BRPI0519562A2 - construÇço proteinÁcea, complexo, mÉtodo para prolongar a meia-vida in vivo de fator viii (fviii) ou um derivado biologicamente ativo do mesmo composiÇço farmacÊutica, e, mÉtodo para formar uma construÇço proteinÁcea - Google Patents
construÇço proteinÁcea, complexo, mÉtodo para prolongar a meia-vida in vivo de fator viii (fviii) ou um derivado biologicamente ativo do mesmo composiÇço farmacÊutica, e, mÉtodo para formar uma construÇço proteinÁceaInfo
- Publication number
- BRPI0519562A2 BRPI0519562A2 BRPI0519562-4A BRPI0519562A BRPI0519562A2 BR PI0519562 A2 BRPI0519562 A2 BR PI0519562A2 BR PI0519562 A BRPI0519562 A BR PI0519562A BR PI0519562 A2 BRPI0519562 A2 BR PI0519562A2
- Authority
- BR
- Brazil
- Prior art keywords
- fviii
- proteinaceous construct
- vwf
- complex
- life
- Prior art date
Links
- 229960000301 factor viii Drugs 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 238000001727 in vivo Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 108010047303 von Willebrand Factor Proteins 0.000 abstract 5
- 102100036537 von Willebrand factor Human genes 0.000 abstract 5
- 229960001134 von willebrand factor Drugs 0.000 abstract 5
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 238000010276 construction Methods 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 108010054218 Factor VIII Proteins 0.000 abstract 1
- 102000001690 Factor VIII Human genes 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000007849 functional defect Effects 0.000 abstract 1
- 208000031169 hemorrhagic disease Diseases 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63924404P | 2004-12-27 | 2004-12-27 | |
| US66837805P | 2005-04-04 | 2005-04-04 | |
| US67190105P | 2005-04-15 | 2005-04-15 | |
| US68508605P | 2005-05-26 | 2005-05-26 | |
| PCT/US2005/046879 WO2006071801A2 (en) | 2004-12-27 | 2005-12-23 | Polymer-von willebrand factor-conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519562A2 true BRPI0519562A2 (pt) | 2009-01-27 |
Family
ID=36540284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519562-4A BRPI0519562A2 (pt) | 2004-12-27 | 2005-12-23 | construÇço proteinÁcea, complexo, mÉtodo para prolongar a meia-vida in vivo de fator viii (fviii) ou um derivado biologicamente ativo do mesmo composiÇço farmacÊutica, e, mÉtodo para formar uma construÇço proteinÁcea |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7884075B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1835938B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5022231B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20070092754A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101163506B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005322067B8 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0519562A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2591852A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1835938T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2434035T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL183634A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007007877A (cg-RX-API-DMAC7.html) |
| PL (1) | PL1835938T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1835938E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006071801A2 (cg-RX-API-DMAC7.html) |
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| US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
| US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| ES2531934T3 (es) | 2006-09-01 | 2015-03-20 | Novo Nordisk Health Care Ag | Glicoproteínas modificadas |
| ES2521490T3 (es) * | 2006-12-15 | 2014-11-12 | Baxter International Inc. | Conjugado de factor VIIa - ácido (poli)siálico con una vida media in vivo prolongada. |
| MX2009007145A (es) * | 2006-12-27 | 2009-08-27 | Nektar Therapeutics Al Corp | Conjugados de polimero con factor viii y factor de von willebrand que tienen una ligadura liberable. |
| KR101156263B1 (ko) * | 2007-05-18 | 2012-06-13 | 박스터 헬쓰케어 에스.에이. | 폰 빌리브란트 인자 프로펩티드로부터 성숙한 폰 빌리브란트 인자를 제조하는 방법 |
| JP2010529155A (ja) * | 2007-06-13 | 2010-08-26 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 出血性疾患の治療及び予防的処置における血管外投与のためのｖｗｆ安定化ｆｖｉｉｉ製剤及びｆｖｉｉｉなしのｖｗｆ製剤の使用 |
| US7700551B2 (en) * | 2007-06-26 | 2010-04-20 | Baxter International Inc. | Hydrolysable polymeric FMOC-linker |
| WO2009062100A1 (en) * | 2007-11-09 | 2009-05-14 | Baxter International Inc. | Modified recombinant factor viii and von willebrand factor and methods of use |
| KR20160012252A (ko) | 2007-12-27 | 2016-02-02 | 백스터 인터내셔널 인코포레이티드 | 생리학적으로 수용가능한 중합체 분자를 특이적으로 검출하기 위한 방법 및 조성물 |
| BRPI0821597A2 (pt) * | 2007-12-27 | 2015-06-16 | Baxter Int | Métodos para quantificar a quantidade de proteína derivada de plasma e proteína recombinante em uma amostra e para diferenciar proteína derivada de plasma e proteína recombinante em uma amostra, e, kit. |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| AR069989A1 (es) | 2007-12-28 | 2010-03-03 | Baxter Int | Formulaciones de vwf recombinantes |
| EP2235188A2 (en) | 2007-12-31 | 2010-10-06 | Baxter International Inc. | Transgenic non-human animals expressing human blood clotting factors |
| KR20110028444A (ko) * | 2008-05-06 | 2011-03-18 | 옥타파마 아게 | 헤파린 결합 단백질 및 헤파린―히드록시알킬 전분 접합체를 포함하는 복합체 |
| DK2865760T3 (en) * | 2008-06-24 | 2018-01-15 | Csl Behring Gmbh | Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life |
| NZ590358A (en) * | 2008-07-23 | 2012-04-27 | Hanmi Holdings Co Ltd | A polypeptide complex comprising non-peptidyl polymer having three functional ends |
| US8575102B2 (en) * | 2008-08-01 | 2013-11-05 | Nektar Therapeutics | Conjugates having a releasable linkage |
| JP5785872B2 (ja) | 2008-10-17 | 2015-09-30 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 低度の水溶性ポリマーを含む改変血液因子 |
| US8586710B2 (en) * | 2008-10-20 | 2013-11-19 | Usv, Ltd. | Process for gram scale production of PEG-r-metHuG-CSF |
| EP2350658A2 (en) * | 2008-10-21 | 2011-08-03 | Baxter International Inc. | Methods for determining active ingredients in pro-drug peg protein conjugates with releasable peg reagents (in vitro de-pegylation) |
| KR101772674B1 (ko) * | 2008-10-21 | 2017-09-01 | 박스알타 인코퍼레이티드 | 동결건조된 재조합 ｖｗｆ 제제 |
| DK2356467T3 (da) * | 2008-12-11 | 2013-10-14 | Baxter Int | Påvisning af fysiologisk acceptable polymermolekyler under anvendelse af nær-infrarød spektroskopi |
| NZ597600A (en) | 2009-07-27 | 2014-05-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
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| JP5908401B2 (ja) | 2009-07-27 | 2016-04-26 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 血液凝固タンパク質複合体 |
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| RU2744370C2 (ru) | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
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-
2005
- 2005-12-23 DK DK05855442.9T patent/DK1835938T3/da active
- 2005-12-23 US US11/317,582 patent/US7884075B2/en active Active
- 2005-12-23 AU AU2005322067A patent/AU2005322067B8/en active Active
- 2005-12-23 BR BRPI0519562-4A patent/BRPI0519562A2/pt not_active IP Right Cessation
- 2005-12-23 WO PCT/US2005/046879 patent/WO2006071801A2/en not_active Ceased
- 2005-12-23 MX MX2007007877A patent/MX2007007877A/es active IP Right Grant
- 2005-12-23 EP EP05855442.9A patent/EP1835938B1/en not_active Expired - Lifetime
- 2005-12-23 PL PL05855442T patent/PL1835938T3/pl unknown
- 2005-12-23 CA CA002591852A patent/CA2591852A1/en not_active Abandoned
- 2005-12-23 CN CN2005800445983A patent/CN101163506B/zh not_active Expired - Lifetime
- 2005-12-23 JP JP2007548552A patent/JP5022231B2/ja not_active Expired - Lifetime
- 2005-12-23 KR KR1020077017261A patent/KR20070092754A/ko not_active Withdrawn
- 2005-12-23 PT PT58554429T patent/PT1835938E/pt unknown
- 2005-12-23 ES ES05855442T patent/ES2434035T3/es not_active Expired - Lifetime
-
2007
- 2007-06-04 IL IL183634A patent/IL183634A/en active IP Right Grant
-
2011
- 2011-01-14 US US13/007,208 patent/US8076463B2/en not_active Expired - Lifetime
- 2011-11-28 US US13/305,334 patent/US8357779B2/en not_active Expired - Lifetime
-
2012
- 2012-03-30 JP JP2012081700A patent/JP5715983B2/ja not_active Expired - Lifetime
- 2012-12-21 US US13/724,831 patent/US8835388B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070092754A (ko) | 2007-09-13 |
| EP1835938B1 (en) | 2013-08-07 |
| US8076463B2 (en) | 2011-12-13 |
| JP5022231B2 (ja) | 2012-09-12 |
| US8357779B2 (en) | 2013-01-22 |
| CN101163506B (zh) | 2012-09-26 |
| HK1105276A1 (en) | 2008-02-06 |
| WO2006071801A2 (en) | 2006-07-06 |
| CA2591852A1 (en) | 2006-07-06 |
| AU2005322067B8 (en) | 2012-07-26 |
| IL183634A (en) | 2012-02-29 |
| US8835388B2 (en) | 2014-09-16 |
| US20130190242A1 (en) | 2013-07-25 |
| US20120135462A1 (en) | 2012-05-31 |
| IL183634A0 (en) | 2007-09-20 |
| JP5715983B2 (ja) | 2015-05-13 |
| AU2005322067B2 (en) | 2012-07-05 |
| CN101163506A (zh) | 2008-04-16 |
| JP2008525491A (ja) | 2008-07-17 |
| PT1835938E (pt) | 2013-11-06 |
| US20110111455A1 (en) | 2011-05-12 |
| AU2005322067A1 (en) | 2006-07-06 |
| US20060160948A1 (en) | 2006-07-20 |
| MX2007007877A (es) | 2007-08-21 |
| EP1835938A2 (en) | 2007-09-26 |
| US7884075B2 (en) | 2011-02-08 |
| ES2434035T3 (es) | 2013-12-13 |
| DK1835938T3 (da) | 2013-11-04 |
| WO2006071801A3 (en) | 2007-08-16 |
| PL1835938T3 (pl) | 2014-01-31 |
| JP2012126750A (ja) | 2012-07-05 |
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