BRPI0515170A - processos para a produção de (s) -2- (1, 6, 7, 8- tetraidro-2h-indeno [5, 4 -b] furan -8- il) etilamina ou um sal do mesmo e para a produção de cristais de (s) -n- [2- (1, 6, 7, 8 - tetraidro -2h- indeno [5, 4 -b] furan -8- il) etil] propionamida, cristais de (s) -n- [2- (1, 6, 7, 8 -tetraidro -2h- indeno [5-4-b] furan -8- il) etil] propionamida, composição, processo para a produção de 1, 2 , 6, 7- tetraidro -8h- indeno [5, 4-b] furan -8- ona, uso dos cristais, e, método para a prevenção ou tratamento de distúrbios do sono - Google Patents

processos para a produção de (s) -2- (1, 6, 7, 8- tetraidro-2h-indeno [5, 4 -b] furan -8- il) etilamina ou um sal do mesmo e para a produção de cristais de (s) -n- [2- (1, 6, 7, 8 - tetraidro -2h- indeno [5, 4 -b] furan -8- il) etil] propionamida, cristais de (s) -n- [2- (1, 6, 7, 8 -tetraidro -2h- indeno [5-4-b] furan -8- il) etil] propionamida, composição, processo para a produção de 1, 2 , 6, 7- tetraidro -8h- indeno [5, 4-b] furan -8- ona, uso dos cristais, e, método para a prevenção ou tratamento de distúrbios do sono

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Publication number
BRPI0515170A
BRPI0515170A BRPI0515170-8A BRPI0515170A BRPI0515170A BR PI0515170 A BRPI0515170 A BR PI0515170A BR PI0515170 A BRPI0515170 A BR PI0515170A BR PI0515170 A BRPI0515170 A BR PI0515170A
Authority
BR
Brazil
Prior art keywords
furan
tetrahydro
production
crystals
indene
Prior art date
Application number
BRPI0515170-8A
Other languages
English (en)
Inventor
Shinichi Urayama
Eigo Mutou
Atsushi Inagaki
Takashi Okada
Shigeharu Sugisaki
Original Assignee
Takeda Pharmaceutical
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36059992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0515170(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of BRPI0515170A publication Critical patent/BRPI0515170A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
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  • Endocrinology (AREA)
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  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
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  • Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

PROCESSOS PARA A PRODUçãO DE (S)-.2-(1,6,7,8- TETRAIDRO-2H-INDENO ¢5,4-B! FURAN-8-IL) ETILAMINA OU UM SAL DO MESMO E PARA A PRODUçãO DE CRISTAIS DE (S)-N-¢2-(1,6,7,8-TETRAIDRO-2H-INDENO ¢5,4-B! FURAN-8-IL) ETIL! PROPIONAMIDA, CRISTAIS DE (S)-N-¢2-(1 ,6,7,8-TETRAIDRO-2H-INDENO ¢5,4-B! FURAN-8-IL) ETIL! PROPIONAMIDA, COMPOSIçãO, PROCESSO PARA A PRODUçãO DE 1,2,6,7-TETRAIDRO-8H-INDENO ¢5,4-B! FURAN-8-ONA, USO DOS CRISTAIS, E, MéTODO PARA A PREVENçãO OU TRATAMENTO DE DISTúRBIOS DO SONO Processo industrial para a produção de derivados de amina opticamente ativos de alta pureza em alto rendimento, ao mesmo tempo em que inibe a formação de subprodutos, que compreende submeter (E)-2-(1 ,6,7,8-tetraidro-2H-indeno ¢5,4-b! furan-8-ilideno) etilanina para redução assimétrica, reduzindo cataliticamente o produto obtido em uma em uma temperatura de 40 a 100<198>C e um pH de 3 a 9, submetendo a (S)-2-(1,6,7,8-tetraidro-2H-indeno ¢5,4-b! furan-8-il) etilamina obtida à propionilação, e então cristalização da mistura da reação.
BRPI0515170-8A 2004-09-13 2005-09-12 processos para a produção de (s) -2- (1, 6, 7, 8- tetraidro-2h-indeno [5, 4 -b] furan -8- il) etilamina ou um sal do mesmo e para a produção de cristais de (s) -n- [2- (1, 6, 7, 8 - tetraidro -2h- indeno [5, 4 -b] furan -8- il) etil] propionamida, cristais de (s) -n- [2- (1, 6, 7, 8 -tetraidro -2h- indeno [5-4-b] furan -8- il) etil] propionamida, composição, processo para a produção de 1, 2 , 6, 7- tetraidro -8h- indeno [5, 4-b] furan -8- ona, uso dos cristais, e, método para a prevenção ou tratamento de distúrbios do sono BRPI0515170A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004265307 2004-09-13
PCT/JP2005/016761 WO2006030739A1 (ja) 2004-09-13 2005-09-12 光学活性アミン誘導体の製造方法

Publications (1)

Publication Number Publication Date
BRPI0515170A true BRPI0515170A (pt) 2008-07-08

Family

ID=36059992

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515170-8A BRPI0515170A (pt) 2004-09-13 2005-09-12 processos para a produção de (s) -2- (1, 6, 7, 8- tetraidro-2h-indeno [5, 4 -b] furan -8- il) etilamina ou um sal do mesmo e para a produção de cristais de (s) -n- [2- (1, 6, 7, 8 - tetraidro -2h- indeno [5, 4 -b] furan -8- il) etil] propionamida, cristais de (s) -n- [2- (1, 6, 7, 8 -tetraidro -2h- indeno [5-4-b] furan -8- il) etil] propionamida, composição, processo para a produção de 1, 2 , 6, 7- tetraidro -8h- indeno [5, 4-b] furan -8- ona, uso dos cristais, e, método para a prevenção ou tratamento de distúrbios do sono

Country Status (31)

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US (4) US8097737B2 (pt)
EP (2) EP2537842A1 (pt)
JP (2) JP5127228B2 (pt)
KR (1) KR101298335B1 (pt)
CN (2) CN102516211A (pt)
AR (1) AR050737A1 (pt)
AU (1) AU2005283521B2 (pt)
BR (1) BRPI0515170A (pt)
CA (2) CA2579121C (pt)
CR (2) CR8975A (pt)
EC (1) ECSP077317A (pt)
ES (1) ES2485890T3 (pt)
GE (1) GEP20094725B (pt)
GT (2) GT200500257AA (pt)
HN (1) HN2005000548A (pt)
IL (2) IL181462A (pt)
MA (1) MA28855B1 (pt)
MX (1) MX2007002822A (pt)
MY (2) MY147822A (pt)
NO (1) NO20071866L (pt)
NZ (1) NZ553562A (pt)
PA (1) PA8645701A1 (pt)
PE (3) PE20060662A1 (pt)
RU (1) RU2385318C2 (pt)
SA (1) SA05260347A (pt)
SG (1) SG151330A1 (pt)
TW (1) TWI400220B (pt)
UA (1) UA95598C2 (pt)
UY (1) UY29118A1 (pt)
WO (1) WO2006030739A1 (pt)
ZA (1) ZA200701724B (pt)

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JP2011528012A (ja) * 2008-07-14 2011-11-10 レツク・フアーマシユーテイカルズ・デー・デー ラメルテオンの調製における中間体としての６，７−ジヒドロ−１ｈ−インデノ［５，４−ｂ］フラン−８（２ｈ）−オンの合成
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CN101824012B (zh) * 2009-03-02 2011-12-07 四川大学 2-(1,6,7,8-四氢-2H-茚并-[5,4-b]呋喃-8-基)乙腈及其制备方法和用途
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CN101665477B (zh) * 2009-09-21 2012-05-09 四川大学 (e)-3-(苯并呋喃-5-基)丙烯酸酯类化合物、其制备方法和用途
CN101648931B (zh) * 2009-09-21 2012-05-09 四川大学 一种3-(2,3-二氢苯并呋喃-5-基)-丙酸的制备方法
EP2483258A1 (en) 2009-09-29 2012-08-08 Lonza Ltd. Process for preparing 1,2,6,7-tetrahydro-8h-indeno[5,4-b]furan-8-one
WO2012035303A2 (en) 2010-09-17 2012-03-22 Cipla Limited Et Al A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon
CN103664849B (zh) * 2012-08-31 2017-03-29 上海阳帆医药科技有限公司 制备2‑(1,6,7,8‑四氢‑2H‑茚并[5,4‑b]呋喃‑8‑亚基乙胺的方法
CN102924410A (zh) * 2012-10-29 2013-02-13 华润赛科药业有限责任公司 一种雷美替胺的制备方法及其中间体
CN103396387A (zh) * 2013-08-07 2013-11-20 安徽联创药物化学有限公司 雷美替胺中间体的制备方法
CN105277628B (zh) * 2014-07-07 2017-05-31 南京长澳医药科技有限公司 通过高效液相色谱法分离测定雷美替胺及其杂质的方法
CN104402848B (zh) * 2014-09-22 2017-02-08 珠海联邦制药股份有限公司 雷美替胺中的杂质化合物的制备方法及制备的标准品
CN105622557B (zh) * 2014-11-05 2018-12-04 上海医药工业研究院 雷美替胺中间体及其制备方法
KR102359229B1 (ko) 2020-04-16 2022-02-07 제이투에이치바이오텍 (주) 라멜테온의 제조 방법 및 이러한 제조 방법에 이용되는 중간체 화합물
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