BRPI0608455A2 - composição compreendendo conjugados de alérgenos de gato bem como vacinas, composições farmacêuticas e medicamentos contendo a mesma, e processo para sua produção - Google Patents

composição compreendendo conjugados de alérgenos de gato bem como vacinas, composições farmacêuticas e medicamentos contendo a mesma, e processo para sua produção Download PDF

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Publication number
BRPI0608455A2
BRPI0608455A2 BRPI0608455-9A BRPI0608455A BRPI0608455A2 BR PI0608455 A2 BRPI0608455 A2 BR PI0608455A2 BR PI0608455 A BRPI0608455 A BR PI0608455A BR PI0608455 A2 BRPI0608455 A2 BR PI0608455A2
Authority
BR
Brazil
Prior art keywords
fel
thr
leu
wing
gly
Prior art date
Application number
BRPI0608455-9A
Other languages
English (en)
Portuguese (pt)
Inventor
Martin Bachmann
Monika Bauer
Klaus Dietmeier
Nicole Schmitz
Stephan Utzinger
Original Assignee
Cytos Biotechnology Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytos Biotechnology Ag filed Critical Cytos Biotechnology Ag
Publication of BRPI0608455A2 publication Critical patent/BRPI0608455A2/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0608455-9A 2005-03-18 2006-03-17 composição compreendendo conjugados de alérgenos de gato bem como vacinas, composições farmacêuticas e medicamentos contendo a mesma, e processo para sua produção BRPI0608455A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66291805P 2005-03-18 2005-03-18
PCT/EP2006/060845 WO2006097530A2 (en) 2005-03-18 2006-03-17 Cat allergen fusion proteins and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0608455A2 true BRPI0608455A2 (pt) 2010-01-05

Family

ID=36843236

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608455-9A BRPI0608455A2 (pt) 2005-03-18 2006-03-17 composição compreendendo conjugados de alérgenos de gato bem como vacinas, composições farmacêuticas e medicamentos contendo a mesma, e processo para sua produção

Country Status (19)

Country Link
US (3) US7767212B2 (enExample)
EP (1) EP1868642B1 (enExample)
JP (2) JP5302671B2 (enExample)
KR (1) KR20070112225A (enExample)
CN (2) CN103203016A (enExample)
AU (1) AU2006224529B2 (enExample)
BR (1) BRPI0608455A2 (enExample)
CA (1) CA2599218C (enExample)
CY (1) CY1114171T1 (enExample)
DK (1) DK1868642T3 (enExample)
ES (1) ES2424229T3 (enExample)
IL (1) IL185103A0 (enExample)
MX (1) MX2007011160A (enExample)
NZ (1) NZ561040A (enExample)
PL (1) PL1868642T3 (enExample)
PT (1) PT1868642E (enExample)
RU (1) RU2414239C2 (enExample)
WO (1) WO2006097530A2 (enExample)
ZA (1) ZA200707413B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
EP1450856B1 (en) 2001-09-14 2009-11-11 Cytos Biotechnology AG Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use
JP4726483B2 (ja) * 2002-07-17 2011-07-20 サイトス バイオテクノロジー アーゲー 分子抗原アレイ
DE60336902D1 (de) * 2002-07-19 2011-06-09 Cytos Biotechnology Ag Impfstoffzusammensetzungen enthaltende amyloid beta 1-6 antigenarrays
PL1868642T3 (pl) * 2005-03-18 2013-10-31 Cytos Biotechnology Ag Białka fuzyjne alergenów kocich i ich zastosowania
WO2007068747A1 (en) * 2005-12-14 2007-06-21 Cytos Biotechnology Ag Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
WO2007113633A2 (en) * 2006-04-03 2007-10-11 Pfizer Products Inc. Immunogenic compositions comprising cat allergen fel dl
AT503690A1 (de) * 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
JP5437797B2 (ja) 2006-06-12 2014-03-12 サイトス バイオテクノロジー アーゲー Rnaバクテリオファージのウイルス様粒子にオリゴヌクレオチドをパッケージ化するための方法
ES2577833T3 (es) 2006-09-29 2016-07-19 Takeda Vaccines, Inc. Formulaciones de vacuna para norovirus
US9388236B2 (en) 2007-07-09 2016-07-12 Nestec Sa Methods for reducing allergies caused by environmental allergens
RU2491937C2 (ru) * 2007-07-09 2013-09-10 Нестек С.А. Способы уменьшения аллергических реакций, вызванных аллергенами окружающей среды
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
SG10201601660YA (en) 2007-09-18 2016-04-28 Takeda Vaccines Inc Method of conferring a protective immune response to norovirus
EP2042193A1 (en) * 2007-09-28 2009-04-01 Biomay AG RNA Vaccines
KR101793161B1 (ko) 2008-08-08 2017-11-03 다케다 백신즈 인코포레이티드 강화된 교차 반응성을 가진 복합체 캡시드 아미노산 서열들을 포함하는 바이러스-유사 입자들
US20130295131A1 (en) * 2009-11-05 2013-11-07 Hal S. Padgett Generation of antigenic virus-like particles through protein-protein linkages
US8321012B2 (en) 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
EP3299030B1 (en) 2011-07-11 2022-06-08 Takeda Vaccines, Inc. Parenteral norovirus vaccine formulations
CN104011080B (zh) 2011-12-22 2017-10-20 弗·哈夫曼-拉罗切有限公司 用于真核细胞的全长抗体展示系统及其用途
JO3820B1 (ar) * 2012-05-03 2021-01-31 Regeneron Pharma أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها
EP3587455A1 (en) * 2012-10-23 2020-01-01 Emory University Gm-csf and il-4 conjugates, compositions, and methods related thereto
US10935554B2 (en) 2013-08-23 2021-03-02 Regeneron Pharmaceuticals, Inc. Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (SIT)
EP3082849B1 (en) * 2013-12-19 2019-11-06 Société des Produits Nestlé S.A. Uses of compositions and methods for reducing cat allergens in the environment
MA40824A (fr) 2014-10-22 2017-08-29 Saiba Gmbh Particules de cmv de type virus modifié
US10526376B2 (en) 2015-01-15 2020-01-07 University Of Copenhagen Virus-like particle with efficient epitope display
WO2016192788A1 (en) * 2015-06-03 2016-12-08 Universität Zürich Prorektorat Mnw Methods and compositions for preventing and treating cat or dog dander allergy
CA2995003A1 (en) * 2015-09-08 2017-03-16 Universitat Zurich Compositions against cat allergy
EP3368068B1 (en) 2015-10-30 2020-11-18 University of Copenhagen Virus like particle with efficient epitope display
CN105219742A (zh) * 2015-11-10 2016-01-06 海南大学 一种展示重组猫致敏原rFel d 1蛋白的免疫增强型病毒样颗粒、其表达载体及其制备与应用
WO2017179025A1 (en) 2016-04-15 2017-10-19 Alk-Abelló A/S Epitope polypeptides of ragweed pollen allergens
FR3054547B1 (fr) * 2016-07-29 2020-06-05 Angany Inc. Particules pseudo-virales et leurs utilisations
US11352417B2 (en) 2016-12-22 2022-06-07 Regeneron Pharmaceuticals, Inc. Method of treating an allergy with allergen-specific monoclonal antibodies
AU2019406749A1 (en) 2018-12-20 2021-05-27 Saiba AG Virus-like particles of CMV modified by fusion
US20250197454A1 (en) * 2022-03-18 2025-06-19 Denka Company Limited Virus-like particle containing capsid proteins connected by linker
CN114933639B (zh) * 2022-05-05 2023-12-29 中国农业科学院兰州兽医研究所 非洲猪瘟病毒p72N抗原表位蛋白及其制备方法和用途
CN117004650B (zh) * 2023-06-25 2024-05-14 山东立菲生物产业有限公司 一种猫皮屑过敏原组分feld1双链二聚体重组蛋白、制备方法及应用
WO2025139524A1 (zh) * 2023-12-28 2025-07-03 江苏众红生物工程创药研究院有限公司 猫重组变应原及其药用组合物、制备方法和应用
WO2025194374A1 (zh) * 2024-03-20 2025-09-25 深圳赫兹生命科学技术有限公司 猫过敏原多肽片段及应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163778A (en) * 1978-05-04 1979-08-07 The Foundation for the Study of Asthma and Related Diseases Asthma immunotherapy
US5374426A (en) 1986-09-03 1994-12-20 University Of Saskatchewan Rotavirus nucleocapsid protein VP6 in vaccine compositions
JPH03504975A (ja) 1988-06-14 1991-10-31 セル―エスシーアイ コーポレイション 異種官能性細胞免疫剤、それを含有するワクチン及びその使用方法
US6120769A (en) 1989-11-03 2000-09-19 Immulogic Pharmaceutical Corporation Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor
WO1992011291A1 (en) 1990-12-20 1992-07-09 Smithkline Beecham Biologicals (S.A.) Vaccines based on hepatitis b surface antigen
GB9114003D0 (en) 1991-06-28 1991-08-14 Mastico Robert A Chimaeric protein
GB9213601D0 (en) 1992-06-26 1992-08-12 Mastico Robert A Protein based delivery system
EP0783322A1 (en) 1994-09-02 1997-07-16 Immunologic Pharmaceutical Corporation Peptide compositions capable of down regulating an antigen specific immune response
US6759234B1 (en) 1994-09-02 2004-07-06 Immulogic Pharmaceutical Corporation Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response
WO1996030523A2 (en) 1995-03-31 1996-10-03 Hans Wolf Antigen presentation system based on retrovirus-like particles
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
US6054312A (en) 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
CA2315537A1 (en) 1997-12-16 1999-06-24 Regents Of The University Of Minnesota Methods to treat undesirable immune responses
AR020102A1 (es) 1998-07-30 2002-04-10 Ucb Sa Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento
WO2000020032A1 (en) 1998-10-06 2000-04-13 Trustees Of Dartmouth College RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY
ATE314095T1 (de) 1998-10-21 2006-01-15 Us Health Virusähnliche partikel zur induktion von autoantikörpern
PL192016B1 (pl) * 1998-11-30 2006-08-31 Cytos Biotechnology Ag Kompozycja, sposób wytwarzania sztucznego, uporządkowanego i powtarzalnego układu antygenu, zastosowanie kompozycji oraz kompozycja szczepionki
IL148843A0 (en) 1999-09-25 2002-09-12 Univ Iowa Res Found Immunostimulatory nucleic acids
WO2001085208A2 (en) 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
KR100919914B1 (ko) 2000-11-16 2009-10-06 알크-아벨로 에이/에스 신규한 돌연변이체 알레르겐
EP1221317A1 (en) 2000-12-28 2002-07-10 SHAN-Beteiligungsgesellschaft m.b.H. Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins
DK1219300T3 (da) 2000-12-28 2007-03-05 Biomay Prod & Handel Behandling af allergi
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
JP2005508134A (ja) 2001-03-02 2005-03-31 ザ ロックフェラー ユニヴァーシティ 天然アレルゲンの免疫原性を保持する、アレルゲン性が低下した組み換えハイブリッドアレルゲン構築体
EP1450856B1 (en) 2001-09-14 2009-11-11 Cytos Biotechnology AG Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use
CA2492823A1 (en) 2001-09-14 2003-03-27 Cytos Biotechnology Ag In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
ES2320638T3 (es) * 2001-11-07 2009-05-27 Cytos Biotechnology Ag Disposicion ordenada de antigenos il-5, il-13 o eotasina, para el tratamiento de enfermedades alergicas con un componente eosinofilico.
BR0213941A (pt) * 2001-11-07 2004-08-31 Cytos Biotechnology Ag Arranjos de antìgeno para o tratamento de doença óssea
JP4726483B2 (ja) * 2002-07-17 2011-07-20 サイトス バイオテクノロジー アーゲー 分子抗原アレイ
MXPA04011247A (es) 2002-07-19 2005-02-17 Cytos Biotechnology Ag Conjugados portadores de grelina.
WO2004018506A2 (en) 2002-08-22 2004-03-04 Cytos Biotechnology Ag Inducible alphaviral/orip based gene expression system
US7384635B2 (en) 2002-11-01 2008-06-10 Alk-Abello A/S Protein variants of naturally occurring allergens
WO2004047793A1 (en) 2002-11-26 2004-06-10 Alk-Abelló A/S Pharmaceutical allergen product
RU2351362C2 (ru) * 2003-03-26 2009-04-10 Цитос Байотекнолоджи Аг КОНЪЮГАТЫ ПЕПТИДА Melan-A, АНАЛОГА ВИРУСОПОДОБНОЙ ЧАСТИЦЫ
US20090117136A1 (en) * 2003-04-24 2009-05-07 Imvision Gmbh Recombinant allergen
EP1644034B1 (en) * 2003-07-10 2011-01-12 Cytos Biotechnology AG Composition for enhancing an immune response comprising packaged virus-like particles
PL1868642T3 (pl) * 2005-03-18 2013-10-31 Cytos Biotechnology Ag Białka fuzyjne alergenów kocich i ich zastosowania

Also Published As

Publication number Publication date
ZA200707413B (en) 2009-01-28
CA2599218A1 (en) 2006-09-21
CN103203016A (zh) 2013-07-17
PT1868642E (pt) 2013-07-10
MX2007011160A (es) 2007-11-13
DK1868642T3 (da) 2013-06-24
CA2599218C (en) 2015-08-11
CN101141979B (zh) 2013-05-08
US20110045013A1 (en) 2011-02-24
KR20070112225A (ko) 2007-11-22
EP1868642A2 (en) 2007-12-26
IL185103A0 (en) 2007-12-03
EP1868642B1 (en) 2013-05-08
US20130344098A1 (en) 2013-12-26
NZ561040A (en) 2009-04-30
PL1868642T3 (pl) 2013-10-31
WO2006097530A3 (en) 2007-06-21
CN101141979A (zh) 2008-03-12
WO2006097530A2 (en) 2006-09-21
AU2006224529B2 (en) 2012-05-24
AU2006224529A1 (en) 2006-09-21
US20090175896A1 (en) 2009-07-09
JP2013155176A (ja) 2013-08-15
CY1114171T1 (el) 2016-08-31
US7767212B2 (en) 2010-08-03
JP5302671B2 (ja) 2013-10-02
RU2414239C2 (ru) 2011-03-20
ES2424229T3 (es) 2013-09-30
JP2008535800A (ja) 2008-09-04
RU2007138265A (ru) 2009-04-27

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Free format text: REF. A RPI NO 2150 DE 20/03/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]