BRPI0614397A2 - compostos de pirimidina como moduladores de receptor de serotonina - Google Patents

compostos de pirimidina como moduladores de receptor de serotonina

Info

Publication number
BRPI0614397A2
BRPI0614397A2 BRPI0614397-0A BRPI0614397A BRPI0614397A2 BR PI0614397 A2 BRPI0614397 A2 BR PI0614397A2 BR PI0614397 A BRPI0614397 A BR PI0614397A BR PI0614397 A2 BRPI0614397 A2 BR PI0614397A2
Authority
BR
Brazil
Prior art keywords
receptor modulators
serotonin receptor
pyrimidine compounds
serotonin
pyrimidine
Prior art date
Application number
BRPI0614397-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Curt A Dvorak
Dale A Rudolph
Brock T Shireman
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0614397A2 publication Critical patent/BRPI0614397A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

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  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
BRPI0614397-0A 2005-08-04 2006-07-27 compostos de pirimidina como moduladores de receptor de serotonina BRPI0614397A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70571905P 2005-08-04 2005-08-04
PCT/US2006/029437 WO2007019083A1 (en) 2005-08-04 2006-07-27 Pyrimidine compounds as serotonin receptor modulators

Publications (1)

Publication Number Publication Date
BRPI0614397A2 true BRPI0614397A2 (pt) 2011-03-29

Family

ID=37400981

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0614397-0A BRPI0614397A2 (pt) 2005-08-04 2006-07-27 compostos de pirimidina como moduladores de receptor de serotonina

Country Status (16)

Country Link
EP (1) EP1928461B1 (cg-RX-API-DMAC7.html)
JP (1) JP5066088B2 (cg-RX-API-DMAC7.html)
KR (1) KR101353268B1 (cg-RX-API-DMAC7.html)
CN (1) CN101277700B (cg-RX-API-DMAC7.html)
AT (1) ATE539753T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006278759B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0614397A2 (cg-RX-API-DMAC7.html)
CA (1) CA2617760C (cg-RX-API-DMAC7.html)
CR (1) CR9791A (cg-RX-API-DMAC7.html)
EA (1) EA014495B1 (cg-RX-API-DMAC7.html)
IL (2) IL189164A (cg-RX-API-DMAC7.html)
NO (1) NO340744B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ565334A (cg-RX-API-DMAC7.html)
UA (1) UA95247C2 (cg-RX-API-DMAC7.html)
WO (1) WO2007019083A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200802010B (cg-RX-API-DMAC7.html)

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SG146683A1 (en) 2003-09-17 2008-10-30 Janssen Pharmaceutica Nv Fused heterocyclic compounds as serotonin receptor modulators
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
PE20080145A1 (es) * 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
WO2008117169A1 (en) * 2007-03-23 2008-10-02 Pfizer Limited Pyrimido [4, 5-d] azepine derivatives as 5-ht2c agonists
PE20091102A1 (es) 2007-12-17 2009-07-25 Janssen Pharmaceutica Nv Moduladores imidazolo-, oxazolo-, y tiazolopirimidina del trpv1
RU2567751C2 (ru) * 2010-05-21 2015-11-10 Эббви Инк. Трициклические производные пирролидина, полезные в качестве модуляторов 5-ht рецепторов
WO2015182712A1 (ja) 2014-05-29 2015-12-03 大鵬薬品工業株式会社 新規テトラヒドロピリドピリミジン化合物又はその塩
CN107365314B (zh) * 2016-05-11 2024-09-27 国药集团国瑞药业有限公司 一种吡唑类化合物、其晶型及其制备方法
KR102590403B1 (ko) * 2016-11-15 2023-10-16 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법
CN110997674B (zh) 2017-05-31 2022-12-20 凯莫森特里克斯股份有限公司 作为C5a抑制剂的6-5稠合环类
ES2980175T3 (es) * 2017-12-22 2024-09-30 Chemocentryx Inc Compuestos anulares fusionados en 6,5 sustituidos con diarilo como inhibidores de C5aR
CR20200553A (es) 2018-04-18 2021-04-08 Constellation Pharmaceuticals Inc Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos
EP3797108B1 (en) 2018-05-21 2022-07-20 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
KR102282569B1 (ko) * 2019-02-08 2021-07-29 (주)퓨쳐켐 새로운 18F-표지된 친디엔체와 테트라진 화합물과의 IeDDA 반응을 이용한 18F-표지 방법
KR102483492B1 (ko) * 2019-09-02 2023-01-02 한양대학교 에리카산학협력단 2,5-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물
MX2022005819A (es) * 2019-11-13 2022-08-16 Univ Temple Nuevas lactonas funcionalizadas como moduladores del receptor 7 de 5-hidroxitriptamina y su método de uso.
KR20230158542A (ko) 2021-03-29 2023-11-20 길리애드 사이언시즈, 인코포레이티드 Khk 억제제
AR128432A1 (es) * 2022-02-02 2024-05-08 The Katholieke Univ Leuven Tetrahidropiridopirimidinas y análogos relacionados para la inhibición de yap / taz-tead

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SG146683A1 (en) * 2003-09-17 2008-10-30 Janssen Pharmaceutica Nv Fused heterocyclic compounds as serotonin receptor modulators

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NO20081034L (no) 2008-02-28
AU2006278759B2 (en) 2012-08-16
CN101277700A (zh) 2008-10-01
NO340744B1 (no) 2017-06-12
NZ565334A (en) 2010-12-24
CR9791A (es) 2010-05-27
ATE539753T1 (de) 2012-01-15
ZA200802010B (en) 2009-09-30
HK1118469A1 (en) 2009-02-13
CN101277700B (zh) 2013-02-20
JP5066088B2 (ja) 2012-11-07
EA200800525A1 (ru) 2008-06-30
KR101353268B1 (ko) 2014-02-06
IL189164A0 (en) 2008-08-07
JP2009503076A (ja) 2009-01-29
UA95247C2 (ru) 2011-07-25
CA2617760C (en) 2015-02-17
AU2006278759A1 (en) 2007-02-15
IL213679A0 (en) 2011-07-31
KR20080033502A (ko) 2008-04-16
CA2617760A1 (en) 2007-02-15
WO2007019083A1 (en) 2007-02-15
EP1928461A1 (en) 2008-06-11
IL189164A (en) 2013-08-29
EA014495B1 (ru) 2010-12-30
EP1928461B1 (en) 2012-01-04

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