CA2054895A1 - Composes de 7-acyl-3-(a substituant carbonoyloxy) cephem et procede pour leur obtention - Google Patents

Composes de 7-acyl-3-(a substituant carbonoyloxy) cephem et procede pour leur obtention

Info

Publication number
CA2054895A1
CA2054895A1 CA2054895A CA2054895A CA2054895A1 CA 2054895 A1 CA2054895 A1 CA 2054895A1 CA 2054895 A CA2054895 A CA 2054895A CA 2054895 A CA2054895 A CA 2054895A CA 2054895 A1 CA2054895 A1 CA 2054895A1
Authority
CA
Canada
Prior art keywords
group
lower alkyl
hydroxyl
substituted
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2054895A
Other languages
English (en)
Other versions
CA2054895C (fr
Inventor
Shigeto Negi
Motosuke Yamanaka
Kanemasa Katsu
Isao Sugiyama
Yuuki Komatu
Atsushi Kamata
Akihiko Tsuruoka
Yoshimasa Machida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Shigeto Negi
Motosuke Yamanaka
Kanemasa Katsu
Isao Sugiyama
Yuuki Komatu
Atsushi Kamata
Akihiko Tsuruoka
Yoshimasa Machida
Eisai Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2302783A external-priority patent/JPH04178392A/ja
Priority claimed from JP3040747A external-priority patent/JPH05331174A/ja
Priority claimed from JP6770991A external-priority patent/JPH04282388A/ja
Priority claimed from JP16951291A external-priority patent/JPH05331173A/ja
Application filed by Shigeto Negi, Motosuke Yamanaka, Kanemasa Katsu, Isao Sugiyama, Yuuki Komatu, Atsushi Kamata, Akihiko Tsuruoka, Yoshimasa Machida, Eisai Co., Ltd. filed Critical Shigeto Negi
Publication of CA2054895A1 publication Critical patent/CA2054895A1/fr
Application granted granted Critical
Publication of CA2054895C publication Critical patent/CA2054895C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002054895A 1990-11-09 1991-11-04 Composes de 7-acyl-3-(a substituant carbonoyloxy) cephem et procede pour leur obtention Expired - Fee Related CA2054895C (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP302,783/90 1990-11-09
JP2302783A JPH04178392A (ja) 1990-11-09 1990-11-09 ７―アシル―３―置換カルバモイルオキシセフェム化合物およびその製造法
JP40,747/91 1991-02-14
JP3040747A JPH05331174A (ja) 1991-02-14 1991-02-14 ７−アシル−３−置換カルバモイルオキシセフェム化合物およびその製造法
JP67,709/91 1991-03-08
JP6770991A JPH04282388A (ja) 1991-03-08 1991-03-08 ７−置換−３−ジメチルカルバモイルオキシメチル−３−セフェム化合物の製造法およびその中間体
JP16951291A JPH05331173A (ja) 1991-04-12 1991-04-12 ７−置換−３−アリールオキシカルボニルオキシメチル−３−セフェム化合物及びその製造法
JP169,512/91 1991-04-12

Publications (2)

Publication Number Publication Date
CA2054895A1 true CA2054895A1 (fr) 1992-05-10
CA2054895C CA2054895C (fr) 2001-02-13

Family

ID=27460944

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002054895A Expired - Fee Related CA2054895C (fr) 1990-11-09 1991-11-04 Composes de 7-acyl-3-(a substituant carbonoyloxy) cephem et procede pour leur obtention

Country Status (20)

Country Link
US (5) US5559225A (fr)
EP (4) EP0761671B1 (fr)
JP (2) JP2867192B2 (fr)
KR (1) KR0166378B1 (fr)
CN (2) CN1038589C (fr)
AT (2) ATE200492T1 (fr)
AU (2) AU654300B2 (fr)
CA (1) CA2054895C (fr)
DE (2) DE69132578T2 (fr)
DK (1) DK0484966T3 (fr)
ES (1) ES2155433T3 (fr)
FI (1) FI915245A (fr)
GR (1) GR3036157T3 (fr)
HU (1) HU221429B (fr)
IL (3) IL99898A (fr)
NO (1) NO302417B1 (fr)
NZ (1) NZ240441A (fr)
PT (1) PT99468B (fr)
RU (1) RU2091378C1 (fr)
YU (1) YU48399B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05230068A (ja) * 1992-02-07 1993-09-07 Kyoto Yakuhin Kogyo Kk ３−ジ置換カルバモイルオキシメチルセファロスポリン化合物、その製造法および中間体化合物
AT401651B (de) * 1994-06-14 1996-11-25 Biochemie Gmbh 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4-
KR100197788B1 (ko) * 1995-06-30 1999-06-15 김충환 세펨 유도체의 제조방법
JP3948628B2 (ja) * 1995-12-27 2007-07-25 ハンミ ファーマシューティカル シーオー．，エルティーディー． セフディニルの製造方法
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2491503A1 (fr) * 2003-12-24 2005-06-24 Chic Optic Inc. Lunettes avec articulations speciales
CN102633816A (zh) * 2012-03-30 2012-08-15 李莎 头孢西丁酯化前体药物化合物及口服制剂
US11222768B2 (en) * 2018-09-07 2022-01-11 Varian Semiconductor Equipment Associates, Inc. Foam in ion implantation system
CN112321606B (zh) * 2020-11-04 2022-05-17 福安药业集团重庆博圣制药有限公司 头孢唑肟钠及其中间体的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7412541A (nl) * 1973-10-12 1975-04-15 Merck & Co Inc Werkwijze voor het bereiden van cefalosporinen, ijze ter bereiding van farmaceutische raten, alsmede de door toepassing daarvan ardigde voorwerpen.
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760484C2 (fr) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
JPS6011713B2 (ja) 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4705704A (en) * 1985-10-01 1987-11-10 General Electric Company Novel aminofunctional polysiloxane emulsions for treating textiles
FI872879A (fi) * 1986-07-21 1988-01-22 Sankei Yakuhin Kk --laktamfoerening, foerfarande foer dess framstaellning, denna innehaollande laekemedelskomposition foer behandling av sjukdom med bakterieinfektion samt mellanprodukter foer dess syntes.
GB8623211D0 (en) * 1986-09-26 1986-10-29 Glaxo Group Ltd Chemical compounds
AU1630988A (en) * 1987-05-30 1988-12-01 Kyoto Pharmaceutical Industries, Ltd. Cephalosporin compound and pharmaceutical composition thereof
JPH0796240B2 (ja) 1987-08-13 1995-10-18 小島プレス工業株式会社 表皮を有する複合成形体
GB2210876A (en) * 1987-10-14 1989-06-21 Glaxo Group Ltd Cephalosporins
DK637888A (da) * 1987-11-24 1989-05-25 Hoffmann La Roche Carboxylsyreestere
CN1018091B (zh) * 1988-01-11 1992-09-02 吉林工业大学 晶体管噪声成份分析与测试系统
CN1015637B (zh) * 1988-02-25 1992-02-26 中国石油化工总公司石油化工科学研究院 含β沸石的烃重整催化剂
GB8907617D0 (en) * 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
JPH0346474A (ja) 1989-07-14 1991-02-27 Victor Co Of Japan Ltd 情報信号記録円盤及びその記録装置
ES2215161T3 (es) * 1991-09-07 2004-10-01 Aventis Pharma Deutschland Gmbh Diastereoisomero del ester 1-(isopropoxicarboniloxi)-etilico del acido 3-cefem-4-carboxilico y procedimiento para su preparacion.

Also Published As

Publication number Publication date
DE69132580D1 (de) 2001-05-17
RU2091378C1 (en) 1997-09-27
EP0484966A2 (fr) 1992-05-13
IL99898A (en) 1996-10-31
IL113744A (en) 1998-06-15
JPH0692969A (ja) 1994-04-05
NZ240441A (en) 1993-03-26
DE69132578T2 (de) 2001-08-23
AU654300B2 (en) 1994-11-03
YU48399B (sh) 1998-07-10
US5563265A (en) 1996-10-08
FI915245A0 (fi) 1991-11-06
JP3143829B2 (ja) 2001-03-07
KR0166378B1 (ko) 1999-01-15
US5604217A (en) 1997-02-18
ES2155433T3 (es) 2001-05-16
HU221429B (en) 2002-10-28
EP1074554A2 (fr) 2001-02-07
KR920009834A (ko) 1992-06-25
NO914375L (no) 1992-05-11
EP0761671A1 (fr) 1997-03-12
JPH1067784A (ja) 1998-03-10
US5559225A (en) 1996-09-24
CN1038589C (zh) 1998-06-03
EP0484966B1 (fr) 2001-04-11
EP0484966A3 (en) 1993-03-10
DE69132578D1 (de) 2001-05-10
AU671310B2 (en) 1996-08-22
DK0484966T3 (da) 2001-05-07
NO914375D0 (no) 1991-11-08
CA2054895C (fr) 2001-02-13
AU5057193A (en) 1994-01-20
US5741902A (en) 1998-04-21
PT99468B (pt) 1999-04-30
JP2867192B2 (ja) 1999-03-08
EP1074553A1 (fr) 2001-02-07
IL113744A0 (en) 1995-08-31
IL99898A0 (en) 1992-08-18
CN1140175A (zh) 1997-01-15
ATE200492T1 (de) 2001-04-15
HUT60275A (en) 1992-08-28
PT99468A (pt) 1992-10-30
NO302417B1 (no) 1998-03-02
EP1074554A3 (fr) 2001-02-28
HU913520D0 (en) 1992-01-28
EP0761671B1 (fr) 2001-04-04
GR3036157T3 (en) 2001-09-28
US5587473A (en) 1996-12-24
FI915245A (fi) 1992-05-10
CN1056847C (zh) 2000-09-27
YU178391A (sh) 1994-01-20
AU8709691A (en) 1992-05-14
DE69132580T2 (de) 2001-10-25
CN1061602A (zh) 1992-06-03
ATE200291T1 (de) 2001-04-15

Similar Documents

Publication Publication Date Title
CA2173150A1 (fr) Nouveau derive peptidique
IE812273L (en) Cephalosporin derivatives
CA2096969A1 (fr) Derives 6-o-methylerythromycine a
NO812956L (no) Fremgangsmaate for fremstilling av nye antibakterielle forbindelser av benzoksazintypen
GR3005315T3 (fr)
CA2053253A1 (fr) Nouveaux derives d'aryl- et d'heteroarylethenylene et procede d'obtention
UA41865C2 (uk) Сполуки цефему, що мають антимікробну активність, та фармацевтична композиція, що їх містить
CA2054895A1 (fr) Composes de 7-acyl-3-(a substituant carbonoyloxy) cephem et procede pour leur obtention
WO1992019210A3 (fr) Inhibiteurs du recaptage de la serotonine pour tomomographie a emetteur gamma
WO2003072576A3 (fr) Composes chimiques
TW342386B (en) Derivatives of benzoylecgonine, ecgonine and ecgonidine and methods for preparing and using same
PL304893A1 (en) Serotoninergic derivatives of ergoline
ES8407052A1 (es) Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas
IE870562L (en) Penem derivatives
SE8405338A (sv) (1,3)oxazino (4,3-a) isokinolinderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande dem
IE850128L (en) Guanidine derivatives
EP0323907A3 (fr) Préparation de dérivés de 5,8,13,14-tétrahydrobenz(5,6)-isoindolo(2,1-b) isoquinoléine-8,13-dione
KR950008520A (ko) 세팔로스포린 유도체 및 그의 제조방법
MY104164A (en) Heterocyclic compounds.

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed