CA2182508A1 - Comprimes a l'epreuve d'un usage abusif - Google Patents

Comprimes a l'epreuve d'un usage abusif

Info

Publication number
CA2182508A1
CA2182508A1 CA002182508A CA2182508A CA2182508A1 CA 2182508 A1 CA2182508 A1 CA 2182508A1 CA 002182508 A CA002182508 A CA 002182508A CA 2182508 A CA2182508 A CA 2182508A CA 2182508 A1 CA2182508 A1 CA 2182508A1
Authority
CA
Canada
Prior art keywords
abuse resistant
abuse
tablet
resistant tablets
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002182508A
Other languages
English (en)
Other versions
CA2182508C (fr
Inventor
Richard James Bastin
Bruce Hamilton Lithgow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2182508A1 publication Critical patent/CA2182508A1/fr
Application granted granted Critical
Publication of CA2182508C publication Critical patent/CA2182508C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Steroid Compounds (AREA)
CA002182508A 1994-02-01 1995-01-24 Comprimes a l'epreuve d'un usage abusif Expired - Fee Related CA2182508C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9401894A GB9401894D0 (en) 1994-02-01 1994-02-01 New compositions of matter
GB9401894.2 1994-02-01
PCT/GB1995/000137 WO1995020947A1 (fr) 1994-02-01 1995-01-24 Comprimes a l'epreuve d'un usage abusif

Publications (2)

Publication Number Publication Date
CA2182508A1 true CA2182508A1 (fr) 1995-08-10
CA2182508C CA2182508C (fr) 2005-08-09

Family

ID=10749671

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002182508A Expired - Fee Related CA2182508C (fr) 1994-02-01 1995-01-24 Comprimes a l'epreuve d'un usage abusif

Country Status (20)

Country Link
US (1) US6309668B1 (fr)
EP (1) EP0742711B1 (fr)
JP (1) JPH09508410A (fr)
AT (1) ATE177630T1 (fr)
AU (1) AU696005B2 (fr)
CA (1) CA2182508C (fr)
CZ (1) CZ291980B6 (fr)
DE (1) DE69508385T2 (fr)
DK (1) DK0742711T3 (fr)
ES (1) ES2132626T3 (fr)
FI (1) FI963025A (fr)
GB (1) GB9401894D0 (fr)
GR (1) GR3029734T3 (fr)
HU (1) HU223144B1 (fr)
IL (1) IL112501A (fr)
NO (1) NO313267B1 (fr)
NZ (1) NZ278643A (fr)
PL (1) PL178572B1 (fr)
WO (1) WO1995020947A1 (fr)
ZA (1) ZA95800B (fr)

Families Citing this family (165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9803240D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
EP1005863A1 (fr) * 1998-12-04 2000-06-07 Synthelabo Formes galeniques a liberation controlee contenant un hypnotique a activite courte ou un sel de ce compose
US20040258750A1 (en) * 1999-06-28 2004-12-23 Gerard Alaux Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
ATE526950T1 (de) 1999-10-29 2011-10-15 Euro Celtique Sa Hydrocodon-formulierungen mit gesteuerter freisetzung
AU5066101A (en) * 2000-04-13 2001-10-30 Synthon B.V. Modified release formulations containing a hypnotic agent
EP2263658A1 (fr) 2000-10-30 2010-12-22 Euro-Celtique S.A. Formulations d'hydrocodone à liberation lente
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
ATE376832T1 (de) * 2001-07-06 2007-11-15 Penwest Pharmaceuticals Co Verzögert freisetzende formulierungen von oxymorphon
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
CA2452871C (fr) * 2001-07-06 2011-10-04 Endo Pharmaceuticals, Inc. Compositions a liberation controlee d'oxymorphone
US7332182B2 (en) 2001-08-06 2008-02-19 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
US7842307B2 (en) 2001-08-06 2010-11-30 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent
US20030068276A1 (en) 2001-09-17 2003-04-10 Lyn Hughes Dosage forms
FR2829933B3 (fr) * 2001-09-21 2004-03-12 Ellipse Pharmaceuticals Procede de fabrication d'un produit pharmaceutique administrable par voie orale avec des agents detrompeurs notamment de gout et produit obtenu
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
CA2480826C (fr) 2002-04-09 2012-02-07 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s)
IL164221A0 (en) 2002-04-09 2005-12-18 Flamel Tech Sa Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10250083A1 (de) * 2002-06-17 2003-12-24 Gruenenthal Gmbh Gegen Missbrauch gesicherte Darreichungsform
US8840928B2 (en) * 2002-07-05 2014-09-23 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
CA2491572C (fr) * 2002-07-05 2010-03-23 Collegium Pharmaceutical, Inc. Compositions pharmaceutiques empechant la consommation abusive d'opioides et d'autres drogues
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8557291B2 (en) 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
EP1551402A4 (fr) * 2002-09-23 2009-05-27 Verion Inc Compositions pharmaceutiques n'induisant pas l'abus
DE10250084A1 (de) * 2002-10-25 2004-05-06 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
CA2523367A1 (fr) * 2003-05-02 2004-11-11 Warner-Lambert Company Llc Produits de confiserie pour administrer dans la gorge des agents pharmaceutiquement actifs
DE60309565T3 (de) * 2003-05-02 2015-01-15 Dexcel Ltd. Tablettenzubereitung mit verlängerter Freisetzung von Venlafaxin
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de) * 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
WO2005061033A1 (fr) * 2003-12-15 2005-07-07 Alexza Pharmaceuticals, Inc. Traitement de douleur aigue par inhalation en aerosol de medicaments
US20050165038A1 (en) † 2004-01-22 2005-07-28 Maxwell Gordon Analgetic dosage forms that are resistant to parenteral and inhalation dosing and have reduced side effects
KR20070030178A (ko) * 2004-02-17 2007-03-15 트랜스오랄 파마슈티칼스, 인코포레이티드 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법
PL1740156T3 (pl) * 2004-04-22 2011-12-30 Gruenenthal Gmbh Sposób wytwarzania zabezpieczonej przed nadużyciem, stałej postaci aplikacyjnej
US7622137B2 (en) * 2004-05-21 2009-11-24 Accu-Break Technologies, Inc. Dosage forms contained within a capsule or sachet
US7838031B2 (en) 2004-05-21 2010-11-23 Lawrence Solomon Method of administering a partial dose using a segmented pharmaceutical tablet
US7318935B2 (en) * 2004-05-21 2008-01-15 Accu-Break Technologies, Inc. Pharmaceutical tablets with active and inactive segments
US7780985B2 (en) * 2005-07-12 2010-08-24 Accu-Break Technologies, Inc. Tablets having a printed separation mark to guide breaking
US7713547B2 (en) 2004-05-21 2010-05-11 Accu-Break Pharmaceuticals, Inc. Method of administering a partial dose of a segmented pharmaceutical tablet
US7329418B2 (en) * 2004-05-21 2008-02-12 Accu Break Technologies, Inc. Pharmaceutical tablets having height greater than width
WO2005112898A1 (fr) * 2004-05-21 2005-12-01 Accu-Break Pharmaceuticals, Inc. Comprimes pharmaceutiques possedant un segment relativement inactif
US8216610B2 (en) * 2004-05-28 2012-07-10 Imaginot Pty Ltd. Oral paracetamol formulations
JP2008500288A (ja) * 2004-05-28 2008-01-10 イメイジノット ピーティーワイ エルティーディー 経口治療用化合物の供給系
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
SI1765292T1 (en) 2004-06-12 2018-04-30 Collegium Pharmaceutical, Inc. Formulations of medicines to discourage abuse
ITMI20041317A1 (it) * 2004-06-30 2004-09-30 Ibsa Inst Biochimique Sa Formulazioni farmaceutiche per la somministrazione sicura di farmaci utilizzati nel trattamento della tossicodipendenza e procedimento per il loro ottenimento
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
MX2007001138A (es) * 2004-07-29 2007-04-19 Sanofi Aventis Comprimido farmaceutico multicapa para la liberacion controlada de ingredientes activos con solubilidad muy dependiente del ph.
WO2006017787A2 (fr) * 2004-08-06 2006-02-16 Grain Processing Corporation Composition d'enrobage de comprime
FR2878161B1 (fr) * 2004-11-23 2008-10-31 Flamel Technologies Sa Forme medicamenteuse orale, solide et concue pour eviter le mesusage
US20070231268A1 (en) * 2004-11-24 2007-10-04 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
US20060177380A1 (en) * 2004-11-24 2006-08-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
FR2878158B1 (fr) * 2004-11-24 2009-01-16 Flamel Technologies Sa Forme pharmaceutique orale, microparticulaire solide concue pour eviter le mesusage
US20080152595A1 (en) * 2004-11-24 2008-06-26 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
US20060110327A1 (en) * 2004-11-24 2006-05-25 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
FR2881652B1 (fr) * 2005-02-08 2007-05-25 Flamel Technologies Sa Forme pharmaceutique orale microparticulaire anti-mesuage
GB0506982D0 (en) * 2005-04-06 2005-05-11 Mw Encap Ltd Abuse resistant capsules
KR100714616B1 (ko) * 2005-06-23 2007-05-07 삼성전기주식회사 지수 함수 발생기 및 이를 이용한 가변 이득 증폭기
US9125833B2 (en) * 2005-11-02 2015-09-08 Relmada Therapeutics, Inc. Multimodal abuse resistant and extended release opioid formulations
US8329744B2 (en) * 2005-11-02 2012-12-11 Relmada Therapeutics, Inc. Methods of preventing the serotonin syndrome and compositions for use thereof
WO2007087452A2 (fr) * 2006-01-27 2007-08-02 Theraquest Biosciences, Llc Formulations à libération prolongée empêchant l'usage abusif et méthodes d'utilisation de celles-ci
WO2007056142A2 (fr) * 2005-11-02 2007-05-18 Theraquest Biosciences, Llc Procedes de prevention du syndrome serotoninergique et compositions utilisees a cette fin
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
WO2007065559A1 (fr) * 2005-11-18 2007-06-14 Synthon B.V. Comprimés de zolpidem
JP5259413B2 (ja) * 2005-11-18 2013-08-07 エーシーシーユー−ブレイク テクノロジーズ，インク． セグメント化した薬の剤形
AU2006317530B2 (en) 2005-11-28 2011-09-01 Imaginot Pty Ltd Oral therapeutic compound delivery system
US8691272B2 (en) * 2005-12-30 2014-04-08 Intelgenx Corp. Multilayer tablet
US20070264346A1 (en) * 2006-02-16 2007-11-15 Flamel Technologies Multimicroparticulate pharmaceutical forms for oral administration
US20070237815A1 (en) * 2006-04-06 2007-10-11 Lawrence Solomon Dosage forms and methods comprising amlodipine and chlorthalidone
JP4720620B2 (ja) * 2006-05-30 2011-07-13 コニカミノルタビジネステクノロジーズ株式会社 カール補正装置及びこれを備えた画像形成装置
US20080069891A1 (en) 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
US20110086092A1 (en) * 2006-08-08 2011-04-14 Accu-Break Technologies, Inc. Pharmacuetical tablets containing a plurality of active ingredients
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
WO2008033351A2 (fr) * 2006-09-11 2008-03-20 Theraquest Biosciences, Inc. Formulations multimode de libération prolongée et résistantes à l'abus
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
US8187636B2 (en) 2006-09-25 2012-05-29 Atlantic Pharmaceuticals, Inc. Dosage forms for tamper prone therapeutic agents
JP2010511627A (ja) * 2006-11-30 2010-04-15 エーシーシーユー−ブレイク テクノロジーズ，インク． 分割可能な浸透性剤形及びその使用方法
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
EP2167049B1 (fr) * 2007-06-04 2016-08-31 Shear/Kershman Laboratories, Inc. Forme de dosage orale à base de lipide inviolable pour des agonistes d'opioïde
WO2008155620A1 (fr) * 2007-06-20 2008-12-24 Develco Pharma Schweiz Ag Forme posologique contenant une matrice dispersible de granulés à libération entretenue
US20080318994A1 (en) 2007-06-21 2008-12-25 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Renal Impairment
US20080318993A1 (en) * 2007-06-21 2008-12-25 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Hepatic Impairment
US20090004231A1 (en) 2007-06-30 2009-01-01 Popp Shane M Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring
BRPI0815387B8 (pt) * 2007-08-13 2021-05-25 Abuse Deterrent Pharmaceutical Llc composição farmacêutica, método para fazer uma composição farmacêutica e uso da composição farmacêutica
EP2219612A4 (fr) 2007-12-17 2013-10-30 Paladin Labs Inc Formulation à libération contrôlée évitant les utilisations impropres
BRPI0906467C1 (pt) 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
KR101690094B1 (ko) 2008-05-09 2016-12-27 그뤼넨탈 게엠베하 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법
US8420700B1 (en) * 2008-06-04 2013-04-16 James M. Bausch Tamper resistant lipid-based oral dosage form for sympathomimetic amines
PE20190391A1 (es) 2008-10-30 2019-03-13 Gruenenthal Chemie Formas de dosificacion del tapentadol novedosas y potentes
PL2379111T3 (pl) * 2008-12-12 2013-08-30 Paladin Labs Inc Preparaty leków narkotycznych o obniżonym potencjale uzależniającym
EP2367541B1 (fr) * 2008-12-16 2014-07-16 Paladin Labs Inc. Composition à libération contrôlée prévenant un mésusage
WO2010088385A1 (fr) * 2009-01-30 2010-08-05 Sepracor Inc. Comprimés de 6-(5-chloro-2-pyridyl)-5-[(4-méthyl-1-pipérazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine enrobés, et procédé pour mesurer l'efficacité de l'enrobage
PE20121067A1 (es) 2009-07-22 2012-09-05 Gruenenthal Chemie Forma de dosificacion de liberacion controlada extruida por fusion en caliente
WO2011009604A1 (fr) 2009-07-22 2011-01-27 Grünenthal GmbH Forme galénique inviolable stabilisée à l’oxydation
AU2010300641B2 (en) * 2009-09-30 2016-03-17 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse
US20110136815A1 (en) 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
ES2606227T3 (es) 2010-02-03 2017-03-23 Grünenthal GmbH Preparación de una composición farmacéutica en polvo mediante una extrusora
MX339408B (es) * 2010-03-09 2016-05-24 Alkermes Pharma Ireland Ltd Composiciones farmaceuticas entericas resistentes al alcohol.
JP2013526523A (ja) 2010-05-11 2013-06-24 シマ ラブス インク． メトプロロールを含むアルコール耐性持続放出性経口剤形
CA2808541C (fr) 2010-09-02 2019-01-08 Gruenenthal Gmbh Forme pharmaceutique inviolable comportant un polymere anionique
WO2012028319A1 (fr) 2010-09-02 2012-03-08 Grünenthal GmbH Forme pharmaceutique inviolable comportant un sel inorganique
SG191288A1 (en) 2010-12-22 2013-07-31 Purdue Pharma Lp Encased tamper resistant controlled release dosage forms
JP5638151B2 (ja) 2010-12-23 2014-12-10 パーデュー、ファーマ、リミテッド、パートナーシップ 不正加工抵抗性の（ｔａｍｐｅｒｒｅｓｉｓｔａｎｔ）固形経口剤形
JP6042880B2 (ja) * 2011-06-01 2016-12-14 エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ 放出を制御された固形剤形
KR20140053158A (ko) 2011-07-29 2014-05-07 그뤼넨탈 게엠베하 즉시 약물 방출을 제공하는 탬퍼-저항성 정제
AR087360A1 (es) 2011-07-29 2014-03-19 Gruenenthal Gmbh Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
JP6138798B2 (ja) * 2011-09-16 2017-05-31 パーデュー ファーマ エルピー 不正改変抵抗性即時放出性製剤
FR2983409B1 (fr) * 2011-12-06 2013-12-27 Ethypharm Sa Comprime susceptible de lutter contre le detournement par voie injectable
CA2864949A1 (fr) 2012-02-28 2013-09-06 Grunenthal Gmbh Forme pharmaceutique inviolable comprenant un compose pharmacologiquement actif et un polymere anionique
JP6282261B2 (ja) 2012-04-18 2018-02-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 不正使用防止および過量放出防止医薬剤形
JP6067100B2 (ja) 2012-04-18 2017-01-25 マリンクロッド エルエルシー 即放性乱用抑止医薬組成物
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
MX362838B (es) 2012-07-12 2019-02-19 SpecGx LLC Composiciones farmacéuticas de liberación prolongada para disuadir el abuso de opioides que comprenden un plastómero, un elastómero y un plastificante delicuescente.
JP5922851B2 (ja) 2012-11-30 2016-05-24 アキュラ・ファーマシューティカルズ・インコーポレーテッド 活性医薬成分の自己制御放出
US9149533B2 (en) 2013-02-05 2015-10-06 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
US20140275038A1 (en) 2013-03-15 2014-09-18 Inspirion Delivery Technologies, Llc Abuse deterrent compositions and methods of use
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
CA2901802C (fr) 2013-03-15 2021-03-02 Mallinckrodt Llc Forme galenique solide dissuasive d'abus pour liberation immediate avec marque fonctionnelle
EP3003279A1 (fr) 2013-05-29 2016-04-13 Grünenthal GmbH Forme pharmaceutique inviolable contenant une ou plusieurs particules
CA2913209A1 (fr) 2013-05-29 2014-12-04 Grunenthal Gmbh Forme dosifiee inviolable a profil de liberation bimodale
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
US20160213628A1 (en) * 2013-09-09 2016-07-28 Nova Southeastern University Deterring abuse of pharmaceutical products and alcohol
ES2855978T3 (es) 2013-10-13 2021-09-27 Univ Nova Southeastern Aplicación terapéutica de IL-15 para la modulación de la función de células NK en pacientes con la enfermedad de la Guerra del Golfo
WO2015066172A1 (fr) * 2013-10-31 2015-05-07 Cima Labs Inc. Formes pharmaceutiques en granulés anti-abus à libération immédiate
US20150118300A1 (en) 2013-10-31 2015-04-30 Cima Labs Inc. Immediate Release Abuse-Deterrent Granulated Dosage Forms
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
WO2015087241A1 (fr) 2013-12-11 2015-06-18 Ranbaxy Laboratories Limited Forme posologique orale, solide, résistante à l'écrasement
EP3079661B1 (fr) 2013-12-11 2021-05-05 Algobate AG Mono-préparation de naloxone
US10105360B2 (en) 2013-12-11 2018-10-23 Develco Pharma Schweiz Ag Method and composition for the treatment of opioid induced constipation
US9062063B1 (en) 2014-03-21 2015-06-23 Johnson Matthey Public Limited Company Forms of oxymorphone hydrochloride
US9616029B2 (en) 2014-03-26 2017-04-11 Sun Pharma Advanced Research Company Ltd. Abuse deterrent immediate release coated reservoir solid dosage form
CA2947786A1 (fr) 2014-05-12 2015-11-19 Grunenthal Gmbh Formulation pour capsule a liberation immediate resistant aux manipulations illicites comprenant du tapentadol
WO2015181059A1 (fr) 2014-05-26 2015-12-03 Grünenthal GmbH Microparticules protégées contre une libération massive dans l'éthanol
MX2017000041A (es) 2014-07-03 2017-05-01 Mallinckrodt Llc Formulaciones de liberacion inmediata disuasivas de abuso que comprenden polisacaridos no celulosicos.
CA2910865C (fr) 2014-07-15 2016-11-29 Isa Odidi Compositions et methodes destines a reduire les surdoses
US9132096B1 (en) 2014-09-12 2015-09-15 Alkermes Pharma Ireland Limited Abuse resistant pharmaceutical compositions
US10729685B2 (en) 2014-09-15 2020-08-04 Ohemo Life Sciences Inc. Orally administrable compositions and methods of deterring abuse by intranasal administration
US9918979B2 (en) 2015-01-29 2018-03-20 Johnson Matthey Public Limited Company Process of preparing low ABUK oxymorphone hydrochloride
JP2018517676A (ja) 2015-04-24 2018-07-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時放出および溶媒抽出に対する耐性を有する改変防止製剤
WO2017040607A1 (fr) 2015-08-31 2017-03-09 Acura Pharmaceuticals, Inc. Procédés et compositions pour la libération auto-régulée d'un ingrédient pharmaceutique actif
WO2017042325A1 (fr) 2015-09-10 2017-03-16 Grünenthal GmbH Protection contre un surdosage par voie orale à l'aide de formulations à libération immédiate dissuasives d'abus
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
US11478426B2 (en) 2018-09-25 2022-10-25 SpecGx LLC Abuse deterrent immediate release capsule dosage forms
JP7304691B2 (ja) * 2018-12-06 2023-07-07 日本ケミファ株式会社 ゾピクロン、その光学異性体又はこれらの塩の何れかを有効成分として含有する錠剤
GR1009791B (el) 2019-03-26 2020-08-03 Φαρματεν Α.Β.Ε.Ε. Σκευασμα παρατεταμενης αποδεσμευσης που περιλαμβανει ταπενταδολη και μεθοδος παρασκευης αυτου
US20220062200A1 (en) 2019-05-07 2022-03-03 Clexio Biosciences Ltd. Abuse-deterrent dosage forms containing esketamine
EP3965733A4 (fr) 2019-05-07 2023-01-11 Clexio Biosciences Ltd. Formes posologiques dissuasives d'abus contenant de l'eskétamine

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE664908C (de) * 1935-07-13 1938-09-07 Joh Paul Schoenthan Von Pernwa Verfahren zur Herstellung leicht schluckbarer Arzneigaben
US3980766A (en) * 1973-08-13 1976-09-14 West Laboratories, Inc. Orally administered drug composition for therapy in the treatment of narcotic drug addiction
DE2530563C2 (de) * 1975-07-09 1986-07-24 Bayer Ag, 5090 Leverkusen Analgetische Arzneimittel mit vermindertem Mißbrauchspotential
JPS5843915A (ja) * 1981-09-09 1983-03-14 Teijin Ltd 口腔粘膜接着形製剤
JPS5858146A (ja) * 1981-10-05 1983-04-06 Tanabe Seiyaku Co Ltd 速放性マイクロカプセル
US4728512A (en) * 1985-05-06 1988-03-01 American Home Products Corporation Formulations providing three distinct releases
JPS6327424A (ja) 1986-07-17 1988-02-05 Shionogi & Co Ltd 徐放性製剤およびその製造法
JPS6344125A (ja) 1986-08-12 1988-02-25 Tama Denki Kogyo Kk ガラスパイプ被覆型センサ−
US4753790A (en) * 1986-12-16 1988-06-28 Warner-Lambert Company Sorbitol coated comestible and method of preparation
IT1201136B (it) 1987-01-13 1989-01-27 Resa Farma Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive
US4786503A (en) * 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
US4814178A (en) * 1987-07-01 1989-03-21 Sanford Bolton Floating sustained release therapeutic compositions
DE3814532A1 (de) 1988-04-29 1989-11-09 Bayer Ag Dhp-retard-zubereitung
US5417985A (en) * 1989-07-20 1995-05-23 Farmalyoc Solid and porous single dosage form comprising particles in the form of beads and its preparation
US5474784A (en) * 1990-03-02 1995-12-12 British Technology Group Limited Dispensing device
DE69222006T2 (de) 1991-10-30 1998-01-22 Glaxo Group Ltd Mehrschichtzusammensetzungen enthaltend Histamin- oder Serotonin- Antagonisten
IT1255522B (it) 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'

Also Published As

Publication number Publication date
EP0742711A1 (fr) 1996-11-20
NO313267B1 (no) 2002-09-09
CZ291980B6 (cs) 2003-06-18
ES2132626T3 (es) 1999-08-16
JPH09508410A (ja) 1997-08-26
WO1995020947A1 (fr) 1995-08-10
HU9602103D0 (en) 1996-09-30
GB9401894D0 (en) 1994-03-30
AU696005B2 (en) 1998-08-27
HUT74903A (en) 1997-03-28
EP0742711B1 (fr) 1999-03-17
AU1461695A (en) 1995-08-21
US6309668B1 (en) 2001-10-30
ZA95800B (en) 1996-08-01
DK0742711T3 (da) 1999-10-11
NZ278643A (en) 1997-12-19
CZ226096A3 (en) 1997-01-15
DE69508385T2 (de) 1999-08-26
IL112501A0 (en) 1995-03-30
NO963202L (no) 1996-09-30
DE69508385D1 (de) 1999-04-22
ATE177630T1 (de) 1999-04-15
IL112501A (en) 2000-08-13
NO963202D0 (no) 1996-07-31
GR3029734T3 (en) 1999-06-30
PL315709A1 (en) 1996-11-25
PL178572B1 (pl) 2000-05-31
FI963025A0 (fi) 1996-07-31
HU223144B1 (hu) 2004-03-29
FI963025A (fi) 1996-07-31
CA2182508C (fr) 2005-08-09

Similar Documents

Publication Publication Date Title
CA2182508A1 (fr) Comprimes a l'epreuve d'un usage abusif
CA2166483A1 (fr) Nouvelle formulation pharmaceutique
CA2145513A1 (fr) Comprime pouvant liberer a differentes vitesses un ou plusieurs medicaments
CA2180816A1 (fr) 6-dimethylaminomethyl-1-phenylcyclohexanes, principes actifs en pharmacie
CA2193337A1 (fr) Composes de type 1-phenyl-2-dimethylaminomethylcyclohexan-1-o1, ingredients pharmaceutiques actifs
CA2326485A1 (fr) Compositions anticancereuses
AU3884589A (en) Intravenous pharmaceutical composition comprising cyclosporins
AU2925295A (en) A novel drug delivery system
HU9502933D0 (en) Pharmaceutical composition containing lipophilic drugs
NZ231247A (en) Two-layer pharmaceutical tablet containing analgesic and decongestant
ZA962536B (en) Pharmaceutical composition for transdermal administration.
CA2131495A1 (fr) Comprimes d'oxcarbazepine a double couche
PL327923A1 (en) Novel combination of active ingredients containing clopidogrel and antithrombotic drug
IL117621A (en) Tricyclic pyrido (3,2-e) pyrazinones their preparation and pharmaceutical compositions containing them
AU1890295A (en) Piperidines and pyrrolidines
AU3136293A (en) Pharmaceutical tablet with pvp having an enhanced drug dissolution rate
PL329789A1 (en) Novel compounds - derivatives of hydrocarbons, pharmaceutic composition containing such derivatives and their application in production of drugs
CA2163197A1 (fr) Triples complexes de platine
FR2703995B1 (fr) 5-acylamino 1,2,4-thiadiazoles, leur preparation et compositions pharmaceutiques en contenant.
ZA989781B (en) Novel bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them.
ZA961983B (en) Bicyclic compounds, preparation thereof and use in pharmaceutical compositions.
EP0649660A3 (fr) Compositions pharmaceutiques pour l'administration parentérale, entérale et dermale d'agents actifs pratiquement insolubles, et procédé pour leur fabrication.
CA2356306A1 (fr) Phosphatidylinositols sulfates, leur preparation et utilisation
CA2150642A1 (fr) Tablette, capsule ou granule renfermant du desogestrel
IL110810A0 (en) 1,5-diphenyl-3-(n-hydroxycarbamoyloxyalkyl) pyrazoles and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130124