CA2203494C - Energy transfer dyes with enhanced fluorescence - Google Patents
Energy transfer dyes with enhanced fluorescence Download PDFInfo
- Publication number
- CA2203494C CA2203494C CA002203494A CA2203494A CA2203494C CA 2203494 C CA2203494 C CA 2203494C CA 002203494 A CA002203494 A CA 002203494A CA 2203494 A CA2203494 A CA 2203494A CA 2203494 C CA2203494 C CA 2203494C
- Authority
- CA
- Canada
- Prior art keywords
- dye
- dyes
- energy transfer
- group
- acceptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
- C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/10—Amino derivatives of triarylmethanes
- C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
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- Analytical Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Coloring (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2297589A CA2297589C (en) | 1996-05-03 | 1997-04-23 | Energy transfer dyes with enhanced fluorescence |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/642,330 | 1996-05-03 | ||
| US08/642,330 US5863727A (en) | 1996-05-03 | 1996-05-03 | Energy transfer dyes with enhanced fluorescence |
| US08/726,462 US5800996A (en) | 1996-05-03 | 1996-10-04 | Energy transfer dyes with enchanced fluorescence |
| US08/726,462 | 1996-10-04 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2297589A Division CA2297589C (en) | 1996-05-03 | 1997-04-23 | Energy transfer dyes with enhanced fluorescence |
Publications (2)
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| CA2203494A1 CA2203494A1 (en) | 1997-11-03 |
| CA2203494C true CA2203494C (en) | 2000-12-26 |
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| CA002203494A Expired - Fee Related CA2203494C (en) | 1996-05-03 | 1997-04-23 | Energy transfer dyes with enhanced fluorescence |
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| Country | Link |
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| US (1) | US5800996A (enExample) |
| EP (2) | EP0940450B1 (enExample) |
| JP (8) | JP3090626B2 (enExample) |
| AT (2) | ATE335051T1 (enExample) |
| CA (1) | CA2203494C (enExample) |
| DE (2) | DE69736434T2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7825237B2 (en) | 1996-05-03 | 2010-11-02 | Applied Biosystems, Llc | Oligonucleotides and analogs labeled with energy transfer dyes |
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| US6723556B1 (en) * | 1982-12-02 | 2004-04-20 | Cornell Research Foundation, Inc. | Nucleic acid encoding a fragment of bovine luteinizing hormone/chorionic gonadotropin receptor |
| US5935522A (en) * | 1990-06-04 | 1999-08-10 | University Of Utah Research Foundation | On-line DNA analysis system with rapid thermal cycling |
| US6787304B1 (en) | 1994-12-28 | 2004-09-07 | Georgetown University | Fluorometric assay for detecting nucleic acid cleavage |
| US20030165908A1 (en) * | 1994-12-30 | 2003-09-04 | Georgetown University | Fluorometric assay for detecting nucleic acid cleavage |
| US5847162A (en) * | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
| US5945526A (en) * | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5863727A (en) * | 1996-05-03 | 1999-01-26 | The Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US7388092B2 (en) | 1996-05-03 | 2008-06-17 | Applera Corporation | Oligonucleotides and analogs labeled with energy transfer dyes |
| ATE390491T1 (de) * | 1996-06-04 | 2008-04-15 | Univ Utah Res Found | Behälter zum durchführen und beobachten biologischer prozesse |
| AU726501B2 (en) * | 1996-06-04 | 2000-11-09 | University Of Utah Research Foundation | Monitoring hybridization during PCR |
| US5804386A (en) * | 1997-01-15 | 1998-09-08 | Incyte Pharmaceuticals, Inc. | Sets of labeled energy transfer fluorescent primers and their use in multi component analysis |
| ATE273381T1 (de) | 1997-02-12 | 2004-08-15 | Eugene Y Chan | Verfahren zur analyse von polymeren |
| EP2208789B1 (en) * | 1997-03-12 | 2015-07-22 | Applied Biosystems, LLC | DNA polymerases having improved labeled nucleotide incorporation properties |
| CA2265551A1 (en) | 1997-07-11 | 1999-01-21 | Wako Pure Chemical Industries Ltd. | Compounds having energy transfer function and method for dna base sequencing by using the same |
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| US6130101A (en) * | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| EP1023463A4 (en) | 1997-10-09 | 2003-01-02 | Transgenomic Inc | MODIFICATION OF DOUBLE-STRANDED DNA TO IMPROVE CHROMATOGRAPHIC SEPARATIONS OF MATCHED ION POLYNUCLEOTIDES |
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| EP1025120B1 (en) * | 1997-10-27 | 2010-08-18 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
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| DE19850593A1 (de) * | 1998-11-03 | 2000-05-04 | Biochip Technologies Gmbh | Verfahren zum Nachweis von Hybridisierungsereignissen bei DNA |
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1996
- 1996-10-04 US US08/726,462 patent/US5800996A/en not_active Expired - Lifetime
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1997
- 1997-04-23 CA CA002203494A patent/CA2203494C/en not_active Expired - Fee Related
- 1997-05-02 EP EP99201120A patent/EP0940450B1/en not_active Expired - Lifetime
- 1997-05-02 DE DE69736434T patent/DE69736434T2/de not_active Expired - Lifetime
- 1997-05-02 EP EP97303039A patent/EP0805190B1/en not_active Expired - Lifetime
- 1997-05-02 AT AT99201120T patent/ATE335051T1/de not_active IP Right Cessation
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- 1997-05-02 AT AT97303039T patent/ATE187752T1/de not_active IP Right Cessation
- 1997-05-06 JP JP09115920A patent/JP3090626B2/ja not_active Expired - Fee Related
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2000
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- 2000-01-19 JP JP2000010932A patent/JP2000187036A/ja active Pending
- 2000-01-19 JP JP2000010931A patent/JP2000154381A/ja not_active Withdrawn
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2003
- 2003-02-05 JP JP2003028821A patent/JP3499238B2/ja not_active Expired - Fee Related
- 2003-08-06 JP JP2003288286A patent/JP2004068023A/ja not_active Withdrawn
- 2003-08-06 JP JP2003288285A patent/JP2004043819A/ja not_active Withdrawn
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7825237B2 (en) | 1996-05-03 | 2010-11-02 | Applied Biosystems, Llc | Oligonucleotides and analogs labeled with energy transfer dyes |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE335051T1 (de) | 2006-08-15 |
| DE69700935T2 (de) | 2000-04-27 |
| DE69700935D1 (de) | 2000-01-20 |
| JP2000154332A (ja) | 2000-06-06 |
| AU691143B2 (en) | 1998-05-07 |
| JP2000154381A (ja) | 2000-06-06 |
| AU1999597A (en) | 1997-11-20 |
| EP0805190B1 (en) | 1999-12-15 |
| EP0805190A3 (en) | 1998-01-07 |
| JP2004068023A (ja) | 2004-03-04 |
| EP0940450B1 (en) | 2006-08-02 |
| JP2004250713A (ja) | 2004-09-09 |
| DE69736434D1 (de) | 2006-09-14 |
| EP0940450A1 (en) | 1999-09-08 |
| JP2004043819A (ja) | 2004-02-12 |
| JP3499238B2 (ja) | 2004-02-23 |
| JP2003274999A (ja) | 2003-09-30 |
| JPH1088124A (ja) | 1998-04-07 |
| JP2000187036A (ja) | 2000-07-04 |
| ATE187752T1 (de) | 2000-01-15 |
| EP0805190A2 (en) | 1997-11-05 |
| JP3090626B2 (ja) | 2000-09-25 |
| DE69736434T2 (de) | 2007-03-01 |
| CA2203494A1 (en) | 1997-11-03 |
| US5800996A (en) | 1998-09-01 |
| JP3592173B2 (ja) | 2004-11-24 |
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