GB1485719A - 1-(beta-(r-thio)phenethyl)imidazoles and derivatives thereof - Google Patents
1-(beta-(r-thio)phenethyl)imidazoles and derivatives thereofInfo
- Publication number
- GB1485719A GB1485719A GB35569/75A GB3556975A GB1485719A GB 1485719 A GB1485719 A GB 1485719A GB 35569/75 A GB35569/75 A GB 35569/75A GB 3556975 A GB3556975 A GB 3556975A GB 1485719 A GB1485719 A GB 1485719A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- compounds
- reacted
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The novel imidazole derivatives correspond to the formula <IMAGE> in which R, R<1> and p have the meanings given in Patent Claim 1, and m is 0, 1 or 2. To prepare the compounds of formula I, wherein m is 0, a compound of formula: <IMAGE> is reacted with a compound of formula RSH. X denotes a group which can be split off. To prepare compounds of formula I, wherein m represents 1 or 2, a) a compound of formula II is reacted with a compound of formula RSH and b) the resulting compound of formula I, wherein m represents O, is oxidised. m conforms to the conditions specified for q in Patent Claim 7. The compounds of formula I are obtained in the form of their free base or of its acid addition salts. These can be converted into one another. An agent for inhibiting the growth of fungi or bacteria in plants or in agricultural or industrial products contains a compound of formula I as active ingredient, mixed with a carrier. The compounds of formula I possess, quite generally, an antifungal and antibacterial action and can also be used for pharmaceutical purposes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50838474A | 1974-09-23 | 1974-09-23 | |
US59362075A | 1975-07-07 | 1975-07-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1485719A true GB1485719A (en) | 1977-09-14 |
Family
ID=27056177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB35569/75A Expired GB1485719A (en) | 1974-09-23 | 1975-08-28 | 1-(beta-(r-thio)phenethyl)imidazoles and derivatives thereof |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS5910344B2 (en) |
AR (1) | AR224222A1 (en) |
AU (1) | AU496881B2 (en) |
CA (1) | CA1064040A (en) |
CH (1) | CH623813A5 (en) |
DE (1) | DE2541833A1 (en) |
DK (1) | DK155283C (en) |
FI (1) | FI64583C (en) |
FR (1) | FR2285126A1 (en) |
GB (1) | GB1485719A (en) |
HK (1) | HK8380A (en) |
IE (1) | IE43267B1 (en) |
IL (1) | IL47885A (en) |
MX (1) | MX4832E (en) |
MY (1) | MY8000270A (en) |
NL (1) | NL174462C (en) |
NO (1) | NO144345C (en) |
SE (1) | SE428471B (en) |
YU (3) | YU39746B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0013786A1 (en) * | 1979-01-22 | 1980-08-06 | Syntex (U.S.A.) Inc. | Imidazole derivatives, pharmaceutical compositions containing them and their preparation |
CN116063234A (en) * | 2022-12-29 | 2023-05-05 | 山东京卫制药有限公司 | Preparation method of sulconazole nitrate |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA755100B (en) * | 1974-09-23 | 1977-03-30 | Syntex Inc | 1-(b-(r-thio) phenethyl) imidazoles and derivatives thereof |
JPS63156228U (en) * | 1987-04-01 | 1988-10-13 | ||
DE3939525A1 (en) * | 1989-11-30 | 1991-06-06 | Hoechst Ag | ARYL-ALKYL-AZOLES SUBSTITUTED WITH MULTIPLE UNSATURATED REMAINS, METHOD FOR THEIR PRODUCTION AND THEIR USE |
IT1303672B1 (en) * | 1998-07-28 | 2001-02-23 | Nicox Sa | NITRATED SALTS OF DRUGS ACTIVE IN BONE DISORDERS |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU557755A3 (en) * | 1968-08-19 | 1977-05-05 | Янссен Фармасьютика Н.В. (Фирма) | Method for preparing imidazole derivatives |
US3658813A (en) * | 1970-01-13 | 1972-04-25 | Janssen Pharmaceutica Nv | 1-(beta-aryl-beta-(r-oxy)-ethyl)-imidazoles |
DE2041771C3 (en) * | 1970-08-22 | 1979-07-26 | Bayer Ag, 5090 Leverkusen | derivatives |
SE364275B (en) * | 1971-06-17 | 1974-02-18 | Janssen Pharmaceutica Nv | |
DE2242454A1 (en) * | 1972-08-29 | 1974-03-07 | Bayer Ag | 1-AETHYL-IMIDAZOLE, METHOD FOR MANUFACTURING IT AND ITS USE AS A MEDICINAL PRODUCT |
-
1975
- 1975-08-06 IL IL47885A patent/IL47885A/en unknown
- 1975-08-18 CA CA233,620A patent/CA1064040A/en not_active Expired
- 1975-08-19 AU AU84081/75A patent/AU496881B2/en not_active Expired
- 1975-08-20 MX MX755341U patent/MX4832E/en unknown
- 1975-08-28 GB GB35569/75A patent/GB1485719A/en not_active Expired
- 1975-08-29 NL NLAANVRAGE7510224,A patent/NL174462C/en not_active IP Right Cessation
- 1975-09-03 AR AR260311A patent/AR224222A1/en active
- 1975-09-05 YU YU2244/75A patent/YU39746B/en unknown
- 1975-09-05 NO NO753048A patent/NO144345C/en unknown
- 1975-09-19 FI FI752614A patent/FI64583C/en not_active IP Right Cessation
- 1975-09-19 IE IE2061/75A patent/IE43267B1/en unknown
- 1975-09-19 DE DE19752541833 patent/DE2541833A1/en active Granted
- 1975-09-19 JP JP50113538A patent/JPS5910344B2/en not_active Expired
- 1975-09-22 FR FR7529009A patent/FR2285126A1/en active Granted
- 1975-09-22 SE SE7510595A patent/SE428471B/en not_active IP Right Cessation
- 1975-09-22 CH CH1225575A patent/CH623813A5/en not_active IP Right Cessation
- 1975-09-23 DK DK427075A patent/DK155283C/en active
-
1980
- 1980-03-06 HK HK83/80A patent/HK8380A/en unknown
- 1980-12-31 MY MY1980270A patent/MY8000270A/en unknown
-
1981
- 1981-09-21 YU YU02270/81A patent/YU227081A/en unknown
- 1981-09-21 YU YU02269/81A patent/YU226981A/en unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0013786A1 (en) * | 1979-01-22 | 1980-08-06 | Syntex (U.S.A.) Inc. | Imidazole derivatives, pharmaceutical compositions containing them and their preparation |
CN116063234A (en) * | 2022-12-29 | 2023-05-05 | 山东京卫制药有限公司 | Preparation method of sulconazole nitrate |
CN116063234B (en) * | 2022-12-29 | 2023-11-24 | 山东京卫制药有限公司 | Preparation method of sulconazole nitrate |
Also Published As
Publication number | Publication date |
---|---|
MX4832E (en) | 1982-10-26 |
YU226981A (en) | 1982-02-28 |
DK155283C (en) | 1989-07-24 |
NL7510224A (en) | 1976-03-25 |
DE2541833A1 (en) | 1976-04-01 |
DE2541833C2 (en) | 1989-09-14 |
NO753048L (en) | 1976-03-24 |
AU496881B2 (en) | 1978-11-09 |
FI752614A (en) | 1976-03-24 |
DK155283B (en) | 1989-03-20 |
JPS5910344B2 (en) | 1984-03-08 |
FI64583C (en) | 1983-12-12 |
FR2285126A1 (en) | 1976-04-16 |
HK8380A (en) | 1980-03-14 |
IL47885A0 (en) | 1975-11-25 |
NO144345B (en) | 1981-05-04 |
AR224222A1 (en) | 1981-11-13 |
YU227081A (en) | 1982-02-28 |
NL174462B (en) | 1984-01-16 |
JPS5157828A (en) | 1976-05-20 |
CH623813A5 (en) | 1981-06-30 |
IE43267L (en) | 1976-03-23 |
YU39746B (en) | 1985-04-30 |
DK427075A (en) | 1976-03-24 |
FI64583B (en) | 1983-08-31 |
CA1064040A (en) | 1979-10-09 |
NL174462C (en) | 1984-06-18 |
YU224475A (en) | 1982-02-28 |
SE428471B (en) | 1983-07-04 |
NO144345C (en) | 1981-08-12 |
IE43267B1 (en) | 1981-01-28 |
AU8408175A (en) | 1977-02-24 |
FR2285126B1 (en) | 1979-09-14 |
IL47885A (en) | 1979-01-31 |
SE7510595L (en) | 1976-03-24 |
MY8000270A (en) | 1980-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
PE20 | Patent expired after termination of 20 years |
Effective date: 19950827 |