CA2301177C - Succinic acid production and purification - Google Patents
Succinic acid production and purification Download PDFInfo
- Publication number
- CA2301177C CA2301177C CA002301177A CA2301177A CA2301177C CA 2301177 C CA2301177 C CA 2301177C CA 002301177 A CA002301177 A CA 002301177A CA 2301177 A CA2301177 A CA 2301177A CA 2301177 C CA2301177 C CA 2301177C
- Authority
- CA
- Canada
- Prior art keywords
- succinic acid
- ammonium
- succinate
- sulfate
- stream
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title claims abstract description 293
- 239000001384 succinic acid Substances 0.000 title claims abstract description 138
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 22
- 238000000746 purification Methods 0.000 title description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 210
- 238000000034 method Methods 0.000 claims abstract description 72
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims abstract description 65
- BIGPRXCJEDHCLP-UHFFFAOYSA-N ammonium bisulfate Chemical compound [NH4+].OS([O-])(=O)=O BIGPRXCJEDHCLP-UHFFFAOYSA-N 0.000 claims abstract description 62
- NHJPVZLSLOHJDM-UHFFFAOYSA-N azane;butanedioic acid Chemical compound [NH4+].[NH4+].[O-]C(=O)CCC([O-])=O NHJPVZLSLOHJDM-UHFFFAOYSA-N 0.000 claims abstract description 48
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims abstract description 43
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims abstract description 43
- 235000011130 ammonium sulphate Nutrition 0.000 claims abstract description 43
- 229910021529 ammonia Inorganic materials 0.000 claims abstract description 28
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims abstract description 21
- 150000003890 succinate salts Chemical class 0.000 claims abstract description 13
- 230000007935 neutral effect Effects 0.000 claims abstract description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims abstract description 8
- 150000001768 cations Chemical class 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 50
- 239000002585 base Substances 0.000 claims description 27
- 238000000855 fermentation Methods 0.000 claims description 26
- 230000004151 fermentation Effects 0.000 claims description 25
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 20
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 16
- 239000007864 aqueous solution Substances 0.000 claims description 15
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 14
- -1 ammonium ions Chemical class 0.000 claims description 11
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 10
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 10
- 150000001720 carbohydrates Chemical class 0.000 claims description 9
- 239000001569 carbon dioxide Substances 0.000 claims description 8
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 8
- 238000005336 cracking Methods 0.000 claims description 8
- 244000005700 microbiome Species 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- 238000001704 evaporation Methods 0.000 claims description 5
- 230000008020 evaporation Effects 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 4
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims description 2
- 229910001415 sodium ion Inorganic materials 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 3
- 229910001413 alkali metal ion Inorganic materials 0.000 claims 1
- 229910000000 metal hydroxide Inorganic materials 0.000 claims 1
- 150000004692 metal hydroxides Chemical class 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract description 50
- 230000008569 process Effects 0.000 abstract description 27
- 239000000463 material Substances 0.000 abstract description 13
- 239000002253 acid Substances 0.000 abstract description 11
- 239000006227 byproduct Substances 0.000 abstract description 11
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 7
- 239000002699 waste material Substances 0.000 abstract description 5
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 238000004090 dissolution Methods 0.000 abstract description 3
- 238000011084 recovery Methods 0.000 abstract description 3
- 238000010992 reflux Methods 0.000 abstract description 2
- 229960005137 succinic acid Drugs 0.000 description 118
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 65
- 239000002002 slurry Substances 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 239000000706 filtrate Substances 0.000 description 18
- 239000000047 product Substances 0.000 description 18
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 16
- 238000004227 thermal cracking Methods 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 9
- 238000004064 recycling Methods 0.000 description 9
- 238000002425 crystallisation Methods 0.000 description 8
- 230000008025 crystallization Effects 0.000 description 8
- 235000010633 broth Nutrition 0.000 description 7
- 235000014633 carbohydrates Nutrition 0.000 description 7
- 239000012141 concentrate Substances 0.000 description 7
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 5
- 239000000908 ammonium hydroxide Substances 0.000 description 5
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000012736 aqueous medium Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 230000003472 neutralizing effect Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 240000008042 Zea mays Species 0.000 description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
- 150000001735 carboxylic acids Chemical class 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 235000005822 corn Nutrition 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 238000000909 electrodialysis Methods 0.000 description 3
- 229910052602 gypsum Inorganic materials 0.000 description 3
- 239000010440 gypsum Substances 0.000 description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 239000011368 organic material Substances 0.000 description 3
- 238000010979 pH adjustment Methods 0.000 description 3
- 230000020477 pH reduction Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000011143 downstream manufacturing Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 238000009621 Solvay process Methods 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052925 anhydrite Inorganic materials 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical compound [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000013409 condiments Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 1
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 1
- 230000000266 injurious effect Effects 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 239000002912 waste gas Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5601397P | 1997-08-18 | 1997-08-18 | |
| US60/056,013 | 1997-08-18 | ||
| US09/134,061 | 1998-08-13 | ||
| US09/134,061 US5958744A (en) | 1997-08-18 | 1998-08-13 | Succinic acid production and purification |
| PCT/US1998/017123 WO1999009196A1 (en) | 1997-08-18 | 1998-08-18 | Succinic acid production and purification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2301177A1 CA2301177A1 (en) | 1999-02-25 |
| CA2301177C true CA2301177C (en) | 2008-01-29 |
Family
ID=26734867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002301177A Expired - Fee Related CA2301177C (en) | 1997-08-18 | 1998-08-18 | Succinic acid production and purification |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5958744A (h) |
| EP (1) | EP1005562B1 (h) |
| JP (1) | JP4242558B2 (h) |
| AR (1) | AR017255A1 (h) |
| AT (1) | ATE260343T1 (h) |
| AU (1) | AU9107598A (h) |
| BR (1) | BR9815652A (h) |
| CA (1) | CA2301177C (h) |
| DE (1) | DE69821951T2 (h) |
| IN (1) | IN190421B (h) |
| WO (1) | WO1999009196A1 (h) |
| ZA (1) | ZA987428B (h) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287480B1 (en) * | 2000-01-11 | 2001-09-11 | Applied Carbochemicals, Inc. | Deicing compositions and methods of use |
| US6635188B1 (en) * | 2002-04-18 | 2003-10-21 | Board Of Trustees Of Michigan State University | Windshield washer and deicer |
| MY137537A (en) * | 2002-05-10 | 2009-02-27 | Mitsubishi Chem Corp | Method for producing organic acid |
| JP4469568B2 (ja) * | 2003-07-09 | 2010-05-26 | 三菱化学株式会社 | 有機酸の製造方法 |
| EP1672077B1 (en) * | 2003-08-28 | 2015-01-21 | Mitsubishi Chemical Corporation | Process for producing succinic acid |
| BRPI0414300A (pt) * | 2003-09-17 | 2006-11-07 | Mitsubishi Chem Corp | método para produzir ácido orgánico não amino |
| BRPI0414764B8 (pt) * | 2003-09-30 | 2018-09-18 | Ajinomoto Kk | método para purificar ácido succínico à partir de caldo de fermentação |
| JP2005295998A (ja) * | 2003-11-07 | 2005-10-27 | Mitsubishi Chemicals Corp | 有機酸アンモニウム溶液の製造方法 |
| WO2005045049A1 (ja) * | 2003-11-07 | 2005-05-19 | Mitsubishi Chemical Corporation | 有機酸アンモニウム溶液の製造方法 |
| US6846431B1 (en) | 2003-12-26 | 2005-01-25 | Diversified Natural Products, Inc. | Environmentally benign, non-toxic, non-corrosive engine coolant/antifreeze |
| WO2005113744A1 (ja) * | 2004-05-20 | 2005-12-01 | Ajinomoto Co., Inc. | コハク酸生産菌及びコハク酸の製造方法 |
| CN1989239B (zh) * | 2004-05-20 | 2013-07-10 | 味之素株式会社 | 生产琥珀酸的细菌和生产琥珀酸的方法 |
| ES2396139T3 (es) * | 2004-12-21 | 2013-02-19 | Basf Se | Método para la producción de pirrolidonas a partir de succinatos de caldos de fermentación |
| KR100672813B1 (ko) * | 2005-01-18 | 2007-01-22 | 한국과학기술원 | 숙신산 정제 방법 |
| JP4537862B2 (ja) * | 2005-01-18 | 2010-09-08 | 財団法人地球環境産業技術研究機構 | 好気性細菌による高効率な有機酸の製造方法 |
| DE602006013810D1 (de) | 2005-04-22 | 2010-06-02 | Mitsubishi Chem Corp | Aus biomasseressourcen gewonnener polyester und herstellungsverfahren dafür |
| JP2006328380A (ja) * | 2005-04-26 | 2006-12-07 | Mitsubishi Chemicals Corp | ポリエステルの製造方法 |
| BRPI0617491B1 (pt) * | 2005-10-18 | 2021-04-27 | Ajinomoto Co., Inc | Processo para produção de ácido succínico |
| US20070122892A1 (en) * | 2005-11-30 | 2007-05-31 | Christian Andersson | Process for producing succinic acid from sucrose |
| EP1995308B1 (en) * | 2006-02-24 | 2014-07-30 | Mitsubishi Chemical Corporation | Bacterium capable of producing organic acid, and method for production of organic acid |
| CN101489970B (zh) * | 2006-07-19 | 2012-08-08 | 昭和电工株式会社 | 琥珀酸的制备方法 |
| JP5333213B2 (ja) * | 2007-05-18 | 2013-11-06 | 味の素株式会社 | コハク酸およびコハク酸アンモニウム溶液の製造方法 |
| FR2925068B1 (fr) * | 2007-12-13 | 2010-01-08 | Roquette Freres | Procedes de production d'acide succinique |
| KR20090066958A (ko) * | 2007-12-20 | 2009-06-24 | 한국과학기술원 | 배양액의 결정화에 의한 숙신산 정제방법 |
| CN101215583B (zh) * | 2008-01-18 | 2010-11-10 | 南京工业大学 | 一种发酵与膜分离单元耦合制备丁二酸的方法 |
| EP2370586B1 (en) | 2008-12-02 | 2017-11-01 | PURAC Biochem BV | Process for the preparation of a monovalent succinate salt |
| WO2011064151A1 (en) * | 2009-11-24 | 2011-06-03 | Dsm Ip Assets B.V. | Process for the crystallization of succinic acid |
| IN2012DN04907A (h) | 2009-12-02 | 2015-09-25 | Univ Michigan State | |
| CN102781900A (zh) * | 2009-12-31 | 2012-11-14 | 麦兰特公司 | 从含有琥珀酸铵的发酵液纯化琥珀酸 |
| BR112012017541A2 (pt) | 2010-01-15 | 2018-04-17 | Mitsubishi Chem Corp | composição contendo nitrogênio e processo para produção do mesmo |
| CN101748161B (zh) * | 2010-01-19 | 2012-06-06 | 南京工业大学 | 一种厌氧发酵纯化丁二酸的工艺 |
| WO2011115136A1 (ja) | 2010-03-16 | 2011-09-22 | 三菱化学株式会社 | コハク酸の製造方法 |
| CN102918017B (zh) * | 2010-03-26 | 2014-12-17 | 生物琥珀酸有限公司 | 从含有琥珀酸二铵、琥珀酸一铵和/或琥珀酸的发酵液制备琥珀酸一铵的方法及琥珀酸一铵到琥珀酸的转化 |
| EP2371802A1 (en) | 2010-03-30 | 2011-10-05 | DSM IP Assets B.V. | Process for the crystallization of succinic acid |
| KR20120132556A (ko) | 2010-04-01 | 2012-12-05 | 바이오엠버, 에스.아.에스. | 숙신산 디암모늄을 함유하는 발효액으로부터 숙신산을 제조하는 방법 |
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| US5143834A (en) * | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| US5034105A (en) * | 1989-07-27 | 1991-07-23 | Michigan Biotechnology Institute | Carboxylic acid purification and crystallization process |
| US5426219A (en) * | 1993-07-26 | 1995-06-20 | A.E. Staley Manufacturing Co. | Process for recovering organic acids |
| US5504004A (en) * | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5573931A (en) * | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
-
1998
- 1998-08-13 US US09/134,061 patent/US5958744A/en not_active Expired - Lifetime
- 1998-08-17 IN IN521BO1998 patent/IN190421B/en unknown
- 1998-08-18 BR BR9815652-7A patent/BR9815652A/pt not_active Application Discontinuation
- 1998-08-18 ZA ZA987428A patent/ZA987428B/xx unknown
- 1998-08-18 EP EP98943239A patent/EP1005562B1/en not_active Expired - Lifetime
- 1998-08-18 WO PCT/US1998/017123 patent/WO1999009196A1/en active IP Right Grant
- 1998-08-18 CA CA002301177A patent/CA2301177C/en not_active Expired - Fee Related
- 1998-08-18 AU AU91075/98A patent/AU9107598A/en not_active Abandoned
- 1998-08-18 AR ARP980104067A patent/AR017255A1/es unknown
- 1998-08-18 DE DE69821951T patent/DE69821951T2/de not_active Expired - Lifetime
- 1998-08-18 AT AT98943239T patent/ATE260343T1/de active
- 1998-08-18 JP JP2000509858A patent/JP4242558B2/ja not_active Expired - Fee Related
-
1999
- 1999-09-02 US US09/389,641 patent/US6265190B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69821951T2 (de) | 2004-12-16 |
| US5958744A (en) | 1999-09-28 |
| WO1999009196A1 (en) | 1999-02-25 |
| EP1005562A1 (en) | 2000-06-07 |
| US6265190B1 (en) | 2001-07-24 |
| BR9815652A (pt) | 2001-08-28 |
| AU9107598A (en) | 1999-03-08 |
| EP1005562A4 (en) | 2002-05-22 |
| ATE260343T1 (de) | 2004-03-15 |
| JP4242558B2 (ja) | 2009-03-25 |
| EP1005562B1 (en) | 2004-02-25 |
| AR017255A1 (es) | 2001-09-05 |
| IN190421B (h) | 2003-07-26 |
| JP2001514900A (ja) | 2001-09-18 |
| DE69821951D1 (de) | 2004-04-01 |
| ZA987428B (en) | 1999-05-18 |
| CA2301177A1 (en) | 1999-02-25 |
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