BRPI0611154A2 - derivados de 4-(piridin-3-il)-2-(piridin-2-il)-1,2-dihidro-3h-pirazol-3-on a como inibidores especìficos das hif-prolil-4-hidroxilases para o tratamento de doenças cardiovasculares e hematológicas - Google Patents

derivados de 4-(piridin-3-il)-2-(piridin-2-il)-1,2-dihidro-3h-pirazol-3-on a como inibidores especìficos das hif-prolil-4-hidroxilases para o tratamento de doenças cardiovasculares e hematológicas Download PDF

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Publication number
BRPI0611154A2
BRPI0611154A2 BRPI0611154-8A BRPI0611154A BRPI0611154A2 BR PI0611154 A2 BRPI0611154 A2 BR PI0611154A2 BR PI0611154 A BRPI0611154 A BR PI0611154A BR PI0611154 A2 BRPI0611154 A2 BR PI0611154A2
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BR
Brazil
Prior art keywords
formula
alkyl
substituted
hydroxy
compound
Prior art date
Application number
BRPI0611154-8A
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English (en)
Portuguese (pt)
Inventor
Ingo Flamme
Jens-Kerim Ergueden
Felix Oehme
Kai Thede
Gunter Karig
Alexander Kuhl
Hanno Wild
Joachim Schuhmacher
Peter Kolkhof
Lars Baerfacker
Joachim Huetter
Original Assignee
Bayer Healthcare Ag
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Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of BRPI0611154A2 publication Critical patent/BRPI0611154A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0611154-8A 2005-04-28 2006-04-15 derivados de 4-(piridin-3-il)-2-(piridin-2-il)-1,2-dihidro-3h-pirazol-3-on a como inibidores especìficos das hif-prolil-4-hidroxilases para o tratamento de doenças cardiovasculares e hematológicas BRPI0611154A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005019712A DE102005019712A1 (de) 2005-04-28 2005-04-28 Dipyridyl-dihydropyrazolone und ihre Verwendung
DE102005019712.4 2005-04-28
PCT/EP2006/003488 WO2006114213A1 (fr) 2005-04-28 2006-04-15 Derives de 4-(pyridin-3-yl)-2-(pyridin-2-yl)-1,2-dihydro-3h-pyrazol-3-one utilises en tant qu'inhibiteurs specifiques des hif-prolyl-4-hydroxylases pour traiter des maladies cardiovasculaires et hematologiques

Publications (1)

Publication Number Publication Date
BRPI0611154A2 true BRPI0611154A2 (pt) 2010-08-17

Family

ID=36889059

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0611154-8A BRPI0611154A2 (pt) 2005-04-28 2006-04-15 derivados de 4-(piridin-3-il)-2-(piridin-2-il)-1,2-dihidro-3h-pirazol-3-on a como inibidores especìficos das hif-prolil-4-hidroxilases para o tratamento de doenças cardiovasculares e hematológicas

Country Status (18)

Country Link
US (2) US8252817B2 (fr)
EP (1) EP1877396B1 (fr)
JP (1) JP5112294B2 (fr)
KR (1) KR101332939B1 (fr)
CN (1) CN101213189B (fr)
AT (1) ATE423112T1 (fr)
AU (1) AU2006239580A1 (fr)
BR (1) BRPI0611154A2 (fr)
CA (1) CA2608099C (fr)
DE (2) DE102005019712A1 (fr)
DK (1) DK1877396T3 (fr)
ES (1) ES2320930T3 (fr)
HK (1) HK1122803A1 (fr)
IL (1) IL186907A0 (fr)
MX (1) MX2007013342A (fr)
PL (1) PL1877396T3 (fr)
PT (1) PT1877396E (fr)
WO (1) WO2006114213A1 (fr)

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DE102006050513A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substitiuierte Dihydropyrazolone und ihre Verwendung

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US9085572B2 (en) 2015-07-21
KR101332939B1 (ko) 2013-11-26
KR20080007482A (ko) 2008-01-21
MX2007013342A (es) 2008-01-18
PT1877396E (pt) 2009-04-13
ES2320930T3 (es) 2009-05-29
CA2608099C (fr) 2013-10-01
CN101213189A (zh) 2008-07-02
DE102005019712A1 (de) 2006-11-09
DE502006002886D1 (de) 2009-04-02
CA2608099A1 (fr) 2006-11-02
US20100035906A1 (en) 2010-02-11
ATE423112T1 (de) 2009-03-15
AU2006239580A1 (en) 2006-11-02
WO2006114213A1 (fr) 2006-11-02
CN101213189B (zh) 2011-06-22
EP1877396B1 (fr) 2009-02-18
US20120322772A1 (en) 2012-12-20
JP5112294B2 (ja) 2013-01-09
PL1877396T3 (pl) 2009-10-30
US8252817B2 (en) 2012-08-28
IL186907A0 (en) 2008-02-09
HK1122803A1 (fr) 2009-05-29
EP1877396A1 (fr) 2008-01-16
JP2008539180A (ja) 2008-11-13

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