CA2226758A1 - New inhibitors of platelet aggregation - Google Patents
New inhibitors of platelet aggregation Download PDFInfo
- Publication number
- CA2226758A1 CA2226758A1 CA002226758A CA2226758A CA2226758A1 CA 2226758 A1 CA2226758 A1 CA 2226758A1 CA 002226758 A CA002226758 A CA 002226758A CA 2226758 A CA2226758 A CA 2226758A CA 2226758 A1 CA2226758 A1 CA 2226758A1
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- 208000010110 spontaneous platelet aggregation Diseases 0.000 title claims abstract description 12
- 239000003112 inhibitor Substances 0.000 title description 2
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- 229910052736 halogen Inorganic materials 0.000 claims abstract description 13
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- CMXPERZAMAQXSF-UHFFFAOYSA-M sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate;1,8-dihydroxyanthracene-9,10-dione Chemical compound [Na+].O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CMXPERZAMAQXSF-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- AFCAKJKUYFLYFK-UHFFFAOYSA-N tetrabutyltin Chemical compound CCCC[Sn](CCCC)(CCCC)CCCC AFCAKJKUYFLYFK-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 230000003582 thrombocytopenic effect Effects 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9514074.5A GB9514074D0 (en) | 1995-07-11 | 1995-07-11 | Compounds |
| GBGB9520311.3A GB9520311D0 (en) | 1995-10-05 | 1995-10-05 | Compounds |
| GB9522837.5 | 1995-11-08 | ||
| GBGB9522837.5A GB9522837D0 (en) | 1995-11-08 | 1995-11-08 | Compounds |
| GB9514074.5 | 1995-11-08 | ||
| GB9520311.3 | 1995-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2226758A1 true CA2226758A1 (en) | 1997-01-30 |
Family
ID=27267806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002226758A Abandoned CA2226758A1 (en) | 1995-07-11 | 1996-07-04 | New inhibitors of platelet aggregation |
Country Status (25)
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| EP (1) | EP0840740B1 (enExample) |
| JP (1) | JP4084415B2 (enExample) |
| KR (1) | KR100444123B1 (enExample) |
| CN (1) | CN1069321C (enExample) |
| AR (1) | AR003453A1 (enExample) |
| AT (1) | ATE217010T1 (enExample) |
| AU (1) | AU699034B2 (enExample) |
| BR (1) | BR9609467A (enExample) |
| CA (1) | CA2226758A1 (enExample) |
| CZ (1) | CZ297200B6 (enExample) |
| DE (1) | DE69621021T2 (enExample) |
| EE (1) | EE03616B1 (enExample) |
| HU (1) | HU221880B1 (enExample) |
| IL (1) | IL122814A (enExample) |
| IS (1) | IS1790B (enExample) |
| MY (1) | MY116542A (enExample) |
| NO (1) | NO310624B1 (enExample) |
| NZ (1) | NZ312258A (enExample) |
| PL (1) | PL182680B1 (enExample) |
| SA (1) | SA96170272B1 (enExample) |
| SK (1) | SK283206B6 (enExample) |
| TR (1) | TR199800019T1 (enExample) |
| TW (1) | TW427996B (enExample) |
| WO (1) | WO1997003084A1 (enExample) |
Families Citing this family (47)
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| JP4125790B2 (ja) * | 1996-12-20 | 2008-07-30 | アストラゼネカ・アクチエボラーグ | トリアゾロ［４，５−ｄ］ピリミジニル誘導体および医薬としてのその使用 |
| SE9702772D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| SE9702773D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| SE9702774D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| TW530058B (en) * | 1997-07-22 | 2003-05-01 | Astra Pharma Prod | Triazolo [4,5-d]pyrimidine compounos and their use and process for preparation |
| DE69905451T2 (de) * | 1998-02-17 | 2003-11-20 | Astrazeneca Uk Ltd., London | Neue triazolo(4,5d) pyrimidinverbindungen |
| SE9802574D0 (sv) * | 1998-07-17 | 1998-07-17 | Astra Pharma Prod | Novel compounds |
| TWI229674B (en) * | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| SE9904129D0 (sv) * | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
| SE9904128D0 (sv) * | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
| SE9904377D0 (sv) * | 1999-12-01 | 1999-12-01 | Astra Pharma Prod | Pharmaceutical combinations |
| GB0013488D0 (en) | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
| GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
| US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US7452870B2 (en) * | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
| AR039558A1 (es) * | 2000-08-21 | 2005-02-23 | Inspire Pharmaceuticals Inc | Composiciones y metodo para el tratamiento de glaucoma o hipertension ocular |
| US7132408B2 (en) * | 2000-08-21 | 2006-11-07 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US6897201B2 (en) * | 2000-08-21 | 2005-05-24 | Inspire Pharmaceuticals, Inc. | Compositions and methods for the treatment of glaucoma or ocular hypertension |
| US7115585B2 (en) * | 2000-08-21 | 2006-10-03 | Inspire Pharmaceuticals, Inc. | Compositions for treating epithelial and retinal tissue diseases |
| GB0100624D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
| SE0101932D0 (sv) * | 2001-05-31 | 2001-05-31 | Astrazeneca Ab | Pharmaceutical combinations |
| US20020169730A1 (en) * | 2001-08-29 | 2002-11-14 | Emmanuel Lazaridis | Methods for classifying objects and identifying latent classes |
| US7435724B2 (en) | 2002-02-27 | 2008-10-14 | Inspire Pharmaceutical, Inc. | Degradation-resistant mononucleoside phosphate compounds |
| DE602004018637D1 (de) * | 2003-04-09 | 2009-02-05 | Biogen Idec Inc | A2a-adenosinrezeptorantagonisten |
| EP1615930A2 (en) * | 2003-04-09 | 2006-01-18 | Biogen Idec MA, Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists |
| EP1618108A2 (en) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines useful as a2a adenosine receptor antagonists |
| WO2004092177A1 (en) * | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| EP1618109A2 (en) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
| GB2422782A (en) * | 2003-10-21 | 2006-08-09 | Inspire Pharmaceuticals Inc | Non-nucleotide compositions and method for treating pain |
| US7749981B2 (en) * | 2003-10-21 | 2010-07-06 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound |
| US7335648B2 (en) * | 2003-10-21 | 2008-02-26 | Inspire Pharmaceuticals, Inc. | Non-nucleotide composition and method for inhibiting platelet aggregation |
| EP1685135B1 (en) * | 2003-10-21 | 2010-05-26 | Inspire Pharmaceuticals, Inc. | TETRAHYDRO-FURO[3,4-d]DIOXOLE COMPOUNDS AND COMPOSITIONS AND METHOD FOR INHIBITING PLATELET AGGREGATION |
| US7504497B2 (en) * | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
| US7932376B2 (en) * | 2005-05-05 | 2011-04-26 | Inspire Pharmaceuticals, Inc. | Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation |
| WO2008054795A2 (en) * | 2006-10-31 | 2008-05-08 | Janssen Pharmaceutica, N.V. | Triazolopyrimidine derivatives as adp p2y12 receptor antagonists |
| UA100864C2 (uk) * | 2007-12-03 | 2013-02-11 | Астразенека Аб | Спосіб лікування або запобігання аневризмі черевної аорти |
| GB0906579D0 (en) | 2009-04-16 | 2009-05-20 | Vernalis R&D Ltd | Pharmaceuticals, compositions and methods of making and using the same |
| JP5654990B2 (ja) * | 2008-08-20 | 2015-01-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | アゾ置換ピリジンおよびピリミジン誘導体ならびにそれらのウイルス感染の治療における使用 |
| US8859769B2 (en) | 2010-02-16 | 2014-10-14 | Actavis Group Ptc Ehf | Processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
| BR112014013085A2 (pt) | 2011-11-30 | 2017-06-13 | Actavis Group Ptc Ehf | forma cristalina do ticagrelor, processo para a preparação da forma cristalina do ticagrelor, composição farmacêutica e processo para preparar uma composição farmacêutica |
| WO2014083139A1 (en) | 2012-11-29 | 2014-06-05 | Actavis Group Ptc Ehf | Novel amorphous form of ticagrelor |
| WO2014206187A1 (zh) | 2013-06-24 | 2014-12-31 | 苏州明锐医药科技有限公司 | 替卡格雷及其中间体的制备方法 |
| WO2014206188A1 (zh) * | 2013-06-27 | 2014-12-31 | 苏州明锐医药科技有限公司 | 替格瑞洛的制备方法 |
| CN105061431B (zh) * | 2015-07-28 | 2017-03-29 | 山东百诺医药股份有限公司 | 6‑n‑（2‑（甲硫基）乙基）‑2‑（（3,3,3‑三氟丙基）硫代）‑9h‑嘌呤及其制备方法和应用 |
| CN112915063B (zh) * | 2021-01-25 | 2022-12-20 | 刘红枚 | 一种用于治疗子宫平滑肌高频率强直性收缩相关疾病的化合物 |
| CN112876485A (zh) * | 2021-01-25 | 2021-06-01 | 郭丽伟 | 一种用于治疗子宫平滑肌高频率强直性收缩相关疾病的化合物 |
| RU2770405C1 (ru) * | 2021-07-05 | 2022-04-15 | федеральное государственное бюджетное образовательное учреждение высшего образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Производные триазола, проявляющие антиагрегационную активность |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4742064A (en) * | 1985-09-10 | 1988-05-03 | Regents Of The University Of Minnesota | Antiviral carbocyclic analogs of xylofuranosylpurines |
| GB8826205D0 (en) * | 1988-11-09 | 1988-12-14 | Wellcome Found | Heterocyclic compounds |
| JP2619710B2 (ja) * | 1989-02-27 | 1997-06-11 | 日本製紙 株式会社 | ２′，３′−ジデオキシプリンヌクレオシド類の製造方法 |
| US5506347A (en) * | 1993-02-03 | 1996-04-09 | Gensia, Inc. | Lyxofuranosyl analogues of adenosine |
| IL108523A0 (en) * | 1993-02-03 | 1994-05-30 | Gensia Inc | Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain |
-
1996
- 1996-07-04 EP EP96923160A patent/EP0840740B1/en not_active Expired - Lifetime
- 1996-07-04 NZ NZ312258A patent/NZ312258A/xx unknown
- 1996-07-04 TW TW085108062A patent/TW427996B/zh not_active IP Right Cessation
- 1996-07-04 CN CN96196720A patent/CN1069321C/zh not_active Expired - Fee Related
- 1996-07-04 AT AT96923160T patent/ATE217010T1/de not_active IP Right Cessation
- 1996-07-04 BR BR9609467A patent/BR9609467A/pt active Search and Examination
- 1996-07-04 US US08/737,005 patent/US5747496A/en not_active Expired - Fee Related
- 1996-07-04 HU HU9802448A patent/HU221880B1/hu active IP Right Grant
- 1996-07-04 KR KR10-1998-0700187A patent/KR100444123B1/ko not_active Expired - Fee Related
- 1996-07-04 WO PCT/SE1996/000911 patent/WO1997003084A1/en not_active Ceased
- 1996-07-04 PL PL96324396A patent/PL182680B1/pl not_active IP Right Cessation
- 1996-07-04 DE DE69621021T patent/DE69621021T2/de not_active Expired - Fee Related
- 1996-07-04 AU AU63751/96A patent/AU699034B2/en not_active Ceased
- 1996-07-04 IL IL12281496A patent/IL122814A/en not_active IP Right Cessation
- 1996-07-04 SK SK23-98A patent/SK283206B6/sk unknown
- 1996-07-04 JP JP50574897A patent/JP4084415B2/ja not_active Expired - Fee Related
- 1996-07-04 TR TR1998/00019T patent/TR199800019T1/xx unknown
- 1996-07-04 CZ CZ0002598A patent/CZ297200B6/cs not_active IP Right Cessation
- 1996-07-04 CA CA002226758A patent/CA2226758A1/en not_active Abandoned
- 1996-07-04 EE EE9800026A patent/EE03616B1/xx not_active IP Right Cessation
- 1996-07-11 AR ARP960103538A patent/AR003453A1/es active IP Right Grant
- 1996-07-11 MY MYPI96002866A patent/MY116542A/en unknown
- 1996-08-28 SA SA96170272A patent/SA96170272B1/ar unknown
-
1998
- 1998-01-08 NO NO19980080A patent/NO310624B1/no unknown
- 1998-01-08 IS IS4647A patent/IS1790B/is unknown
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |