BRPI0718483A2 - Variantes de mutação múltipla de serina protease - Google Patents
Variantes de mutação múltipla de serina protease Download PDFInfo
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- BRPI0718483A2 BRPI0718483A2 BRPI0718483-2A2A BRPI0718483A BRPI0718483A2 BR PI0718483 A2 BRPI0718483 A2 BR PI0718483A2 BR PI0718483 A BRPI0718483 A BR PI0718483A BR PI0718483 A2 BRPI0718483 A2 BR PI0718483A2
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- Prior art keywords
- protease
- variant
- amino acid
- acid sequence
- seq
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Links
- 102000012479 Serine Proteases Human genes 0.000 title claims description 107
- 108010022999 Serine Proteases Proteins 0.000 title claims description 107
- 230000035772 mutation Effects 0.000 title description 43
- 102220261385 rs151112761 Human genes 0.000 claims description 355
- 102000035195 Peptidases Human genes 0.000 claims description 227
- 108091005804 Peptidases Proteins 0.000 claims description 227
- 239000004365 Protease Substances 0.000 claims description 223
- 102200006616 rs104894230 Human genes 0.000 claims description 194
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 155
- 238000006467 substitution reaction Methods 0.000 claims description 134
- 102220534607 Caspase recruitment domain-containing protein 9_R35E_mutation Human genes 0.000 claims description 129
- 239000000203 mixture Substances 0.000 claims description 117
- 102220624725 Atrial natriuretic peptide receptor 2_N24Q_mutation Human genes 0.000 claims description 104
- 241000186321 Cellulomonas Species 0.000 claims description 103
- 102220067471 rs377354475 Human genes 0.000 claims description 99
- 102220044570 rs587781404 Human genes 0.000 claims description 99
- 102220586763 Thioredoxin reductase 2, mitochondrial_R14L_mutation Human genes 0.000 claims description 97
- 102220214681 rs1060502012 Human genes 0.000 claims description 90
- 102220537828 Nebulette_S15E_mutation Human genes 0.000 claims description 85
- 102220466383 PRA1 family protein 2_S76V_mutation Human genes 0.000 claims description 82
- 102220370301 c.47G>A Human genes 0.000 claims description 81
- 102220473072 Chemerin-like receptor 2_R14Q_mutation Human genes 0.000 claims description 78
- 238000004140 cleaning Methods 0.000 claims description 77
- 102220642036 Lipoma-preferred partner_S76N_mutation Human genes 0.000 claims description 69
- 102220615939 Apolipoprotein E_R79T_mutation Human genes 0.000 claims description 64
- 102220625809 Phosphatidylethanolamine-binding protein 1_R14M_mutation Human genes 0.000 claims description 58
- 102200103823 rs104886043 Human genes 0.000 claims description 53
- 238000000034 method Methods 0.000 claims description 51
- 102220588928 60S ribosomal protein L30_A93V_mutation Human genes 0.000 claims description 49
- 102000040430 polynucleotide Human genes 0.000 claims description 42
- 108091033319 polynucleotide Proteins 0.000 claims description 42
- 239000002157 polynucleotide Substances 0.000 claims description 42
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- 229940088598 enzyme Drugs 0.000 claims description 41
- 102220491114 ADP-ribosylation factor 6_T116Y_mutation Human genes 0.000 claims description 39
- 102220595711 Lanosterol 14-alpha demethylase_G54W_mutation Human genes 0.000 claims description 38
- 102220520019 Guanylyl cyclase-activating protein 1_T86K_mutation Human genes 0.000 claims description 36
- 102220473729 Ras-related protein Rab-5A_G54Q_mutation Human genes 0.000 claims description 31
- 102220509369 Myeloid differentiation primary response protein MyD88_N67A_mutation Human genes 0.000 claims description 26
- 102220501440 Cytosolic iron-sulfur assembly component 3_N24H_mutation Human genes 0.000 claims description 23
- 239000000463 material Substances 0.000 claims description 23
- 102220536072 Lysophospholipase_R61S_mutation Human genes 0.000 claims description 22
- 102220473903 Desumoylating isopeptidase 1_S76D_mutation Human genes 0.000 claims description 21
- 102220233810 rs1085308047 Human genes 0.000 claims description 21
- 102220277845 rs532711949 Human genes 0.000 claims description 21
- 102220499772 Carbonic anhydrase 2_N67L_mutation Human genes 0.000 claims description 20
- 230000000694 effects Effects 0.000 claims description 20
- 102220264985 rs182760732 Human genes 0.000 claims description 19
- 102220622672 Ferroxidase HEPHL1_R14E_mutation Human genes 0.000 claims description 18
- 102200032507 rs121918222 Human genes 0.000 claims description 17
- 102220264366 rs981346599 Human genes 0.000 claims description 16
- 238000005406 washing Methods 0.000 claims description 16
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- 102220551871 Fibroblast growth factor 13_R14T_mutation Human genes 0.000 claims description 14
- 102220591745 NF-kappa-B inhibitor-interacting Ras-like protein 1_N24F_mutation Human genes 0.000 claims description 14
- 102220508341 E3 ubiquitin-protein ligase XIAP_Y75G_mutation Human genes 0.000 claims description 13
- 102220588823 Acidic mammalian chitinase_R61M_mutation Human genes 0.000 claims description 11
- 102220527020 Cytochrome b5 reductase 4_S99V_mutation Human genes 0.000 claims description 11
- 102220327945 rs780020430 Human genes 0.000 claims description 11
- 102220495810 Alkaline ceramidase 3_N24G_mutation Human genes 0.000 claims description 10
- 102220491279 Peripheral myelin protein 22_S76I_mutation Human genes 0.000 claims description 10
- 102220614767 Ras-related protein Rab-3B_T36N_mutation Human genes 0.000 claims description 10
- 238000006460 hydrolysis reaction Methods 0.000 claims description 10
- 102220011740 rs386833408 Human genes 0.000 claims description 10
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- 102220506801 Vitelline membrane outer layer protein 1 homolog_N73T_mutation Human genes 0.000 claims description 9
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- 102220561347 KH homology domain-containing protein 1_N112E_mutation Human genes 0.000 claims description 8
- 102220510525 Retinoic acid receptor alpha_R14D_mutation Human genes 0.000 claims description 8
- 102220547916 Serine protease HTRA2, mitochondrial_A93D_mutation Human genes 0.000 claims description 8
- 102220484278 Thioredoxin domain-containing protein 8_R35A_mutation Human genes 0.000 claims description 8
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- 102220262976 rs1554306427 Human genes 0.000 claims description 8
- 102220013614 rs397516692 Human genes 0.000 claims description 8
- -1 sodium alkyl sulfate Chemical class 0.000 claims description 8
- 102220547700 Carcinoembryonic antigen-related cell adhesion molecule 3_N74G_mutation Human genes 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 7
- 102220631334 NCK-interacting protein with SH3 domain_S92G_mutation Human genes 0.000 claims description 7
- 102220620755 Phosphatidylserine decarboxylase proenzyme, mitochondrial_A41N_mutation Human genes 0.000 claims description 7
- 102220473585 Putative ankyrin repeat domain-containing protein 26-like protein_S51A_mutation Human genes 0.000 claims description 7
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 102220580971 Induced myeloid leukemia cell differentiation protein Mcl-1_F47W_mutation Human genes 0.000 claims description 6
- 102220580942 Induced myeloid leukemia cell differentiation protein Mcl-1_Y57Y_mutation Human genes 0.000 claims description 6
- 102220624591 Kelch repeat and BTB domain-containing protein 3_T36Y_mutation Human genes 0.000 claims description 6
- 102220606006 Sorting nexin-10_R16L_mutation Human genes 0.000 claims description 6
- 102220608115 TYRO protein tyrosine kinase-binding protein_G49L_mutation Human genes 0.000 claims description 6
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- 102220346476 c.199A>T Human genes 0.000 claims description 6
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- 102220095350 rs876659324 Human genes 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 102220542336 60S ribosomal protein L27_H85T_mutation Human genes 0.000 claims description 5
- 102220499774 Carbonic anhydrase 2_N67Q_mutation Human genes 0.000 claims description 5
- 102220568823 Dual specificity mitogen-activated protein kinase kinase 1_G65V_mutation Human genes 0.000 claims description 5
- 102220604794 Leukocyte immunoglobulin-like receptor subfamily A member 6_L69W_mutation Human genes 0.000 claims description 5
- 102220511417 Proteasome subunit beta type-10_G49D_mutation Human genes 0.000 claims description 5
- 102220614752 Ras-related protein Rab-3B_T86E_mutation Human genes 0.000 claims description 5
- 102220568341 Segment polarity protein dishevelled homolog DVL-3_V66D_mutation Human genes 0.000 claims description 5
- 102220591670 WW domain-binding protein 2_Y75F_mutation Human genes 0.000 claims description 5
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- 102220488764 ADP-ribosylation factor 1_Q71L_mutation Human genes 0.000 claims description 4
- 102220554057 APC membrane recruitment protein 1_R61K_mutation Human genes 0.000 claims description 4
- 102220487923 Alkaline phosphatase, tissue-nonspecific isozyme_G63R_mutation Human genes 0.000 claims description 4
- 241000228257 Aspergillus sp. Species 0.000 claims description 4
- 102220624687 Atrial natriuretic peptide receptor 1_A70D_mutation Human genes 0.000 claims description 4
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 claims description 4
- 102220582890 Cellular tumor antigen p53_S15R_mutation Human genes 0.000 claims description 4
- 102220597418 Fizzy-related protein homolog_T86M_mutation Human genes 0.000 claims description 4
- 102220581630 Haptoglobin-related protein_N42H_mutation Human genes 0.000 claims description 4
- 102100021174 Lipoyl synthase, mitochondrial Human genes 0.000 claims description 4
- 102220502464 Polyadenylate-binding protein 2_R79E_mutation Human genes 0.000 claims description 4
- 102220477122 Putative uncharacterized protein PP632_R96E_mutation Human genes 0.000 claims description 4
- 102220573044 RNA polymerase II subunit A C-terminal domain phosphatase_T10Q_mutation Human genes 0.000 claims description 4
- 102220528606 Ribonuclease P/MRP protein subunit POP5_S99D_mutation Human genes 0.000 claims description 4
- 102220587185 SPOC domain-containing protein 1_T46V_mutation Human genes 0.000 claims description 4
- 102220493820 STAM-binding protein_R14P_mutation Human genes 0.000 claims description 4
- 102220584892 Tectonic-1_Q81K_mutation Human genes 0.000 claims description 4
- 102220589231 WW domain-containing transcription regulator protein 1_S51D_mutation Human genes 0.000 claims description 4
- 102220363043 c.43A>G Human genes 0.000 claims description 4
- 102220353933 c.72C>A Human genes 0.000 claims description 4
- 230000002860 competitive effect Effects 0.000 claims description 4
- 230000009260 cross reactivity Effects 0.000 claims description 4
- 230000001900 immune effect Effects 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
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- 239000003381 stabilizer Substances 0.000 claims description 4
- 102220490416 DNA mismatch repair protein Mlh3_A41S_mutation Human genes 0.000 claims description 3
- 102220577246 Density-regulated protein_A86Y_mutation Human genes 0.000 claims description 3
- 102000011782 Keratins Human genes 0.000 claims description 3
- 108010076876 Keratins Proteins 0.000 claims description 3
- 102220490323 Matrix metalloproteinase-27_N55Q_mutation Human genes 0.000 claims description 3
- 102220558400 Olfactory receptor 9G1_T62I_mutation Human genes 0.000 claims description 3
- 102220553957 Protein Mpv17_V66E_mutation Human genes 0.000 claims description 3
- 102220502777 Putative C->U-editing enzyme APOBEC-4_G49K_mutation Human genes 0.000 claims description 3
- 241000187180 Streptomyces sp. Species 0.000 claims description 3
- 241001557886 Trichoderma sp. Species 0.000 claims description 3
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- 102220151559 rs886060514 Human genes 0.000 claims description 3
- 102220485316 ATP-dependent DNA/RNA helicase DHX36_G63L_mutation Human genes 0.000 claims description 2
- 102220485317 ATP-dependent DNA/RNA helicase DHX36_G63P_mutation Human genes 0.000 claims description 2
- 108010065511 Amylases Proteins 0.000 claims description 2
- 102000013142 Amylases Human genes 0.000 claims description 2
- 102220466011 Angiogenin_H32A_mutation Human genes 0.000 claims description 2
- 102100032487 Beta-mannosidase Human genes 0.000 claims description 2
- 102220617295 CPX chromosomal region candidate gene 1 protein_A83F_mutation Human genes 0.000 claims description 2
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- 102220519282 Conserved oligomeric Golgi complex subunit 3_P89D_mutation Human genes 0.000 claims description 2
- 102220485974 Dihydropteridine reductase_S51T_mutation Human genes 0.000 claims description 2
- 102220472493 EF-hand calcium-binding domain-containing protein 7_F27I_mutation Human genes 0.000 claims description 2
- 102220482162 Endothelial differentiation-related factor 1_T40D_mutation Human genes 0.000 claims description 2
- 102220559991 Epsilon-sarcoglycan_T36R_mutation Human genes 0.000 claims description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
- 102220523126 Eukaryotic translation initiation factor 4E-binding protein 2_T46E_mutation Human genes 0.000 claims description 2
- 102220497493 Fatty acid-binding protein, liver_N55V_mutation Human genes 0.000 claims description 2
- 102220590602 Gap junction beta-1 protein_T86N_mutation Human genes 0.000 claims description 2
- 102220571078 Growth arrest and DNA damage-inducible protein GADD45 gamma_A83R_mutation Human genes 0.000 claims description 2
- 102220514941 HMG domain-containing protein 3_S18E_mutation Human genes 0.000 claims description 2
- 102220593922 HORMA domain-containing protein 1_R16K_mutation Human genes 0.000 claims description 2
- 102220465474 Insulin-like growth factor II_R61E_mutation Human genes 0.000 claims description 2
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- 102220555777 MORC family CW-type zinc finger protein 1_R14K_mutation Human genes 0.000 claims description 2
- 102220508063 Mitochondrial folate transporter/carrier_G91R_mutation Human genes 0.000 claims description 2
- 102220559160 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial_S15T_mutation Human genes 0.000 claims description 2
- 102220482843 Nucleoredoxin-like protein 2_S76C_mutation Human genes 0.000 claims description 2
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- 108090000854 Oxidoreductases Proteins 0.000 claims description 2
- 108010059820 Polygalacturonase Proteins 0.000 claims description 2
- 102220535519 Probable methyltransferase TARBP1_T86F_mutation Human genes 0.000 claims description 2
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- 102220537319 Protein NDRG2_G26K_mutation Human genes 0.000 claims description 2
- 102220644605 Ribonuclease H2 subunit B_P43H_mutation Human genes 0.000 claims description 2
- 102220608661 Secreted phosphoprotein 24_I11A_mutation Human genes 0.000 claims description 2
- 102220513027 Succinate-semialdehyde dehydrogenase, mitochondrial_R16A_mutation Human genes 0.000 claims description 2
- 102220532305 Testis-expressed protein 10_R79A_mutation Human genes 0.000 claims description 2
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- 102220522584 Ubiquitin-fold modifier 1_A48Q_mutation Human genes 0.000 claims description 2
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- 235000019418 amylase Nutrition 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
- D06M16/003—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic with enzymes or microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Food Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Textile Engineering (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58333406A | 2006-10-19 | 2006-10-19 | |
| US11/583,334 | 2006-10-19 | ||
| US11/809,104 | 2007-05-31 | ||
| US11/809,104 US7985569B2 (en) | 2003-11-19 | 2007-05-31 | Cellulomonas 69B4 serine protease variants |
| PCT/US2007/018909 WO2008048392A1 (en) | 2006-10-19 | 2007-08-29 | Multiple mutation variants of serine protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0718483A2 true BRPI0718483A2 (pt) | 2013-11-26 |
Family
ID=38982619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0718483-2A2A BRPI0718483A2 (pt) | 2006-10-19 | 2007-08-29 | Variantes de mutação múltipla de serina protease |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7985569B2 (https=) |
| EP (1) | EP2084273A1 (https=) |
| JP (1) | JP5775666B2 (https=) |
| KR (2) | KR20090075825A (https=) |
| BR (1) | BRPI0718483A2 (https=) |
| CA (1) | CA2667043A1 (https=) |
| MX (1) | MX2009003936A (https=) |
| RU (1) | RU2558261C2 (https=) |
| WO (1) | WO2008048392A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE450606T1 (de) * | 2002-01-16 | 2009-12-15 | Genencor Int | Mehrfachsubstituierte proteasevarianten |
| MXPA04006811A (es) * | 2002-01-16 | 2004-10-11 | Genencor Int | Variantes de proteasa substituidas con multiplos. |
| JP5785686B2 (ja) * | 2006-06-23 | 2015-09-30 | ダニスコ・ユーエス・インク、ジェネンコー・ディビジョン | 複数の性質をエンジニアリングするための部位評価ライブラリーを用いた、配列と活性との関係の系統的な評価 |
| WO2008044016A1 (en) * | 2006-10-14 | 2008-04-17 | Reckitt Benckiser N.V. | Composition |
| EP2118121A1 (en) * | 2007-03-01 | 2009-11-18 | Novo Nordisk A/S | Expression of proteins in e. coli |
| CN101889084A (zh) * | 2007-12-04 | 2010-11-17 | 诺维信公司 | 供药学应用的蛋白酶变体 |
| US20090209447A1 (en) * | 2008-02-15 | 2009-08-20 | Michelle Meek | Cleaning compositions |
| MX2010009457A (es) * | 2008-02-29 | 2010-09-24 | Procter & Gamble | Composicion detergente que comprende lipasa. |
| WO2009107091A2 (en) * | 2008-02-29 | 2009-09-03 | The Procter & Gamble Company | Detergent composition comprising lipase |
| EP2100947A1 (en) | 2008-03-14 | 2009-09-16 | The Procter and Gamble Company | Automatic dishwashing detergent composition |
| US20090233830A1 (en) | 2008-03-14 | 2009-09-17 | Penny Sue Dirr | Automatic detergent dishwashing composition |
| EP2166073A1 (en) * | 2008-09-23 | 2010-03-24 | The Procter & Gamble Company | Cleaning composition |
| EP2166075A1 (en) * | 2008-09-23 | 2010-03-24 | The Procter and Gamble Company | Cleaning composition |
| US8096062B1 (en) * | 2008-10-08 | 2012-01-17 | Bellen Mark L | Towel drying system |
| US20100125046A1 (en) | 2008-11-20 | 2010-05-20 | Denome Frank William | Cleaning products |
| US20140014137A1 (en) | 2009-09-18 | 2014-01-16 | Ecolab Usa Inc. | Treatment of non-trans fats with acidic tetra sodium l-glutamic acid, n, n-diacetic acid (glda) |
| MX2012006616A (es) | 2009-12-09 | 2012-06-21 | Procter & Gamble | Productos para el cuidado de las telas y el hogar. |
| EP2380478A1 (en) | 2010-04-23 | 2011-10-26 | The Procter & Gamble Company | Automatic dishwashing product |
| ES2682051T3 (es) | 2010-04-23 | 2018-09-18 | The Procter & Gamble Company | Composición detergente |
| ES2565192T3 (es) | 2010-04-23 | 2016-04-01 | The Procter & Gamble Company | Método para perfumar |
| ES2533368T3 (es) | 2010-04-23 | 2015-04-09 | The Procter & Gamble Company | Producto para lavavajillas |
| EP2383329A1 (en) | 2010-04-23 | 2011-11-02 | The Procter & Gamble Company | Particle |
| EP2380962B1 (en) | 2010-04-23 | 2016-03-30 | The Procter and Gamble Company | Particle |
| EP3095861B1 (en) | 2010-05-06 | 2019-06-26 | The Procter and Gamble Company | Consumer products with protease variants |
| FI123425B (fi) * | 2011-03-31 | 2013-04-30 | Ab Enzymes Oy | Proteaasientsyymi ja sen käytöt |
| ES2834102T3 (es) | 2011-06-30 | 2021-06-16 | Novozymes As | Variantes de alfa-amilasa |
| BR112014017919A2 (pt) | 2012-01-26 | 2017-06-27 | Novozymes As | uso de um poliptídeo variante, composição, polinucleotídeo isolado, constructo de ácido nucleico ou vetor de expressão, célula hospedeira de expressão recombinante, métodos de produção do pilipeptídeo, para melhoria do valor nutricional de uma ração animal, e para o tratamento de proteínas, planta, parte de planta ou célula de planta transgênica, aditivo de ração animal, ração animal, e, composição de ração animal ou detergente |
| ES2599504T3 (es) | 2012-05-30 | 2017-02-02 | Clariant International Ltd | Utilización de N-metil-N-acil-glucaminas como agentes solubilizantes |
| IN2014DN09937A (https=) | 2012-05-30 | 2015-08-14 | Clariant Int Ltd | |
| EP2866895B1 (de) * | 2012-05-30 | 2016-08-31 | Clariant International Ltd | Tensidlösungen mit n-methyl-n-oleylglucamin und n-methyl-n-c12-c14-acylglucamin |
| AU2013279440B2 (en) | 2012-06-20 | 2016-10-06 | Novozymes A/S | Use of polypeptides having protease activity in animal feed and detergents |
| US10253281B2 (en) | 2012-08-20 | 2019-04-09 | Ecolab Usa Inc. | Method of washing textile articles |
| DE102012021647A1 (de) | 2012-11-03 | 2014-05-08 | Clariant International Ltd. | Wässrige Adjuvant-Zusammensetzungen |
| AU2014214032A1 (en) | 2013-02-06 | 2015-07-09 | Novozymes A/S | Use of polypeptides having protease activity in animal feed |
| US20160068620A1 (en) | 2013-03-15 | 2016-03-10 | Lubrizol Advanced Materials, Inc. | Itaconic Acid Polymers |
| WO2015042013A1 (en) | 2013-09-18 | 2015-03-26 | Lubrizol Advanced Materials, Inc. | Stable linear polymers |
| BR112016021154A2 (pt) | 2014-03-14 | 2021-08-24 | Lubrizol Advanced Materials, Inc. | Polímeros e copolímeros de ácido itacônico |
| DE102014005771A1 (de) | 2014-04-23 | 2015-10-29 | Clariant International Ltd. | Verwendung von wässrigen driftreduzierenden Zusammensetzungen |
| CN106687572A (zh) | 2014-09-10 | 2017-05-17 | 巴斯夫欧洲公司 | 包封清洁组合物 |
| BR112017009320A2 (pt) | 2014-11-04 | 2017-12-19 | Novozymes As | ração animal ou aditivo de ração animal, uso de ração animal ou aditivo de ração animal, e, métodos para preparação de uma ração animal, para melhoria do valor nutricional de uma ração animal, para tratamento de proteínas aumento da digestibilidade e/ou solubilidade da proteína, para melhoria de um ou mais parâmetros de desempenho em um animal e para produção de um polipeptídeo. |
| EP3034596B2 (en) | 2014-12-17 | 2021-11-10 | The Procter & Gamble Company | Detergent composition |
| EP3034590A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Method of automatic dishwashing |
| EP3034591A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Method of automatic dishwashing |
| ES2733300T3 (es) | 2014-12-17 | 2019-11-28 | Procter & Gamble | Composición detergente |
| EP3034592A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Method of automatic dishwashing |
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-
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- 2007-08-29 WO PCT/US2007/018909 patent/WO2008048392A1/en not_active Ceased
- 2007-08-29 KR KR1020097007937A patent/KR20090075825A/ko not_active Ceased
- 2007-08-29 EP EP07837430A patent/EP2084273A1/en not_active Withdrawn
- 2007-08-29 RU RU2009118608/10A patent/RU2558261C2/ru not_active IP Right Cessation
- 2007-08-29 JP JP2009533297A patent/JP5775666B2/ja not_active Expired - Fee Related
- 2007-08-29 CA CA002667043A patent/CA2667043A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| MX2009003936A (es) | 2009-04-23 |
| KR20090075825A (ko) | 2009-07-09 |
| EP2084273A1 (en) | 2009-08-05 |
| RU2558261C2 (ru) | 2015-07-27 |
| US8455234B2 (en) | 2013-06-04 |
| US7985569B2 (en) | 2011-07-26 |
| US20080063774A1 (en) | 2008-03-13 |
| US20150072913A1 (en) | 2015-03-12 |
| WO2008048392A1 (en) | 2008-04-24 |
| JP5775666B2 (ja) | 2015-09-09 |
| JP2010506590A (ja) | 2010-03-04 |
| US20110251116A1 (en) | 2011-10-13 |
| KR20140136033A (ko) | 2014-11-27 |
| RU2009118608A (ru) | 2010-11-27 |
| CA2667043A1 (en) | 2008-04-24 |
| US20140005094A1 (en) | 2014-01-02 |
| US8865449B2 (en) | 2014-10-21 |
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