WO2008123067A1 - アリルアミン不斉水素化法 - Google Patents
アリルアミン不斉水素化法 Download PDFInfo
- Publication number
- WO2008123067A1 WO2008123067A1 PCT/JP2008/054973 JP2008054973W WO2008123067A1 WO 2008123067 A1 WO2008123067 A1 WO 2008123067A1 JP 2008054973 W JP2008054973 W JP 2008054973W WO 2008123067 A1 WO2008123067 A1 WO 2008123067A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ring
- substituent
- optically active
- atom
- asymmetric hydrogenation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/822—Rhodium
Abstract
式 (II0)〔式中、R1及びR2はそれぞれ水素原子、置換基を有してもよい、炭化水素基または複素環基を示すか、或いはR1とR2は隣接する炭素原子と一緒に置換基を有してもよいスピロ環を形成していてもよく、点線は上記R1とR2が結合して環を形成してもよいことを示し、Xは(CH2)n(nは1~4の整数を示す)、窒素原子、酸素原子または硫黄原子を示し、環A0は置換基を有してもよい不飽和6員環を、環Bは置換基を有してもよい5~7員複素環を示す。〕で表される化合物またはその塩を、ロジウム-光学活性フェロセン系ホスフィン錯体触媒の存在下、不斉水素化反応に付すことを特徴とする式(I0)〔式中、*は不斉中心を、その他の記号は前記と同意義を示す。〕で表される化合物の光学活性体またはその塩の製造法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009509032A JP5450056B2 (ja) | 2007-03-19 | 2008-03-18 | アリルアミン不斉水素化法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007070871 | 2007-03-19 | ||
JP2007-070871 | 2007-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008123067A1 true WO2008123067A1 (ja) | 2008-10-16 |
Family
ID=39830569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/054973 WO2008123067A1 (ja) | 2007-03-19 | 2008-03-18 | アリルアミン不斉水素化法 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP5450056B2 (ja) |
WO (1) | WO2008123067A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8084630B2 (en) | 2007-05-31 | 2011-12-27 | Teva Pharmaceutical Industries Ltd. | Process for the synthesis of ramelteon and its intermediates |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11140073A (ja) * | 1997-02-13 | 1999-05-25 | Takasago Internatl Corp | 光学活性アミン誘導体の製造法 |
WO2006052514A1 (en) * | 2004-11-04 | 2006-05-18 | Merck & Co., Inc. | Asymmetric hydrogenation of enamides |
WO2006060225A2 (en) * | 2004-11-23 | 2006-06-08 | Merck & Co., Inc. | Process for asymmetric synthesis of hexahydropyrimido[1,2-a] azepine-2-carboxamides and related compounds |
WO2006069287A1 (en) * | 2004-12-22 | 2006-06-29 | Merck & Co., Inc. | Process for making substituted piperidines |
JP2006521354A (ja) * | 2003-03-19 | 2006-09-21 | メルク エンド カムパニー インコーポレーテッド | 不斉水素化によるキラルなベータアミノ酸誘導体の製造方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2884153B2 (ja) * | 1996-03-08 | 1999-04-19 | 武田薬品工業株式会社 | 三環性化合物、その製造法および剤 |
JP2002253297A (ja) * | 2001-02-27 | 2002-09-10 | Takeda Chem Ind Ltd | 微生物による光学活性体の製造法 |
TWI400220B (zh) * | 2004-09-13 | 2013-07-01 | Takeda Pharmaceutical | 光活性胺衍生物的製法 |
-
2008
- 2008-03-18 JP JP2009509032A patent/JP5450056B2/ja active Active
- 2008-03-18 WO PCT/JP2008/054973 patent/WO2008123067A1/ja active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11140073A (ja) * | 1997-02-13 | 1999-05-25 | Takasago Internatl Corp | 光学活性アミン誘導体の製造法 |
JP2006521354A (ja) * | 2003-03-19 | 2006-09-21 | メルク エンド カムパニー インコーポレーテッド | 不斉水素化によるキラルなベータアミノ酸誘導体の製造方法 |
WO2006052514A1 (en) * | 2004-11-04 | 2006-05-18 | Merck & Co., Inc. | Asymmetric hydrogenation of enamides |
WO2006060225A2 (en) * | 2004-11-23 | 2006-06-08 | Merck & Co., Inc. | Process for asymmetric synthesis of hexahydropyrimido[1,2-a] azepine-2-carboxamides and related compounds |
WO2006069287A1 (en) * | 2004-12-22 | 2006-06-29 | Merck & Co., Inc. | Process for making substituted piperidines |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8084630B2 (en) | 2007-05-31 | 2011-12-27 | Teva Pharmaceutical Industries Ltd. | Process for the synthesis of ramelteon and its intermediates |
Also Published As
Publication number | Publication date |
---|---|
JPWO2008123067A1 (ja) | 2010-07-15 |
JP5450056B2 (ja) | 2014-03-26 |
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