CN101141979B - 猫变应原融合蛋白及其用途 - Google Patents

猫变应原融合蛋白及其用途 Download PDF

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Publication number
CN101141979B
CN101141979B CN2006800088726A CN200680008872A CN101141979B CN 101141979 B CN101141979 B CN 101141979B CN 2006800088726 A CN2006800088726 A CN 2006800088726A CN 200680008872 A CN200680008872 A CN 200680008872A CN 101141979 B CN101141979 B CN 101141979B
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compositions
fel
seq
attachment site
chain
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Chinese (zh)
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CN101141979A (zh
Inventor
M·巴克曼
M·鲍尔
K·迪特迈尔
N·施米茨
S·尤特津格尔
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Cytos Biotechnology AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2006800088726A 2005-03-18 2006-03-17 猫变应原融合蛋白及其用途 Expired - Fee Related CN101141979B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66291805P 2005-03-18 2005-03-18
US60/662,918 2005-03-18
PCT/EP2006/060845 WO2006097530A2 (en) 2005-03-18 2006-03-17 Cat allergen fusion proteins and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2013101152149A Division CN103203016A (zh) 2005-03-18 2006-03-17 猫变应原融合蛋白及其用途

Publications (2)

Publication Number Publication Date
CN101141979A CN101141979A (zh) 2008-03-12
CN101141979B true CN101141979B (zh) 2013-05-08

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CN2006800088726A Expired - Fee Related CN101141979B (zh) 2005-03-18 2006-03-17 猫变应原融合蛋白及其用途
CN2013101152149A Pending CN103203016A (zh) 2005-03-18 2006-03-17 猫变应原融合蛋白及其用途

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CN2013101152149A Pending CN103203016A (zh) 2005-03-18 2006-03-17 猫变应原融合蛋白及其用途

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US (3) US7767212B2 (enExample)
EP (1) EP1868642B1 (enExample)
JP (2) JP5302671B2 (enExample)
KR (1) KR20070112225A (enExample)
CN (2) CN101141979B (enExample)
AU (1) AU2006224529B2 (enExample)
BR (1) BRPI0608455A2 (enExample)
CA (1) CA2599218C (enExample)
CY (1) CY1114171T1 (enExample)
DK (1) DK1868642T3 (enExample)
ES (1) ES2424229T3 (enExample)
IL (1) IL185103A0 (enExample)
MX (1) MX2007011160A (enExample)
NZ (1) NZ561040A (enExample)
PL (1) PL1868642T3 (enExample)
PT (1) PT1868642E (enExample)
RU (1) RU2414239C2 (enExample)
WO (1) WO2006097530A2 (enExample)
ZA (1) ZA200707413B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
ATE447967T1 (de) 2001-09-14 2009-11-15 Cytos Biotechnology Ag Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung
RU2324704C2 (ru) * 2002-07-17 2008-05-20 Цитос Байотекнолоджи Аг Молекулярные массивы антигенов
RU2450827C2 (ru) * 2002-07-19 2012-05-20 Цитос Биотехнологи Аг Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6
KR20070112225A (ko) * 2005-03-18 2007-11-22 사이토스 바이오테크놀로지 아게 고양이 알레르겐 컨쥬게이트 및 그의 용도
EP1973608A1 (en) * 2005-12-14 2008-10-01 Cytos Biotechnology AG Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
WO2007113633A2 (en) * 2006-04-03 2007-10-11 Pfizer Products Inc. Immunogenic compositions comprising cat allergen fel dl
AT503690A1 (de) * 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
NZ573622A (en) 2006-06-12 2011-12-22 Cytos Biotechnology Ag Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages
ES2618885T3 (es) 2006-09-29 2017-06-22 Takeda Vaccines, Inc. Formulaciones de vacuna para norovirus
CA2693416C (en) 2007-07-09 2018-01-09 Nestec S.A. Methods for reducing allergies caused by environmental allergens
US9388236B2 (en) 2007-07-09 2016-07-12 Nestec Sa Methods for reducing allergies caused by environmental allergens
KR20100083150A (ko) 2007-09-18 2010-07-21 리고사이트 파머슈티컬즈 인코퍼레이티드 노로바이러스에 대한 보호면역반응을 제공하는 방법
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
EP2042193A1 (en) * 2007-09-28 2009-04-01 Biomay AG RNA Vaccines
AU2009279456B2 (en) 2008-08-08 2015-02-05 Takeda Vaccines, Inc. Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
CA2816401C (en) * 2009-11-05 2017-07-18 Novici Biotech Llc Generation of antigenic virus-like particles through protein-protein linkages
US8321012B2 (en) 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
HK1199202A1 (en) 2011-07-11 2015-06-26 武田疫苗股份有限公司 Parenteral norovirus vaccine formulations
EP2794662A1 (en) 2011-12-22 2014-10-29 F.Hoffmann-La Roche Ag Full length antibody display system for eukaryotic cells and its use
JO3820B1 (ar) * 2012-05-03 2021-01-31 Regeneron Pharma أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها
EP2912069B1 (en) * 2012-10-23 2019-07-31 Emory University Gm-csf and il-4 conjugates, compositions, and methods related thereto
WO2015027154A2 (en) 2013-08-23 2015-02-26 Regeneron Pharmaceuticals, Inc. Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (sit)
ES2759066T3 (es) * 2013-12-19 2020-05-07 Nestle Sa Usos de composiciones y métodos para reducir los alérgenos de gato en el ambiente
MA40824A (fr) 2014-10-22 2017-08-29 Saiba Gmbh Particules de cmv de type virus modifié
WO2016112921A1 (en) 2015-01-15 2016-07-21 University Of Copenhagen Virus-like particle with efficient epitope display
WO2016192788A1 (en) * 2015-06-03 2016-12-08 Universität Zürich Prorektorat Mnw Methods and compositions for preventing and treating cat or dog dander allergy
KR102812106B1 (ko) * 2015-09-08 2025-05-22 유니베르시태트 취리히 고양이 알레르기 억제 조성물
WO2017071713A1 (en) 2015-10-30 2017-05-04 University Of Copenhagen Virus like particle with efficient epitope display
CN105219742A (zh) * 2015-11-10 2016-01-06 海南大学 一种展示重组猫致敏原rFel d 1蛋白的免疫增强型病毒样颗粒、其表达载体及其制备与应用
WO2017179025A1 (en) 2016-04-15 2017-10-19 Alk-Abelló A/S Epitope polypeptides of ragweed pollen allergens
FR3054547B1 (fr) * 2016-07-29 2020-06-05 Angany Inc. Particules pseudo-virales et leurs utilisations
EP3558347A1 (en) 2016-12-22 2019-10-30 Regeneron Pharmaceuticals, Inc. Method of treating an allergy with allergen-specific monoclonal antibodies
PH12021550898A1 (en) 2018-12-20 2022-05-02 Saiba AG Virus-like particles of cmv modified by fusion
KR20240145520A (ko) * 2022-03-18 2024-10-07 덴카 주식회사 링커에 의해 연결된 캡시드 단백질을 포함하는 바이러스 유사입자
CN114933639B (zh) * 2022-05-05 2023-12-29 中国农业科学院兰州兽医研究所 非洲猪瘟病毒p72N抗原表位蛋白及其制备方法和用途
CN117004650B (zh) * 2023-06-25 2024-05-14 山东立菲生物产业有限公司 一种猫皮屑过敏原组分feld1双链二聚体重组蛋白、制备方法及应用
WO2025139524A1 (zh) * 2023-12-28 2025-07-03 江苏众红生物工程创药研究院有限公司 猫重组变应原及其药用组合物、制备方法和应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163778A (en) * 1978-05-04 1979-08-07 The Foundation for the Study of Asthma and Related Diseases Asthma immunotherapy
US5374426A (en) 1986-09-03 1994-12-20 University Of Saskatchewan Rotavirus nucleocapsid protein VP6 in vaccine compositions
WO1989012458A1 (en) 1988-06-14 1989-12-28 Cell Med, Inc. Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same
US6120769A (en) 1989-11-03 2000-09-19 Immulogic Pharmaceutical Corporation Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor
JPH06503821A (ja) 1990-12-20 1994-04-28 スミスクライン・ビーチャム・バイオロジカルス（ソシエテ・アノニム） Ｂ型肝炎表面抗原に基づくワクチン
GB9114003D0 (en) 1991-06-28 1991-08-14 Mastico Robert A Chimaeric protein
GB9213601D0 (en) 1992-06-26 1992-08-12 Mastico Robert A Protein based delivery system
JPH10505356A (ja) 1994-09-02 1998-05-26 イミユロジク・フアーマシユーチカル・コーポレーシヨン ヒトへの投与のための組成物および方法、抗原特異的免疫応答のダウンレギュレーションを行うことが可能なペプチド
US6759234B1 (en) 1994-09-02 2004-07-06 Immulogic Pharmaceutical Corporation Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response
EP0817854A2 (en) 1995-03-31 1998-01-14 Wolf, Hans, Prof. Dr. Antigen presentation system based on retrovirus-like particles
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
US6054312A (en) 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
AU3179999A (en) 1997-12-16 1999-07-05 Regents Of The University Of Minnesota Methods to treat undesirable immune responses
AR020102A1 (es) 1998-07-30 2002-04-10 Ucb Sa Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento
WO2000020032A1 (en) 1998-10-06 2000-04-13 Trustees Of Dartmouth College RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY
AU770802B2 (en) 1998-10-21 2004-03-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Virus-like particles for the induction of autoantibodies
ES2317711T3 (es) * 1998-11-30 2009-04-16 Cytos Biotechnology Ag Presentacion molecular de alergenos, metodos de preparacion y uso.
UA77152C2 (en) 1999-09-25 2006-11-15 Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma
AU2001252458A1 (en) 2000-05-05 2001-11-20 Martin Bachmann Molecular antigen arrays and vaccines
KR100919914B1 (ko) 2000-11-16 2009-10-06 알크-아벨로 에이/에스 신규한 돌연변이체 알레르겐
EP1221317A1 (en) 2000-12-28 2002-07-10 SHAN-Beteiligungsgesellschaft m.b.H. Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins
DE60032250T2 (de) 2000-12-28 2007-03-15 Biomay Produktions- Und Handels-Aktiengesellschaft Behandlung von Allergien
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
CA2441476A1 (en) 2001-03-02 2002-09-12 The Rockefeller University Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
ATE447967T1 (de) 2001-09-14 2009-11-15 Cytos Biotechnology Ag Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung
EP1425040A2 (en) 2001-09-14 2004-06-09 Cytos Biotechnology AG In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
KR20050044316A (ko) * 2001-11-07 2005-05-12 사이토스 바이오테크놀로지 아게 호산구성 알레르기 질환 치료용의 ｉｌ-5, ｉｌ-13 또는에오탁신을 제시하는 항원 어레이
PL369863A1 (en) * 2001-11-07 2005-05-02 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
RU2324704C2 (ru) * 2002-07-17 2008-05-20 Цитос Байотекнолоджи Аг Молекулярные массивы антигенов
WO2004009124A2 (en) 2002-07-19 2004-01-29 Cytos Biotechnology Ag Ghrelin-carrier conjugates
AU2003266301A1 (en) 2002-08-22 2004-03-11 Cytos Biotechnology Ag Inducible alphaviral/orip based gene expression system
WO2004039834A2 (en) 2002-11-01 2004-05-13 Alk-Abelló A/S Recombinant protein variants
MXPA05005528A (es) 2002-11-26 2006-04-05 Alk Abello As Producto farmaceutico de alergeno.
JP5022028B2 (ja) * 2003-03-26 2012-09-12 サイトス・バイオテクノロジー・アクチェンゲゼルシャフト メラン−ａペプチドアナログ−ウイルス様粒子コンジュゲート
DK1620554T3 (da) 2003-04-24 2008-06-02 Imvision Gmbh Rekombinant Fel d 1-allergen
CA2527102A1 (en) * 2003-07-10 2005-01-20 Cytos Biotechnology Ag Packaged virus-like particles
KR20070112225A (ko) * 2005-03-18 2007-11-22 사이토스 바이오테크놀로지 아게 고양이 알레르겐 컨쥬게이트 및 그의 용도

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Hans Gronlund et al..Formation of Disulfide Bonds and Homodimers of the Major Cat Allergen Fel d1 Equivalent to the Natural Allergen by Expression in Escherichia coli.THE JOURNAL OF BIOLOGICAL CHEMISTRY.2003,(41),摘要、第40145页左栏第2-3段，图1. *
Lisa D.Vailes et al..High-level expression of immunoreactiverecombinant cat allergen (Fel d 1):Targeting to antigen-presenting cells.J ALLERGY CLIN IMMUNOL.2002,110(5),摘要、第758、761页. *
Liselotte Kaiser et al..The Crystal Structure of the Major Cat Allergen Fel d1,a Member of the Secretoglobin Family.THE JOURNAL OF BIOLOGICAL CHEMISTRY.2003,(39),摘要、第37734页右栏第2段. *
LiselotteKaiseretal..TheCrystalStructureoftheMajorCatAllergenFeld1 a Member of the Secretoglobin Family.THE JOURNAL OF BIOLOGICAL CHEMISTRY.2003
刘春国等.病毒样颗粒技术应用的研究进展.中国预防兽医学报.2005,27(2),第159页2.3节. *

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Publication number Publication date
CY1114171T1 (el) 2016-08-31
NZ561040A (en) 2009-04-30
ZA200707413B (en) 2009-01-28
JP2008535800A (ja) 2008-09-04
US7767212B2 (en) 2010-08-03
CN101141979A (zh) 2008-03-12
KR20070112225A (ko) 2007-11-22
PL1868642T3 (pl) 2013-10-31
IL185103A0 (en) 2007-12-03
ES2424229T3 (es) 2013-09-30
CA2599218C (en) 2015-08-11
RU2007138265A (ru) 2009-04-27
PT1868642E (pt) 2013-07-10
JP2013155176A (ja) 2013-08-15
CA2599218A1 (en) 2006-09-21
CN103203016A (zh) 2013-07-17
WO2006097530A2 (en) 2006-09-21
US20110045013A1 (en) 2011-02-24
US20090175896A1 (en) 2009-07-09
JP5302671B2 (ja) 2013-10-02
AU2006224529B2 (en) 2012-05-24
EP1868642A2 (en) 2007-12-26
WO2006097530A3 (en) 2007-06-21
BRPI0608455A2 (pt) 2010-01-05
US20130344098A1 (en) 2013-12-26
RU2414239C2 (ru) 2011-03-20
DK1868642T3 (da) 2013-06-24
MX2007011160A (es) 2007-11-13
EP1868642B1 (en) 2013-05-08
AU2006224529A1 (en) 2006-09-21

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