CA1064040A - 1-(.beta.-(R-THIO) PHENETHYL) IMIDAZOLES AND DERIVATIVES THEREOF - Google Patents

1-(.beta.-(R-THIO) PHENETHYL) IMIDAZOLES AND DERIVATIVES THEREOF

Info

Publication number
CA1064040A
CA1064040A CA233,620A CA233620A CA1064040A CA 1064040 A CA1064040 A CA 1064040A CA 233620 A CA233620 A CA 233620A CA 1064040 A CA1064040 A CA 1064040A
Authority
CA
Canada
Prior art keywords
phenethyl
imidazole
dichloro
acid addition
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA233,620A
Other languages
English (en)
French (fr)
Inventor
Keith A.M. Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of CA1064040A publication Critical patent/CA1064040A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA233,620A 1974-09-23 1975-08-18 1-(.beta.-(R-THIO) PHENETHYL) IMIDAZOLES AND DERIVATIVES THEREOF Expired CA1064040A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50838474A 1974-09-23 1974-09-23
US59362075A 1975-07-07 1975-07-07

Publications (1)

Publication Number Publication Date
CA1064040A true CA1064040A (en) 1979-10-09

Family

ID=27056177

Family Applications (1)

Application Number Title Priority Date Filing Date
CA233,620A Expired CA1064040A (en) 1974-09-23 1975-08-18 1-(.beta.-(R-THIO) PHENETHYL) IMIDAZOLES AND DERIVATIVES THEREOF

Country Status (19)

Country Link
JP (1) JPS5910344B2 (xx)
AR (1) AR224222A1 (xx)
AU (1) AU496881B2 (xx)
CA (1) CA1064040A (xx)
CH (1) CH623813A5 (xx)
DE (1) DE2541833A1 (xx)
DK (1) DK155283C (xx)
FI (1) FI64583C (xx)
FR (1) FR2285126A1 (xx)
GB (1) GB1485719A (xx)
HK (1) HK8380A (xx)
IE (1) IE43267B1 (xx)
IL (1) IL47885A (xx)
MX (1) MX4832E (xx)
MY (1) MY8000270A (xx)
NL (1) NL174462C (xx)
NO (1) NO144345C (xx)
SE (1) SE428471B (xx)
YU (3) YU39746B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA755100B (en) * 1974-09-23 1977-03-30 Syntex Inc 1-(b-(r-thio) phenethyl) imidazoles and derivatives thereof
EP0013786B1 (en) * 1979-01-22 1982-10-06 Syntex (U.S.A.) Inc. Imidazole derivatives, pharmaceutical compositions containing them and their preparation
JPS63156228U (xx) * 1987-04-01 1988-10-13
DE3939525A1 (de) * 1989-11-30 1991-06-06 Hoechst Ag Mit mehrfach ungesaettigten resten substituierte aryl-alkyl-azole, verfahren zu ihrer herstellung und ihre verwendung
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
CN116063234B (zh) * 2022-12-29 2023-11-24 山东京卫制药有限公司 一种硝酸硫康唑的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU557755A3 (ru) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Способ получени производных имидазола
US3658813A (en) * 1970-01-13 1972-04-25 Janssen Pharmaceutica Nv 1-(beta-aryl-beta-(r-oxy)-ethyl)-imidazoles
DE2041771C3 (de) * 1970-08-22 1979-07-26 Bayer Ag, 5090 Leverkusen derivate
SE364275B (xx) * 1971-06-17 1974-02-18 Janssen Pharmaceutica Nv
DE2242454A1 (de) * 1972-08-29 1974-03-07 Bayer Ag 1-aethyl-imidazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
DK155283C (da) 1989-07-24
DE2541833A1 (de) 1976-04-01
JPS5910344B2 (ja) 1984-03-08
DK155283B (da) 1989-03-20
NL174462C (nl) 1984-06-18
YU227081A (en) 1982-02-28
FI752614A (xx) 1976-03-24
MY8000270A (en) 1980-12-31
FI64583C (fi) 1983-12-12
MX4832E (es) 1982-10-26
AU496881B2 (en) 1978-11-09
NL174462B (nl) 1984-01-16
YU224475A (en) 1982-02-28
AR224222A1 (es) 1981-11-13
SE7510595L (sv) 1976-03-24
NL7510224A (nl) 1976-03-25
YU226981A (en) 1982-02-28
IE43267B1 (en) 1981-01-28
JPS5157828A (en) 1976-05-20
NO144345B (no) 1981-05-04
DK427075A (da) 1976-03-24
GB1485719A (en) 1977-09-14
AU8408175A (en) 1977-02-24
DE2541833C2 (xx) 1989-09-14
FI64583B (fi) 1983-08-31
IL47885A (en) 1979-01-31
IL47885A0 (en) 1975-11-25
HK8380A (en) 1980-03-14
FR2285126A1 (fr) 1976-04-16
FR2285126B1 (xx) 1979-09-14
NO144345C (no) 1981-08-12
YU39746B (en) 1985-04-30
CH623813A5 (en) 1981-06-30
IE43267L (en) 1976-03-23
NO753048L (xx) 1976-03-24
SE428471B (sv) 1983-07-04

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