ATE170845T1 - Plättchenaggregationsinhibitoren - Google Patents
PlättchenaggregationsinhibitorenInfo
- Publication number
- ATE170845T1 ATE170845T1 AT95908814T AT95908814T ATE170845T1 AT E170845 T1 ATE170845 T1 AT E170845T1 AT 95908814 T AT95908814 T AT 95908814T AT 95908814 T AT95908814 T AT 95908814T AT E170845 T1 ATE170845 T1 AT E170845T1
- Authority
- AT
- Austria
- Prior art keywords
- platele
- aggregation inhibitors
- compounds
- platelet aggregation
- compositions
- Prior art date
Links
- 230000002776 aggregation Effects 0.000 title 1
- 238000004220 aggregation Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Steroid Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/111,671 US5430043A (en) | 1993-08-24 | 1993-08-24 | Platelet aggregation inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE170845T1 true ATE170845T1 (de) | 1998-09-15 |
Family
ID=22339828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95908814T ATE170845T1 (de) | 1993-08-24 | 1994-07-27 | Plättchenaggregationsinhibitoren |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5430043A (de) |
| EP (1) | EP0715623B1 (de) |
| JP (1) | JPH09501692A (de) |
| AT (1) | ATE170845T1 (de) |
| AU (1) | AU7401994A (de) |
| CA (1) | CA2168345A1 (de) |
| DE (1) | DE69413237T2 (de) |
| DK (1) | DK0715623T3 (de) |
| ES (1) | ES2120728T3 (de) |
| WO (1) | WO1995006038A1 (de) |
| ZA (1) | ZA945836B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| ZA963391B (en) * | 1995-05-24 | 1997-10-29 | Du Pont Merck Pharma | Isoxazoline fibrinogen receptor antagonists. |
| US5532357A (en) * | 1995-06-07 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas |
| US6013651A (en) * | 1995-08-30 | 2000-01-11 | G. D. Searle & Co. | Meta-azacyclic amino benzoic acid compounds and derivatives thereof |
| US5925635A (en) * | 1996-04-17 | 1999-07-20 | Dupont Pharmaceuticals Company | N-(amidinophenyl) cyclourea analogs as factor XA inhibitors |
| ATE269312T1 (de) * | 1996-04-17 | 2004-07-15 | Bristol Myers Squibb Pharma Co | N-(amidinophenyl)-n'-(subst.)-3h-2,4- benzodiazepin-3-on derivative als faktor xa inhibitoren |
| US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
| US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
| US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| CA2285705A1 (en) * | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| CA2285659A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| EP0977772A1 (de) | 1997-04-14 | 2000-02-09 | Cor Therapeutics, Inc. | Selektive faktor xa-inhibitoren |
| US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
| CA2303438A1 (en) * | 1997-09-09 | 1999-03-18 | Bristol-Myers Squibb Pharma Company | Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor xa |
| US5872122A (en) * | 1997-10-16 | 1999-02-16 | Monsanto Company | Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation |
| EP1047425A4 (de) * | 1997-12-17 | 2009-04-22 | Merck & Co Inc | Integrinrezeptor antagonisten |
| US6211191B1 (en) * | 1997-12-17 | 2001-04-03 | Merck & Co., Inc. | Integrin receptor antagonists |
| US6066648A (en) | 1997-12-17 | 2000-05-23 | Merck & Co., Inc. | Integrin receptor antagonists |
| AU748621B2 (en) * | 1998-08-13 | 2002-06-06 | Merck & Co., Inc. | Integrin receptor antagonists |
| US6037365A (en) * | 1998-09-25 | 2000-03-14 | G.D. Searle & Co. | Aminobenzamidinosuccinyl lactone derivatives useful as inhibitors of platelet aggregation |
| US7989554B2 (en) * | 2006-01-10 | 2011-08-02 | Enzon Pharmaceuticals, Inc. | Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid |
| ES2610556T3 (es) | 2011-01-31 | 2017-04-28 | Council Of Scientific & Industrial Research | 1-(4-metilfenilmetil)-5-oxo-{N-[(3-t-butoxicarbonil-aminometil)]-piperidin-1-il}-pirrolidin-2-carboxamidas quirales como inhibidores de la activación y adhesión de plaquetas inducidas por colágeno |
| CN103012274B (zh) * | 2013-01-17 | 2017-08-25 | 上海汇伦生命科技有限公司 | 异羟肟酸类化合物，制备方法和用途 |
| US11043823B2 (en) * | 2017-04-06 | 2021-06-22 | Tesla, Inc. | System and method for facilitating conditioning and testing of rechargeable battery cells |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
| DE4107857A1 (de) * | 1991-03-12 | 1992-09-17 | Thomae Gmbh Dr K | Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5239113A (en) * | 1991-10-15 | 1993-08-24 | Monsanto Company | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
| CA2115848A1 (en) * | 1991-10-15 | 1993-04-16 | Philippe Roger Bovy | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors |
| US5272162A (en) * | 1992-07-02 | 1993-12-21 | G. D. Searle & Co. | Platelet aggregation inhibitors |
| US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
| WO1994021602A1 (en) * | 1993-03-15 | 1994-09-29 | G.D. Searle & Co. | Urea derivatives useful as platelet aggregation inhibitors |
-
1993
- 1993-08-24 US US08/111,671 patent/US5430043A/en not_active Expired - Fee Related
-
1994
- 1994-07-27 DE DE69413237T patent/DE69413237T2/de not_active Expired - Fee Related
- 1994-07-27 ES ES95908814T patent/ES2120728T3/es not_active Expired - Lifetime
- 1994-07-27 CA CA002168345A patent/CA2168345A1/en not_active Abandoned
- 1994-07-27 WO PCT/US1994/008210 patent/WO1995006038A1/en not_active Ceased
- 1994-07-27 EP EP95908814A patent/EP0715623B1/de not_active Expired - Lifetime
- 1994-07-27 DK DK95908814T patent/DK0715623T3/da active
- 1994-07-27 AU AU74019/94A patent/AU7401994A/en not_active Abandoned
- 1994-07-27 AT AT95908814T patent/ATE170845T1/de not_active IP Right Cessation
- 1994-07-27 JP JP7507575A patent/JPH09501692A/ja not_active Ceased
- 1994-08-04 ZA ZA945836A patent/ZA945836B/xx unknown
-
1995
- 1995-03-30 US US08/413,671 patent/US5489594A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0715623A1 (de) | 1996-06-12 |
| EP0715623B1 (de) | 1998-09-09 |
| CA2168345A1 (en) | 1995-03-02 |
| ES2120728T3 (es) | 1998-11-01 |
| US5430043A (en) | 1995-07-04 |
| US5489594A (en) | 1996-02-06 |
| JPH09501692A (ja) | 1997-02-18 |
| DE69413237T2 (de) | 1999-03-11 |
| DE69413237D1 (en) | 1998-10-15 |
| AU7401994A (en) | 1995-03-21 |
| DK0715623T3 (da) | 1999-02-22 |
| WO1995006038A1 (en) | 1995-03-02 |
| ZA945836B (en) | 1995-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE170845T1 (de) | Plättchenaggregationsinhibitoren | |
| FI954609A0 (fi) | 1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina | |
| WO1992015607A3 (en) | Phenyl amidines derivatives useful as platelet aggregation inhibitors | |
| ES2160949T3 (es) | Derivados de fenilen-sulfonamida sustituidos en meta. | |
| DK0659193T3 (da) | Blodpladeaggregationsinhibitorer | |
| ES2158537T3 (es) | Derivados de acidos ciclopropilalcanoicos. | |
| ATE235468T1 (de) | Plättchenaggregationsinhibitoren | |
| DK0513675T3 (da) | Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf | |
| ES2181879T3 (es) | Inhibidores de la agkytubacuib de las plaquetas que contienen restos de aminoacidos con cadenas laterales de c-terminal aminergicos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |