MX9800308A - Nuevos inhibidores de agregacion de plaquetas. - Google Patents

Nuevos inhibidores de agregacion de plaquetas.

Info

Publication number
MX9800308A
MX9800308A MX9800308A MX9800308A MX9800308A MX 9800308 A MX9800308 A MX 9800308A MX 9800308 A MX9800308 A MX 9800308A MX 9800308 A MX9800308 A MX 9800308A MX 9800308 A MX9800308 A MX 9800308A
Authority
MX
Mexico
Prior art keywords
compounds
alkyl
platelet aggregation
cooh
novel
Prior art date
Application number
MX9800308A
Other languages
English (en)
Other versions
MXPA98000308A (es
Inventor
David Cox
Anthony Ingall
Paul Willis
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9514074.5A external-priority patent/GB9514074D0/en
Priority claimed from GBGB9520311.3A external-priority patent/GB9520311D0/en
Priority claimed from GBGB9522837.5A external-priority patent/GB9522837D0/en
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Publication of MX9800308A publication Critical patent/MX9800308A/es
Publication of MXPA98000308A publication Critical patent/MXPA98000308A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen compuestos de la formula (I), en donde B es 0 o CH2; X se selecciona de NR1R2, SR1, y alquilo C1-C7; Y se selecciona de SR1NR1R2, y alquilo C1-C7; R1 y R2 son cada uno seleccionados independientemente de H, o alquilo C1-C7 opcionalmente sustituido sobre o dentro de la cadena del alquilo por uno más de O, S, N o halogeno, R3 y R4 son ambos h, a R3 y R4 juntos forman un enlace; A es COOH, C(O)NH(CH2)pCOOH, C(O)N[(CH2)qCOOH]2; C(O)NHCH(COOH)(CH2)rCOOH,o 5-tetrazolilo, en donde p, q y r son cada uno e independientemente 1, 2 o 3; así como las sales farmacéuticamente aceptables y promedicamentos de los mismos, composiciones farmacéuticas que comprenden los compuestos novedosos y el uso de los compuestos en terapia. También dentro del alcance de la invencion están intermediarios novedosos para los compuestos novedosos. Los compuestos novedosos son en particular utiles en la prevencion de agregacion de plaquetas.
MXPA/A/1998/000308A 1995-07-11 1998-01-09 Nuevos inhibidores de agregacion de plaquetas MXPA98000308A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9514074.5A GB9514074D0 (en) 1995-07-11 1995-07-11 Compounds
GB9514074.5 1995-07-11
GB9520311.3 1995-10-05
GBGB9520311.3A GB9520311D0 (en) 1995-10-05 1995-10-05 Compounds
GBGB9522837.5A GB9522837D0 (en) 1995-11-08 1995-11-08 Compounds
GB9522837.5 1995-11-08

Publications (2)

Publication Number Publication Date
MX9800308A true MX9800308A (es) 1998-09-30
MXPA98000308A MXPA98000308A (es) 1998-11-16

Family

ID=

Also Published As

Publication number Publication date
DE69621021T2 (de) 2002-10-31
TW427996B (en) 2001-04-01
HU221880B1 (hu) 2003-02-28
CN1069321C (zh) 2001-08-08
WO1997003084A1 (en) 1997-01-30
IL122814A0 (en) 1998-08-16
CZ2598A3 (cs) 1998-08-12
IS4647A (is) 1998-01-08
PL182680B1 (pl) 2002-02-28
AU699034B2 (en) 1998-11-19
NO310624B1 (no) 2001-07-30
CZ297200B6 (cs) 2006-09-13
CA2226758A1 (en) 1997-01-30
HUP9802448A2 (hu) 1999-05-28
PL324396A1 (en) 1998-05-25
JP4084415B2 (ja) 2008-04-30
MY116542A (en) 2004-02-28
EE03616B1 (et) 2002-02-15
EP0840740B1 (en) 2002-05-02
CN1195353A (zh) 1998-10-07
JPH11508914A (ja) 1999-08-03
IL122814A (en) 2001-04-30
BR9609467A (pt) 1999-03-02
NZ312258A (en) 1999-08-30
IS1790B (is) 2001-11-28
NO980080L (no) 1998-03-06
AR003453A1 (es) 1998-08-05
SK283206B6 (sk) 2003-03-04
EP0840740A1 (en) 1998-05-13
US5747496A (en) 1998-05-05
HUP9802448A3 (en) 2000-03-28
KR100444123B1 (ko) 2004-10-14
SA96170272B1 (ar) 2006-06-04
ATE217010T1 (de) 2002-05-15
TR199800019T1 (xx) 1998-05-21
KR19990028885A (ko) 1999-04-15
DE69621021D1 (de) 2002-06-06
EE9800026A (et) 1998-08-17
SK2398A3 (en) 1999-01-11
NO980080D0 (no) 1998-01-08
AU6375196A (en) 1997-02-10

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: ASTRAZENECA AB

MM Annulment or lapse due to non-payment of fees