HK1122803A1 - - Google Patents
Info
- Publication number
- HK1122803A1 HK1122803A1 HK08114005.6A HK08114005A HK1122803A1 HK 1122803 A1 HK1122803 A1 HK 1122803A1 HK 08114005 A HK08114005 A HK 08114005A HK 1122803 A1 HK1122803 A1 HK 1122803A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- diseases
- prophylaxis
- preparation
- treatment
- dihydropyrazolones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005019712A DE102005019712A1 (de) | 2005-04-28 | 2005-04-28 | Dipyridyl-dihydropyrazolone und ihre Verwendung |
PCT/EP2006/003488 WO2006114213A1 (de) | 2005-04-28 | 2006-04-15 | Dipyridyl-dihydropyrazolone und ihre verwendung 4- (pyridin-3-yl) -2- (pyridin-2-yl) -1,2-dihydro-3h-pyrazol-3-on derivate als spezifische hemmstoffe der hif-prolyl-4-hydroxylasen zur behandlung kardiovaskulärer und hämatologischer erkrankungen |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1122803A1 true HK1122803A1 (xx) | 2009-05-29 |
Family
ID=36889059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08114005.6A HK1122803A1 (xx) | 2005-04-28 | 2008-12-29 |
Country Status (18)
Country | Link |
---|---|
US (2) | US8252817B2 (xx) |
EP (1) | EP1877396B1 (xx) |
JP (1) | JP5112294B2 (xx) |
KR (1) | KR101332939B1 (xx) |
CN (1) | CN101213189B (xx) |
AT (1) | ATE423112T1 (xx) |
AU (1) | AU2006239580A1 (xx) |
BR (1) | BRPI0611154A2 (xx) |
CA (1) | CA2608099C (xx) |
DE (2) | DE102005019712A1 (xx) |
DK (1) | DK1877396T3 (xx) |
ES (1) | ES2320930T3 (xx) |
HK (1) | HK1122803A1 (xx) |
IL (1) | IL186907A0 (xx) |
MX (1) | MX2007013342A (xx) |
PL (1) | PL1877396T3 (xx) |
PT (1) | PT1877396E (xx) |
WO (1) | WO2006114213A1 (xx) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102008020113A1 (de) | 2008-04-23 | 2009-10-29 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dihydropyrazolone und ihre Verwendung |
DE102005019712A1 (de) | 2005-04-28 | 2006-11-09 | Bayer Healthcare Ag | Dipyridyl-dihydropyrazolone und ihre Verwendung |
US7588924B2 (en) | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
EP2044005B8 (en) | 2006-06-26 | 2012-12-05 | Warner Chilcott Company, LLC | Prolyl hydroxylase inhibitors and methods of use |
DE102006050515A1 (de) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substituierte Dipyridiyl-dihydropyrazolone und ihre Verwendung |
DE102006050516A1 (de) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substituierte Dihydropyrazolone und ihre Verwendung |
DE102006050513A1 (de) * | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substitiuierte Dihydropyrazolone und ihre Verwendung |
US8410155B2 (en) | 2006-12-15 | 2013-04-02 | Bristol-Myers Squibb Company | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors |
CA2685942A1 (en) * | 2007-05-16 | 2008-11-27 | Merck & Co., Inc. | Spiroindalones |
WO2008157177A1 (en) * | 2007-06-13 | 2008-12-24 | The Uab Research Foundation | Methods for modulating osteoblast cell differentiation and bone generation through inhibition of a prolyl hydroxylase |
US20110123481A1 (en) * | 2007-08-16 | 2011-05-26 | Remedor Biomed Ltd. | Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications |
DE102007044032A1 (de) | 2007-09-14 | 2009-03-19 | Bayer Healthcare Ag | Substituierte heterocyclische Verbindungen und ihre Verwendung |
DE102007048447A1 (de) | 2007-10-10 | 2009-04-16 | Bayer Healthcare Ag | Substituierte Dihydropyrazolthione und ihre Verwendung |
PL2294066T3 (pl) | 2008-04-28 | 2015-02-27 | Janssen Pharmaceutica Nv | Benzimidazole jako inhibitory hydroksylazy prolilowej |
JP2011519934A (ja) * | 2008-05-08 | 2011-07-14 | メルク・シャープ・エンド・ドーム・コーポレイション | スピロアザインドール |
EP2135865A1 (de) | 2008-06-17 | 2009-12-23 | Bayer CropScience AG | Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
US8536176B2 (en) | 2008-08-01 | 2013-09-17 | Nippon Chemiphar Co., Ltd. | GPR119 agonist |
US8598209B2 (en) * | 2008-10-31 | 2013-12-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
EP2194052A1 (de) | 2008-12-06 | 2010-06-09 | Bayer CropScience AG | Substituierte 1-(Thiazolyl)- und 1-(Isothiazolyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
FR2940651B1 (fr) * | 2008-12-29 | 2013-05-03 | Sanofi Aventis | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif |
FR2949466A1 (fr) * | 2009-08-28 | 2011-03-04 | Sanofi Aventis | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif |
PE20120338A1 (es) | 2008-12-29 | 2012-04-30 | Sanofi Sa | Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, su preparacion y su aplicacion en terapeutica |
WO2010076524A2 (fr) * | 2008-12-29 | 2010-07-08 | Sanofi-Aventis | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif |
EP2474540A4 (en) | 2009-08-31 | 2013-03-13 | Nippon Chemiphar Co | GPR119 AGONIST |
US9144557B2 (en) * | 2009-10-13 | 2015-09-29 | Ligand Pharmaceuticals Inc. | Hematopoietic growth factor mimetic small molecule compounds and their uses |
US8536181B2 (en) | 2009-11-06 | 2013-09-17 | Aerpio Therapeutics Inc. | Prolyl hydroxylase inhibitors |
WO2011073098A1 (de) | 2009-12-15 | 2011-06-23 | Bayer Cropscience Ag | 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
CA2803687C (en) | 2010-07-20 | 2019-04-30 | Vestaron Corporation | Insecticidal triazines and pyrimidines |
JP5953308B2 (ja) * | 2010-10-22 | 2016-07-20 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 殺害虫剤としての新規ヘテロ環式化合物 |
DE102010044131A1 (de) | 2010-11-18 | 2012-05-24 | Bayer Schering Pharma Aktiengesellschaft | Substituiertes Natrium-1H-pyrazol-5-olat |
GB201102659D0 (en) | 2011-02-15 | 2011-03-30 | Isis Innovation | Assay |
NO2686520T3 (xx) | 2011-06-06 | 2018-03-17 | ||
US8865748B2 (en) | 2011-06-06 | 2014-10-21 | Akebia Therapeutics Inc. | Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
GB201113101D0 (en) | 2011-07-28 | 2011-09-14 | Isis Innovation | Assay |
TW201400470A (zh) * | 2012-03-30 | 2014-01-01 | Daiichi Sankyo Co Ltd | 4-烷醇胺-3-吡唑哢衍生物 |
WO2014021281A1 (ja) | 2012-07-30 | 2014-02-06 | 大正製薬株式会社 | 部分的に飽和された含窒素複素環化合物 |
US8734250B2 (en) | 2012-10-05 | 2014-05-27 | Wargaming.Net Llp | Control of vehicles in three dimensional space |
CA2903875C (en) | 2013-03-29 | 2021-07-20 | Takeda Pharmaceutical Company Limited | 6-(5-hydroxy-1h-pyrazol-1-yl)nicotinamide derivatives and their use as phd inhibitors |
EP3007695B1 (en) | 2013-06-13 | 2024-02-07 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
CN103396365A (zh) * | 2013-08-06 | 2013-11-20 | 新乡学院 | 一种吡唑啉酮的合成方法 |
EP3030194B1 (en) | 2013-08-09 | 2019-03-13 | Merit Medical Systems, Inc. | Vascular filter delivery systems |
MA39033A1 (fr) | 2013-11-15 | 2017-11-30 | Akebia Therapeutics Inc | Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations |
CN103755587B (zh) * | 2014-01-06 | 2015-06-10 | 华东师范大学 | 4-多氟烷基-2,4-二取代吡咯衍生物及其制备方法 |
EP2957283B1 (de) | 2014-06-19 | 2022-12-21 | Symrise AG | Verfahren zur Identifizierung von Medikamenten zur Beschleunigung der Wundheilung |
US10065928B2 (en) | 2014-09-02 | 2018-09-04 | Sunshine Lake Pharma Co., Ltd. | Quinolinone compound and use thereof |
BR112017015852A2 (pt) | 2015-01-23 | 2018-03-27 | Akebia Therapeutics Inc | forma de cristal, sal hemicálcico, sal hemicálcico di-hidratado, sal monossódico hidratado, sal bissódico monoidratado, sal monossódico anidro e método para preparar o composto 1 |
DK3277270T3 (da) | 2015-04-01 | 2021-12-06 | Akebia Therapeutics Inc | Sammensætninger og fremgangsmåder til behandling af anæmi |
CN105218437A (zh) * | 2015-10-31 | 2016-01-06 | 高大元 | 一种3-氯-5-溴-2-吡啶甲酸的合成方法 |
US11713298B2 (en) | 2018-05-09 | 2023-08-01 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
CA3106385A1 (en) * | 2018-09-13 | 2020-03-19 | Kissei Pharmaceutical Co., Ltd. | Imidazopyridinone compound |
US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
JP7504822B2 (ja) | 2020-03-12 | 2024-06-24 | キッセイ薬品工業株式会社 | イミダゾピリジノン化合物を含む医薬組成物 |
KR20220156889A (ko) * | 2020-03-20 | 2022-11-28 | 아케비아 테라퓨틱스 인코포레이티드 | Phd 억제제 화합물, 조성물, 및 용도 |
AR121621A1 (es) * | 2020-03-20 | 2022-06-22 | Akebia Therapeutics Inc | Compuestos inhibidores de phd, composiciones y métodos de uso |
TW202140444A (zh) * | 2020-03-20 | 2021-11-01 | 美商阿克比治療有限公司 | Phd抑制劑化合物、組成物及使用方法 |
WO2022111793A1 (en) | 2020-11-24 | 2022-06-02 | Symrise Ag | Medicament for accelerated wound healing |
WO2022161593A1 (en) | 2021-01-26 | 2022-08-04 | Symrise Ag | Medicament for accelerated wound healing |
CN114904474B (zh) * | 2022-05-26 | 2024-02-09 | 内蒙古新农基科技有限公司 | 5-溴甲基吡啶-2,3-二羧酸二乙酯反应装置及方法 |
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GR63123B (en) | 1975-12-11 | 1979-09-11 | Lilly Co Eli | Preparation process of novel 1,4-diphenyl-3-pyrazolin-5-ones |
US4075003A (en) * | 1975-12-11 | 1978-02-21 | Eli Lilly And Company | Novel herbicidal method utilizing 1,4-diphenyl-3-pyrazolin-5-ones |
PL103509B1 (pl) * | 1976-09-20 | 1979-06-30 | Lilly Co Eli | Srodek chwastobojczy |
US4663327A (en) | 1984-05-23 | 1987-05-05 | Bayer Aktiengesellschaft | 1-heteroaryl-4-aryl-pyrazolin-5-ones |
DE3443308A1 (de) * | 1984-11-28 | 1986-05-28 | Bayer Ag, 5090 Leverkusen | 1-heteroaryl-4-aryl-pyrazolin-5-one zur verwendung als arzneimittel |
DE3527157A1 (de) * | 1985-07-30 | 1987-02-12 | Bayer Ag | 1-heteroaryl-4-aryl-pyrazol-derivate |
FR2725988B1 (fr) | 1994-10-24 | 1997-01-24 | Roussel Uclaf | Nouveaux derives de pyrazolones et pyrazoles acides, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
DE19909237A1 (de) | 1999-03-03 | 2000-09-07 | Merck Patent Gmbh | Pyrazol-3-on-derivate |
AU2002241154A1 (en) * | 2001-03-21 | 2002-10-03 | Isis Innovation Ltd. | Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase |
US6878729B2 (en) * | 2001-05-04 | 2005-04-12 | The Procter & Gamble Company | Medicinal uses of dihydropyrazoles |
JP4316893B2 (ja) | 2001-05-16 | 2009-08-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | Srcおよび他のプロテインキナーゼのインヒビター |
CN102526044A (zh) * | 2001-12-06 | 2012-07-04 | 法布罗根股份有限公司 | 提高内源性红细胞生成素(epo)的方法 |
ES2295441T3 (es) | 2001-12-18 | 2008-04-16 | MERCK & CO., INC. | Moduladores de pirazol heteroaril sustituido de receptor 5 metabotropico de glutamato. |
US20040176372A1 (en) | 2002-03-01 | 2004-09-09 | Pintex Pharmaceuticals, Inc. | Pin1-modulating compounds and methods of use thereof |
GB0206711D0 (en) * | 2002-03-21 | 2002-05-01 | Isis Innovation | HIF Inhibitor |
US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
US7652033B2 (en) | 2003-03-27 | 2010-01-26 | Emory University | HIF-1 inhibitors |
CN100387594C (zh) | 2003-04-03 | 2008-05-14 | 麦克公司 | 二芳基取代的吡唑类代谢型谷氨酸受体-5调节剂 |
EP1626718A4 (en) * | 2003-05-01 | 2010-05-05 | Panacea Pharmaceuticals Inc | METHOD FOR THE TREATMENT OF ISCHEMIC ILLNESSES |
US7226941B2 (en) * | 2003-06-30 | 2007-06-05 | Hif Bio, Inc. | Compound for treating angiogenesis |
WO2006088491A2 (en) * | 2004-06-29 | 2006-08-24 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
AT504818A1 (de) | 2004-07-30 | 2008-08-15 | Windtec Consulting Gmbh | Triebstrang einer windkraftanlage |
DE102008020113A1 (de) | 2008-04-23 | 2009-10-29 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dihydropyrazolone und ihre Verwendung |
EP1861375A1 (en) | 2005-03-16 | 2007-12-05 | Aventis Pharmaceuticals Inc. | Dipyrazoles as central nervous system agents |
DE102005019712A1 (de) | 2005-04-28 | 2006-11-09 | Bayer Healthcare Ag | Dipyridyl-dihydropyrazolone und ihre Verwendung |
WO2007008541A2 (en) | 2005-07-08 | 2007-01-18 | Kalypsys, Inc. | Cellular cholesterol absorption modifiers |
DE102006050515A1 (de) * | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substituierte Dipyridiyl-dihydropyrazolone und ihre Verwendung |
DE102006050513A1 (de) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substitiuierte Dihydropyrazolone und ihre Verwendung |
-
2005
- 2005-04-28 DE DE102005019712A patent/DE102005019712A1/de not_active Withdrawn
-
2006
- 2006-04-15 CA CA2608099A patent/CA2608099C/en not_active Expired - Fee Related
- 2006-04-15 CN CN2006800236821A patent/CN101213189B/zh not_active Expired - Fee Related
- 2006-04-15 KR KR1020077027579A patent/KR101332939B1/ko not_active IP Right Cessation
- 2006-04-15 US US11/919,478 patent/US8252817B2/en not_active Expired - Fee Related
- 2006-04-15 PL PL06724361T patent/PL1877396T3/pl unknown
- 2006-04-15 EP EP06724361A patent/EP1877396B1/de not_active Not-in-force
- 2006-04-15 BR BRPI0611154-8A patent/BRPI0611154A2/pt not_active Application Discontinuation
- 2006-04-15 ES ES06724361T patent/ES2320930T3/es active Active
- 2006-04-15 MX MX2007013342A patent/MX2007013342A/es not_active Application Discontinuation
- 2006-04-15 JP JP2008508115A patent/JP5112294B2/ja not_active Expired - Fee Related
- 2006-04-15 DE DE502006002886T patent/DE502006002886D1/de active Active
- 2006-04-15 AU AU2006239580A patent/AU2006239580A1/en not_active Abandoned
- 2006-04-15 PT PT06724361T patent/PT1877396E/pt unknown
- 2006-04-15 DK DK06724361T patent/DK1877396T3/da active
- 2006-04-15 AT AT06724361T patent/ATE423112T1/de active
- 2006-04-15 WO PCT/EP2006/003488 patent/WO2006114213A1/de active Application Filing
-
2007
- 2007-10-25 IL IL186907A patent/IL186907A0/en unknown
-
2008
- 2008-12-29 HK HK08114005.6A patent/HK1122803A1/xx not_active IP Right Cessation
-
2012
- 2012-08-24 US US13/594,622 patent/US9085572B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PL1877396T3 (pl) | 2009-10-30 |
IL186907A0 (en) | 2008-02-09 |
JP5112294B2 (ja) | 2013-01-09 |
MX2007013342A (es) | 2008-01-18 |
US8252817B2 (en) | 2012-08-28 |
WO2006114213A1 (de) | 2006-11-02 |
DE502006002886D1 (de) | 2009-04-02 |
ES2320930T3 (es) | 2009-05-29 |
AU2006239580A1 (en) | 2006-11-02 |
US20120322772A1 (en) | 2012-12-20 |
JP2008539180A (ja) | 2008-11-13 |
PT1877396E (pt) | 2009-04-13 |
EP1877396B1 (de) | 2009-02-18 |
EP1877396A1 (de) | 2008-01-16 |
DE102005019712A1 (de) | 2006-11-09 |
ATE423112T1 (de) | 2009-03-15 |
CN101213189A (zh) | 2008-07-02 |
US20100035906A1 (en) | 2010-02-11 |
KR101332939B1 (ko) | 2013-11-26 |
CA2608099A1 (en) | 2006-11-02 |
CN101213189B (zh) | 2011-06-22 |
BRPI0611154A2 (pt) | 2010-08-17 |
CA2608099C (en) | 2013-10-01 |
DK1877396T3 (da) | 2009-04-27 |
US9085572B2 (en) | 2015-07-21 |
KR20080007482A (ko) | 2008-01-21 |
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PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20170415 |