CA2472249A1 - Pharmaceutical compositions for hepatitis c viral protease inhibitors - Google Patents
Pharmaceutical compositions for hepatitis c viral protease inhibitors Download PDFInfo
- Publication number
- CA2472249A1 CA2472249A1 CA002472249A CA2472249A CA2472249A1 CA 2472249 A1 CA2472249 A1 CA 2472249A1 CA 002472249 A CA002472249 A CA 002472249A CA 2472249 A CA2472249 A CA 2472249A CA 2472249 A1 CA2472249 A1 CA 2472249A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutically acceptable
- pharmaceutical composition
- composition according
- compound
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 67
- 230000003612 virological effect Effects 0.000 title claims abstract description 7
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract description 9
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract description 6
- 208000006454 hepatitis Diseases 0.000 title description 2
- 231100000283 hepatitis Toxicity 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 216
- 150000001412 amines Chemical class 0.000 claims abstract description 48
- 238000000034 method Methods 0.000 claims abstract description 34
- 241000711549 Hepacivirus C Species 0.000 claims abstract description 19
- 208000005176 Hepatitis C Diseases 0.000 claims abstract description 17
- 238000011282 treatment Methods 0.000 claims abstract description 9
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 8
- 230000010076 replication Effects 0.000 claims abstract description 6
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- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical group NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
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- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims description 4
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- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims description 3
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- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 claims description 3
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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Landscapes
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- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35569402P | 2002-02-07 | 2002-02-07 | |
| US60/355,694 | 2002-02-07 | ||
| PCT/US2003/003380 WO2003066103A1 (en) | 2002-02-07 | 2003-02-05 | Pharmaceutical compositions for hepatitis c viral protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2472249A1 true CA2472249A1 (en) | 2003-08-14 |
Family
ID=27734548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002472249A Abandoned CA2472249A1 (en) | 2002-02-07 | 2003-02-05 | Pharmaceutical compositions for hepatitis c viral protease inhibitors |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6828301B2 (enExample) |
| EP (1) | EP1474172B1 (enExample) |
| JP (1) | JP2005518423A (enExample) |
| KR (1) | KR20040089605A (enExample) |
| CN (1) | CN1627959A (enExample) |
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| DE2907460A1 (de) | 1978-03-07 | 1979-09-13 | Sandoz Ag | Neue resorbierbare galenische kompositionen |
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2003
- 2003-02-04 US US10/357,919 patent/US6828301B2/en not_active Expired - Lifetime
- 2003-02-05 HR HR20040720A patent/HRP20040720A2/hr not_active Application Discontinuation
- 2003-02-05 UY UY27650A patent/UY27650A1/es not_active Application Discontinuation
- 2003-02-05 AU AU2003208989A patent/AU2003208989A1/en not_active Abandoned
- 2003-02-05 DE DE60309433T patent/DE60309433T2/de not_active Expired - Fee Related
- 2003-02-05 EA EA200400991A patent/EA200400991A1/ru unknown
- 2003-02-05 MX MXPA04007699A patent/MXPA04007699A/es not_active Application Discontinuation
- 2003-02-05 JP JP2003565526A patent/JP2005518423A/ja active Pending
- 2003-02-05 PE PE2003000135A patent/PE20030865A1/es not_active Application Discontinuation
- 2003-02-05 CA CA002472249A patent/CA2472249A1/en not_active Abandoned
- 2003-02-05 PL PL03371287A patent/PL371287A1/xx not_active Application Discontinuation
- 2003-02-05 IL IL16267303A patent/IL162673A0/xx unknown
- 2003-02-05 CN CNA03803395XA patent/CN1627959A/zh active Pending
- 2003-02-05 AT AT03707713T patent/ATE344056T1/de not_active IP Right Cessation
- 2003-02-05 EP EP03707713A patent/EP1474172B1/en not_active Expired - Lifetime
- 2003-02-05 ES ES03707713T patent/ES2276045T3/es not_active Expired - Lifetime
- 2003-02-05 WO PCT/US2003/003380 patent/WO2003066103A1/en not_active Ceased
- 2003-02-05 KR KR10-2004-7012235A patent/KR20040089605A/ko not_active Withdrawn
- 2003-02-05 BR BR0307524-9A patent/BR0307524A/pt not_active Application Discontinuation
- 2003-02-06 TW TW092102382A patent/TW200302734A/zh unknown
- 2003-02-07 AR ARP030100386A patent/AR038823A1/es unknown
-
2004
- 2004-06-25 ZA ZA200405064A patent/ZA200405064B/en unknown
- 2004-08-06 EC EC2004005223A patent/ECSP045223A/es unknown
- 2004-09-06 NO NO20043722A patent/NO20043722L/no not_active Application Discontinuation
- 2004-09-07 CO CO04088288A patent/CO5611167A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6828301B2 (en) | 2004-12-07 |
| WO2003066103A1 (en) | 2003-08-14 |
| ECSP045223A (es) | 2004-09-28 |
| UY27650A1 (es) | 2003-09-30 |
| PE20030865A1 (es) | 2003-11-26 |
| AU2003208989A1 (en) | 2003-09-02 |
| KR20040089605A (ko) | 2004-10-21 |
| JP2005518423A (ja) | 2005-06-23 |
| HRP20040720A2 (en) | 2005-04-30 |
| BR0307524A (pt) | 2004-12-21 |
| MXPA04007699A (es) | 2004-11-10 |
| EP1474172A1 (en) | 2004-11-10 |
| ES2276045T3 (es) | 2007-06-16 |
| ATE344056T1 (de) | 2006-11-15 |
| EP1474172B1 (en) | 2006-11-02 |
| AR038823A1 (es) | 2005-01-26 |
| NO20043722L (no) | 2004-09-06 |
| CN1627959A (zh) | 2005-06-15 |
| CO5611167A2 (es) | 2006-02-28 |
| PL371287A1 (en) | 2005-06-13 |
| DE60309433D1 (de) | 2006-12-14 |
| DE60309433T2 (de) | 2007-05-03 |
| IL162673A0 (en) | 2005-11-20 |
| TW200302734A (en) | 2003-08-16 |
| EA200400991A1 (ru) | 2005-02-24 |
| ZA200405064B (en) | 2005-05-30 |
| US20030195228A1 (en) | 2003-10-16 |
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| EEER | Examination request | ||
| FZDE | Discontinued |