CA2198899C - Procedes de production de banques d'anticorps au moyen de chaines legeres d'immunoglobuline universelles ou rendues alleatoires - Google Patents
Procedes de production de banques d'anticorps au moyen de chaines legeres d'immunoglobuline universelles ou rendues alleatoires Download PDFInfo
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- CA2198899C CA2198899C CA2198899A CA2198899A CA2198899C CA 2198899 C CA2198899 C CA 2198899C CA 2198899 A CA2198899 A CA 2198899A CA 2198899 A CA2198899 A CA 2198899A CA 2198899 C CA2198899 C CA 2198899C
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- light chain
- seq
- immunoglobulin
- sequence
- heavy
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Abstract
La présente invention concerne des procédés permettant de produire des banques d'anticorps, et particulièrement d'augmenter la diversité de banques d'anticorps par induction d'une mutagenèse dans les régions déterminantes complémentaires (CDR) de chaînes lourdes ou légères d'immunoglobuline qui apparaissent à la surface de particules de phages filamenteux, comprenant la banque. L'invention concerne également des oligonucléotides utilisés pour augmenter la diversité des banques, ainsi que des chaînes légères universelles utilisées dans lesdits procédés de production de banques d'anticorps.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/300,386 | 1994-09-02 | ||
US08/300,386 US5667988A (en) | 1992-01-27 | 1994-09-02 | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
PCT/US1995/011235 WO1996007754A1 (fr) | 1994-09-02 | 1995-09-01 | Procedes de production de banques d'anticorps au moyen de chaines legeres d'immunoglobuline universelles ou rendues alleatoires |
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CA2198899A1 CA2198899A1 (fr) | 1996-03-14 |
CA2198899C true CA2198899C (fr) | 2010-02-23 |
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CA2198899A Expired - Lifetime CA2198899C (fr) | 1994-09-02 | 1995-09-01 | Procedes de production de banques d'anticorps au moyen de chaines legeres d'immunoglobuline universelles ou rendues alleatoires |
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US (2) | US5667988A (fr) |
EP (1) | EP0779933B1 (fr) |
JP (1) | JPH10504970A (fr) |
AT (1) | ATE236992T1 (fr) |
AU (1) | AU706343B2 (fr) |
CA (1) | CA2198899C (fr) |
DE (1) | DE69530305T2 (fr) |
DK (1) | DK0779933T3 (fr) |
ES (1) | ES2196077T3 (fr) |
PT (1) | PT779933E (fr) |
WO (1) | WO1996007754A1 (fr) |
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US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US6955900B1 (en) * | 1993-02-02 | 2005-10-18 | The Scripps Research Institute | Methods for producing polypeptide binding sites, monoclonal antibodies and compositions thereof |
AU6132994A (en) * | 1993-02-02 | 1994-08-29 | Scripps Research Institute, The | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
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- 1994-09-02 US US08/300,386 patent/US5667988A/en not_active Expired - Lifetime
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- 1995-09-01 CA CA2198899A patent/CA2198899C/fr not_active Expired - Lifetime
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- 1995-09-01 WO PCT/US1995/011235 patent/WO1996007754A1/fr active IP Right Grant
- 1995-09-01 EP EP95931709A patent/EP0779933B1/fr not_active Expired - Lifetime
- 1995-09-01 AU AU35046/95A patent/AU706343B2/en not_active Expired
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- 1995-09-01 DE DE69530305T patent/DE69530305T2/de not_active Expired - Lifetime
- 1995-09-01 DK DK95931709T patent/DK0779933T3/da active
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WO1996007754A1 (fr) | 1996-03-14 |
EP0779933A4 (fr) | 1999-10-06 |
DE69530305T2 (de) | 2004-02-12 |
AU706343B2 (en) | 1999-06-17 |
ES2196077T3 (es) | 2003-12-16 |
PT779933E (pt) | 2003-08-29 |
DE69530305D1 (de) | 2003-05-15 |
US5667988A (en) | 1997-09-16 |
CA2198899A1 (fr) | 1996-03-14 |
AU3504695A (en) | 1996-03-27 |
US6096551A (en) | 2000-08-01 |
EP0779933A1 (fr) | 1997-06-25 |
EP0779933B1 (fr) | 2003-04-09 |
JPH10504970A (ja) | 1998-05-19 |
DK0779933T3 (da) | 2003-07-28 |
ATE236992T1 (de) | 2003-04-15 |
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