CA2328471C - Polyhydroxyalkanoate biopolymer compositions - Google Patents

Polyhydroxyalkanoate biopolymer compositions Download PDF

Info

Publication number
CA2328471C
CA2328471C CA2328471A CA2328471A CA2328471C CA 2328471 C CA2328471 C CA 2328471C CA 2328471 A CA2328471 A CA 2328471A CA 2328471 A CA2328471 A CA 2328471A CA 2328471 C CA2328471 C CA 2328471C
Authority
CA
Canada
Prior art keywords
hydroxybutyrate
hydroxyvalerate
polymer
poly
bacterial system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2328471A
Other languages
English (en)
French (fr)
Other versions
CA2328471A1 (en
Inventor
Frank A. Skraly
Oliver P. Peoples
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
Priority to CA2726139A priority Critical patent/CA2726139A1/en
Publication of CA2328471A1 publication Critical patent/CA2328471A1/en
Application granted granted Critical
Publication of CA2328471C publication Critical patent/CA2328471C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
CA2328471A 1998-05-22 1999-05-21 Polyhydroxyalkanoate biopolymer compositions Expired - Fee Related CA2328471C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2726139A CA2726139A1 (en) 1998-05-22 1999-05-21 Polyhdroxyalkanoate biopolymer compositions

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8639698P 1998-05-22 1998-05-22
US60/086,396 1998-05-22
PCT/US1999/011417 WO1999061624A2 (en) 1998-05-22 1999-05-21 Polyhydroxyalkanoate biopolymer compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2726139A Division CA2726139A1 (en) 1998-05-22 1999-05-21 Polyhdroxyalkanoate biopolymer compositions

Publications (2)

Publication Number Publication Date
CA2328471A1 CA2328471A1 (en) 1999-12-02
CA2328471C true CA2328471C (en) 2013-09-17

Family

ID=22198310

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2726139A Abandoned CA2726139A1 (en) 1998-05-22 1999-05-21 Polyhdroxyalkanoate biopolymer compositions
CA2328471A Expired - Fee Related CA2328471C (en) 1998-05-22 1999-05-21 Polyhydroxyalkanoate biopolymer compositions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2726139A Abandoned CA2726139A1 (en) 1998-05-22 1999-05-21 Polyhdroxyalkanoate biopolymer compositions

Country Status (9)

Country Link
US (3) US6323010B1 (enExample)
EP (2) EP1078068B1 (enExample)
JP (2) JP2002516384A (enExample)
AT (1) ATE483023T1 (enExample)
AU (1) AU4199599A (enExample)
CA (2) CA2726139A1 (enExample)
DE (1) DE69942799D1 (enExample)
MX (1) MXPA00011401A (enExample)
WO (1) WO1999061624A2 (enExample)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1867348B1 (en) 1999-03-25 2012-05-16 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
JP3684150B2 (ja) * 1999-12-27 2005-08-17 キヤノン株式会社 ポリヒドロキシアルカノエート
US6225438B1 (en) * 2000-01-31 2001-05-01 The Procter & Gamble Company Medium chain length PHA copolymer and process for producing same
AU2001275996B2 (en) * 2000-07-21 2005-08-04 Cj Cheiljedang Corporation Production of polyhydroxyalkanoates from polyols
WO2002042418A2 (en) 2000-11-20 2002-05-30 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
US7230144B2 (en) 2001-12-18 2007-06-12 Metabolix Inc. Methods of making intermediates from polyhydroxyalkanoates
KR100482776B1 (ko) 2003-04-23 2005-04-14 한국과학기술원 ＭａｏＣ 단백질을 이용한 폴리히드록시알칸산의 제조방법
ES2819189T3 (es) 2003-05-08 2021-04-15 Tepha Inc Tejidos y fibras médicos de polihidroxialcanoato
US7353020B2 (en) * 2003-11-17 2008-04-01 Hitachi Communication Technologies, Ltd. Radio access point testing apparatus and method of testing radio access point
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
US7641825B2 (en) 2004-08-03 2010-01-05 Tepha, Inc. Method of making a polyhydroxyalkanoate filament
KR100979694B1 (ko) 2005-05-24 2010-09-02 한국과학기술원 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
US8637126B2 (en) * 2006-02-06 2014-01-28 International Paper Co. Biodegradable paper-based laminate with oxygen and moisture barrier properties and method for making biodegradable paper-based laminate
ATE520425T1 (de) * 2006-02-07 2011-09-15 Tepha Inc Verstärkte polymilchsäurepolymere und -copolymere
ES2624589T3 (es) * 2006-02-07 2017-07-17 Tepha, Inc. Métodos y dispositivos para la reparación del manguito de los rotadores
US8979921B2 (en) * 2006-02-07 2015-03-17 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US9592325B2 (en) * 2006-02-07 2017-03-14 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US9089627B2 (en) 2006-07-11 2015-07-28 Abbott Cardiovascular Systems Inc. Stent fabricated from polymer composite toughened by a dispersed phase
AU2007297645B2 (en) * 2006-09-19 2013-01-17 E. I. Du Pont De Nemours And Company Toughened poly(hydroxyalkanoic acid) compositions
EP4047033A1 (en) 2006-11-21 2022-08-24 LG Chem, Ltd. Copolymer comprising 4-hydroxybutyrate unit and lactate unit and its manufacturing method
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
EP2111186A1 (en) * 2007-02-02 2009-10-28 Tornier, Inc. System and method for repairing tendons and ligaments
WO2009003178A2 (en) * 2007-06-27 2008-12-31 Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Reagents and methods for cyanobacterial production of bioplastics and biomaterials
WO2009085823A1 (en) * 2007-12-19 2009-07-09 Tepha, Inc. Medical devices containing melt-blown non-wovens of poly-r-hydroxybutyrate and copolymers
WO2009145840A2 (en) * 2008-04-04 2009-12-03 Massachusetts Institute Of Technology Cellular production of hydroxyvalerates from levulinate
US9090898B2 (en) * 2008-12-12 2015-07-28 Metabolix, Inc. Green process and compositions for producing poly(5HV) and 5 carbon chemicals
US20110028622A1 (en) 2009-07-28 2011-02-03 E. I. Du Pont De Nemours And Company Poly(hydroxyalkanoic acid) blown film
BR112012005591A2 (pt) 2009-09-15 2015-09-01 Metabolix Inc Geração de sementes oleaginosas produzindo alto poliidroxibutirato.
US8349955B2 (en) 2009-09-24 2013-01-08 E I Du Pont De Nemours And Company Poly(hydroxyalkanoic acid) plasticized with poly(trimethylene ether) glycol
RU2012133186A (ru) 2010-02-11 2014-03-20 Метаболикс, Инк. Способ получения гамма-бутиролактона
EP3639861B1 (en) 2010-03-26 2022-04-20 Tepha, Inc. Coatings for the manufacture and application of polyhydroxyalkanoate medical devices
WO2011159784A1 (en) 2010-06-15 2011-12-22 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers
US9511169B2 (en) 2010-06-15 2016-12-06 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
EP2637734B1 (en) 2010-11-09 2017-09-13 Tepha, Inc. Drug eluting cochlear implants
WO2012075051A1 (en) 2010-11-29 2012-06-07 Micromidas, Inc. Pha-producing bacteria
KR101575585B1 (ko) 2011-03-11 2015-12-21 한국과학기술원 글루코오스로부터〔락테이트­ｃｏ­글리콜레이트〕공중합체 생산능을 가지는 재조합 미생물 및 이를 이용한 〔락테이트­ｃｏ­글리콜레이트〕공중합체의 제조방법
KR101328567B1 (ko) * 2011-03-11 2013-11-13 한국화학연구원 ２­하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트를 생산하는 능력을 가지는 재조합 미생물 및 이를 이용한 ２­하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트의 제조방법
EP3266806A1 (en) 2011-09-27 2018-01-10 Tepha, Inc. A method of making an article comrising poly-4-hydroxybutyrate or a copolymer thereof
WO2013063310A1 (en) 2011-10-26 2013-05-02 E. I. Du Pont De Nemours And Company Multilayer film structure comprising renewably sourced materials
KR101630003B1 (ko) * 2011-11-28 2016-06-13 주식회사 엘지화학 2-하이드록시알카노에이트 중합체의 제조방법
EP3238751B1 (en) 2012-05-21 2020-07-08 Tepha, Inc. Resorbable bioceramic compositions of poly-4-hydroxybutyrate and copolymers
US9359283B2 (en) 2012-05-31 2016-06-07 Micromidas, Inc. Polyhydroxyalkanoate derivatives, preparation and uses thereof
US9850192B2 (en) 2012-06-08 2017-12-26 Cj Cheiljedang Corporation Renewable acrylic acid production and products made therefrom
ES2751398T3 (es) 2013-01-15 2020-03-31 Tepha Inc Implantes para regeneración de tejido blando y tejido duro
WO2014127053A2 (en) 2013-02-13 2014-08-21 Metabolix, Inc. Process for ultra pure chemical production from biobased raw starting materials
US10201640B2 (en) 2013-03-13 2019-02-12 Tepha, Inc. Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof
EP3036277B1 (en) 2013-08-20 2021-05-26 Tepha, Inc. Closed cell foams including poly-4-hydroxybutyrate and copolymers thereof
US9687585B2 (en) 2013-08-20 2017-06-27 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
US9302029B2 (en) 2013-10-31 2016-04-05 Tepha, Inc. Pultrusion of poly-4-hydroxybutyrate and copolymers thereof
US9480780B2 (en) 2013-11-05 2016-11-01 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
US11154642B2 (en) 2013-12-26 2021-10-26 Tepha, Inc. Medical implants including laminates of poly-4-hydroxybutyrate and copolymers thereof
ES2685963T3 (es) 2014-03-18 2018-10-15 Tepha, Inc. Bandas de microfibras de poli-4-hidroxibutirato y sus copolímeros producidas por hilado centrífugo
ES2911675T3 (es) 2014-04-30 2022-05-20 Tepha Inc Implantes tridimensionales reabsorbibles para el refuerzo de tejidos y la reparación de hernias
WO2016057083A2 (en) 2014-05-16 2016-04-14 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
WO2016028292A1 (en) 2014-08-20 2016-02-25 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
WO2016048950A1 (en) 2014-09-22 2016-03-31 Tepha, Inc. Oriented p4hb implants containing antimicrobial agents
CA2969429C (en) 2014-12-11 2020-10-27 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
EP3365427B1 (en) 2015-10-23 2020-08-19 Metabolic Explorer Microorganism modified for the assimilation of levulinic acid
KR101774431B1 (ko) 2016-01-28 2017-09-05 한국과학기술원 자일로즈로부터 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체 생산능을 가지는 재조합 미생물 및 이를 이용한 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체의 제조방법
US20230183418A1 (en) * 2016-03-28 2023-06-15 Lg Chem,Ltd Liquid biopolymer, use thereof, and preparation method
KR102036828B1 (ko) 2017-02-28 2019-10-25 한국과학기술원 2-하이드록시이소카프로에이트-CoA 전이효소를 이용한 폴리하이드록시알카노에이트의 제조방법
WO2018159965A1 (ko) 2017-02-28 2018-09-07 한국과학기술원 2-하이드록시이소카프로에이트-CoA 전이효소를 이용한 폴리하이드록시알카노에이트의 제조방법
ES2935295T3 (es) 2017-05-25 2023-03-03 Tepha Inc Formación continua de tubos de poli-4-hidroxibutirato y sus copolímeros
CA3074733C (en) 2017-09-06 2022-06-21 Tepha, Inc. Calendered surgical meshes comprising polyhydroxyalkanoates
WO2019112925A1 (en) 2017-12-04 2019-06-13 Tepha, Inc. Vacuum membrane thermoformed poly-4-hydroxybutyrate medical implants
WO2019241227A2 (en) 2018-06-11 2019-12-19 Tepha, Inc. Methods for 3d printing of poly-4-hydroxybutyrate and copolymers
ES2956815T3 (es) 2018-10-29 2023-12-28 Tepha Inc Procedimientos de fabricación de suturas de malla a partir de poli-4-hidroxibutirato y sus copolímeros
CN109913510B (zh) * 2019-03-29 2021-04-13 长春理工大学 一种聚羟基脂肪酸酯的体外合成方法
JP7764034B2 (ja) * 2020-02-28 2025-11-05 国立大学法人北海道大学 ブロック共重合体、及びその製造方法
CA3213145A1 (en) 2021-03-11 2022-09-15 Tepha, Inc. Breast reconstruction implant

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275610A (en) * 1964-03-24 1966-09-27 Mobil Oil Corp Microbial synthesis of polymers
US4477654A (en) 1981-07-07 1984-10-16 Imperial Chemical Industries Plc 3-Hydroxybutyrate polymers
US5229279A (en) 1987-06-29 1993-07-20 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5250430A (en) * 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
EP0870837B1 (en) * 1989-07-10 2002-11-06 Massachusetts Institute Of Technology A recombinant plant or plant cell capable of producing polyhydroxybutyrate or another polyhydroxyalkanoate
JPH03224492A (ja) * 1990-01-29 1991-10-03 Showa Denko Kk 共重合体およびその製造法
JPH0465425A (ja) * 1990-07-06 1992-03-02 Showa Denko Kk 共重合体及びその製造法
JPH04104717A (ja) * 1990-08-23 1992-04-07 Mitsubishi Agricult Mach Co Ltd チューブ肥料
GB9108756D0 (en) * 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
US5610041A (en) 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
JP2777757B2 (ja) * 1991-09-17 1998-07-23 鐘淵化学工業株式会社 共重合体およびその製造方法
EP0560984B1 (en) 1991-09-27 1999-05-26 Terumo Kabushiki Kaisha Flexible member for medical use
BR9506664A (pt) 1994-01-28 1997-09-16 Procter & Gamble Copolímeros biodegradâveis e artigos plásticos compreendendo copolímeros biodegradâveis de 3-hidroxihexanoato
JP2000502256A (ja) * 1995-12-19 2000-02-29 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ ポリヒドロキシアルカノエートモノマーシンターゼの代謝エンジニアリング
US5750848A (en) * 1996-08-13 1998-05-12 Monsanto Company DNA sequence useful for the production of polyhydroxyalkanoates
ATE297469T1 (de) 1997-03-03 2005-06-15 Metabolix Inc Verfahren zur polyestern-biosynthese
EP1015565B1 (en) 1997-09-19 2006-04-12 Metabolix, Inc. Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids

Also Published As

Publication number Publication date
EP2267133B1 (en) 2017-07-12
DE69942799D1 (en) 2010-11-11
CA2328471A1 (en) 1999-12-02
CA2726139A1 (en) 1999-12-02
EP2267133A2 (en) 2010-12-29
US6323010B1 (en) 2001-11-27
US20040033572A1 (en) 2004-02-19
JP2002516384A (ja) 2002-06-04
ATE483023T1 (de) 2010-10-15
EP2267133A3 (en) 2011-09-14
US20080275208A1 (en) 2008-11-06
US8093022B2 (en) 2012-01-10
EP1078068B1 (en) 2010-09-29
WO1999061624A3 (en) 2000-02-17
US7202064B2 (en) 2007-04-10
JP2010213700A (ja) 2010-09-30
AU4199599A (en) 1999-12-13
EP1078068A2 (en) 2001-02-28
MXPA00011401A (es) 2003-04-22
WO1999061624A2 (en) 1999-12-02

Similar Documents

Publication Publication Date Title
CA2328471C (en) Polyhydroxyalkanoate biopolymer compositions
JP5042407B2 (ja) ポリオールからのポリヒドロキシアルカノエートの産生
EP1581619B1 (en) Polyhydroxyalkanoate production by coenzyme a-dependent aldehyde dehydrogenase pathways
EP1208208B1 (en) Transgenic systems for the manufacture of poly(3-hydroxy -butyrate -co -3- hydroxyhexanoate)
EP2669365B1 (en) Method for producing high-molecular-weight pha
US20130017583A1 (en) Methods for producing polyhydroxyalkanoate copolymer with high medium chain length monomer content
KR20150004830A (ko) 유전적으로 조작된 pha 생산 미생물
Aldor et al. Metabolic engineering of poly (3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) composition in recombinant Salmonella enterica serovar typhimurium
AU2003200941B2 (en) Polyhydroxyalkanoate biopolymer compositions
CA2730220A1 (en) Method for polymerising glycolic acid with microorganisms
JP5103619B2 (ja) 共重合ポリエステルの製造法
Wang et al. Cloning and expression of the PHA synthase genes phaC1 and phaC1AB into Bacillus subtilis
Lee et al. Polyhydroxyalkanoates, a Family of Biodegradable Polymers
HK1161900A (en) Polyhydroxyalkanoate production by coenzyme a-dependent aldehyde dehydrogenase pathways
HK1132297A (en) Transgenic systems for the manufacture of poly(3-hydroxy-butyrate-co-3-hydroxyhexanoate)

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20190521