CA1077948A - 1,-5 disubstituted-2-pyrrolidones and processes for their production - Google Patents

1,-5 disubstituted-2-pyrrolidones and processes for their production

Info

Publication number
CA1077948A
CA1077948A CA283,598A CA283598A CA1077948A CA 1077948 A CA1077948 A CA 1077948A CA 283598 A CA283598 A CA 283598A CA 1077948 A CA1077948 A CA 1077948A
Authority
CA
Canada
Prior art keywords
pyrrolidone
compound
ppm
group
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA283,598A
Other languages
English (en)
French (fr)
Inventor
Albin J. Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Priority to CA343,178A priority Critical patent/CA1084939A/en
Application granted granted Critical
Publication of CA1077948A publication Critical patent/CA1077948A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA283,598A 1976-08-06 1977-07-27 1,-5 disubstituted-2-pyrrolidones and processes for their production Expired CA1077948A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA343,178A CA1084939A (en) 1976-08-06 1980-01-07 Preparation of novel pyrrolidone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71236276A 1976-08-06 1976-08-06

Publications (1)

Publication Number Publication Date
CA1077948A true CA1077948A (en) 1980-05-20

Family

ID=24861795

Family Applications (1)

Application Number Title Priority Date Filing Date
CA283,598A Expired CA1077948A (en) 1976-08-06 1977-07-27 1,-5 disubstituted-2-pyrrolidones and processes for their production

Country Status (31)

Country Link
JP (2) JPS5321159A (fi)
AR (1) AR217080A1 (fi)
AT (1) AT362887B (fi)
AU (1) AU508007B2 (fi)
BE (1) BE857506A (fi)
BG (1) BG31073A3 (fi)
CA (1) CA1077948A (fi)
CH (1) CH624934A5 (fi)
CS (1) CS221269B2 (fi)
DD (2) DD143768A5 (fi)
DE (1) DE2735904A1 (fi)
DK (1) DK352077A (fi)
ES (2) ES461388A1 (fi)
FI (1) FI70009C (fi)
FR (1) FR2369260A1 (fi)
GB (2) GB1556570A (fi)
GR (1) GR68688B (fi)
HU (1) HU180273B (fi)
IE (1) IE45505B1 (fi)
IL (1) IL52615A (fi)
LU (1) LU77936A1 (fi)
NL (1) NL7708637A (fi)
NO (1) NO772752L (fi)
NZ (1) NZ184806A (fi)
PH (1) PH17398A (fi)
PL (2) PL112931B1 (fi)
PT (1) PT66891B (fi)
SE (1) SE423813B (fi)
SU (3) SU703016A3 (fi)
YU (1) YU192577A (fi)
ZA (1) ZA774704B (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5695569A (en) * 1979-12-27 1981-08-03 Canon Inc Forming method for bar lens sphere face
US4321201A (en) * 1980-09-22 1982-03-23 E. I. Du Pont De Nemours And Company Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl) heptanoates
JPS59137224A (ja) * 1983-01-25 1984-08-07 Mitsubishi Electric Corp 電気鉄道用き電電圧補償装置
IL141120A0 (en) 2000-01-31 2002-02-10 Pfizer Prod Inc Use of prostaglandin (pge2) receptor 4 (epa) selective agonists for the treatment of acute and chronic renal failure
WO2002024647A1 (fr) * 2000-09-21 2002-03-28 Ono Pharmaceutical Co., Ltd. Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine
CN1476429A (zh) * 2000-11-27 2004-02-18 �Ʒ� 治疗骨质疏松的ep4受体选择性激动剂
WO2003009872A1 (en) * 2001-07-23 2003-02-06 Ono Pharmaceutical Co., Ltd. Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient
DE60307607T2 (de) * 2002-03-18 2007-08-09 Pfizer Products Inc., Groton Verwendung von selektiven ep4 rezeptor agonisten zur behandlung von krankheiten
US6573294B1 (en) * 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
EP1586564B1 (en) * 2003-01-21 2012-11-28 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivatives and medicinal uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1386146A (en) * 1972-05-03 1975-03-05 Ici Ltd Cyclopentane derivatives
JPS511460A (en) * 1974-06-24 1976-01-08 Tanabe Seiyaku Co 22 piroridonjudotaino seiho
JPS514166A (ja) * 1974-06-28 1976-01-14 Tanabe Seiyaku Co 22piroridonjudotaino seiho
US3975399A (en) * 1974-08-06 1976-08-17 E. I. Du Pont De Nemours And Company 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones
DE2528664A1 (de) * 1975-06-27 1977-01-13 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ES471349A1 (es) 1979-09-16
PL112931B1 (en) 1980-11-29
YU192577A (en) 1983-04-30
ES461388A1 (es) 1978-12-01
SE423813B (sv) 1982-06-07
IL52615A (en) 1981-09-13
JPS585196B2 (ja) 1983-01-29
BE857506A (fr) 1978-02-06
GB1556569A (en) 1979-11-28
NZ184806A (en) 1980-04-28
GR68688B (fi) 1982-02-01
FI70009B (fi) 1986-01-31
AT362887B (de) 1981-06-25
BG31073A3 (en) 1981-10-15
PT66891B (en) 1979-01-26
JPS5555161A (en) 1980-04-22
AU508007B2 (en) 1980-03-06
JPS5321159A (en) 1978-02-27
IL52615A0 (en) 1977-10-31
PT66891A (en) 1977-09-01
CH624934A5 (fi) 1981-08-31
FI70009C (fi) 1986-09-12
HU180273B (en) 1983-02-28
FI772376A (fi) 1978-02-07
AR217080A1 (es) 1980-02-29
JPS5531147B2 (fi) 1980-08-15
GB1556570A (en) 1979-11-28
PH17398A (en) 1984-08-08
AU2751577A (en) 1979-02-08
ATA579477A (de) 1980-11-15
ZA774704B (en) 1978-06-28
LU77936A1 (fi) 1978-04-27
DD143768A5 (de) 1980-09-10
PL200124A1 (pl) 1978-05-22
SU850000A3 (ru) 1981-07-23
SU818480A3 (ru) 1981-03-30
NL7708637A (nl) 1978-02-08
DE2735904A1 (de) 1978-02-09
SE7708642L (sv) 1978-02-07
CS221269B2 (en) 1983-04-29
SU703016A3 (ru) 1979-12-05
DD136135A5 (de) 1979-06-20
FR2369260A1 (fr) 1978-05-26
DK352077A (da) 1978-02-07
NO772752L (no) 1978-02-07
FR2369260B1 (fi) 1982-02-12
IE45505L (en) 1978-02-06
IE45505B1 (en) 1982-09-08

Similar Documents

Publication Publication Date Title
US4177346A (en) 1,5-Disubstituted-2-pyrrolidones
US4116988A (en) 16-Phenoxy prostaglandin E1 analogs
JPH02167248A (ja) カルバサイクリン製造中間体
CA1077948A (en) 1,-5 disubstituted-2-pyrrolidones and processes for their production
US4403096A (en) Optically active imidazolidin-2-one derivatives
EP0198348A2 (en) Process for preparing (+)S-2-hydroxy-2-methyl-hexanoic acid
US4126754A (en) 11-Deoxy-cis-4,5-didehydro-ω-aryl-PGE compounds
US4070384A (en) Process for preparing thromboxane B compounds from prostaglandin fα co
AU600149B2 (en) A thiophene derivative and process for preparing the same
US4100192A (en) Inter-phenylene-PG amides
US4107427A (en) Process and intermediates for preparing Thromboxane B1
US4029693A (en) 2A,2B-Dihomo-11-deoxy-17(substituted phenyl)-18,19,20-trinor-PGE2 compounds and their corresponding esters
US4092349A (en) 11-Desoxy-15-thiaprostaglandins
KR810000657B1 (ko) 피롤리돈 화합물의 제조방법
US4213907A (en) Prostaglandin intermediates
US4052552A (en) Thromboxane b analogs
CA1131236A (en) 2,9-dioxatricyclo[4,3,1,0 su3,7 xx]decane derivatives, processes for their preparation and pharmaceutical compositions thereof
DK146179B (da) 1,5-disubstituerede 3ae-oxo-2-pyrrolidon-forbindelser til anvendelse som mellemprodukter ved fremstilling af 1,5-disubstituerede 2-pyrrolidon-forbindelser
US4277403A (en) Prostaglandin intermediates
US4144245A (en) 4-Hydroxymethyl-2-pyrrolidinones
US4169849A (en) 11-desoxy-15-thiaprostaglandins
CA1084939A (en) Preparation of novel pyrrolidone derivatives
IE45506B1 (en) 1,5-disubstituted-2-pyrrolidones
US4148804A (en) 2-Descarboxy-2-(tetrazol-5-yl) 11-desoxy-15-thiaprostaglandins
US4033949A (en) Analogs of thromboxane B2 and processes for their synthesis

Legal Events

Date Code Title Description
MKEX Expiry