BRPI0407708A - 3-substituìdo-2(arilalquila)-1-azabicicloalcanos e métodos de seu uso - Google Patents

3-substituìdo-2(arilalquila)-1-azabicicloalcanos e métodos de seu uso

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Publication number
BRPI0407708A
BRPI0407708A BRPI0407708-3A BRPI0407708A BRPI0407708A BR PI0407708 A BRPI0407708 A BR PI0407708A BR PI0407708 A BRPI0407708 A BR PI0407708A BR PI0407708 A BRPI0407708 A BR PI0407708A
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Prior art keywords
methods
neurotransmission
azabicycloalkanes
arylalkyl
compounds
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BRPI0407708-3A
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English (en)
Inventor
Anatoly A Mazurov
Jozef Klucik
Lan Miao
Angela S Seamans
Teresa Youngpetae Phillips
Jeffrey Daniel Schmitt
Craig Harrison Miller
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Targacept Inc
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Application filed by Targacept Inc filed Critical Targacept Inc
Publication of BRPI0407708A publication Critical patent/BRPI0407708A/pt

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract

"3-SUBSTITUìDO-2(ARILALQUILA)-1-AZABICICLOALCANOS E MéTODOS DE SEU USO". A presente invenção diz respeito aos 3-substituído-2-(arilalquila) -1-azabicicloalcanos, métodos de preparação dos compostos e métodos de tratamento usando os compostos. Os azabicicloalcanos geralmente são azabicicLoeptanos, azabiciclooctanos ou azabicicLononanos. O grupo de arila na porção de arilalquila é um anel de 5 ou 6 membros heteroaromático, preferivelmente porções de 3-piridinila e 5-pirimidinila, e o grupo de alquila é tipicamente uma alquila C~ 1-4~. O substituinte na posição 3 do 1-azabicicloalcano é uma porção contendo grupo de carbonila, tal como uma amida, carbamato, uréia, tioamida, tiocarbamato, tiouréia ou funcionalidade similar. Os compostos apresentam atividade nos receptores de acetilcoliona nicotínicos (nAChRs), particularmente o subtipo de nAChR <244>7, e são úteis com respeito à modulação da neurotransmissão e a liberação de ligandos envolvidos na neurotransmissão. Métodos para a prevenção ou tratamento das condições e distúrbios, incluindo os distúrbios do sistema nervoso central (CNS), que são caracterizados por uma alteração na neurotransmissão normal, são também apresentados. Da mesma forma apresentados são os métodos para o tratamento de inflamação, distúrbios autoimunes, dor e excesso de neovascularização, tal como aqueles associado com o crescimento tumoral.
BRPI0407708-3A 2003-02-21 2004-02-20 3-substituìdo-2(arilalquila)-1-azabicicloalcanos e métodos de seu uso BRPI0407708A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/372,642 US6953855B2 (en) 1998-12-11 2003-02-21 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
PCT/US2004/005044 WO2004076449A2 (en) 2003-02-21 2004-02-20 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0407708A true BRPI0407708A (pt) 2006-02-14

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ID=32926222

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407708-3A BRPI0407708A (pt) 2003-02-21 2004-02-20 3-substituìdo-2(arilalquila)-1-azabicicloalcanos e métodos de seu uso

Country Status (23)

Country Link
US (11) US6953855B2 (pt)
EP (1) EP1594869B9 (pt)
JP (3) JP4828407B2 (pt)
KR (3) KR101098481B1 (pt)
CN (2) CN1751041B (pt)
AT (1) ATE381563T1 (pt)
AU (1) AU2004215386B2 (pt)
BR (1) BRPI0407708A (pt)
CA (1) CA2514135C (pt)
CY (1) CY1107175T1 (pt)
DE (1) DE602004010787T2 (pt)
DK (1) DK1594869T3 (pt)
EA (1) EA011033B1 (pt)
ES (1) ES2300749T3 (pt)
HK (1) HK1083627A1 (pt)
IL (3) IL169797A (pt)
MX (1) MXPA05008926A (pt)
NO (3) NO332757B1 (pt)
NZ (3) NZ565178A (pt)
PL (3) PL395718A1 (pt)
PT (1) PT1594869E (pt)
WO (1) WO2004076449A2 (pt)
ZA (1) ZA200506515B (pt)

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