances 0.000 description 1
- 229910052853 topaz Inorganic materials 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0023—Mouthpieces therefor retractable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
- A61M16/049—Mouthpieces
- A61M16/0495—Mouthpieces with tongue depressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0816—Joints or connectors
- A61M16/0825—Joints or connectors with ball-sockets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/43—General characteristics of the apparatus making noise when used correctly
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention porte sur un inhalateur à poudre sèche possédant de meilleures propriétés aérodynamiques permettant de diluer, de répandre et de doser des particules médicamenteuses afin d'augmenter l'efficacité de l'administration d'un médicament pulmonaire à un patient. Généralement, l'inhalateur comprend un logement doté d'une entrée d'air, une vanne de contrôle/surveillance de flux, une section de mélange et un embout. Une cartouche chargée d'une dose unique de médicament peut être installée dans la section de mélange.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2635665 CA2635665C (fr) | 2003-09-04 | 2004-09-03 | Cartouche a dose unitaire et inhalateur a poudre seche |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/655,153 US7464706B2 (en) | 1999-07-23 | 2003-09-04 | Unit dose cartridge and dry powder inhaler |
US10/655,153 | 2003-09-04 | ||
PCT/US2004/028699 WO2005023348A2 (fr) | 2003-09-04 | 2004-09-03 | Cartouche a dose unitaire et inhalateur a poudre seche |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2635665 Division CA2635665C (fr) | 2003-09-04 | 2004-09-03 | Cartouche a dose unitaire et inhalateur a poudre seche |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2537498A1 CA2537498A1 (fr) | 2005-03-17 |
CA2537498C true CA2537498C (fr) | 2009-03-24 |
Family
ID=34273452
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002537498A Expired - Lifetime CA2537498C (fr) | 2003-09-04 | 2004-09-03 | Cartouche a dose unitaire et inhalateur a poudre seche |
CA 2635665 Expired - Lifetime CA2635665C (fr) | 2003-09-04 | 2004-09-03 | Cartouche a dose unitaire et inhalateur a poudre seche |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2635665 Expired - Lifetime CA2635665C (fr) | 2003-09-04 | 2004-09-03 | Cartouche a dose unitaire et inhalateur a poudre seche |
Country Status (14)
Country | Link |
---|---|
US (4) | US7464706B2 (fr) |
EP (1) | EP1670532B1 (fr) |
JP (2) | JP4456116B2 (fr) |
KR (3) | KR20090074284A (fr) |
CN (2) | CN101554504B (fr) |
AU (3) | AU2004270204B2 (fr) |
BR (1) | BRPI0414085A (fr) |
CA (2) | CA2537498C (fr) |
DK (1) | DK1670532T3 (fr) |
ES (1) | ES2638279T3 (fr) |
IL (1) | IL174041A (fr) |
MX (1) | MXPA06002544A (fr) |
NZ (2) | NZ545733A (fr) |
WO (1) | WO2005023348A2 (fr) |
Families Citing this family (138)
Publication number | Priority date | Publication date | Assignee | Title |
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US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
JP4713798B2 (ja) * | 1999-06-29 | 2011-06-29 | マンカインド コーポレイション | ペプチドおよびタンパク質の薬学的因子の精製および安定化 |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
GB0025749D0 (en) * | 2000-10-20 | 2000-12-06 | Glaxo Group Ltd | Inhaler |
US6994083B2 (en) | 2001-12-21 | 2006-02-07 | Trudell Medical International | Nebulizer apparatus and method |
ES2300568T3 (es) | 2002-03-20 | 2008-06-16 | Mannkind Corporation | Aparato de inhalacion. |
US20080260838A1 (en) * | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
US9078866B2 (en) | 2003-08-01 | 2015-07-14 | Mannkind Corporation | Method for treating hyperglycemia with GLP-1 |
DE10345950A1 (de) * | 2003-10-02 | 2005-05-19 | Pari GmbH Spezialisten für effektive Inhalation | Inhalationstherapievorrichtung mit Ventil |
US20070027063A1 (en) * | 2004-01-12 | 2007-02-01 | Mannkind Corporation | Method of preserving the function of insulin-producing cells |
ES2584867T3 (es) * | 2004-01-12 | 2016-09-29 | Mannkind Corporation | Un método que reduce los niveles séricos de proinsulina en diabéticos de tipo 2 |
US9016273B2 (en) * | 2004-02-19 | 2015-04-28 | Akihiko Miyamoto | Inhaler aid with reed for minute powdery curative medicine |
US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
US20080085298A1 (en) * | 2004-03-12 | 2008-04-10 | Biodel, Inc. | Rapid Mucosal Gel or Film Insulin Compositions |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
US20050263153A1 (en) * | 2004-05-28 | 2005-12-01 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
MX2007001903A (es) | 2004-08-20 | 2007-08-02 | Mannkind Corp | Catalisis de sintesis de dicetopiperazina. |
DK1791542T3 (en) * | 2004-08-23 | 2015-06-15 | Mannkind Corp | Diketopiperazinsalte for pharmaceutical delivery |
WO2006076277A1 (fr) * | 2005-01-10 | 2006-07-20 | Nektar Therapeutics | Compositions et methodes permettant d'augmenter la biodisponibilite d'insuline administree par voie pulmonaire |
CN100431634C (zh) * | 2005-04-04 | 2008-11-12 | 陈庆堂 | 干粉气溶胶化吸入器 |
US20070042870A1 (en) * | 2005-06-23 | 2007-02-22 | Bohman Patricia J | Spirometer Toy |
US20090159062A1 (en) * | 2005-06-23 | 2009-06-25 | Patricia Bohman | Spirometer Toy |
US20080251072A1 (en) * | 2005-07-13 | 2008-10-16 | Amar Lulla | Inhaler Device |
US8763605B2 (en) | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
CA2621806C (fr) | 2005-09-14 | 2016-08-02 | Mannkind Corporation | Procede de preparation de medicaments fonde sur l'accroissement de l'affinite des surfaces de microparticules cristallines pour des principes actifs |
US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US20070086952A1 (en) * | 2005-09-29 | 2007-04-19 | Biodel, Inc. | Rapid Acting and Prolonged Acting Inhalable Insulin Preparations |
US7713929B2 (en) * | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
SG2014014195A (en) * | 2005-11-21 | 2014-04-28 | Mannkind Corp | Powder dispensing and sensing apparatus and methods |
US7987845B2 (en) | 2006-01-31 | 2011-08-02 | Oriel Therapeutics, Inc. | Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods |
CN101389348A (zh) | 2006-02-22 | 2009-03-18 | 曼金德公司 | 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法 |
AU2007238114B2 (en) * | 2006-04-12 | 2010-10-14 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
EP1844806A1 (fr) * | 2006-04-13 | 2007-10-17 | Boehringer Ingelheim Pharma GmbH | Distributeur de medicaments, magasin de medicaments pour ledit distributeur, et procédé de prélèvement de médicament d'un réservoir |
GB0623732D0 (en) * | 2006-11-28 | 2007-01-10 | Optinose As | Powder delivery devices |
WO2008124522A2 (fr) * | 2007-04-04 | 2008-10-16 | Biodel, Inc. | Formulations contenant de l'amyline |
US11224704B2 (en) * | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
EP2170444B1 (fr) | 2007-07-06 | 2016-09-07 | Manta Devices, LLC | Dispositifs d'inhalation pour stocker et delivrer le medicament |
GB0719299D0 (en) | 2007-10-03 | 2007-11-14 | Optinose As | Nasal delivery devices |
US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
KR20100090692A (ko) * | 2007-10-24 | 2010-08-16 | 맨카인드 코포레이션 | 활성제의 전달 |
EP2211842B1 (fr) | 2007-10-24 | 2015-08-12 | MannKind Corporation | Une formulation de poudre sèche inhalable comprenant de glp-1 pour l'utilisation dans le traitement de l'hyperglycémie et du diabète par administration pulmonaire |
US9179691B2 (en) | 2007-12-14 | 2015-11-10 | Aerodesigns, Inc. | Delivering aerosolizable food products |
GB0802028D0 (en) * | 2008-02-05 | 2008-03-12 | Dunne Stephen T | Powder inhaler flow regulator |
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DK2254629T3 (en) * | 2008-03-27 | 2016-01-25 | Mannkind Corp | The dry powder inhalation |
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EP3281663B8 (fr) | 2008-06-13 | 2022-09-21 | MannKind Corporation | Inhalateur de poudre sèche alimenté par la respiration pour l'administration de médicaments |
US20190262557A1 (en) * | 2010-03-04 | 2019-08-29 | Mannkind Corporation | Dry powder drug delivery system |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
AU2015275293B2 (en) * | 2008-06-13 | 2018-06-07 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
AU2014200952B2 (en) * | 2008-06-13 | 2014-12-11 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
ES2421385T3 (es) | 2008-06-20 | 2013-09-02 | Mannkind Corp | Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación |
JP5339797B2 (ja) * | 2008-07-08 | 2013-11-13 | キヤノン株式会社 | 吸入装置 |
CA2733017A1 (fr) | 2008-08-05 | 2010-02-11 | Mannkind Corporation | Modules de distributeur de poudre et ensembles distributeurs de poudre ameliores |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
JP5026597B2 (ja) | 2008-11-04 | 2012-09-12 | パナソニック株式会社 | 測定装置、測定方法及びプログラム |
US9956359B2 (en) | 2008-12-23 | 2018-05-01 | Koninklijke Philips N.V. | Method and apparatus comprising stepped mouthpiece for aerosol drug delivery |
ES2531009T3 (es) | 2008-12-29 | 2015-03-09 | Mannkind Corp | Análogos sustituidos de dicetopiperazina para su uso como agentes para la administración de fármacos |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US8550074B2 (en) * | 2009-01-15 | 2013-10-08 | Manta Devices, Llc | Delivery device and related methods |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
MX2011009251A (es) * | 2009-03-04 | 2011-11-18 | Mannkind Corp | Sistema mejorado de suministro de farmaco en polvo seco. |
WO2010105094A1 (fr) | 2009-03-11 | 2010-09-16 | Mannkind Corporation | Appareil, système et procédé de mesure de résistance d'un inhalateur |
BRPI1008998A2 (pt) * | 2009-03-18 | 2016-03-22 | Mannkind Corp | adaptador de inalador para um aparelho de difração de laser e método para medir a distribuição de tamanho de partícula |
CN102421474B (zh) * | 2009-05-11 | 2014-07-02 | 皇家飞利浦电子股份有限公司 | 气雾药物输送装置与方法 |
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2003
- 2003-09-04 US US10/655,153 patent/US7464706B2/en not_active Expired - Lifetime
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2004
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- 2004-09-03 BR BRPI0414085-0A patent/BRPI0414085A/pt not_active Application Discontinuation
- 2004-09-03 NZ NZ577038A patent/NZ577038A/en not_active IP Right Cessation
- 2004-09-03 AU AU2004270204A patent/AU2004270204B2/en not_active Ceased
- 2004-09-03 KR KR1020077029059A patent/KR20080003462A/ko not_active Application Discontinuation
- 2004-09-03 EP EP04783061.7A patent/EP1670532B1/fr not_active Expired - Lifetime
- 2004-09-03 CN CN200910133514.3A patent/CN101554504B/zh not_active Expired - Fee Related
- 2004-09-03 CA CA002537498A patent/CA2537498C/fr not_active Expired - Lifetime
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- 2004-09-03 MX MXPA06002544A patent/MXPA06002544A/es active IP Right Grant
- 2004-09-03 CA CA 2635665 patent/CA2635665C/fr not_active Expired - Lifetime
- 2004-09-03 WO PCT/US2004/028699 patent/WO2005023348A2/fr active Application Filing
- 2004-09-03 DK DK04783061.7T patent/DK1670532T3/en active
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