BRPI0510115B1 - Método para produzir um isoprenóide ou precursor de isoprenóide através de uma via de mevalonato em escherichia coli e célula hospedeira geneticamente modificada que os produz - Google Patents
Método para produzir um isoprenóide ou precursor de isoprenóide através de uma via de mevalonato em escherichia coli e célula hospedeira geneticamente modificada que os produz Download PDFInfo
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- BRPI0510115B1 BRPI0510115B1 BRPI0510115-8A BRPI0510115A BRPI0510115B1 BR PI0510115 B1 BRPI0510115 B1 BR PI0510115B1 BR PI0510115 A BRPI0510115 A BR PI0510115A BR PI0510115 B1 BRPI0510115 B1 BR PI0510115B1
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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| PCT/US2005/017874 WO2006085899A2 (en) | 2004-05-21 | 2005-05-20 | Method for enhancing production of isoprenoid compounds |
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| BRPI0510115A BRPI0510115A (pt) | 2007-09-25 |
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| US20050287596A9 (en) * | 1998-06-26 | 2005-12-29 | Braisted Andrew C | Novel ligands and libraries of ligands |
| US20030033626A1 (en) * | 2000-07-31 | 2003-02-13 | Hahn Frederick M. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| US7172886B2 (en) * | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| DE60325847D1 (de) * | 2002-03-11 | 2009-03-05 | Caprotec Bioanalytics Gmbh | Verbindungen und verfahren für die analyse des proteoms |
| US20060051879A9 (en) * | 2003-01-16 | 2006-03-09 | Hubert Koster | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| CN104745486B (zh) | 2005-06-07 | 2018-01-16 | 帝斯曼营养品股份公司 | 生产脂质和抗氧化剂的真核微生物 |
| US8097438B2 (en) * | 2005-10-07 | 2012-01-17 | The Regents Of The University Of California | Nucleic acids encoding modified cytochrome P450 enzymes and methods of use thereof |
| US8114645B2 (en) * | 2006-05-19 | 2012-02-14 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
| US9765363B1 (en) * | 2006-05-26 | 2017-09-19 | Amyris, Inc. | Apparatus for making bio-organic compounds |
| WO2008129358A2 (en) * | 2006-08-01 | 2008-10-30 | Ocean Nutrition Canada Ltd. | Oil producing microbes and methods of modification thereof |
| BRPI0716954B1 (pt) * | 2006-09-26 | 2024-04-30 | The Regents Of The University Of California | Microrganismos geneticamente modificados capazes de produzir um isoprenóide |
| US8234641B2 (en) * | 2006-10-17 | 2012-07-31 | Managelq, Inc. | Compliance-based adaptations in managed virtual systems |
| WO2008094546A2 (en) * | 2007-01-31 | 2008-08-07 | The Regents Of The University Of California | Genetically modified host cells for increased p450 activity levels and methods of use thereof |
| WO2009006386A2 (en) | 2007-06-29 | 2009-01-08 | The Regents Of The University Of California | Host cells and methods for producing isoprenyl alkanoates |
| US8067632B2 (en) * | 2007-07-26 | 2011-11-29 | The Board Of Trustees Of The Leland Stanford Junior University | Process to produce prostratin and structural or functional analogs thereof |
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| SG162265A1 (en) * | 2007-12-13 | 2010-07-29 | Danisco Us Inc | Compositions and methods for producing isoprene |
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| AU2009248852B9 (en) * | 2008-05-23 | 2015-08-13 | Cibus Europe B.V. | Production of squalene using yeast |
| US8420759B2 (en) * | 2008-06-30 | 2013-04-16 | The Goodyear Tire & Rubber Company | Polymers of isoprene from renewable resources |
| AU2009266938B2 (en) | 2008-07-02 | 2013-10-17 | Danisco Us Inc. | Compositions and methods for producing isoprene free of C5 hydrocarbons under decoupling conditions and/or safe operating ranges |
| CA2737158A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
| CA2737082A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| CA3146669A1 (en) | 2008-10-28 | 2010-06-03 | Genomatica, Inc. | Methods for producing a fatty alcohol in a host cell |
| CA2759700A1 (en) | 2009-04-23 | 2010-10-28 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| CN102666837A (zh) * | 2009-11-23 | 2012-09-12 | 纽塞利斯公司 | 使用酵母产生角鲨烯的方法和组合物 |
| BR122021005283B1 (pt) | 2010-06-02 | 2022-02-22 | Evolva, Inc | Hospedeiro recombinante que compreende genes recombinantes para produção deesteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol |
| US9273298B2 (en) | 2010-10-27 | 2016-03-01 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
| CN103764818B (zh) | 2011-08-08 | 2017-05-31 | 埃沃尔瓦公司 | 用于重组产生藏红花化合物的方法和物质 |
| BR122021015509B1 (pt) | 2011-08-08 | 2022-03-29 | Evolva Sa | Método para produzir um glicosídeo de esteviol alvo |
| IN2014CN03791A (enExample) * | 2011-11-09 | 2015-10-16 | Amyris Inc | |
| US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
| JP5827601B2 (ja) * | 2012-07-04 | 2015-12-02 | 住友ゴム工業株式会社 | 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| CN103087972B (zh) | 2013-02-01 | 2014-11-05 | 中国科学院天津工业生物技术研究所 | 生产萜类化合物的重组微生物及构建方法 |
| CN105051195B (zh) | 2013-02-06 | 2019-09-06 | 埃沃尔瓦公司 | 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法 |
| MX2015010098A (es) | 2013-02-11 | 2016-04-19 | Evolva Sa | Producción eficiente de glicosidos de esteviol en huéspedes recombinantes. |
| DK2970926T3 (en) | 2013-03-13 | 2018-04-16 | Dsm Nutritional Products Ag | GENMANIPULATION OF MICROorganisms |
| JP6282813B2 (ja) * | 2013-07-16 | 2018-02-21 | 住友ゴム工業株式会社 | ヒドロキシメチルグルタリルＣｏＡレダクターゼの発現をｂＺＩＰ型転写因子により調整する方法、ｂＺＩＰ型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| CN103602626B (zh) * | 2013-10-12 | 2016-02-10 | 中国科学院青岛生物能源与过程研究所 | 一种以油脂为原料生产甲羟戊酸的方法及其构建的基因工程菌 |
| BR112017002783A2 (pt) | 2014-08-11 | 2017-12-19 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| US10612064B2 (en) | 2014-09-09 | 2020-04-07 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2973674A1 (en) | 2015-01-30 | 2016-08-04 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US10604743B2 (en) | 2015-03-16 | 2020-03-31 | Dsm Ip Assets B.V. | UDP-glycosyltransferases |
| CA2995067A1 (en) | 2015-08-07 | 2017-02-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201808856TA (en) | 2016-04-13 | 2018-11-29 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN109312378A (zh) | 2016-05-16 | 2019-02-05 | 埃沃尔瓦公司 | 在重组宿主中产生甜菊醇糖苷 |
| CN106367508B (zh) * | 2016-09-13 | 2019-10-29 | 东北农业大学 | 一种用于鉴定杂合型类异戊二烯化合物产生菌的简并引物与应用 |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US11365417B2 (en) * | 2017-09-12 | 2022-06-21 | Bio Capital Holdings, LLC | Biological devices and methods of use thereof to produce steviol glycosides |
| WO2019090286A2 (en) * | 2017-11-06 | 2019-05-09 | The Regents Of The University Of California | Production of valerenic acid in fungal cells |
| KR20200095534A (ko) | 2017-12-07 | 2020-08-10 | 지머젠 인코포레이티드 | 발효에 의한 (6e)-8-히드록시제라니올의 제조를 위해 조작된 생합성 경로 |
| KR20200111172A (ko) | 2017-12-21 | 2020-09-28 | 지머젠 인코포레이티드 | 네페탈락톨 산화 환원 효소, 네페탈락톨 합성 효소, 및 네페탈락톤을 생산할 수 있는 미생물 |
| CN109777815B (zh) * | 2019-03-28 | 2021-10-29 | 昆明理工大学 | HMG-CoA合成酶基因RKHMGCS及其应用 |
| CN117165502A (zh) | 2022-05-26 | 2023-12-05 | 牛津大学(苏州)科技有限公司 | 一种合成萜类化合物的共培养系统和方法 |
| NL2032683B1 (en) * | 2022-07-18 | 2024-01-26 | Sestina Bio Llc | Bioproduction of isoprenoids |
| EP4565691A1 (en) * | 2022-11-14 | 2025-06-11 | Agency for Science, Technology and Research | Biosynthesis of isoprenoid |
| CN116925991B (zh) * | 2023-07-28 | 2024-08-09 | 天津大学 | 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用 |
| CN120041291A (zh) * | 2023-11-24 | 2025-05-27 | 牛津大学(苏州)科技有限公司 | 用于合成目标化合物的共培养系统和方法 |
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| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| KR20060099543A (ko) | 1994-12-09 | 2006-09-19 | 임페리얼 컬리지 이노베이션스 리미티드 | 유전자의 동정 |
| US6740506B2 (en) | 1995-12-07 | 2004-05-25 | Diversa Corporation | End selection in directed evolution |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
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| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US7927794B2 (en) * | 2003-09-29 | 2011-04-19 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
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| US7670825B2 (en) | 2010-03-02 |
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| US20060079476A1 (en) | 2006-04-13 |
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| BRPI0510115A (pt) | 2007-09-25 |
| MXPA06013502A (es) | 2007-03-01 |
| EP2365090A1 (en) | 2011-09-14 |
| WO2006085899A3 (en) | 2007-05-18 |
| ATE537269T1 (de) | 2011-12-15 |
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| AU2005327292A1 (en) | 2006-08-17 |
| JP4926061B2 (ja) | 2012-05-09 |
| EP1765418B1 (en) | 2011-12-14 |
| CN101023181A (zh) | 2007-08-22 |
| US7183089B2 (en) | 2007-02-27 |
| WO2006085899A2 (en) | 2006-08-17 |
| US20090004724A1 (en) | 2009-01-01 |
| CA2567547C (en) | 2012-10-23 |
| JP2008500063A (ja) | 2008-01-10 |
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| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/05/2005, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |