BRPI0819273B8 - Célula microbiana eucariótica recombinante e processo para a preparação de um ácido dicarboxílico - Google Patents
Célula microbiana eucariótica recombinante e processo para a preparação de um ácido dicarboxílicoInfo
- Publication number
- BRPI0819273B8 BRPI0819273B8 BRPI0819273A BRPI0819273A BRPI0819273B8 BR PI0819273 B8 BRPI0819273 B8 BR PI0819273B8 BR PI0819273 A BRPI0819273 A BR PI0819273A BR PI0819273 A BRPI0819273 A BR PI0819273A BR PI0819273 B8 BRPI0819273 B8 BR PI0819273B8
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- dicarboxylic acid
- recombinant eukaryotic
- microbial cell
- eukaryotic microbial
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fuel Cell (AREA)
Abstract
PRODUÇÃO DE ÁCIDO DICARBOXÍLICO EM EUCARIONTES. A presente invenção relaciona-se a uma célula microbiana eucariótica recombinante compreendendo uma sequência de nucleotídeo codificando uma enzima heteróloga catalisando a conversão de fosfoenolpiruvato ao oxaloacetato onde ATP é gerado. A invenção ainda relacionase a um processo para a preparação de um ácido dicarboxílico, tal como ácido succínico e ácido fumárico, compreendendo fermentar a célula microbiana eucariótica de acordo com a invenção em um meio de fermentação apropriado.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07121113.0 | 2007-11-20 | ||
EP07121120 | 2007-11-20 | ||
EP07121117 | 2007-11-20 | ||
EP07121113 | 2007-11-20 | ||
EP07121117.1 | 2007-11-20 | ||
EP07121120.5 | 2007-11-20 | ||
EP08156960 | 2008-05-27 | ||
EP08156961 | 2008-05-27 | ||
EP08156960.0 | 2008-05-27 | ||
EP08156959 | 2008-05-27 | ||
PCT/EP2008/065588 WO2009065780A1 (en) | 2007-11-20 | 2008-11-14 | Dicarboxylic acid production in eukaryotes |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0819273A2 BRPI0819273A2 (pt) | 2014-10-14 |
BRPI0819273B1 BRPI0819273B1 (pt) | 2022-05-17 |
BRPI0819273B8 true BRPI0819273B8 (pt) | 2022-07-19 |
Family
ID=40268299
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0819273A BRPI0819273B8 (pt) | 2007-11-20 | 2008-11-14 | Célula microbiana eucariótica recombinante e processo para a preparação de um ácido dicarboxílico |
BRPI0819275A BRPI0819275B8 (pt) | 2007-11-20 | 2008-11-14 | Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0819275A BRPI0819275B8 (pt) | 2007-11-20 | 2008-11-14 | Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico |
Country Status (10)
Country | Link |
---|---|
US (3) | US9340804B2 (pt) |
EP (3) | EP2220232B1 (pt) |
JP (2) | JP5641938B2 (pt) |
CN (3) | CN101903522B (pt) |
AT (1) | ATE555203T1 (pt) |
BR (2) | BRPI0819273B8 (pt) |
CA (2) | CA2875319A1 (pt) |
EA (1) | EA032726B1 (pt) |
ES (2) | ES2383473T3 (pt) |
WO (2) | WO2009065780A1 (pt) |
Families Citing this family (56)
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CA2714088A1 (en) * | 2008-02-15 | 2009-08-20 | Dsm Ip Assets B.V. | Process for the production of a dicarboxylic acid |
CN107267561A (zh) | 2008-07-08 | 2017-10-20 | 帝斯曼知识产权资产管理有限公司 | 通过在低pH下发酵生产二羧酸 |
RU2422526C2 (ru) * | 2009-01-30 | 2011-06-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов (ФГУП ГосНИИгенетика) | СПОСОБ ПОЛУЧЕНИЯ ЯНТАРНОЙ КИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ ДРОЖЖЕЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Yarrowia |
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2008
- 2008-11-14 CN CN200880117105.8A patent/CN101903522B/zh active Active
- 2008-11-14 JP JP2010533596A patent/JP5641938B2/ja active Active
- 2008-11-14 CA CA2875319A patent/CA2875319A1/en not_active Abandoned
- 2008-11-14 BR BRPI0819273A patent/BRPI0819273B8/pt active IP Right Grant
- 2008-11-14 BR BRPI0819275A patent/BRPI0819275B8/pt active IP Right Grant
- 2008-11-14 WO PCT/EP2008/065588 patent/WO2009065780A1/en active Application Filing
- 2008-11-14 CA CA2704654A patent/CA2704654C/en active Active
- 2008-11-14 ES ES08851601T patent/ES2383473T3/es active Active
- 2008-11-14 AT AT08851601T patent/ATE555203T1/de active
- 2008-11-14 ES ES08851178.7T patent/ES2522622T3/es active Active
- 2008-11-14 EP EP08851178.7A patent/EP2220232B1/en active Active
- 2008-11-14 CN CN200880117129.3A patent/CN101978063B/zh active Active
- 2008-11-14 CN CN201510186003.3A patent/CN104818224A/zh active Pending
- 2008-11-14 EA EA201000837A patent/EA032726B1/ru not_active IP Right Cessation
- 2008-11-14 US US12/743,927 patent/US9340804B2/en active Active
- 2008-11-14 EP EP13170415.7A patent/EP2687602A1/en not_active Withdrawn
- 2008-11-14 EP EP08851601A patent/EP2220233B1/en active Active
- 2008-11-14 US US12/743,106 patent/US20120165569A1/en not_active Abandoned
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2013
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2014
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Also Published As
Publication number | Publication date |
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BRPI0819275B1 (pt) | 2022-05-17 |
CA2704654C (en) | 2015-02-10 |
EP2220233B1 (en) | 2012-04-25 |
US20140031587A1 (en) | 2014-01-30 |
CN101978063B (zh) | 2018-10-16 |
WO2009065780A1 (en) | 2009-05-28 |
EA201000837A1 (ru) | 2010-12-30 |
US9689005B2 (en) | 2017-06-27 |
JP2011502524A (ja) | 2011-01-27 |
CN104818224A (zh) | 2015-08-05 |
EP2687602A1 (en) | 2014-01-22 |
US20110081694A1 (en) | 2011-04-07 |
BRPI0819273B1 (pt) | 2022-05-17 |
WO2009065778A1 (en) | 2009-05-28 |
BRPI0819275A2 (pt) | 2014-10-14 |
CA2875319A1 (en) | 2009-05-28 |
CN101978063A (zh) | 2011-02-16 |
ES2522622T3 (es) | 2014-11-17 |
JP2014236739A (ja) | 2014-12-18 |
BRPI0819273A2 (pt) | 2014-10-14 |
CN101903522A (zh) | 2010-12-01 |
CN101903522B (zh) | 2015-08-05 |
EP2220232B1 (en) | 2014-09-03 |
US20120165569A1 (en) | 2012-06-28 |
JP5641938B2 (ja) | 2014-12-17 |
ATE555203T1 (de) | 2012-05-15 |
EP2220232A1 (en) | 2010-08-25 |
EP2220233A1 (en) | 2010-08-25 |
ES2383473T3 (es) | 2012-06-21 |
EA032726B1 (ru) | 2019-07-31 |
CA2704654A1 (en) | 2009-05-28 |
BRPI0819275B8 (pt) | 2022-07-19 |
US9340804B2 (en) | 2016-05-17 |
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