CA2420987A1 - Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine - Google Patents

Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine Download PDF

Info

Publication number
CA2420987A1
CA2420987A1 CA002420987A CA2420987A CA2420987A1 CA 2420987 A1 CA2420987 A1 CA 2420987A1 CA 002420987 A CA002420987 A CA 002420987A CA 2420987 A CA2420987 A CA 2420987A CA 2420987 A1 CA2420987 A1 CA 2420987A1
Authority
CA
Canada
Prior art keywords
olanzapine
methyl
thieno
dichloromethane
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002420987A
Other languages
English (en)
French (fr)
Inventor
Robert Koprowski
Buchi Reddy Reguri
Ramesh Chakka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2420987A1 publication Critical patent/CA2420987A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002420987A 2000-08-31 2001-03-07 Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine Abandoned CA2420987A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN709/MAS/2000 2000-08-31
IN711CH2000 2000-08-31
IN709CH2000 2000-08-31
IN711/MAS/2000 2000-08-31
PCT/US2001/007258 WO2002018390A1 (en) 2000-08-31 2001-03-07 Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine

Publications (1)

Publication Number Publication Date
CA2420987A1 true CA2420987A1 (en) 2002-03-07

Family

ID=26324874

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002420987A Abandoned CA2420987A1 (en) 2000-08-31 2001-03-07 Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine

Country Status (12)

Country Link
EP (1) EP1313742A1 (sk)
JP (1) JP2004507548A (sk)
AU (1) AU2001243475A1 (sk)
BR (1) BR0114031A (sk)
CA (1) CA2420987A1 (sk)
CZ (1) CZ2003566A3 (sk)
HU (1) HUP0300875A3 (sk)
IL (1) IL154688A0 (sk)
NO (1) NO20030926L (sk)
RU (1) RU2003108745A (sk)
SK (1) SK2502003A3 (sk)
WO (1) WO2002018390A1 (sk)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002340328A1 (en) * 2001-10-29 2003-05-12 Janet I. Cord Olanzapine dihydrate-ii a process for its preparation and use thereof
WO2003091260A1 (en) * 2002-04-23 2003-11-06 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
AU2002251329A1 (en) * 2002-04-25 2003-11-10 Generics (Uk) Limited Novel crystalline forms of celecoxib and other compounds
PL196814B1 (pl) * 2002-05-17 2008-02-29 Inst Farmaceutyczny Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
ATE500258T1 (de) 2002-05-31 2011-03-15 Sandoz Ag Verfahren zur herstellung von olanzapin form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
EP1575962A1 (en) 2002-12-24 2005-09-21 Teva Pharmaceutical Industries Limited Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
EP1611139B1 (en) 2003-12-22 2008-06-04 Teva Pharmaceutical Industries Ltd. Methods of preparing olanzapine
AR047460A1 (es) * 2004-01-27 2006-01-18 Synthon Bv Proceso para la fabricacion de acetato de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (acetato de olanzapina)
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
US20070072845A1 (en) * 2004-02-19 2007-03-29 Davuluri Rammohan Rao Process for the preparation of olanzapine form 1 useful as antipsychotic drug
WO2005107375A2 (en) * 2004-05-06 2005-11-17 Matrix Laboratories Ltd Process for the preparation of olanzapine form-i
US20080009481A1 (en) * 2004-07-14 2008-01-10 Shasun Chemicals And Drugs Limited Process For Making Form I Of Olanzapine
CA2576862C (en) 2004-07-14 2012-09-11 Jubilant Organosys Limited A process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2,3-b][1,5]benzodiazepine
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
WO2006025065A1 (en) * 2004-08-31 2006-03-09 Lee Pharma Private Limited A process for the preparation of anhydrous olanzopine hydrochloride of form-1
ES2303462B1 (es) * 2004-09-06 2009-06-05 Shasun Chemicals And Drugs Limited Nuevo procedimiento para la preparacion de una forma polimorfica i de olanzapina farmaceuticamente pura.
US7932249B2 (en) * 2005-01-05 2011-04-26 Eli Lilly And Company Olanzapine pamoate dihydrate
WO2006102176A2 (en) * 2005-03-21 2006-09-28 Dr. Reddy's Laboratories Ltd. Process for preparing crystalline form i of olanzapine
HUP0501046A2 (en) * 2005-11-11 2007-08-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of olanzapine
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
PL381564A1 (pl) 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
CA2687143A1 (en) * 2007-05-15 2008-11-20 Generics [Uk] Limited Process for the purification of olanzapine
EP2292624A1 (en) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Process for the purification of olanzapine
CN102093386B (zh) * 2011-01-05 2016-06-01 浙江华海药业股份有限公司 一种制备奥兰扎平晶型ⅱ的方法
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法
FI3466934T3 (fi) 2016-05-31 2024-04-23 Taiho Pharmaceutical Co Ltd Sulfonamidiyhdisteitä tai niiden suola ribonukleotidireduktaasin inhibiittoreina syövän hoitamiseksi

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9009229D0 (en) 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
ID21924A (id) * 1996-09-23 1999-08-12 Lilly Co Eli Olanzapin dihidrat d
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine

Also Published As

Publication number Publication date
WO2002018390A1 (en) 2002-03-07
BR0114031A (pt) 2003-09-09
CZ2003566A3 (cs) 2004-01-14
RU2003108745A (ru) 2005-01-10
SK2502003A3 (en) 2004-03-02
EP1313742A1 (en) 2003-05-28
HUP0300875A3 (en) 2005-09-28
AU2001243475A1 (en) 2002-03-13
HUP0300875A2 (hu) 2003-12-29
JP2004507548A (ja) 2004-03-11
IL154688A0 (en) 2003-09-17
NO20030926D0 (no) 2003-02-27
NO20030926L (no) 2003-04-24

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Legal Events

Date Code Title Description
FZDE Discontinued