BRPI0619795B8 - composição imunogênica, composição adjuvante, e, uso de uma composição imunogênica e um adjuvante - Google Patents
composição imunogênica, composição adjuvante, e, uso de uma composição imunogênica e um adjuvanteInfo
- Publication number
- BRPI0619795B8 BRPI0619795B8 BRPI0619795A BRPI0619795A BRPI0619795B8 BR PI0619795 B8 BRPI0619795 B8 BR PI0619795B8 BR PI0619795 A BRPI0619795 A BR PI0619795A BR PI0619795 A BRPI0619795 A BR PI0619795A BR PI0619795 B8 BRPI0619795 B8 BR PI0619795B8
- Authority
- BR
- Brazil
- Prior art keywords
- adjuvant
- composition
- immunogenic composition
- lipopolysaccharide
- present
- Prior art date
Links
- 239000002671 adjuvant Substances 0.000 title abstract 7
- 230000002163 immunogen Effects 0.000 title abstract 4
- 239000002158 endotoxin Substances 0.000 abstract 3
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 abstract 3
- 229930182490 saponin Natural products 0.000 abstract 3
- 150000007949 saponins Chemical class 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000002502 liposome Substances 0.000 abstract 2
- 241001092142 Molina Species 0.000 abstract 1
- 241000219287 Saponaria Species 0.000 abstract 1
Classifications
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Abstract
composição imunogênica, composição adjuvante, e, uso de um antígeno ou sua preparação antigênica e um adjuvante. a presente invenção fornece uma dose humana de uma composição imunogênica compreendendo um antígeno ou preparação antigênica, em combinação com um adjuvante, adjuvante este compreendendo uma fração de saponina imunologicamente ativa, derivada da casca de quiliaja saponaria molina, apresentada na forma de um lipossoma e um lipopolissacarídeo, em que dita fração de saponina e dito lipopolissacarídeo estão ambos presentes em dita dose humana em um nível abaixo de 30 (mi)g. a presente invenção fornece ainda uma composição adjuvante em um volume adequado para dose humana, compreendendo entre 1 e 30 (mi)g de um lipopolissacarídeo e entre 1 e 30 (mi)g de uma fração de saponina imunologicamente ativa, apresentada na forma de um lipossoma.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0525321.6A GB0525321D0 (en) | 2005-12-13 | 2005-12-13 | Novel compositions |
GB0525321.6 | 2005-12-13 | ||
GB0609902.2 | 2006-05-18 | ||
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2013
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2014
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