BRPI0808442A2 - Composições de àcido nucleico de filamento duplo fechado - Google Patents
Composições de àcido nucleico de filamento duplo fechado Download PDFInfo
- Publication number
- BRPI0808442A2 BRPI0808442A2 BRPI0808442-4A BRPI0808442A BRPI0808442A2 BR PI0808442 A2 BRPI0808442 A2 BR PI0808442A2 BR PI0808442 A BRPI0808442 A BR PI0808442A BR PI0808442 A2 BRPI0808442 A2 BR PI0808442A2
- Authority
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- Prior art keywords
- formula
- nucleoside
- integer
- analog
- inosine
- Prior art date
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Landscapes
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Applications Claiming Priority (5)
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| US95027107P | 2007-07-17 | 2007-07-17 | |
| US60/950,271 | 2007-07-17 | ||
| PCT/CA2008/000473 WO2008106803A1 (en) | 2007-03-07 | 2008-03-07 | Double-stranded locked nucleic acid compositions |
Publications (1)
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| BRPI0808442A2 true BRPI0808442A2 (pt) | 2014-08-05 |
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| GB0228540D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Novel compositions |
| AU2009255947B2 (en) | 2008-06-06 | 2014-12-18 | Aurora Algae, Inc. | Vcp-based vectors for algal cell transformation |
| CA2735724C (en) | 2008-06-19 | 2018-07-24 | Variation Biotechnologies Inc. | Compositions and methods for treating influenza |
| JP2012520761A (ja) | 2009-03-19 | 2012-09-10 | イー・エム・デイー・ミリポア・コーポレイシヨン | ナノ繊維濾過媒体を用いる、流体資料からの微生物の除去 |
| US20110097418A1 (en) * | 2009-05-29 | 2011-04-28 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
| US8865468B2 (en) | 2009-10-19 | 2014-10-21 | Aurora Algae, Inc. | Homologous recombination in an algal nuclear genome |
| US8809046B2 (en) | 2011-04-28 | 2014-08-19 | Aurora Algae, Inc. | Algal elongases |
| US9029137B2 (en) | 2009-06-08 | 2015-05-12 | Aurora Algae, Inc. | ACP promoter |
| WO2011005769A1 (en) | 2009-07-06 | 2011-01-13 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| CA2803282C (en) | 2009-07-06 | 2018-05-01 | David E. Anderson | Methods for preparing vesicles and formulations produced therefrom |
| US8709765B2 (en) | 2009-07-20 | 2014-04-29 | Aurora Algae, Inc. | Manipulation of an alternative respiratory pathway in photo-autotrophs |
| US9366667B2 (en) * | 2009-10-02 | 2016-06-14 | The Trustees Of Columbia University In The City Of New York | Piscine reovirus diagnostic compositions |
| US8846388B2 (en) * | 2009-10-16 | 2014-09-30 | Zoetis Llc | Infectious clones of torque teno virus |
| WO2012027017A2 (en) * | 2010-06-25 | 2012-03-01 | Idera Pharmaceuticals, Inc. | Novel agonists of toll-like receptor 3 and methods of their use |
| CA2840079C (en) | 2010-07-06 | 2018-07-03 | Variation Biotechnologies Inc. | Compositions and methods for treating influenza |
| SG185659A1 (en) | 2010-08-10 | 2012-12-28 | Emd Millipore Corp | Method for retrovirus removal |
| EP2655612B1 (en) * | 2010-12-23 | 2017-07-19 | Shell Internationale Research Maatschappij B.V. | Gene disruptants producing fatty acyl-coa derivatives |
| MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
| BR112013018074A2 (pt) | 2011-01-13 | 2020-12-01 | Variation Biotechnologies, Inc. | métodos para a preparação de vesículas e formulações produzidas a partir dessas |
| US8722359B2 (en) | 2011-01-21 | 2014-05-13 | Aurora Algae, Inc. | Genes for enhanced lipid metabolism for accumulation of lipids |
| US11154821B2 (en) | 2011-04-01 | 2021-10-26 | Emd Millipore Corporation | Nanofiber containing composite membrane structures |
| CN103974966A (zh) | 2011-04-28 | 2014-08-06 | 奥罗拉藻类股份有限公司 | 藻类去饱和酶 |
| WO2013096680A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| US20140356399A1 (en) | 2012-01-12 | 2014-12-04 | Variation Biotechnologies, Inc. | Compositions and methods for treating viral infections |
| WO2013111012A2 (en) | 2012-01-27 | 2013-08-01 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9157101B2 (en) | 2012-12-21 | 2015-10-13 | Algenol Biotech LLC | Cyanobacterium sp. for production of compounds |
| AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
| US9994831B2 (en) | 2013-12-12 | 2018-06-12 | The Regents Of The University Of California | Methods and compositions for modifying a single stranded target nucleic acid |
| CN112957789A (zh) | 2014-06-26 | 2021-06-15 | Emd密理博公司 | 具有增强的污垢容纳能力的过滤器结构 |
| EP3206751A4 (en) | 2014-10-14 | 2018-06-13 | The J. David Gladstone Institutes | Compositions and methods for reactivating latent immunodeficiency virus |
| WO2016105483A1 (en) | 2014-12-23 | 2016-06-30 | Algenol Biotech LLC | Methods for increasing the stability of production of compounds in microbial host cells |
| DK3283202T3 (da) | 2015-04-17 | 2025-12-01 | Emd Millipore Corp | Fremgangsmåde til rensning af et biologisk materiale af interesse i en prøve gennem brug af ultrafiltreringsmembraner af nanofibre i tangentiel strømningsfiltreringstilstand |
| WO2016196655A1 (en) | 2015-06-03 | 2016-12-08 | The Regents Of The University Of California | Cas9 variants and methods of use thereof |
| US10138489B2 (en) | 2016-10-20 | 2018-11-27 | Algenol Biotech LLC | Cyanobacterial strains capable of utilizing phosphite |
| WO2019016605A1 (en) | 2017-07-21 | 2019-01-24 | Merck Millipore Ltd | MEMBRANES OF NONWOVEN FIBERS |
| WO2019066571A2 (ko) | 2017-09-28 | 2019-04-04 | 연세대학교 산학협력단 | 골수유래 면역반응 억제세포의 제조방법, 이에 의해 제조된 골수유래 면역반응 억제세포 및 그 용도 |
| CA3097620A1 (en) * | 2018-05-04 | 2019-11-07 | Tollys | Tlr3 ligands that activate both epithelial and myeloid cells |
| WO2020041456A1 (en) | 2018-08-22 | 2020-02-27 | The Regents Of The University Of California | Variant type v crispr/cas effector polypeptides and methods of use thereof |
| EP3877517A4 (en) | 2018-11-09 | 2022-09-07 | Inari Agriculture, Inc. | RNA-DRIVEN NUCLEASES AND DNA-BINDING PROTEINS |
| MX2021010559A (es) | 2019-03-07 | 2021-12-15 | Univ California | Polipéptidos efectores de crispr-cas y métodos de uso de estos. |
| EP3994265A4 (en) * | 2019-07-02 | 2023-11-29 | NA Vaccine Institute | NOVEL RIBONUCLEIC ACID AND PHARMACEUTICAL COMPOSITION BASED THEREOF |
| CA3186367A1 (en) * | 2020-08-14 | 2022-02-17 | Tanya DAIGLE | Artificial expression constructs for modulating gene expression in striatal neurons |
| JP2024517181A (ja) | 2021-04-28 | 2024-04-19 | ウエヌイグレックオ・ファーマ | 組合せ治療としてｆｘｒアゴニストを使用するｔｌｒ３アゴニストの効果の強い増強 |
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| US3692899A (en) * | 1969-12-17 | 1972-09-19 | Us Health Education & Welfare | Inhibition of transplanted tumor growth by polyinosinic-polycytidylic acid in mice |
| US4024241A (en) * | 1974-09-27 | 1977-05-17 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| US3952097A (en) * | 1974-09-27 | 1976-04-20 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| US4349538A (en) * | 1979-12-07 | 1982-09-14 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| JP3468773B2 (ja) * | 1994-07-15 | 2003-11-17 | ザ ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 免疫調節オリゴヌクレオチド |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US7157089B1 (en) * | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
| JP3756313B2 (ja) * | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| CA2203843C (en) * | 1997-04-28 | 2013-07-23 | Her Majesty The Queen, In Right Of Canada, As Represented By The Ministe R Of National Defence | Liposome-encapsulated poly iclc |
| US6794499B2 (en) * | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6083482A (en) * | 1999-05-11 | 2000-07-04 | Icn Pharmaceuticals, Inc. | Conformationally locked nucleosides and oligonucleotides |
| AT410173B (de) * | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| CA2474709A1 (en) * | 2002-02-04 | 2003-08-14 | Biomira, Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
| AU2003248791A1 (en) * | 2002-07-03 | 2005-11-09 | Oncovir, Inc. | Method for preparation of poly-iclc and uses thereof |
| GB0228540D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Novel compositions |
| WO2005004794A2 (en) * | 2003-06-09 | 2005-01-20 | Alnylam Pharmaceuticals Inc. | Method of treating neurodegenerative disease |
| WO2006054129A1 (en) * | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
| US7834064B2 (en) * | 2005-01-03 | 2010-11-16 | Andres Mario Salazar | Clinical method for the immunomodulatory and vaccine adjuvant use of poly-ICLC and other dsRNAs |
| WO2007050990A2 (en) * | 2005-10-27 | 2007-05-03 | Rosetta Inpharmatics Llc | Nucleic acid amplification using non-random primers |
| US20070197460A1 (en) * | 2005-11-01 | 2007-08-23 | Alnylam Pharmaceuticals, Inc. | Rnai inhibition of influenza virus replication |
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- 2008-03-07 JP JP2009552038A patent/JP2010519915A/ja not_active Abandoned
- 2008-03-07 CN CN200880014144A patent/CN101687900A/zh active Pending
- 2008-03-07 US US12/044,895 patent/US20090041809A1/en not_active Abandoned
- 2008-03-07 KR KR1020097020608A patent/KR20100051041A/ko not_active Withdrawn
- 2008-03-07 AU AU2008222523A patent/AU2008222523A1/en not_active Abandoned
- 2008-03-07 EP EP08733577A patent/EP2125853A1/en not_active Withdrawn
- 2008-03-07 BR BRPI0808442-4A patent/BRPI0808442A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010519915A (ja) | 2010-06-10 |
| AU2008222523A1 (en) | 2008-09-12 |
| EP2125853A1 (en) | 2009-12-02 |
| CA2680060A1 (en) | 2008-09-12 |
| KR20100051041A (ko) | 2010-05-14 |
| CN101687900A (zh) | 2010-03-31 |
| US20090041809A1 (en) | 2009-02-12 |
| WO2008106803A1 (en) | 2008-09-12 |
| MX2009009530A (es) | 2010-05-19 |
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