CA2499756C - Imidazopyrazines as cyclin dependent kinase inhibitors - Google Patents

Imidazopyrazines as cyclin dependent kinase inhibitors Download PDF

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Publication number
CA2499756C
CA2499756C CA2499756A CA2499756A CA2499756C CA 2499756 C CA2499756 C CA 2499756C CA 2499756 A CA2499756 A CA 2499756A CA 2499756 A CA2499756 A CA 2499756A CA 2499756 C CA2499756 C CA 2499756C
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Prior art keywords
aryl
group
compound
alkyl
nr5r6
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Expired - Fee Related
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CA2499756A
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English (en)
French (fr)
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CA2499756A1 (en
Inventor
Kamil Paruch
Timothy J. Guzi
Michael P. Dwyer
Ronald J. Doll
Viyyoor M. Girijavallabhan
Alan K. Mallams
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Merck Sharp & Dohme LLC
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Schering Corp
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Publication of CA2499756C publication Critical patent/CA2499756C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2499756A 2002-09-23 2003-09-19 Imidazopyrazines as cyclin dependent kinase inhibitors Expired - Fee Related CA2499756C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41299702P 2002-09-23 2002-09-23
US60/412,997 2002-09-23
PCT/US2003/029209 WO2004026877A1 (en) 2002-09-23 2003-09-19 Imidazopyrazines as cyclin dependent kinase inhibitors

Publications (2)

Publication Number Publication Date
CA2499756A1 CA2499756A1 (en) 2004-04-01
CA2499756C true CA2499756C (en) 2011-07-12

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Family Applications (1)

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CA2499756A Expired - Fee Related CA2499756C (en) 2002-09-23 2003-09-19 Imidazopyrazines as cyclin dependent kinase inhibitors

Country Status (18)

Country Link
US (2) US6919341B2 (cg-RX-API-DMAC10.html)
EP (1) EP1543008B1 (cg-RX-API-DMAC10.html)
JP (1) JP4799864B2 (cg-RX-API-DMAC10.html)
KR (1) KR20050057520A (cg-RX-API-DMAC10.html)
CN (1) CN1694886A (cg-RX-API-DMAC10.html)
AR (1) AR041347A1 (cg-RX-API-DMAC10.html)
AT (1) ATE377600T1 (cg-RX-API-DMAC10.html)
AU (1) AU2003272476B2 (cg-RX-API-DMAC10.html)
CA (1) CA2499756C (cg-RX-API-DMAC10.html)
DE (1) DE60317353T2 (cg-RX-API-DMAC10.html)
ES (1) ES2293015T3 (cg-RX-API-DMAC10.html)
MX (1) MXPA05003120A (cg-RX-API-DMAC10.html)
MY (1) MY134589A (cg-RX-API-DMAC10.html)
NZ (2) NZ538685A (cg-RX-API-DMAC10.html)
PE (1) PE20050081A1 (cg-RX-API-DMAC10.html)
TW (1) TW200413378A (cg-RX-API-DMAC10.html)
WO (1) WO2004026877A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200502375B (cg-RX-API-DMAC10.html)

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HK1072056A1 (en) 2005-08-12
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AU2003272476B2 (en) 2007-07-05
ZA200502375B (en) 2005-09-27
US7432265B2 (en) 2008-10-07
EP1543008A1 (en) 2005-06-22
DE60317353D1 (de) 2007-12-20
CA2499756A1 (en) 2004-04-01
JP2006507253A (ja) 2006-03-02
NZ538685A (en) 2008-02-29
DE60317353T2 (de) 2008-08-28
EP1543008B1 (en) 2007-11-07
CN1694886A (zh) 2005-11-09
US20050130980A1 (en) 2005-06-16
ATE377600T1 (de) 2007-11-15
TW200413378A (en) 2004-08-01
US20040063715A1 (en) 2004-04-01
JP4799864B2 (ja) 2011-10-26
MY134589A (en) 2007-12-31
AR041347A1 (es) 2005-05-11
ES2293015T3 (es) 2008-03-16
WO2004026877A1 (en) 2004-04-01
US6919341B2 (en) 2005-07-19
PE20050081A1 (es) 2005-03-01
NZ563374A (en) 2009-06-26
MXPA05003120A (es) 2005-06-22

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