BRPI1014123A2 - produção de isopreno melhorada usando o caminho dxp e mva. - Google Patents

produção de isopreno melhorada usando o caminho dxp e mva.

Info

Publication number
BRPI1014123A2
BRPI1014123A2 BRPI1014123A BRPI1014123A BRPI1014123A2 BR PI1014123 A2 BRPI1014123 A2 BR PI1014123A2 BR PI1014123 A BRPI1014123 A BR PI1014123A BR PI1014123 A BRPI1014123 A BR PI1014123A BR PI1014123 A2 BRPI1014123 A2 BR PI1014123A2
Authority
BR
Brazil
Prior art keywords
path
dxp
mva
isoprene production
improved isoprene
Prior art date
Application number
BRPI1014123A
Other languages
English (en)
Inventor
T Nielsen Alex
M Peres Caroline
H Wells Derek
V Vaviline Dmitrii
K Chotani Gopal
C Mcauliffe Joseph
Charles Miller Michael
Erin Muir Rachel
Weyler Walter
Quinn Beck Zachary
Original Assignee
Danisco Us Inc
Goodyear Tire & Rubber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc, Goodyear Tire & Rubber filed Critical Danisco Us Inc
Publication of BRPI1014123A2 publication Critical patent/BRPI1014123A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

produção de isopreno melhorada usando o caminho dxp e mva a presente invenção refere-se a métodos de produção de isopreno a partir de células cultivadas, com o uso de vários componentes do caminho dxp e caminho mva, ou componentes associados ao caminho dxp e ao caminho mva, polipeptídeos redox de interação por agrupamento ferro-enxofre e isopreno sintase. a invenção também fornece composições que incluem estas células cultivadas.
BRPI1014123A 2009-06-17 2010-06-16 produção de isopreno melhorada usando o caminho dxp e mva. BRPI1014123A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18793009P 2009-06-17 2009-06-17
US18794109P 2009-06-17 2009-06-17
US31497910P 2010-03-17 2010-03-17
US31498510P 2010-03-17 2010-03-17
PCT/US2010/038904 WO2010148150A1 (en) 2009-06-17 2010-06-16 Improved isoprene production using the dxp and mva pathway

Publications (1)

Publication Number Publication Date
BRPI1014123A2 true BRPI1014123A2 (pt) 2019-07-02

Family

ID=43356749

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1014123A BRPI1014123A2 (pt) 2009-06-17 2010-06-16 produção de isopreno melhorada usando o caminho dxp e mva.

Country Status (10)

Country Link
US (2) US8507235B2 (pt)
EP (1) EP2443244A4 (pt)
CN (1) CN102753697A (pt)
AR (1) AR077115A1 (pt)
BR (1) BRPI1014123A2 (pt)
CA (1) CA2765805A1 (pt)
MY (1) MY158160A (pt)
SG (2) SG176936A1 (pt)
TW (2) TWI427149B (pt)
WO (1) WO2010148150A1 (pt)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG165884A1 (en) 2008-04-23 2010-11-29 Goodyear Tire & Rubber Isoprene synthase variants for improved microbial production of isoprene
US8470581B2 (en) * 2008-09-15 2013-06-25 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
WO2010031077A1 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
EP2334788A1 (en) * 2008-09-15 2011-06-22 Danisco US Inc. Increased isoprene production using the archaeal lower mevalonate pathway
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
AU2010238770A1 (en) 2009-04-23 2011-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI427149B (zh) 2009-06-17 2014-02-21 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
US20110039323A1 (en) * 2009-08-14 2011-02-17 Eric Lawrence Singsaas Isoprene Production
EP2513021A2 (en) 2009-12-18 2012-10-24 Danisco US Inc. Purification of isoprene from renewable resources
JP5855576B2 (ja) * 2009-12-22 2016-02-09 ダニスコ・ユーエス・インク イソプレンガスの生成量を増大させるための膜バイオリアクター
US8933282B2 (en) 2010-06-17 2015-01-13 Danisco Us Inc. Fuel compositions comprising isoprene derivatives
CA2807558A1 (en) 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
JP2014502148A (ja) 2010-10-27 2014-01-30 ダニスコ・ユーエス・インク イソプレン生産の向上を目的としたイソプレン合成酵素変異体
BR112013018316A2 (pt) 2010-12-22 2018-09-11 Danisco Us Inc composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg
BR112013016264A2 (pt) 2010-12-22 2018-06-19 Danisco Us Inc produção biológica de açúcares de pentose com o uso de células recombinantes
WO2012135591A2 (en) * 2011-03-30 2012-10-04 Amyris, Inc. Microbial isoprenoid production using a heterologous dxp pathway
CN103764814B (zh) 2011-04-29 2016-11-16 丹尼斯科美国公司 利用编码具有硫解酶、hmg-coa合酶和hmg-coa还原酶酶活性的多肽的基因产生甲羟戊酸、异戊二烯和类异戊二烯
AU2012249320A1 (en) 2011-04-29 2013-11-14 Danisco Us Inc. Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
BR112014002661A2 (pt) 2011-08-04 2019-09-24 Danisco Us Inc produção de isopreno, precursores de isoprenoide, e isoprenoides com o uso de acetoacetil-coa sintase
BR112014002745A8 (pt) 2011-08-05 2017-06-20 Danisco Us Inc produção de isoprenoides sob condições de ph neutro
PL222067B1 (pl) * 2011-08-11 2016-06-30 Inst Biotechnologii I Antybiotyków Kaseta ekspresyjna, zastosowanie kasety ekspresyjnej, wektor ekspresyjny, komórka prokariotycznego gospodarza zawierająca wektor ekspresyjny, szczep bakteryjny oraz sposób wytwarzania polipeptydu
EP3339426B1 (en) 2011-10-07 2022-08-24 Danisco US Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
EP2771460B1 (en) 2011-10-27 2017-04-26 Danisco US Inc. Isoprene synthase variants with improved solubility for production of isoprene
WO2013096917A1 (en) 2011-12-23 2013-06-27 Danisco Us Inc. Production of isoprene under reduced oxygen inlet levels
WO2013096863A1 (en) * 2011-12-23 2013-06-27 The Regents Of The University Of California Constructs and methods for improved isoprene biosynthesis
MX2014007623A (es) 2011-12-23 2015-02-04 Danisco Us Inc Produccion mejorada de isopreno con el uso de celulas hospederas que tienen actividad de ispa reducida.
US9315831B2 (en) 2012-03-30 2016-04-19 Danisco Us Inc. Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US20130323820A1 (en) * 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
WO2013181647A2 (en) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
CN104781385A (zh) 2012-09-20 2015-07-15 丹尼斯科美国公司 用于对细胞培养物控释培养组分的微量滴定板
WO2014066892A1 (en) * 2012-10-26 2014-05-01 Coelho Pedro S De novo metabolic pathways for isoprene biosynthesis
JP2016511630A (ja) 2012-12-21 2016-04-21 ダニスコ・ユーエス・インク 代案の下流メバロン酸経路を使用するイソプレン、イソプレノイド、およびイソプレノイド前駆体の生成
US20160017374A1 (en) * 2013-03-07 2016-01-21 Calysta, Inc. Compositions and methods for biological production of isoprene
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
EP2984105B1 (en) 2013-04-10 2019-05-22 Danisco US Inc. Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
CN105518130A (zh) 2013-06-21 2016-04-20 丹尼斯科美国公司 用于梭菌转化的组合物和方法
CN103602626B (zh) * 2013-10-12 2016-02-10 中国科学院青岛生物能源与过程研究所 一种以油脂为原料生产甲羟戊酸的方法及其构建的基因工程菌
CN103667153B (zh) * 2013-12-19 2015-05-13 中国石油大学(华东) 一株产聚3-羟基丁酸酯的嗜热菌
JP6744819B2 (ja) 2014-02-20 2020-08-19 ダニスコ・ユーエス・インク メバロン酸、イソプレン、イソプレノイド前駆体、イソプレノイド、およびアセチルＣｏＡ由来産物の生産向上のための組換え微生物
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
WO2016015021A1 (en) 2014-07-24 2016-01-28 The Regents Of The University Of California Oxidative starch degradation by a new family of pmos
CN106061870B (zh) 2014-09-17 2018-10-02 Wcco传送带公司 对环境友好的橡胶组合物
CN104372017B (zh) * 2014-11-05 2017-06-30 中国科学院青岛生物能源与过程研究所 一种提高基因工程菌异戊二烯及其衍生物产量的方法及应用
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN110869500B (zh) * 2017-01-26 2023-10-27 马努斯生物合成股份有限公司 用于萜类化合物产物的微生物生产的代谢工程化
US10662442B2 (en) * 2017-02-03 2020-05-26 Manus Bio Inc. Metabolic engineering for microbial production of terpenoid products
CN110468091B (zh) * 2018-05-09 2023-07-11 深圳艾格鑫科技有限公司 微生物及其用途
CN110468090B (zh) * 2018-05-09 2023-07-04 深圳艾格鑫科技有限公司 微生物及其用途
CN108715825B (zh) * 2018-06-01 2021-03-09 天津大学 基因过表达及获得的菌株、应用
US20200239796A1 (en) * 2018-09-28 2020-07-30 The Regents Of The University Of California Host cells and methods for producing tricyclic sesquiterpenes, aviation and missile fuel precursors
CN109609424B (zh) * 2018-12-26 2020-07-31 浙江医药股份有限公司 用于生产法尼烯的大肠杆菌
US20220162188A1 (en) * 2019-01-15 2022-05-26 North Carolina State University Isoprenoids and methods of making thereof
EP3683227A1 (en) * 2019-01-16 2020-07-22 Biosyntia ApS Cell factories for improved production of compounds and proteins dependent on iron sulfur clusters

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8407828D0 (en) * 1984-03-27 1984-05-02 Ontario Research Foundation In situ preparation
US4570029A (en) * 1985-03-04 1986-02-11 Uop Inc. Process for separating isoprene
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
ATE117020T1 (de) 1985-08-29 1995-01-15 Genencor Int Expression von heterologen polypeptiden in filamentösen pilzen, verfahren zu deren herstellung und vektoren zu deren herstellung.
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
CA2097180C (en) * 1990-12-10 2007-08-14 Timothy Fowler Saccharification of cellulose by cloning and amplification of the .beta.-glucosidase gene of trichoderma reesei
WO1995004134A1 (en) 1993-08-02 1995-02-09 Genencor International, Inc. Method of reducing complex carbohydrates in fermentation products
US5861271A (en) * 1993-12-17 1999-01-19 Fowler; Timothy Cellulase enzymes and systems for their expressions
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5849970A (en) 1995-06-23 1998-12-15 The Regents Of The University Of Colorado Materials and methods for the bacterial production of isoprene
DE19629568C1 (de) 1996-07-15 1998-01-08 Fraunhofer Ges Forschung Verfahren zur Herstellung von Isopren
US6176176B1 (en) * 1998-04-30 2001-01-23 Board Of Trustees Operating Michigan State University Apparatus for treating cellulosic materials
US6268328B1 (en) * 1998-12-18 2001-07-31 Genencor International, Inc. Variant EGIII-like cellulase compositions
US6316695B1 (en) * 1999-04-22 2001-11-13 Korea Kumho Petrochemical Co., Ltd. Isopentenyl diphosphate isomerase from Hevea brasiliensis and rubber producing method using the same
WO2002010398A2 (en) * 2000-07-31 2002-02-07 Hahn Frederick M Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
CA2443145C (en) * 2001-04-04 2013-01-22 Genencor International, Inc. Uncoupled productive and catabolic host cell pathways
US6998471B2 (en) * 2001-07-25 2006-02-14 E.I. Du Pont De Nemours And Company Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods
KR20040104581A (ko) * 2002-04-22 2004-12-10 이 아이 듀폰 디 네모아 앤드 캄파니 유전공학용 프로모터 및 플라스미드 시스템
US20050079617A1 (en) * 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
CA2501574C (en) 2002-10-04 2013-12-03 E. I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
EP1862539B1 (en) 2003-05-29 2012-01-25 Danisco US Inc. Novel trichoderma genes
CA2546659C (en) * 2003-11-21 2014-02-18 Genencor International, Inc. Expression of granular starch hydrolyzing enzymes in trichoderma and process for producing glucose from granular starch substrates
US20050287625A1 (en) * 2004-03-05 2005-12-29 Miller Edward S Jr Process for expression of foreign genes in methylotrophic bacteria through chromosomal integration
MX284139B (es) * 2006-05-26 2011-02-18 Amyris Biotechnologies Inc Produccion de isoprenoides.
US7947478B2 (en) 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
WO2008128159A1 (en) 2007-04-16 2008-10-23 Amyris Biotechnologies, Inc. Production of isoprenoids
US11725225B2 (en) * 2007-09-20 2023-08-15 Amyris, Inc. Production of isoprenoids
JP5262044B2 (ja) 2007-09-27 2013-08-14 凸版印刷株式会社 太陽電池裏面封止用シート及びこれを用いた太陽電池モジュール
SG162265A1 (en) * 2007-12-13 2010-07-29 Danisco Us Inc Compositions and methods for producing isoprene
US20090153993A1 (en) 2007-12-18 2009-06-18 Teradyne, Inc. Disk Drive Testing
WO2009100231A2 (en) * 2008-02-06 2009-08-13 The Regents Of The University Of California Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi
SG165884A1 (en) 2008-04-23 2010-11-29 Goodyear Tire & Rubber Isoprene synthase variants for improved microbial production of isoprene
US7632995B2 (en) * 2008-05-09 2009-12-15 Monsanto Technology Llc Plants and seeds of hybrid corn variety CH852179
CA2729801A1 (en) 2008-07-02 2010-01-07 Danisco Us Inc. Compositions and methods for producing isoprene free of c5 hydrocarbons under decoupling conditions and/or safe operating ranges
US8470581B2 (en) * 2008-09-15 2013-06-25 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
WO2010031077A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
EP2334788A1 (en) * 2008-09-15 2011-06-22 Danisco US Inc. Increased isoprene production using the archaeal lower mevalonate pathway
SG169641A1 (en) 2008-09-15 2011-04-29 Danisco Us Inc Systems using cell culture for production of isoprene
WO2010031076A2 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Conversion of prenyl derivatives to isoprene
CN102333866B (zh) 2008-12-30 2015-04-29 丹尼斯科美国公司 生产异戊二烯和共同产物的方法
US20100297749A1 (en) * 2009-04-21 2010-11-25 Sapphire Energy, Inc. Methods and systems for biofuel production
AU2010238770A1 (en) 2009-04-23 2011-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
TWI427149B (zh) * 2009-06-17 2014-02-21 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
EP2477478B1 (en) 2009-09-15 2016-11-30 Sapphire Energy, Inc. A system for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp.
EP2513021A2 (en) * 2009-12-18 2012-10-24 Danisco US Inc. Purification of isoprene from renewable resources
JP2014502148A (ja) 2010-10-27 2014-01-30 ダニスコ・ユーエス・インク イソプレン生産の向上を目的としたイソプレン合成酵素変異体
BR112013016264A2 (pt) 2010-12-22 2018-06-19 Danisco Us Inc produção biológica de açúcares de pentose com o uso de células recombinantes
BR112013018316A2 (pt) 2010-12-22 2018-09-11 Danisco Us Inc composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg

Also Published As

Publication number Publication date
TWI427149B (zh) 2014-02-21
US20110014672A1 (en) 2011-01-20
AR077115A1 (es) 2011-08-03
SG10201403297UA (en) 2014-10-30
US20140162337A1 (en) 2014-06-12
CN102753697A (zh) 2012-10-24
EP2443244A1 (en) 2012-04-25
MY158160A (en) 2016-09-15
TW201111512A (en) 2011-04-01
SG176936A1 (en) 2012-02-28
CA2765805A1 (en) 2010-12-23
WO2010148150A1 (en) 2010-12-23
US8507235B2 (en) 2013-08-13
TW201412988A (zh) 2014-04-01
EP2443244A4 (en) 2014-11-26

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