BRPI0711121B8 - derivados de benzonitrila substituídos por glucopiranosila, composições farmacêuticas que contêm tais compostos, e seu uso - Google Patents

derivados de benzonitrila substituídos por glucopiranosila, composições farmacêuticas que contêm tais compostos, e seu uso

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Publication number
BRPI0711121B8
BRPI0711121B8 BRPI0711121A BRPI0711121A BRPI0711121B8 BR PI0711121 B8 BRPI0711121 B8 BR PI0711121B8 BR PI0711121 A BRPI0711121 A BR PI0711121A BR PI0711121 A BRPI0711121 A BR PI0711121A BR PI0711121 B8 BRPI0711121 B8 BR PI0711121B8
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BR
Brazil
Prior art keywords
hydroxy
methyl
ethyl
glucopyranosyl
compounds
Prior art date
Application number
BRPI0711121A
Other languages
English (en)
Inventor
Sauer Achim
Himmelsbach Frank
Thomas Leo
Eckhardt Matthias
Eickelmann Peter
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38885607&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0711121(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2007/051411 external-priority patent/WO2007093610A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0711121A2 publication Critical patent/BRPI0711121A2/pt
Publication of BRPI0711121A8 publication Critical patent/BRPI0711121A8/pt
Publication of BRPI0711121B1 publication Critical patent/BRPI0711121B1/pt
Publication of BRPI0711121B8 publication Critical patent/BRPI0711121B8/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04Carbocyclic radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/02Suppositories; Bougies; Bases therefor; Ovules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
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  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

derivados de benzonitrila substituidos por glucopiranosila, composições , farmacêuticas que contêm tais compostos, seu uso e processo para a sua fabricação. a presente invenção refere-se a derivados de benzonitrila substituídos por glucopiranosila definidos de acordo com a reivindicação 1, incluindo os tautômeros dos mesmos, estereoisômeros, as misturas dos mesmos e os sais dos mesmos. os compostos de acordo com a invenção são apropriados para o tratamento de distúrbios metabólicos. a fórmula (i) em que r(3) denota hidrogênio, flúor, cloro, bromo, iodo, metila, etila, propila, isopropila, butila, sec-butila, isobutila, terc-butila, 3-metil-but-1-ila, ciclopropila, ciclobutila, ciclopentila, cicloexila, 1-hidróxi ciclopropila, 1-hidróxi ciclobutila, 1-hidróxi ciclopentila, 1-hidróxi cicloexila, difluorometila, trifluorometua, pentafluoroetula, 2-hidróxi etila, hidróxi metila, 3-hidróxi propila, 2-hidróxi- 2-metil-prop-1-ila, 3-hidróxi-3-metil-but-1-ila, 1-hidróxi-1-metil etila, 2,2,2-triflúor-1-hidróxi-1-metil etila, 2,2,2-triflúor-1 hidróxi-1-trifluorometil etila, 2-metóxi etila, 2-etóxi etila, hidróxi, difluorometilóxi, trifluorometilóxi, 2-metilóxi etilóxi, metil sulfanila, metil sulfinila, metil sulfonila, etil sulfinila, etil sulfonila, trimetil silila ou ciano.
BRPI0711121A 2006-05-03 2007-05-02 derivados de benzonitrila substituídos por glucopiranosila, composições farmacêuticas que contêm tais compostos, e seu uso BRPI0711121B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP06113412 2006-05-03
EP06113412.8 2006-05-03
EP06124833 2006-11-27
EP06124833.2 2006-11-27
PCT/EP2007/051411 WO2007093610A1 (en) 2006-02-15 2007-02-14 Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
EPPCT/EP2007/051411 2007-02-14
PCT/EP2007/054248 WO2007128749A1 (en) 2006-05-03 2007-05-02 Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture

Publications (4)

Publication Number Publication Date
BRPI0711121A2 BRPI0711121A2 (pt) 2011-08-30
BRPI0711121A8 BRPI0711121A8 (pt) 2019-01-15
BRPI0711121B1 BRPI0711121B1 (pt) 2019-04-24
BRPI0711121B8 true BRPI0711121B8 (pt) 2021-05-25

Family

ID=38885607

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0711121A BRPI0711121B8 (pt) 2006-05-03 2007-05-02 derivados de benzonitrila substituídos por glucopiranosila, composições farmacêuticas que contêm tais compostos, e seu uso

Country Status (28)

Country Link
US (2) US7776830B2 (pt)
EP (1) EP2024352B1 (pt)
JP (1) JP5093524B2 (pt)
KR (1) KR101458372B1 (pt)
CN (2) CN102351918B (pt)
AR (1) AR060831A1 (pt)
AU (1) AU2007247218B2 (pt)
BR (1) BRPI0711121B8 (pt)
CA (1) CA2645638C (pt)
CY (1) CY1114187T1 (pt)
DK (1) DK2024352T3 (pt)
EA (1) EA200802185A1 (pt)
EC (1) ECSP088774A (pt)
ES (1) ES2422863T3 (pt)
FI (1) FIC20240011I1 (pt)
HR (1) HRP20130656T1 (pt)
IL (1) IL195028A0 (pt)
MX (1) MX2008013680A (pt)
MY (1) MY146368A (pt)
NO (1) NO20083947L (pt)
NZ (1) NZ573216A (pt)
PE (1) PE20080697A1 (pt)
PL (1) PL2024352T3 (pt)
PT (1) PT2024352E (pt)
SI (1) SI2024352T1 (pt)
TW (2) TW201427964A (pt)
UY (1) UY30314A1 (pt)
WO (1) WO2007128749A1 (pt)

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