AU2005327292B2 - Method for enhancing production of isoprenoid compounds - Google Patents
Method for enhancing production of isoprenoid compounds Download PDFInfo
- Publication number
- AU2005327292B2 AU2005327292B2 AU2005327292A AU2005327292A AU2005327292B2 AU 2005327292 B2 AU2005327292 B2 AU 2005327292B2 AU 2005327292 A AU2005327292 A AU 2005327292A AU 2005327292 A AU2005327292 A AU 2005327292A AU 2005327292 B2 AU2005327292 B2 AU 2005327292B2
- Authority
- AU
- Australia
- Prior art keywords
- genetically modified
- host cell
- coa
- cell
- isoprenoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57349204P | 2004-05-21 | 2004-05-21 | |
| US60/573,492 | 2004-05-21 | ||
| PCT/US2005/017874 WO2006085899A2 (en) | 2004-05-21 | 2005-05-20 | Method for enhancing production of isoprenoid compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2005327292A1 AU2005327292A1 (en) | 2006-08-17 |
| AU2005327292B2 true AU2005327292B2 (en) | 2010-11-04 |
Family
ID=36793476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005327292A Expired AU2005327292B2 (en) | 2004-05-21 | 2005-05-20 | Method for enhancing production of isoprenoid compounds |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7183089B2 (enExample) |
| EP (2) | EP2365090A1 (enExample) |
| JP (1) | JP4926061B2 (enExample) |
| CN (1) | CN101023181A (enExample) |
| AT (1) | ATE537269T1 (enExample) |
| AU (1) | AU2005327292B2 (enExample) |
| BR (1) | BRPI0510115B1 (enExample) |
| CA (1) | CA2567547C (enExample) |
| ES (1) | ES2379368T3 (enExample) |
| MX (1) | MXPA06013502A (enExample) |
| WO (1) | WO2006085899A2 (enExample) |
Families Citing this family (64)
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| EP0898575B1 (en) * | 1996-04-17 | 2004-12-29 | KÖSTER, Hubert, Dr. | A combinatorial protecting group strategy for multifunctional molecules |
| US20050287596A9 (en) * | 1998-06-26 | 2005-12-29 | Braisted Andrew C | Novel ligands and libraries of ligands |
| AU2001278098A1 (en) * | 2000-07-31 | 2002-02-13 | Frederick M. Hahn | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| US7172886B2 (en) * | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| WO2003077851A2 (en) * | 2002-03-11 | 2003-09-25 | Hk Pharmaceuticals, Inc. | Compounds and methods for analyzing the proteome |
| ATE489629T1 (de) * | 2003-01-16 | 2010-12-15 | Caprotec Bioanalytics Gmbh | Verfahren zur identifizierung von auf arzneimittel nicht-zielgerichteten proteinen |
| JP5886511B2 (ja) | 2005-06-07 | 2016-03-16 | ディーエスエム ニュートリショナル プロダクツ アーゲーDSM Nutritional Products AG | 脂質および抗酸化剤の製造のための真核微生物 |
| EP1931770A4 (en) * | 2005-10-07 | 2009-11-25 | Univ California | NUCLEIC ACIDS CODING FOR MODIFIED CYTOCHROM P450 ENZYME AND METHOD OF USE THEREOF |
| WO2007136847A2 (en) * | 2006-05-19 | 2007-11-29 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
| MX293430B (es) * | 2006-05-26 | 2011-12-09 | Amyris Biotechnologies Inc | Aparato para elaborar compuestos bio-organicos. |
| AU2007351658B2 (en) * | 2006-08-01 | 2013-05-30 | Dsm Nutritional Products Ag | Oil producing microbes and methods of modification thereof |
| EP3020799B1 (en) | 2006-09-26 | 2020-08-26 | The Regents of The University of California | Production of isoprenoids and isoprenoid precursors |
| US8234641B2 (en) * | 2006-10-17 | 2012-07-31 | Managelq, Inc. | Compliance-based adaptations in managed virtual systems |
| WO2008094546A2 (en) * | 2007-01-31 | 2008-08-07 | The Regents Of The University Of California | Genetically modified host cells for increased p450 activity levels and methods of use thereof |
| WO2009006386A2 (en) | 2007-06-29 | 2009-01-08 | The Regents Of The University Of California | Host cells and methods for producing isoprenyl alkanoates |
| US8067632B2 (en) * | 2007-07-26 | 2011-11-29 | The Board Of Trustees Of The Leland Stanford Junior University | Process to produce prostratin and structural or functional analogs thereof |
| WO2009064910A2 (en) * | 2007-11-13 | 2009-05-22 | Synthetic Genomics, Inc. | Dimethyloctane as an advanced biofuel |
| SG162265A1 (en) * | 2007-12-13 | 2010-07-29 | Danisco Us Inc | Compositions and methods for producing isoprene |
| WO2009097339A1 (en) * | 2008-01-31 | 2009-08-06 | Amyris Biotechnologies, Inc. | Methods of monitoring metabolic pathways |
| US7799545B2 (en) * | 2008-03-27 | 2010-09-21 | Genomatica, Inc. | Microorganisms for the production of adipic acid and other compounds |
| US20090253174A1 (en) * | 2008-04-08 | 2009-10-08 | Zach Serber | Expression of Heterologous Sequences |
| ZA201007564B (en) | 2008-04-23 | 2012-01-25 | Goodyear Tire & Rubber | Isoprene synthase variants for improved microbial production of isoprene |
| MX350285B (es) | 2008-05-16 | 2017-09-04 | Reg Life Sciences Llc | Métodos y composiciones para producir hidrocarburos. |
| EP3260549A1 (en) * | 2008-05-23 | 2017-12-27 | Nucelis LLC | Production of squalene using yeast |
| EP2307552B1 (en) * | 2008-06-30 | 2022-10-26 | The Goodyear Tire & Rubber Company | Polymers of isoprene from renewable resources |
| CN105112347A (zh) | 2008-07-02 | 2015-12-02 | 丹尼斯科美国公司 | 用于在去偶联条件和/或安全操作范围下产生不含c5烃的异戊二烯的方法和组合物 |
| EP2334788A1 (en) * | 2008-09-15 | 2011-06-22 | Danisco US Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
| CA2737082A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| ES2505115T3 (es) | 2008-10-28 | 2014-10-09 | Ls9, Inc. | Métodos para producir alcoholes grasos |
| CN102656265A (zh) | 2009-04-23 | 2012-09-05 | 丹尼斯科美国公司 | 异戊二烯合酶的三维结构及其用于产生变体的用途 |
| CN107058145A (zh) | 2009-11-23 | 2017-08-18 | 纽塞利斯公司 | 使用酵母产生角鲨烯的方法和组合物 |
| KR102181638B1 (ko) | 2010-06-02 | 2020-11-24 | 에볼바, 인크. | 스테비올 글리코시드의 재조합 생산 |
| US9273298B2 (en) | 2010-10-27 | 2016-03-01 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
| EP3792350A1 (en) | 2011-08-08 | 2021-03-17 | Evolva SA | Recombinant production of steviol glycosides |
| KR101815063B1 (ko) | 2011-08-08 | 2018-01-05 | 에볼바 에스아 | 사프란 화합물의 재조합 생성을 위한 방법 및 물질 |
| BR112014010750B1 (pt) * | 2011-11-09 | 2021-09-21 | Amyris, Inc | Produção de isoprenoides derivados de acetil-coenzima a |
| US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
| JP5827601B2 (ja) * | 2012-07-04 | 2015-12-02 | 住友ゴム工業株式会社 | 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| CN103087972B (zh) | 2013-02-01 | 2014-11-05 | 中国科学院天津工业生物技术研究所 | 生产萜类化合物的重组微生物及构建方法 |
| SG10201705926YA (en) | 2013-02-06 | 2017-08-30 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| MX2015010098A (es) | 2013-02-11 | 2016-04-19 | Evolva Sa | Producción eficiente de glicosidos de esteviol en huéspedes recombinantes. |
| AU2014229307B2 (en) | 2013-03-13 | 2017-08-31 | Dsm Nutritional Products Ag | Engineering microorganisms |
| JP6282813B2 (ja) * | 2013-07-16 | 2018-02-21 | 住友ゴム工業株式会社 | ヒドロキシメチルグルタリルCoAレダクターゼの発現をbZIP型転写因子により調整する方法、bZIP型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| CN103602626B (zh) * | 2013-10-12 | 2016-02-10 | 中国科学院青岛生物能源与过程研究所 | 一种以油脂为原料生产甲羟戊酸的方法及其构建的基因工程菌 |
| SG11201700651RA (en) | 2014-08-11 | 2017-02-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| MX2017003130A (es) | 2014-09-09 | 2017-10-24 | Evolva Sa | Produccion de glucosidos de esteviol en hospederos recombinantes. |
| US10364450B2 (en) | 2015-01-30 | 2019-07-30 | Evolva Sa | Production of steviol glycoside in recombinant hosts |
| EP3271457B1 (en) | 2015-03-16 | 2021-01-20 | DSM IP Assets B.V. | Udp-glycosyltransferases |
| JP2018522569A (ja) | 2015-08-07 | 2018-08-16 | エヴォルヴァ エスアー.Evolva Sa. | 組換え宿主内でのステビオールグリコシドの産生 |
| BR112018071144B1 (pt) | 2016-04-13 | 2023-04-18 | Evolva Sa | Célula hospedeira recombinante que produz um ou mais glicosídeos de esteviol ou uma composição de glicosídeo de esteviol em uma cultura de células e métodos para produzir um ou mais glicosídeos de esteviol ou uma composição de glicosídeo de esteviol, bem como cultura de células e lisado celular da dita célula hospedeira recombinante |
| EP3458599A1 (en) | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| CN106367508B (zh) * | 2016-09-13 | 2019-10-29 | 东北农业大学 | 一种用于鉴定杂合型类异戊二烯化合物产生菌的简并引物与应用 |
| CN110100006A (zh) | 2016-11-07 | 2019-08-06 | 埃沃尔瓦公司 | 重组宿主中甜菊糖苷的生产 |
| US11365417B2 (en) * | 2017-09-12 | 2022-06-21 | Bio Capital Holdings, LLC | Biological devices and methods of use thereof to produce steviol glycosides |
| WO2019090286A2 (en) * | 2017-11-06 | 2019-05-09 | The Regents Of The University Of California | Production of valerenic acid in fungal cells |
| WO2019113387A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| KR20200111172A (ko) | 2017-12-21 | 2020-09-28 | 지머젠 인코포레이티드 | 네페탈락톨 산화 환원 효소, 네페탈락톨 합성 효소, 및 네페탈락톤을 생산할 수 있는 미생물 |
| CN109777815B (zh) * | 2019-03-28 | 2021-10-29 | 昆明理工大学 | HMG-CoA合成酶基因RKHMGCS及其应用 |
| CN117165502A (zh) | 2022-05-26 | 2023-12-05 | 牛津大学(苏州)科技有限公司 | 一种合成萜类化合物的共培养系统和方法 |
| NL2032683B1 (en) * | 2022-07-18 | 2024-01-26 | Sestina Bio Llc | Bioproduction of isoprenoids |
| WO2024107105A1 (en) * | 2022-11-14 | 2024-05-23 | Agency For Science, Technology And Research | Biosynthesis of isoprenoid |
| CN116925991B (zh) * | 2023-07-28 | 2024-08-09 | 天津大学 | 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用 |
| CN120041291A (zh) * | 2023-11-24 | 2025-05-27 | 牛津大学(苏州)科技有限公司 | 用于合成目标化合物的共培养系统和方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000001649A1 (en) * | 1998-07-06 | 2000-01-13 | Dcv, Inc. Doing Business As Bio-Technical Resources | Method of vitamin production |
| WO2001031043A1 (en) * | 1999-10-27 | 2001-05-03 | The University Of Bristol | Increasing isoprenoid biosynthesis |
| US20030148416A1 (en) * | 2001-06-06 | 2003-08-07 | Roche Vitamins Inc. | Isoprenoid production |
| WO2005033287A2 (en) * | 2003-09-29 | 2005-04-14 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| EP1285960A3 (en) | 1994-12-09 | 2003-05-07 | Imperial College Innovations Limited | Virulence genes from Salmonella typhimurium |
| US6740506B2 (en) | 1995-12-07 | 2004-05-25 | Diversa Corporation | End selection in directed evolution |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| AU2253397A (en) | 1996-01-23 | 1997-08-20 | Affymetrix, Inc. | Nucleic acid analysis techniques |
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| AU2001278098A1 (en) | 2000-07-31 | 2002-02-13 | Frederick M. Hahn | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
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| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
-
2005
- 2005-05-20 AU AU2005327292A patent/AU2005327292B2/en not_active Expired
- 2005-05-20 BR BRPI0510115-8A patent/BRPI0510115B1/pt active IP Right Grant
- 2005-05-20 ES ES05857432T patent/ES2379368T3/es not_active Expired - Lifetime
- 2005-05-20 EP EP10177421A patent/EP2365090A1/en not_active Withdrawn
- 2005-05-20 AT AT05857432T patent/ATE537269T1/de active
- 2005-05-20 EP EP05857432A patent/EP1765418B1/en not_active Expired - Lifetime
- 2005-05-20 CN CNA2005800243430A patent/CN101023181A/zh active Pending
- 2005-05-20 CA CA2567547A patent/CA2567547C/en not_active Expired - Lifetime
- 2005-05-20 MX MXPA06013502A patent/MXPA06013502A/es active IP Right Grant
- 2005-05-20 US US11/134,705 patent/US7183089B2/en not_active Expired - Lifetime
- 2005-05-20 WO PCT/US2005/017874 patent/WO2006085899A2/en not_active Ceased
- 2005-05-20 JP JP2007527501A patent/JP4926061B2/ja not_active Expired - Lifetime
-
2007
- 2007-01-17 US US11/624,094 patent/US7670825B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000001649A1 (en) * | 1998-07-06 | 2000-01-13 | Dcv, Inc. Doing Business As Bio-Technical Resources | Method of vitamin production |
| WO2001031043A1 (en) * | 1999-10-27 | 2001-05-03 | The University Of Bristol | Increasing isoprenoid biosynthesis |
| US20030148416A1 (en) * | 2001-06-06 | 2003-08-07 | Roche Vitamins Inc. | Isoprenoid production |
| WO2005033287A2 (en) * | 2003-09-29 | 2005-04-14 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
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|---|---|
| EP1765418A2 (en) | 2007-03-28 |
| JP2008500063A (ja) | 2008-01-10 |
| US7183089B2 (en) | 2007-02-27 |
| EP2365090A1 (en) | 2011-09-14 |
| CN101023181A (zh) | 2007-08-22 |
| US7670825B2 (en) | 2010-03-02 |
| BRPI0510115A (pt) | 2007-09-25 |
| US20090004724A1 (en) | 2009-01-01 |
| EP1765418B1 (en) | 2011-12-14 |
| CA2567547C (en) | 2012-10-23 |
| WO2006085899A2 (en) | 2006-08-17 |
| JP4926061B2 (ja) | 2012-05-09 |
| MXPA06013502A (es) | 2007-03-01 |
| AU2005327292A1 (en) | 2006-08-17 |
| ES2379368T3 (es) | 2012-04-25 |
| EP1765418A4 (en) | 2008-07-02 |
| BRPI0510115B1 (pt) | 2022-09-27 |
| US20060079476A1 (en) | 2006-04-13 |
| WO2006085899A3 (en) | 2007-05-18 |
| ATE537269T1 (de) | 2011-12-15 |
| CA2567547A1 (en) | 2006-08-17 |
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