SG11201808856TA - Production of steviol glycosides in recombinant hosts - Google Patents
Production of steviol glycosides in recombinant hostsInfo
- Publication number
- SG11201808856TA SG11201808856TA SG11201808856TA SG11201808856TA SG11201808856TA SG 11201808856T A SG11201808856T A SG 11201808856TA SG 11201808856T A SG11201808856T A SG 11201808856TA SG 11201808856T A SG11201808856T A SG 11201808856TA SG 11201808856T A SG11201808856T A SG 11201808856TA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- steviol glycosides
- english
- april
- Prior art date
Links
- 239000004383 Steviol glycoside Substances 0.000 title abstract 4
- 229930182488 steviol glycoside Natural products 0.000 title abstract 4
- 150000008144 steviol glycosides Chemical class 0.000 title abstract 4
- 235000019411 steviol glycoside Nutrition 0.000 title abstract 3
- 235000019202 steviosides Nutrition 0.000 title abstract 3
- 102220547770 Inducible T-cell costimulator_A23L_mutation Human genes 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
- C12Y207/04006—Nucleoside-diphosphate kinase (2.7.4.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07009—UTP-glucose-1-phosphate uridylyltransferase (2.7.7.9), i.e. UDP-glucose-pyrophosphorylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
- C12Y504/02002—Phosphoglucomutase (5.4.2.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
- C12Y504/02007—Phosphopentomutase (5.4.2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization IIIM1111101110101011111 $111110111010111110110110010111111101111011# International Bureau .. ..... ..Yi j (10) International Publication Number ..... .....1 (43) International Publication Date WO 2017/178632 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: A23L 27/30 (2016.01) C12N 15/63 (2006.01) A23L 2/60 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: PCT/EP2017/059028 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: 13 April 2017 (13.04.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: 62/321,850 13 April 2016 (13.04.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: EVOLVA SA [CH/CH]; Duggingerstrasse 23, CH-4153 Reinach (CH). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: DOUCHIN, Veronique; Aurikelvej 2-4th 2000 Frederiksberg (DK). HALLWYL, Swee Chuang Lim; Amalieparken 87, 4-4, 2665 Vallensbaek Strand LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (DK). OLSSON, Kim; Stenhuggervej 1, lth, 2400 Copen- Published: hagen (DK). — with international search report (Art. 21(3)) (74) Agent: REES, Kerry; WP Thompson, 138 Fetter Lane, London EC4A 1BT (GB). with sequence listing part of description (Rule 5.2(a)) = Designated States (unless otherwise indicated, for every (81) = kind of national protection available): AE, AG, AL, AM, — = = = = = = = = = = = Il N M ,tD GC IN 1-1 IN 1-1 0 N (54) Title: PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTS P ,.. (57) : The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glyc- oside precursors.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662321850P | 2016-04-13 | 2016-04-13 | |
PCT/EP2017/059028 WO2017178632A1 (en) | 2016-04-13 | 2017-04-13 | Production of steviol glycosides in recombinant hosts |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808856TA true SG11201808856TA (en) | 2018-11-29 |
Family
ID=58645018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808856TA SG11201808856TA (en) | 2016-04-13 | 2017-04-13 | Production of steviol glycosides in recombinant hosts |
Country Status (12)
Country | Link |
---|---|
US (2) | US10982249B2 (en) |
EP (1) | EP3442355A1 (en) |
JP (1) | JP2019513392A (en) |
KR (1) | KR20180132696A (en) |
CN (1) | CN109195457A (en) |
AU (1) | AU2017251462B2 (en) |
BR (1) | BR112018071144B1 (en) |
CA (1) | CA3020671A1 (en) |
MX (1) | MX2018012561A (en) |
MY (1) | MY198001A (en) |
SG (1) | SG11201808856TA (en) |
WO (1) | WO2017178632A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3020671A1 (en) * | 2016-04-13 | 2017-10-19 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
US10815514B2 (en) | 2016-05-16 | 2020-10-27 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
US11091743B2 (en) | 2016-08-12 | 2021-08-17 | Amyris, Inc. | UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides |
CN110100006A (en) | 2016-11-07 | 2019-08-06 | 埃沃尔瓦公司 | The production of steviol glycoside in recombinant host |
KR102606350B1 (en) | 2017-02-03 | 2023-11-23 | 코덱시스, 인코포레이티드 | Engineered glycosyltransferase and steviol glycoside glucosylation method |
US20200291442A1 (en) * | 2017-12-05 | 2020-09-17 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
US11299700B1 (en) | 2021-02-19 | 2022-04-12 | Acequia Biotechnology, Llc | Bioreactor containers and methods of growing hairy roots using the same |
CN113444131B (en) * | 2021-06-24 | 2022-10-21 | 鲁东大学 | N-acetylglucosamine compounds, and preparation method and application thereof |
Family Cites Families (149)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58149697A (en) | 1982-02-27 | 1983-09-06 | Dainippon Ink & Chem Inc | Preparation of beta-1,3-glycosyl stevioside |
JPS59101408A (en) | 1982-12-02 | 1984-06-12 | Junichi Iwamura | Plant growth regulator |
US5198360A (en) | 1990-01-19 | 1993-03-30 | Eli Lilly And Company | Dna sequence conferring a plaque inhibition phenotype |
US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
JPH03277275A (en) | 1990-03-28 | 1991-12-09 | Dainippon Ink & Chem Inc | Novel enzyme and method for preparing glycoside with same enzyme |
US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
US5306862A (en) | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
US5712112A (en) | 1992-11-04 | 1998-01-27 | National Science Council Of R.O.C. | Gene expression system comprising the promoter region of the alpha-amylase genes |
AU691510B2 (en) | 1993-07-15 | 1998-05-21 | Neose Pharmaceuticals | Method of synthesizing saccharide compositions |
US7186891B1 (en) | 1996-04-12 | 2007-03-06 | University Of Kentucky, Research Foundation | Plant cells and plants expressing chimeric isoprenoid synthases |
JPH10117776A (en) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | Transformation of indica rice |
AU9455398A (en) | 1997-10-06 | 1999-04-27 | Centre National De La Recherche Scientifique | Plant fatty acid hydroxylase genes |
US6255557B1 (en) | 1998-03-31 | 2001-07-03 | Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada | Stevia rebaudiana with altered steviol glycoside composition |
CA2736981A1 (en) | 1998-04-14 | 1999-10-21 | Kyowa Hakko Bio Co., Ltd. | Process for producing isoprenoid compounds by microorganisms |
TWI250210B (en) | 1998-05-06 | 2006-03-01 | Dsm Ip Assets Bv | An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate |
EP0955363A3 (en) | 1998-05-06 | 2004-01-28 | F. Hoffmann-La Roche Ag | Dna sequences encoding enzymes involved in production of isoprenoids |
EP1947189B1 (en) | 1998-07-06 | 2010-12-01 | DCV Inc. doing business as Bio-Technical Resourses | Method of vitamin production |
EP2305825B1 (en) | 1998-07-06 | 2015-01-14 | DCV Inc. doing business as Bio-Technical Resourses | Method of vitamin production |
AR021636A1 (en) | 1998-12-17 | 2002-07-31 | Rubicon Forests Holdings Ltd | MATERIALS AND METHODS FOR THE MODIFICATION OF CONTENT, COMPOSITION AND METABOLISM OF ISOPRENOIDS |
WO2000037663A2 (en) | 1998-12-23 | 2000-06-29 | The Samuel Roberts Noble Foundation, Inc. | Plant transformation process |
ATE358723T1 (en) | 1999-04-15 | 2007-04-15 | Calgene Llc | NUCLEIC ACID SEQUENCES FOR PROTEINS INVOLVED IN ISOPRENOID SYNTHESIS |
AU4365200A (en) | 1999-04-21 | 2000-11-02 | Samuel Roberts Noble Foundation, Inc., The | Plant transformation process |
DE60036477T2 (en) | 1999-08-04 | 2008-06-12 | Bacher, Adelbert, Prof. Dr.med. Dr.rer.nat. | ISOPRENOID BIOSYNTHESIS |
AU6780700A (en) | 1999-08-18 | 2001-03-13 | Paradigm Genetics, Inc. | Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration |
WO2001083769A2 (en) | 2000-05-03 | 2001-11-08 | The Salk Institute For Biological Studies | Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis |
DE10027821A1 (en) | 2000-06-05 | 2001-12-06 | Adelbert Bacher | New intermediate in isoprenoid biosynthesis, useful in screening for potential herbicides, comprises mutant encoding-enzymes sequences for imparting herbicide resistance |
EP2281890A1 (en) | 2000-07-31 | 2011-02-09 | Danisco US Inc. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
AU2001286811B2 (en) | 2000-08-24 | 2007-03-01 | Syngenta Participations Ag | Stress-regulated genes of plants, transgenic plants containing same, and methods of use |
US6660507B2 (en) | 2000-09-01 | 2003-12-09 | E. I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
US6818424B2 (en) | 2000-09-01 | 2004-11-16 | E. I. Du Pont De Nemours And Company | Production of cyclic terpenoids |
US6689601B2 (en) | 2000-09-01 | 2004-02-10 | E. I. Du Pont De Nemours And Company | High growth methanotropic bacterial strain |
AU2001291114A1 (en) | 2000-09-19 | 2002-04-02 | Microbia, Inc. | Modulation of secondary metabolite production by zinc binuclear cluster proteins |
AU2001296359B2 (en) | 2000-09-29 | 2006-04-27 | Cargill Incorporated | Isoprenoid production |
US6949362B2 (en) | 2000-12-12 | 2005-09-27 | E. I. Du Pont De Nemours And Company | Rhodococcus cloning and expression vectors |
WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
US20040078846A1 (en) | 2002-01-25 | 2004-04-22 | Desouza Mervyn L. | Carotenoid biosynthesis |
US20050003474A1 (en) | 2001-01-26 | 2005-01-06 | Desouza Mervyn L. | Carotenoid biosynthesis |
DE10201458A1 (en) | 2001-04-11 | 2002-10-17 | Adelbert Bacher | New proteins involved in isoprenoid biosynthesis, useful in screening for inhibitors, also new intermediates, potential therapeutic agents, nucleic acids and antibodies |
US7034140B2 (en) | 2001-04-24 | 2006-04-25 | E.I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
AU2002316966B2 (en) | 2001-06-06 | 2007-05-17 | Dsm Ip Assets B.V. | Improved isoprenoid production |
AU2002341541A1 (en) | 2001-06-22 | 2003-03-03 | Syngenta Participations Ag | Abiotic stress responsive polynucleotides and polypeptides |
NZ513755A (en) | 2001-08-24 | 2001-09-28 | Ann Rachel Holmes | Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs |
US20040072311A1 (en) | 2001-08-28 | 2004-04-15 | Dicosimo Deana J. | Production of cyclic terpenoids |
US20040010815A1 (en) | 2001-09-26 | 2004-01-15 | Lange B. Markus | Identification and characterization of plant genes |
US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
EP1544300B1 (en) | 2002-08-20 | 2009-09-30 | Suntory Holdings Limited | Novel glycosyltransferase genes |
KR101204225B1 (en) | 2002-09-27 | 2012-11-27 | 디에스엠 아이피 어셋츠 비.브이. | Squalene synthase 8sqs9 gene |
US7098000B2 (en) | 2003-06-04 | 2006-08-29 | E. I. Du Pont De Nemoure And Company | Method for production of C30-aldehyde carotenoids |
KR101190897B1 (en) | 2003-06-12 | 2012-10-12 | 디에스엠 아이피 어셋츠 비.브이. | Feedback-resistant mevalonate kinases |
US7569389B2 (en) | 2004-09-30 | 2009-08-04 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
ES2379368T3 (en) | 2004-05-21 | 2012-04-25 | The Regents Of The University Of California | Method to increase the production of isoprenoid compounds |
EP2080769A3 (en) | 2004-07-02 | 2010-12-01 | Metanomics GmbH | Process for the production of fine chemicals |
US20060014264A1 (en) | 2004-07-13 | 2006-01-19 | Stowers Institute For Medical Research | Cre/lox system with lox sites having an extended spacer region |
JPWO2006016395A1 (en) | 2004-08-09 | 2008-05-01 | 国立大学法人東北大学 | UDP-glucuronyltransferase and gene thereof |
US7572609B2 (en) | 2004-08-19 | 2009-08-11 | Dsm Ip Assets B.V. | Production of isoprenoids |
US7923552B2 (en) | 2004-10-18 | 2011-04-12 | SGF Holdings, LLC | High yield method of producing pure rebaudioside A |
US8338155B2 (en) | 2004-12-14 | 2012-12-25 | Dsm Ip Assets B.V. | Modified mevalonate kinase with reduced feedback inhibition |
EP2194140A2 (en) | 2005-03-02 | 2010-06-09 | Metanomics GmbH | Process for the production of fine chemicals |
JP4284562B2 (en) | 2005-03-04 | 2009-06-24 | 独立行政法人産業技術総合研究所 | Method for producing UDP-xylose |
WO2006096392A2 (en) | 2005-03-04 | 2006-09-14 | Diversa Corporation | Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them |
US7989677B2 (en) | 2005-08-17 | 2011-08-02 | Nestec S. A. | Nucleic acids and proteins associated with sucrose accumulation in coffee |
US20080216397A1 (en) | 2005-08-22 | 2008-09-11 | Co2 Boost Llc | Device and Process to Generate Co2 Used for Indoor Crop Production and Underwater Gardening |
US8293307B2 (en) | 2005-10-11 | 2012-10-23 | Purecircle Sdn Bhd | Process for manufacturing a sweetener and use thereof |
JP2009517022A (en) | 2005-11-23 | 2009-04-30 | ザ・コカ−コーラ・カンパニー | Natural high-intensity sweetener compositions having improved time-course profiles and / or flavor profiles, methods of formulation and use thereof |
KR100784261B1 (en) | 2006-01-02 | 2007-12-11 | 한국과학기술원 | Method for Cell Surface Displaying of Target Proteins Using Bacillus anthracis Exosporium |
US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
EP2090662A3 (en) | 2006-04-05 | 2012-10-31 | Metanomics GmbH | Process for the production of a fine chemical |
US8114645B2 (en) | 2006-05-19 | 2012-02-14 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
US7964376B2 (en) | 2006-06-19 | 2011-06-21 | Givaudan Sa | Chimeric proteins and their use in methods to screen for sweet taste modulators |
WO2008008256A2 (en) | 2006-07-07 | 2008-01-17 | The Regents Of The University Of California | Methods for enhancing production of isoprenoid compounds by host cells |
EP3020799B1 (en) | 2006-09-26 | 2020-08-26 | The Regents of The University of California | Production of isoprenoids and isoprenoid precursors |
US7741119B2 (en) | 2006-09-28 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production |
US7629156B2 (en) | 2006-09-28 | 2009-12-08 | E.I. Du Pont De Nemours And Company | Ethanol production in fermentation of mixed sugars containing xylose |
CN101200480B (en) | 2006-12-15 | 2011-03-30 | 成都华高药业有限公司 | Rebaudioside A extraction method |
JP4915917B2 (en) | 2006-12-22 | 2012-04-11 | 独立行政法人農業・食品産業技術総合研究機構 | Method for producing lacto-N-biose I and galacto-N-biose |
MY148593A (en) | 2007-01-22 | 2013-05-15 | Cargill Inc | Method of producing purified rebaudioside a compositions using solvent/antisolvent crystallization |
JP2008237110A (en) | 2007-03-27 | 2008-10-09 | Institute Of Physical & Chemical Research | Steviol synthetic enzyme gene and method for producing steviol |
WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
US20080292775A1 (en) | 2007-05-22 | 2008-11-27 | The Coca-Cola Company | Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses |
WO2009005704A1 (en) | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
JP2009034080A (en) | 2007-08-03 | 2009-02-19 | Sanei Gen Ffi Inc | New glycosyltransferase and method for producing glycoside by utilizing the same |
US7964232B2 (en) | 2007-09-17 | 2011-06-21 | Pepsico, Inc. | Steviol glycoside isomers |
CA2712326A1 (en) | 2007-09-21 | 2009-03-26 | Basf Plant Science Gmbh | Plants with increased yield comprising increased glutamine synthetase activity |
MY155722A (en) | 2007-12-03 | 2015-11-30 | Dsm Ip Assets Bv | Novel nutraceutical compositions containing stevia extract or stevia extract constituents and uses thereof |
AU2008343039B2 (en) | 2007-12-27 | 2014-04-24 | Heartland Consumer Products, Llc | Synergistic sweetening compositions |
CA2715397A1 (en) | 2008-02-20 | 2009-08-27 | Ceres, Inc. | Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants |
TWI475963B (en) | 2008-02-25 | 2015-03-11 | Coca Cola Co | Rebaudioside a derivative products and methods for making |
EP2706111A1 (en) | 2008-03-03 | 2014-03-12 | Joule Unlimited Technologies, Inc. | Engineered CO2 fixing microorganisms producing carbon-based products of interest |
US9005444B2 (en) | 2008-05-13 | 2015-04-14 | Cargill, Incorporated | Separation of rebaudioside A from stevia glycosides using chromatography |
WO2010021001A2 (en) | 2008-08-19 | 2010-02-25 | Kaushik Ramakrishnan S | Process for preparing sweetener from stevia rebaudiana |
CN116102603A (en) | 2008-10-03 | 2023-05-12 | 守田化学工业株式会社 | Steviol glycoside |
CN101720910B (en) | 2008-10-23 | 2012-07-25 | 大闽食品(漳州)有限公司 | Method for preparing stevioside |
US8614085B2 (en) | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
US20100297722A1 (en) | 2009-05-20 | 2010-11-25 | Board Of Trustees Of Southern Illinois University | Transgenic moss producing terpenoids |
EP2440661B1 (en) | 2009-06-08 | 2017-12-06 | Jennewein Biotechnologie GmbH | Hmo synthesis |
DK2482676T3 (en) | 2009-06-16 | 2015-01-19 | Epc Beijing Natural Products Co Ltd | Reduction or elimination of the aftertaste of a sweetener, using rebaudioside D |
US20120164083A1 (en) | 2009-09-04 | 2012-06-28 | Redpoint Bio Corporation | Sweetness Enhancers Including Rebaudioside A or D |
MX2012003489A (en) | 2009-09-22 | 2012-07-30 | Redpoint Bio Corp | Novel polymorphs of rebaudioside c and methods for making and using the same. |
CA2775732C (en) | 2009-10-15 | 2018-10-09 | Purecircle Sdn Bhd | High-purity rebaudioside d and applications |
US8299224B2 (en) | 2009-10-15 | 2012-10-30 | Purecircle Sdn Bhd | High-purity Rebaudioside D |
US8703224B2 (en) | 2009-11-04 | 2014-04-22 | Pepsico, Inc. | Method to improve water solubility of Rebaudioside D |
EP2594648B1 (en) | 2009-11-10 | 2016-03-16 | Massachusetts Institute of Technology | Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway |
WO2011062748A1 (en) | 2009-11-23 | 2011-05-26 | E.I. Du Pont De Nemours And Company | Sucrose transporter genes for increasing plant seed lipids |
KR102110725B1 (en) | 2009-12-10 | 2020-05-13 | 리전츠 오브 더 유니버스티 오브 미네소타 | Tal effector-mediated dna modification |
CN104855925B (en) | 2009-12-28 | 2017-04-26 | 可口可乐公司 | Sweetness Enhancers, Compositions Thereof, And Methods For Use |
KR101244315B1 (en) | 2010-10-19 | 2013-03-14 | 이화여자대학교 산학협력단 | Ethanol―Resistant Yeast Genes and Uses Thereof |
US9441233B2 (en) | 2010-05-06 | 2016-09-13 | Ceres, Inc. | Transgenic plants having increased biomass |
EP2571991A1 (en) | 2010-05-20 | 2013-03-27 | Evolva SA | Method of producing isoprenoid compounds in yeast |
WO2011151326A2 (en) | 2010-05-31 | 2011-12-08 | Vib Vzw | The use of transporters to modulate flavor production by yeast |
BR122021005287B1 (en) | 2010-06-02 | 2022-02-22 | Evolva, Inc | Recombinant host comprising a recombinant gene for producing steviol or steviol glycoside |
US20120021111A1 (en) | 2010-07-23 | 2012-01-26 | Aexelon Therapeutics, Inc. | Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture |
US20120083593A1 (en) | 2010-10-01 | 2012-04-05 | Shanghai Yongyou Bioscience Inc. | Separation and Purification of Stevioside and Rebaudioside A |
CA2819253A1 (en) | 2010-11-30 | 2012-06-07 | Massachusetts Institute Of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
KR20130014227A (en) | 2011-07-29 | 2013-02-07 | 한국생명공학연구원 | NOVEL α-GLUCOSYL STEVIOSIDES AND PROCESS FOR PRODUCING THE SAME |
EP2742131B1 (en) | 2011-08-08 | 2018-11-28 | Evolva SA | Methods and materials for recombinant production of saffron compounds |
KR102114493B1 (en) | 2011-08-08 | 2020-05-26 | 에볼바 에스아 | Recombinant production of steviol glycosides |
CN103958693B (en) | 2011-11-23 | 2016-08-24 | 埃沃尔瓦公司 | Method and material for enzyme' s catalysis Momordia grosvenori aglycone compound |
CN103159808B (en) | 2011-12-09 | 2017-03-29 | 上海泓博智源医药股份有限公司 | A kind of process for preparing natural sweetener |
EP3345490B1 (en) | 2011-12-19 | 2023-11-08 | The Coca-Cola Company | Beverage comprising rebaudioside x |
CA2862980A1 (en) | 2012-01-23 | 2013-08-01 | Dsm Ip Assets B.V. | Diterpene production |
CA2867112C (en) | 2012-03-16 | 2021-04-20 | Suntory Holdings Limited | Steviol glucosyltransferases and genes encoding the same |
CN110358795A (en) | 2012-05-22 | 2019-10-22 | 谱赛科有限责任公司 | The steviol glycoside of high-purity |
WO2014048392A1 (en) | 2012-09-29 | 2014-04-03 | 中国科学院上海生命科学研究院 | Method for producing stevioside compounds by microorganism |
US20150342234A1 (en) | 2012-12-05 | 2015-12-03 | Evolva Sa | Steviol Glycoside Compositions Sensory Properties |
SG10201705926YA (en) | 2013-02-06 | 2017-08-30 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
BR112015019160A2 (en) | 2013-02-11 | 2017-08-22 | Dalgaard Mikkelsen Michael | PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTERS |
AU2014273054A1 (en) | 2013-05-31 | 2015-12-03 | Dsm Ip Assets B.V. | Extracellular diterpene production |
AU2014273055A1 (en) | 2013-05-31 | 2015-12-17 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
KR101559478B1 (en) * | 2013-06-24 | 2015-10-13 | 한국생명공학연구원 | Method for Preparing Natural High Intensity Sweetener Rebaudiside A by Using Enzymatic Conversion |
CN108064135A (en) | 2013-07-15 | 2018-05-22 | 帝斯曼知识产权资产管理有限公司 | The production of diterpene |
EP3024941B1 (en) | 2013-07-23 | 2019-07-03 | DSM IP Assets B.V. | Diterpene production in yarrowia |
DK3027632T3 (en) | 2013-07-31 | 2019-06-17 | Dsm Ip Assets Bv | RECYCLING STEVIOL GLYCOSIDES FROM A FERMENTATION MEDIUM |
BR112016001950A2 (en) * | 2013-07-31 | 2017-08-29 | Dsm Ip Assets Bv | STEVIOL GLYCOSIDES |
WO2015016393A1 (en) | 2013-08-02 | 2015-02-05 | サントリーホールディングス株式会社 | Method for using hexenol glycosyl transferase |
CN103397064B (en) | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | Method for preparing rebaudioside M through enzyme method |
WO2015028324A2 (en) | 2013-08-30 | 2015-03-05 | Evolva Sa | A method for producing modified resveratrol |
WO2015051454A1 (en) | 2013-10-07 | 2015-04-16 | Vineland Research And Innovation Centre | Compositions and methods for producing steviol and steviol glycosides |
SG10201807693YA (en) | 2014-03-07 | 2018-10-30 | Evolva Sa | Methods for recombinant production of saffron compounds |
CN106572688B (en) | 2014-08-11 | 2022-01-25 | 埃沃尔瓦公司 | Production of steviol glycosides in recombinant hosts |
US10612064B2 (en) * | 2014-09-09 | 2020-04-07 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
MX367090B (en) | 2014-10-03 | 2019-08-05 | Conagen Inc | Non-caloric sweeteners and methods for synthesizing. |
EP3250686A1 (en) | 2015-01-30 | 2017-12-06 | Evolva SA | Production of steviol glycosides in recombinant hosts |
EP3271457B1 (en) | 2015-03-16 | 2021-01-20 | DSM IP Assets B.V. | Udp-glycosyltransferases |
CN104845990A (en) | 2015-06-11 | 2015-08-19 | 山东大学 | Application of Arabidopsis glycosyltransferase gene UGT73C7 in improving plant disease resistance |
US10837041B2 (en) | 2015-08-07 | 2020-11-17 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
CN108473995B (en) | 2015-12-10 | 2022-10-18 | 埃沃尔瓦公司 | Production of steviol glycosides in recombinant hosts |
CA3020671A1 (en) * | 2016-04-13 | 2017-10-19 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
-
2017
- 2017-04-13 CA CA3020671A patent/CA3020671A1/en active Pending
- 2017-04-13 CN CN201780023636.XA patent/CN109195457A/en active Pending
- 2017-04-13 JP JP2018553949A patent/JP2019513392A/en active Pending
- 2017-04-13 BR BR112018071144-6A patent/BR112018071144B1/en active IP Right Grant
- 2017-04-13 WO PCT/EP2017/059028 patent/WO2017178632A1/en active Application Filing
- 2017-04-13 AU AU2017251462A patent/AU2017251462B2/en active Active
- 2017-04-13 US US16/091,536 patent/US10982249B2/en active Active
- 2017-04-13 KR KR1020187029594A patent/KR20180132696A/en unknown
- 2017-04-13 SG SG11201808856TA patent/SG11201808856TA/en unknown
- 2017-04-13 MY MYPI2018001702A patent/MY198001A/en unknown
- 2017-04-13 MX MX2018012561A patent/MX2018012561A/en unknown
- 2017-04-13 EP EP17720386.6A patent/EP3442355A1/en active Pending
-
2021
- 2021-03-12 US US17/200,673 patent/US11821015B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US11821015B2 (en) | 2023-11-21 |
AU2017251462A1 (en) | 2018-10-18 |
KR20180132696A (en) | 2018-12-12 |
CN109195457A (en) | 2019-01-11 |
US20190203245A1 (en) | 2019-07-04 |
AU2017251462B2 (en) | 2022-02-03 |
EP3442355A1 (en) | 2019-02-20 |
BR112018071144B1 (en) | 2023-04-18 |
CA3020671A1 (en) | 2017-10-19 |
MY198001A (en) | 2023-07-25 |
MX2018012561A (en) | 2019-01-17 |
BR112018071144A2 (en) | 2019-02-26 |
US10982249B2 (en) | 2021-04-20 |
WO2017178632A1 (en) | 2017-10-19 |
US20210403970A1 (en) | 2021-12-30 |
JP2019513392A (en) | 2019-05-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201808856TA (en) | Production of steviol glycosides in recombinant hosts | |
SG11201803918VA (en) | Production of steviol glycosides in recombinant hosts | |
SG11201909777YA (en) | Modulatory polynucleotides | |
SG11201811431VA (en) | Multispecific antibodies against cd40 and cd137 | |
SG11201804510PA (en) | Biparatopic polypeptides antagonizing wnt signaling in tumor cells | |
SG11201909949XA (en) | Targeted immunotolerance | |
SG11201809912UA (en) | Hybrid carriers for nucleic acid cargo | |
SG11201808457PA (en) | Icos ligand variant immunomodulatory proteins and uses thereof | |
SG11201407579QA (en) | Interleukin-2 fusion proteins and uses thereof | |
SG11201907857RA (en) | Edible and biodegradable utensils | |
SG11201804915RA (en) | Methods for treating huntington's disease | |
SG11201808125RA (en) | Methods for solid tumor treatment | |
SG11201901494UA (en) | Acid-alpha glucosidase variants and uses thereof | |
SG11201809908TA (en) | Stabilized glycopeptide antibiotic formulations | |
SG11201908325PA (en) | Process for the preparation of glucuronide drug-linkers and intermediates thereof | |
SG11201807827VA (en) | Process for the preparation of pegylated drug-linkers and intermediates thereof | |
SG11201809483UA (en) | Production of steviol glycosides in recombinant hosts | |
SG11201407655TA (en) | Therapeutic uses of fibroblast growth factor 21 proteins | |
SG11201805001UA (en) | Method of treating influenza a | |
SG11201809830WA (en) | Selective reduction of cysteine-engineered antibodies | |
SG11201805191SA (en) | Yeast cell | |
SG11201906436VA (en) | Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same | |
SG11201808525UA (en) | Anti-complement factor bb antibodies and uses thereof | |
SG11201805204WA (en) | Nicotine particle capsule | |
SG11202000333UA (en) | Bicyclic ketone compounds and methods of use thereof |