BRPI0418133A2 - pró-fármaco de florfenicol tendo solubilidade em água melhorada - Google Patents

pró-fármaco de florfenicol tendo solubilidade em água melhorada

Info

Publication number
BRPI0418133A2
BRPI0418133A2 BRPI0418133-6A BRPI0418133A BRPI0418133A2 BR PI0418133 A2 BRPI0418133 A2 BR PI0418133A2 BR PI0418133 A BRPI0418133 A BR PI0418133A BR PI0418133 A2 BRPI0418133 A2 BR PI0418133A2
Authority
BR
Brazil
Prior art keywords
florfenicol
water solubility
improved water
florfenicol prodrug
solubility
Prior art date
Application number
BRPI0418133-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Scott J Hecker
Sunil V Pansare
Tomasz W Glinka
Original Assignee
Schering Plough Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34738768&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0418133(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Plough Ltd filed Critical Schering Plough Ltd
Publication of BRPI0418133A2 publication Critical patent/BRPI0418133A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0418133-6A 2003-12-23 2004-12-20 pró-fármaco de florfenicol tendo solubilidade em água melhorada BRPI0418133A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53222703P 2003-12-23 2003-12-23
PCT/US2004/042591 WO2005063257A1 (en) 2003-12-23 2004-12-20 Florfenicol prodrug having improved water solubility

Publications (1)

Publication Number Publication Date
BRPI0418133A2 true BRPI0418133A2 (pt) 2009-03-24

Family

ID=34738768

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418133-6A BRPI0418133A2 (pt) 2003-12-23 2004-12-20 pró-fármaco de florfenicol tendo solubilidade em água melhorada

Country Status (18)

Country Link
US (2) US7153842B2 (https=)
EP (1) EP1696934B1 (https=)
JP (2) JP4719160B2 (https=)
KR (1) KR20060111605A (https=)
CN (1) CN100579532C (https=)
AR (1) AR046970A1 (https=)
BR (1) BRPI0418133A2 (https=)
CA (1) CA2550660C (https=)
EC (1) ECSP066670A (https=)
IL (2) IL176342A (https=)
MX (1) MXPA06007215A (https=)
NO (1) NO20063244L (https=)
NZ (1) NZ547592A (https=)
PE (1) PE20050822A1 (https=)
RU (1) RU2006126519A (https=)
TW (1) TWI262181B (https=)
WO (1) WO2005063257A1 (https=)
ZA (1) ZA200605165B (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200505425A (en) 2003-05-29 2005-02-16 Schering Plough Ltd Compositions and method for treating infection in cattle and swine
US7439268B2 (en) 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
CA2550660C (en) * 2003-12-23 2011-03-15 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
US7361689B2 (en) * 2003-12-31 2008-04-22 Schering-Plough Animal Health Corporation Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof
BRPI0515917A (pt) 2004-09-23 2008-08-12 Schering Plough Ltd controle de parasitas em animais pelo uso de novos derivados de éter de oxima de trifluorometanossulfonanilida
EP1811841B1 (en) 2004-11-19 2009-10-28 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
WO2006135648A2 (en) * 2005-06-09 2006-12-21 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
WO2008076259A1 (en) 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
CN101600422A (zh) * 2006-12-13 2009-12-09 先灵-普劳有限公司 在亲脂性溶媒系统中的水溶性苯丙醇前药
CA2672795A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
KR101769728B1 (ko) 2007-06-27 2017-08-18 이 아이 듀폰 디 네모아 앤드 캄파니 동물 해충 방제 방법
PE20091171A1 (es) * 2007-12-14 2009-08-03 Schering Plough Ltd Proceso para recuperar florfenicol y analogos de florfenicol
WO2010014566A2 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
US20120122680A1 (en) 2009-08-05 2012-05-17 E.I. Du Pont De Nemours And Company Mesoionic pesticides
KR20120050467A (ko) 2009-08-05 2012-05-18 이 아이 듀폰 디 네모아 앤드 캄파니 메소이온성 살충제
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2012150520A1 (en) 2011-05-02 2012-11-08 Pfizer Inc. Novel cephalosporins useful as antibacterial agents
JP2014520151A (ja) 2011-06-20 2014-08-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 蠕虫感染を処置するためのヘテロ環式化合物
TW201326128A (zh) 2011-11-28 2013-07-01 Du Pont 磺醯胺驅蟲劑
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
CN103242363B (zh) * 2013-04-18 2015-10-28 湖北龙翔药业有限公司 氟苯尼考磷酸二酯及盐及其制备方法
CN103923118A (zh) * 2014-04-08 2014-07-16 张家港威胜生物医药有限公司 一种水溶性氟苯尼考衍生物的合成方法
CN105111234B (zh) * 2015-09-23 2017-05-17 河北远征禾木药业有限公司 一种氟苯尼考磷酸酯的合成方法
CN110078729A (zh) * 2019-06-11 2019-08-02 石家庄学院 一种水溶性氟苯尼考前药及其制备方法
CN115286544A (zh) * 2022-10-08 2022-11-04 世华合创生物技术开发(山东)有限公司 一种氟苯尼考衍生物、制备方法及其在抗细菌感染的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776992A (en) * 1956-03-14 1957-01-08 Du Pont Trifluoromethylsulfonylphenyldichloracetamidopropandiol
US4235892A (en) * 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
FR2562543B1 (fr) * 1984-04-10 1987-09-25 Elf Aquitaine Nouveaux phosphonites cycliques, leur preparation et applications
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US6864240B1 (en) * 1999-06-15 2005-03-08 Elan Pharmaceuticals, Inc. Dipeptide inhibitors of β-secretase
US6670344B2 (en) 2000-09-14 2003-12-30 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts
US7547686B2 (en) 2001-06-15 2009-06-16 Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on Behalf of the Arizona State University Combretastatin A-3 prodrug
CN1649829A (zh) * 2002-03-08 2005-08-03 先灵-普劳有限公司 新型氟苯尼考类抗生素
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
CA2550660C (en) 2003-12-23 2011-03-15 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
US7361689B2 (en) 2003-12-31 2008-04-22 Schering-Plough Animal Health Corporation Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof

Also Published As

Publication number Publication date
JP2007516286A (ja) 2007-06-21
MXPA06007215A (es) 2006-08-18
AU2004308913A1 (en) 2005-07-14
US7572777B2 (en) 2009-08-11
NO20063244L (no) 2006-09-20
CN100579532C (zh) 2010-01-13
AR046970A1 (es) 2006-01-04
IL176342A0 (en) 2006-10-05
ECSP066670A (es) 2006-10-25
EP1696934A1 (en) 2006-09-06
IL176342A (en) 2011-08-31
IL200041A0 (en) 2010-04-15
RU2006126519A (ru) 2008-01-27
PE20050822A1 (es) 2005-10-01
CA2550660A1 (en) 2005-07-14
TW200533640A (en) 2005-10-16
CA2550660C (en) 2011-03-15
JP4719160B2 (ja) 2011-07-06
NZ547592A (en) 2009-07-31
US20070021387A1 (en) 2007-01-25
CN1897954A (zh) 2007-01-17
TWI262181B (en) 2006-09-21
US7153842B2 (en) 2006-12-26
ZA200605165B (en) 2007-12-27
KR20060111605A (ko) 2006-10-27
EP1696934B1 (en) 2013-05-29
JP2011148804A (ja) 2011-08-04
US20050182031A1 (en) 2005-08-18
WO2005063257A1 (en) 2005-07-14

Similar Documents

Publication Publication Date Title
BRPI0418133A2 (pt) pró-fármaco de florfenicol tendo solubilidade em água melhorada
DE60232653D1 (de) Pharmazeutisch wirksame uridinester
AR025444A1 (es) Derivados de sulfonil-carboxamida, procedimientos para su preparacion y su utilizacion como medicamentos
AR035284A1 (es) Formulaciones en combinacion de derivados de propanol-amina sustituidos con arilo, junto con otras sustancias activas y su utilizacion
UY30426A1 (es) Derivados sustituidos del 3-(4-metoxi-fenil)-3h-isoindol-1-ilamina trifluoroacetado, sus sales o solvatos farmaceuticamente aceptables, formulaciones farmacéuticas y aplicaciones.
PA8553001A1 (es) Compuestos biciclicos aromaticos sustituidos con amino-alquilo, procedimiento para su preparacion y su utilizacion como medicamentos.
PA8595901A1 (es) "n-arilheterociclos sustituidos, procedimientos para su preparacion, y su empleo como medicamentos
BR0116026A (pt) Imidazoquinolinas substituìdas por tioéter
BR0307998A (pt) Hidroxietilaminas substituìdas
BRPI0404989A (pt) Faixa implantável com mecanismo de ligação transversal
HN2002000247A (es) Derivados de sulfonamida
ECSP034913A (es) Composiciones farmacéuticas que comprenden fármacos de solubilidad baja y/o sensibles a ácidos, y polimeros ácidos neutralizados
BRPI0307702B8 (pt) formulações de solução contendo anticorpo
BR0117123A (pt) Dispositivo de retenção gástrica expansìvel
BRPI0620229B8 (pt) formulações farmaceuticas e processos de produção da ditas formulações
BR0311642A (pt) Formulação de divalproex de sódio de liberação aumentada
BRPI0408848A (pt) formulações orais de cladribine
GT200800066A (es) Derivados de 9-cloro-15-deoxiprostaglandina, procedimiento para su preparacion y su uso como medicamento.
ECSP066291A (es) Sistemas emulsionantes que contienen derivados de azetidina
BRPI0519764A2 (pt) composiÇÕes farmacÊuticas derivadas de Ácido xanturÊnico e mÉtodos relacionados a estas
PA8596701A1 (es) Derivados de aminoacidos sustituidos con cicloalquilo, procedimiento para su preparacion y su uso como medicamentos
BRPI0415428A (pt) formulações terapêuticas
UY28421A1 (es) Sistemas semi-sólidos que contienen derivados de azetidina
BRPI0416679B8 (pt) formulação farmacêutica estável de eritropoietina
BRPI0600822A (pt) sistema de guia estético para planejamento de dentadura

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.

B15K Others concerning applications: alteration of classification

Ipc: C07F 9/09 (2006.01), A61P 31/00 (2006.01), C07F 9/