CA2078990C - Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs - Google Patents
Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs Download PDFInfo
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- CA2078990C CA2078990C CA002078990A CA2078990A CA2078990C CA 2078990 C CA2078990 C CA 2078990C CA 002078990 A CA002078990 A CA 002078990A CA 2078990 A CA2078990 A CA 2078990A CA 2078990 C CA2078990 C CA 2078990C
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- water
- drug
- membrane
- lipid
- particles
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/514,012 US5091188A (en) | 1990-04-26 | 1990-04-26 | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US514,012 | 1990-04-26 | ||
| PCT/US1991/002804 WO1991016068A1 (en) | 1990-04-26 | 1991-04-23 | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2078990A1 CA2078990A1 (en) | 1991-10-27 |
| CA2078990C true CA2078990C (en) | 2002-06-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002078990A Expired - Lifetime CA2078990C (en) | 1990-04-26 | 1991-04-23 | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5091188A (ref) |
| EP (1) | EP0533690B1 (ref) |
| JP (1) | JP3261129B2 (ref) |
| KR (1) | KR0159114B1 (ref) |
| AT (1) | ATE181234T1 (ref) |
| AU (1) | AU7852891A (ref) |
| CA (1) | CA2078990C (ref) |
| DE (1) | DE69131349T2 (ref) |
| DK (1) | DK0533690T3 (ref) |
| ES (1) | ES2134776T3 (ref) |
| GR (1) | GR3030825T3 (ref) |
| MX (1) | MX25532A (ref) |
| RU (1) | RU2100030C1 (ref) |
| TW (1) | TW203559B (ref) |
| WO (1) | WO1991016068A1 (ref) |
| ZA (1) | ZA913122B (ref) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9498493B2 (en) | 2007-09-27 | 2016-11-22 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
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| US5552160A (en) * | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
| US5399363A (en) * | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
| WO1993015731A1 (en) * | 1992-02-14 | 1993-08-19 | Robert Lamb | Phosphate derivatives of vitamin e to protect cells from effects of aging and injury |
| DE4221268C2 (de) * | 1992-06-26 | 1997-06-12 | Lancaster Group Ag | Verwendung eines Dermatikums zur Unterstützung des Sauerstofftransportes in der Haut |
| US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| US5336507A (en) * | 1992-12-11 | 1994-08-09 | Sterling Winthrop Inc. | Use of charged phospholipids to reduce nanoparticle aggregation |
| US20070116761A1 (en) * | 1993-02-22 | 2007-05-24 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US20030073642A1 (en) * | 1993-02-22 | 2003-04-17 | American Bioscience, Inc. | Methods and formulations for delivery of pharmacologically active agents |
| FR2702160B1 (fr) * | 1993-03-02 | 1995-06-02 | Biovecteurs As | Vecteurs particulaires synthétiques et procédé de préparation. |
| DE19609538A1 (de) * | 1996-03-11 | 1997-09-18 | Basf Ag | Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung |
| DE4322158C2 (de) * | 1993-07-03 | 1997-04-10 | Rhone Poulenc Rorer Gmbh | Phospholipidische Zusammensetzung sowie Verwendung einer derartigen Zusammensetzung |
| US5393461A (en) * | 1993-10-04 | 1995-02-28 | Rtd Corporation | Preparation of stable aqueous emulsions of water-insoluble particles |
| WO1996025918A1 (en) * | 1995-02-24 | 1996-08-29 | Nanosystems L.L.C. | Aerosols containing nanoparticle dispersions |
| US5747001A (en) * | 1995-02-24 | 1998-05-05 | Nanosystems, L.L.C. | Aerosols containing beclomethazone nanoparticle dispersions |
| DE19511276C2 (de) * | 1995-03-27 | 1999-02-18 | Immuno Ag | Adjuvans auf der Basis kolloidaler Eisenverbindungen |
| US5788959A (en) | 1995-04-24 | 1998-08-04 | University Of Maryland, Baltimore County | Drug delivery device and method for employing the same |
| US5785975A (en) * | 1995-06-26 | 1998-07-28 | Research Triangle Pharmaceuticals | Adjuvant compositions and vaccine formulations comprising same |
| US5931809A (en) * | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| US5834025A (en) | 1995-09-29 | 1998-11-10 | Nanosystems L.L.C. | Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions |
| KR100508910B1 (ko) * | 1995-10-17 | 2006-04-20 | 알티피 파마 코포레이션 | 불용성약물방출 |
| RO120603B1 (ro) * | 1996-08-22 | 2006-05-30 | Research Triangle Pharmaceuticals Ltd. | Compoziţie conţinând microparticule de substanţe insolubile în apă şi procedeu de preparare |
| US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
| US7255877B2 (en) * | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
| US8137684B2 (en) | 1996-10-01 | 2012-03-20 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US20070185032A1 (en) * | 1996-12-11 | 2007-08-09 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| ES2158611T3 (es) * | 1996-12-20 | 2001-09-01 | Alza Corp | Composicion en gel inyectable con efecto retard y procedimiento para la preparacion de dicha composicion. |
| FR2757768B1 (fr) * | 1996-12-27 | 1999-04-02 | Biovector Therapeutics Sa | Vecteur particulaire homeocharge et composition pharmaceutique ou cosmetique le contenant |
| CN1178653C (zh) * | 1997-02-27 | 2004-12-08 | 三菱制药株式会社 | 药物组合物 |
| AU7133898A (en) * | 1997-04-18 | 1998-11-13 | Vertex Pharmaceuticals Incorporated | Nanosized aspartyl protease inhibitors |
| NZ502500A (en) * | 1997-06-27 | 2002-03-28 | Vivorx Pharmaceuticals Inc | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
| US20060165606A1 (en) * | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| HUP0101139A3 (en) * | 1997-12-02 | 2003-11-28 | Powderject Vaccines Inc Madiso | Transdermal delivery of particulate vaccine compositions |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| ES2201673T3 (es) * | 1998-02-11 | 2004-03-16 | Rtp Pharma Corporation | Combinacion de esteroides y acidos grasos poiinsaturados para el tratamiento de estados inflamatorios. |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| SE9801287D0 (sv) * | 1998-04-14 | 1998-04-14 | Astra Ab | Incorporation of active substances in carrier matrixes |
| WO1999061001A1 (en) | 1998-05-29 | 1999-12-02 | Rtp Pharma Inc. | Thermoprotected microparticle compositions and process for terminal steam sterilization thereof |
| US7343710B2 (en) * | 1998-07-03 | 2008-03-18 | I.D.A Limited | Method and apparatus for controlling pests |
| GB9814507D0 (en) * | 1998-07-03 | 1998-09-02 | Univ Southampton | A method and apparatus for controlling pests |
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- 1991-04-23 AT AT91908933T patent/ATE181234T1/de not_active IP Right Cessation
- 1991-04-23 RU RU9292016352A patent/RU2100030C1/ru active
- 1991-04-23 AU AU78528/91A patent/AU7852891A/en not_active Abandoned
- 1991-04-23 WO PCT/US1991/002804 patent/WO1991016068A1/en not_active Ceased
- 1991-04-23 KR KR1019920702656A patent/KR0159114B1/ko not_active Expired - Lifetime
- 1991-04-23 DK DK91908933T patent/DK0533690T3/da active
- 1991-04-23 JP JP50885491A patent/JP3261129B2/ja not_active Expired - Lifetime
- 1991-04-23 ES ES91908933T patent/ES2134776T3/es not_active Expired - Lifetime
- 1991-04-23 EP EP91908933A patent/EP0533690B1/en not_active Expired - Lifetime
- 1991-04-23 DE DE69131349T patent/DE69131349T2/de not_active Expired - Lifetime
- 1991-04-25 ZA ZA913122A patent/ZA913122B/xx unknown
- 1991-04-26 MX MX2553291A patent/MX25532A/es unknown
- 1991-05-22 TW TW080103981A patent/TW203559B/zh not_active IP Right Cessation
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1994
- 1994-09-12 US US08/304,225 patent/USRE35338E/en not_active Expired - Lifetime
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9498493B2 (en) | 2007-09-27 | 2016-11-22 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69131349T2 (de) | 1999-11-18 |
| MX25532A (es) | 1993-10-01 |
| USRE35338E (en) | 1996-09-24 |
| CA2078990A1 (en) | 1991-10-27 |
| KR0159114B1 (ko) | 1998-12-01 |
| ES2134776T3 (es) | 1999-10-16 |
| EP0533690A4 (en) | 1993-04-14 |
| ATE181234T1 (de) | 1999-07-15 |
| JPH05507685A (ja) | 1993-11-04 |
| US5091188A (en) | 1992-02-25 |
| WO1991016068A1 (en) | 1991-10-31 |
| JP3261129B2 (ja) | 2002-02-25 |
| DE69131349D1 (de) | 1999-07-22 |
| GR3030825T3 (en) | 1999-11-30 |
| EP0533690A1 (en) | 1993-03-31 |
| DK0533690T3 (da) | 1999-11-22 |
| AU7852891A (en) | 1991-11-11 |
| ZA913122B (en) | 1992-04-29 |
| TW203559B (ref) | 1993-04-11 |
| RU2100030C1 (ru) | 1997-12-27 |
| EP0533690B1 (en) | 1999-06-16 |
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