CA2222559A1 - Encapsulated cells producing viral particles - Google Patents
Encapsulated cells producing viral particles Download PDFInfo
- Publication number
- CA2222559A1 CA2222559A1 CA002222559A CA2222559A CA2222559A1 CA 2222559 A1 CA2222559 A1 CA 2222559A1 CA 002222559 A CA002222559 A CA 002222559A CA 2222559 A CA2222559 A CA 2222559A CA 2222559 A1 CA2222559 A1 CA 2222559A1
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- Prior art keywords
- cells
- sulphate
- encapsulated cells
- genes
- encapsulated
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- 239000002773 nucleotide Substances 0.000 description 1
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- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
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- 230000010076 replication Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- JJICLMJFIKGAAU-UHFFFAOYSA-M sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate Chemical compound [Na+].NC1=NC([O-])=C2N=CN(COC(CO)CO)C2=N1 JJICLMJFIKGAAU-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 231100000617 superantigen Toxicity 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK0740/95 | 1995-06-27 | ||
| DK74095 | 1995-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2222559A1 true CA2222559A1 (en) | 1997-01-16 |
Family
ID=8097001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002222559A Abandoned CA2222559A1 (en) | 1995-06-27 | 1996-06-24 | Encapsulated cells producing viral particles |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6776985B1 (enExample) |
| EP (1) | EP0835137B1 (enExample) |
| JP (2) | JP4119952B2 (enExample) |
| KR (1) | KR100484883B1 (enExample) |
| CN (1) | CN1187095C (enExample) |
| AT (1) | ATE309000T1 (enExample) |
| AU (1) | AU708273B2 (enExample) |
| CA (1) | CA2222559A1 (enExample) |
| CZ (1) | CZ286979B6 (enExample) |
| DE (1) | DE69633180D1 (enExample) |
| DK (1) | DK0835137T3 (enExample) |
| ES (1) | ES2253754T3 (enExample) |
| IL (1) | IL122119A (enExample) |
| NO (1) | NO321427B1 (enExample) |
| NZ (1) | NZ312671A (enExample) |
| PL (1) | PL185338B1 (enExample) |
| PT (1) | PT835137E (enExample) |
| RU (1) | RU2187301C2 (enExample) |
| SI (1) | SI0835137T1 (enExample) |
| UA (1) | UA65525C2 (enExample) |
| WO (1) | WO1997001357A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996028563A1 (en) | 1995-03-09 | 1996-09-19 | Bavarian Nordic | Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy |
| CZ286979B6 (en) | 1995-06-27 | 2000-08-16 | Bavarian Nordic Res Inst As | Capsule encapsulating cells producing viral particles, process of its preparation and pharmaceutical preparation for gene therapy |
| IL125795A0 (en) | 1996-03-27 | 1999-04-11 | Bavarian Nordic Res Inst As | Retroviral vectors encoding a cytochrome p450 gene |
| US6540995B1 (en) | 1996-03-27 | 2003-04-01 | Bavarian Nordic Research Institute Gmbh | Encapsulated cells producing cytochrome P450 |
| EP0994680A1 (en) | 1998-05-05 | 2000-04-26 | Koninklijke Philips Electronics N.V. | Toothbrush comprising a brush member having a bristle field and an interdental bristle field |
| NZ550542A (en) | 2004-03-30 | 2009-03-31 | Nsgene As | Therapeutic use of a growth factor, NsG33 |
| US20090022785A1 (en) * | 2005-05-03 | 2009-01-22 | Veterinarmedizinische Universitat Wien | Permeable Capsules |
| WO2009085850A2 (en) * | 2007-12-20 | 2009-07-09 | Ethicon, Incorporated | Encapsulated kidney tissue |
| KR101250925B1 (ko) * | 2011-10-28 | 2013-04-04 | 한화케미칼 주식회사 | 캡슐 세포용 구조체 |
| GB201408233D0 (en) | 2014-05-09 | 2014-06-25 | Austrianova Singapore Pte Ltd | Use of polyanionic composition |
| KR102067352B1 (ko) * | 2015-11-24 | 2020-01-16 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 레트로바이러스 생산을 위한 일시적인 형질감염 방법 |
| US20170145388A1 (en) * | 2015-11-24 | 2017-05-25 | Glaxosmithkline Intellectual Property Development Limited | Stable cell lines for retroviral production |
| AU2017269371B2 (en) | 2016-05-25 | 2021-08-05 | Lonza Houston Inc. | Methods for isolating adeno-associated virus using a polydiallyldialkylammonium salt |
| RU2688383C2 (ru) * | 2017-07-10 | 2019-05-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского" | Способ синтеза белка в культуре бактериальных клеток |
| JP2024519909A (ja) * | 2021-05-21 | 2024-05-21 | バイオナット ラブス リミテッド | マイクロボット媒介治療送達のためのシステム及び方法 |
| CN115820683B (zh) * | 2022-09-28 | 2024-04-05 | 西南大学 | 家蚕Cyp9a20基因及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
| DD160393A3 (de) * | 1980-11-14 | 1983-07-27 | Horst Dautzenberg | Mikrokapseln und verfahren zu ihrer herstellung |
| US4686098A (en) * | 1984-05-14 | 1987-08-11 | Merck & Co., Inc. | Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo |
| US4680174A (en) * | 1984-05-24 | 1987-07-14 | Damon Biotech, Inc. | Induction of immune response by immunization with encapsulated antigen-producing cells |
| EP0199362A3 (en) * | 1985-04-26 | 1987-10-07 | Massachusetts Institute Of Technology | System and apparatus for delayed and pulsed release of biologically active substances |
| CA1310924C (en) * | 1986-04-24 | 1992-12-01 | Francis P. Mccormick | Infective drug delivery system |
| AU631554B2 (en) | 1988-05-17 | 1992-12-03 | Sloan-Kettering Institute For Cancer Research | Retroviral vector |
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| DE4021050A1 (de) * | 1990-06-29 | 1992-01-02 | Akad Wissenschaften Ddr | Verfahren zur herstellung von mikrokapseln |
| CA2051288C (en) * | 1990-09-14 | 2002-02-05 | Robert L. Martuza | Viral targeted destruction of neoplastic cells |
| CA2098510A1 (en) * | 1990-12-13 | 1992-06-14 | Kenneth W. Culver | Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy |
| WO1994029437A1 (en) | 1993-06-07 | 1994-12-22 | University Of Medicine & Dentistry Of New Jersey | Highly-efficient, self-inactivating, recombination-free, u3-free retroviral vectors |
| US5688773A (en) | 1994-08-17 | 1997-11-18 | The General Hospital Corporation | Method of selectively destroying neoplastic cells |
| ATE200517T1 (de) | 1994-09-02 | 2001-04-15 | Gsf Forschungszentrum Umwelt | Nicht selbstinaktivierende retrovirale vektoren mit gezielter expression |
| CZ286979B6 (en) | 1995-06-27 | 2000-08-16 | Bavarian Nordic Res Inst As | Capsule encapsulating cells producing viral particles, process of its preparation and pharmaceutical preparation for gene therapy |
| ES2174103T3 (es) | 1995-09-06 | 2002-11-01 | Austrian Nordic Biotherapeutic | Uso de las secuencias reguladoras de wap o mmtv para expresion dirigida de genes heterologos ligados en celulas mamarias humanas, con inclusion de celulas de carcinoma mamario humano. |
| IL125795A0 (en) | 1996-03-27 | 1999-04-11 | Bavarian Nordic Res Inst As | Retroviral vectors encoding a cytochrome p450 gene |
-
1996
- 1996-06-24 CZ CZ19974195A patent/CZ286979B6/cs not_active IP Right Cessation
- 1996-06-24 CN CNB961950501A patent/CN1187095C/zh not_active Expired - Fee Related
- 1996-06-24 RU RU98101362/13A patent/RU2187301C2/ru not_active IP Right Cessation
- 1996-06-24 JP JP50416597A patent/JP4119952B2/ja not_active Expired - Lifetime
- 1996-06-24 CA CA002222559A patent/CA2222559A1/en not_active Abandoned
- 1996-06-24 AU AU64154/96A patent/AU708273B2/en not_active Expired
- 1996-06-24 NZ NZ312671A patent/NZ312671A/xx not_active IP Right Cessation
- 1996-06-24 ES ES96923905T patent/ES2253754T3/es not_active Expired - Lifetime
- 1996-06-24 PL PL96324289A patent/PL185338B1/pl not_active IP Right Cessation
- 1996-06-24 EP EP96923905A patent/EP0835137B1/en not_active Expired - Lifetime
- 1996-06-24 KR KR1019970709807A patent/KR100484883B1/ko not_active Expired - Lifetime
- 1996-06-24 DK DK96923905T patent/DK0835137T3/da active
- 1996-06-24 UA UA97126354A patent/UA65525C2/uk unknown
- 1996-06-24 PT PT96923905T patent/PT835137E/pt unknown
- 1996-06-24 AT AT96923905T patent/ATE309000T1/de not_active IP Right Cessation
- 1996-06-24 WO PCT/EP1996/002748 patent/WO1997001357A1/en not_active Ceased
- 1996-06-24 IL IL12211996A patent/IL122119A/en not_active IP Right Cessation
- 1996-06-24 SI SI9630729T patent/SI0835137T1/sl unknown
- 1996-06-24 DE DE69633180T patent/DE69633180D1/de not_active Expired - Lifetime
-
1997
- 1997-12-10 NO NO19975813A patent/NO321427B1/no not_active IP Right Cessation
- 1997-12-23 US US08/996,460 patent/US6776985B1/en not_active Expired - Lifetime
-
2007
- 2007-11-21 JP JP2007301109A patent/JP4848348B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0835137B1 (en) | 2005-11-09 |
| HK1010139A1 (en) | 1999-06-17 |
| JP4848348B2 (ja) | 2011-12-28 |
| NO975813D0 (no) | 1997-12-10 |
| WO1997001357A1 (en) | 1997-01-16 |
| CZ286979B6 (en) | 2000-08-16 |
| JP4119952B2 (ja) | 2008-07-16 |
| KR100484883B1 (ko) | 2005-09-02 |
| DK0835137T3 (da) | 2006-03-06 |
| EP0835137A1 (en) | 1998-04-15 |
| NZ312671A (en) | 1999-10-28 |
| CN1189104A (zh) | 1998-07-29 |
| RU2187301C2 (ru) | 2002-08-20 |
| UA65525C2 (en) | 2004-04-15 |
| DE69633180D1 (de) | 2004-09-23 |
| ATE309000T1 (de) | 2005-11-15 |
| SI0835137T1 (sl) | 2006-04-30 |
| PT835137E (pt) | 2004-12-31 |
| JP2008101011A (ja) | 2008-05-01 |
| ES2253754T3 (es) | 2006-06-01 |
| US6776985B1 (en) | 2004-08-17 |
| NO321427B1 (no) | 2006-05-08 |
| NO975813L (no) | 1998-02-23 |
| CZ419597A3 (cs) | 1998-03-18 |
| PL324289A1 (en) | 1998-05-11 |
| KR19990028491A (ko) | 1999-04-15 |
| CN1187095C (zh) | 2005-02-02 |
| IL122119A (en) | 2004-06-01 |
| AU6415496A (en) | 1997-01-30 |
| AU708273B2 (en) | 1999-07-29 |
| PL185338B1 (pl) | 2003-04-30 |
| JPH11508768A (ja) | 1999-08-03 |
| IL122119A0 (en) | 1998-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |