ATE525359T1 - Modulatoren der aktivität des glucokortikoidrezeptors von ap-1 und/oder von nf- kb und anwendung davon - Google Patents
Modulatoren der aktivität des glucokortikoidrezeptors von ap-1 und/oder von nf- kb und anwendung davonInfo
- Publication number
- ATE525359T1 ATE525359T1 AT06773159T AT06773159T ATE525359T1 AT E525359 T1 ATE525359 T1 AT E525359T1 AT 06773159 T AT06773159 T AT 06773159T AT 06773159 T AT06773159 T AT 06773159T AT E525359 T1 ATE525359 T1 AT E525359T1
- Authority
- AT
- Austria
- Prior art keywords
- glucocorticoid receptor
- modulators
- application
- receptor activity
- diseases
- Prior art date
Links
- 102000003676 Glucocorticoid Receptors Human genes 0.000 title abstract 2
- 108090000079 Glucocorticoid Receptors Proteins 0.000 title abstract 2
- 102000003945 NF-kappa B Human genes 0.000 title abstract 2
- 108010057466 NF-kappa B Proteins 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69035505P | 2005-06-14 | 2005-06-14 | |
| US78263606P | 2006-03-15 | 2006-03-15 | |
| US11/451,660 US7888381B2 (en) | 2005-06-14 | 2006-06-13 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
| PCT/US2006/023164 WO2006138373A2 (en) | 2005-06-14 | 2006-06-14 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE525359T1 true ATE525359T1 (de) | 2011-10-15 |
Family
ID=37401459
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06773159T ATE525359T1 (de) | 2005-06-14 | 2006-06-14 | Modulatoren der aktivität des glucokortikoidrezeptors von ap-1 und/oder von nf- kb und anwendung davon |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7888381B2 (de) |
| EP (1) | EP1896424B1 (de) |
| JP (1) | JP2008546702A (de) |
| AT (1) | ATE525359T1 (de) |
| WO (1) | WO2006138373A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY28526A1 (es) * | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| WO2008057856A2 (en) * | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, ap-1 and/or nf-kappab activity and use thereof |
| JP2010508358A (ja) * | 2006-11-01 | 2010-03-18 | ブリストル−マイヤーズ スクイブ カンパニー | グルココルチコイド受容体、AP−1、および/またはNF−κB活性の調節剤、並びにその使用 |
| TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
| MX2009005264A (es) * | 2006-12-06 | 2009-05-28 | Boehringer Ingelheim Int | Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos. |
| JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| EP2022783A1 (de) | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | 1-Phenyl-2-Pyridinylalkyl-Alkoholderivate als Phosphodiesterasehemmer |
| CA2719767A1 (en) * | 2008-03-27 | 2009-10-01 | Burnham Institute For Medical Research | Inhibitors of antigen receptor-induced nf-.kappa.b activation |
| SA109300309B1 (ar) | 2008-05-20 | 2013-01-22 | باير شيرنج فارما ايه جي | مشتقات فينيل وبنزو داي أوكسينيل إندازول بها استبدال |
| WO2009152152A1 (en) * | 2008-06-09 | 2009-12-17 | Amarillo Biosciences, Inc. | Treatment of obesity with an interferon |
| KR102635931B1 (ko) * | 2016-12-14 | 2024-02-13 | 에스케이바이오팜 주식회사 | 가려움증의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도 |
| CN112194685A (zh) * | 2020-10-27 | 2021-01-08 | 西安凯立新材料股份有限公司 | [(s)-(-)-2,2`-双(二苯基膦)-1,1`-联萘]二氯化钯的制备方法 |
| USD1082165S1 (en) | 2022-06-11 | 2025-07-01 | Maria Crenshaw | Watering station |
| USD1082166S1 (en) | 2022-11-14 | 2025-07-01 | Maria Crenshaw | Watering station |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB284425A (en) | 1926-11-22 | 1928-02-02 | James Last | Improvements in and relating to sand or like moulds for making castings |
| US3452085A (en) | 1966-02-11 | 1969-06-24 | Carbo Erba Spa | Alpha-(5-indanyl)-butyric acid |
| DE1948793A1 (de) | 1969-09-26 | 1971-04-01 | Rhein Chemie Rheinau Gmbh | Verfahren zur Herstellung von 4,5,6,7-Tetrahydroindazolen |
| GB1406085A (en) * | 1972-09-15 | 1975-09-10 | Shell Int Research | Process for the recovery of sulphur from hydrogen sulphide and sulphur dioxide |
| AR198886A1 (es) | 1972-11-01 | 1974-07-24 | Kowa Co | Procedimiento para preparar compuestos de acido tetrahidroindazol-5-carboxilicos |
| JPS5118428B2 (de) * | 1972-12-19 | 1976-06-09 | ||
| CH592598A5 (de) | 1973-10-30 | 1977-10-31 | Hexachimie | |
| JPS5426538B2 (de) * | 1973-12-27 | 1979-09-04 | ||
| JPS554745B2 (de) * | 1974-02-22 | 1980-01-31 | ||
| US4046889A (en) | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
| JPS53112868A (en) | 1977-03-11 | 1978-10-02 | Sagami Chem Res Center | Production of thienylacetic acid derivative |
| NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| JPS54141768A (en) | 1978-04-27 | 1979-11-05 | Teijin Ltd | 5-substituted indazole derivative |
| JPS5519226A (en) | 1978-07-28 | 1980-02-09 | Teijin Ltd | 5-acyloxymethylindazole derivative, its preparation, and preparation including the same |
| DE2951135A1 (de) | 1979-12-19 | 1981-06-25 | Hoechst Ag, 6230 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
| US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| JPS6051189A (ja) | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| US4722810A (en) | 1984-08-16 | 1988-02-02 | E. R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
| DE3543999A1 (de) | 1985-12-13 | 1987-06-19 | Bayer Ag | Hochreine acarbose |
| US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| US4749688A (en) | 1986-06-20 | 1988-06-07 | Schering Corporation | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension |
| US5100889A (en) | 1989-04-03 | 1992-03-31 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
| US5223516A (en) | 1990-03-22 | 1993-06-29 | E. R. Squibb & Sons, Inc. | 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same |
| US5108485A (en) | 1990-08-31 | 1992-04-28 | American Cyanamid Company | Herbicidal 2-(2-imidazolin-2-yl)-benzazoles |
| CA2053340C (en) | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5225401A (en) | 1991-08-12 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Treatment of congestive heart failure |
| CA2078758C (en) | 1991-09-27 | 2003-12-09 | Alan M. Warshawsky | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| CA2078759C (en) | 1991-09-27 | 2003-09-16 | Alan M. Warshawsky | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace |
| AU657793B2 (en) | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| US5595872A (en) | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
| DK36392D0 (da) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
| US5447954A (en) | 1992-05-05 | 1995-09-05 | Smithkline Beecham P.L.C. | Phenylderivate as inhibitors of ATP citrate lyase |
| US5552397A (en) | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
| CA2133963C (en) | 1992-05-15 | 1998-07-07 | Gary A. Flynn | Novel mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2-a][1,2]diazepine and pyrazolo[1,2-a][1,2]diazepine derivatives useful as inhibitors of enkephalinase and ace |
| RU2124503C1 (ru) | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
| US5504080A (en) | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
| US5594016A (en) | 1992-12-28 | 1997-01-14 | Mitsubishi Chemical Corporation | Naphthalene derivatives |
| US5346701A (en) | 1993-02-22 | 1994-09-13 | Theratech, Inc. | Transmucosal delivery of macromolecular drugs |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| US5362727A (en) | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5525723A (en) | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
| US5776983A (en) | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| US5488064A (en) | 1994-05-02 | 1996-01-30 | Bristol-Myers Squibb Company | Benzo 1,3 dioxole derivatives |
| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| US5491134A (en) | 1994-09-16 | 1996-02-13 | Bristol-Myers Squibb Company | Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives |
| US5541204A (en) | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
| US5620997A (en) | 1995-05-31 | 1997-04-15 | Warner-Lambert Company | Isothiazolones |
| AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
| WO1997021993A2 (en) | 1995-12-13 | 1997-06-19 | The Regents Of The University Of California | Nuclear receptor ligands and ligand binding domains |
| US5770615A (en) | 1996-04-04 | 1998-06-23 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| US5962440A (en) | 1996-05-09 | 1999-10-05 | Bristol-Myers Squibb Company | Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method |
| US5827875A (en) | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5885983A (en) | 1996-05-10 | 1999-03-23 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| HRP970330B1 (en) | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| GB9713739D0 (en) | 1997-06-27 | 1997-09-03 | Karobio Ab | Thyroid receptor ligands |
| DE04029691T1 (de) | 1998-02-02 | 2007-11-08 | Trustees Of Tufts College, Medford | Verwendung von Dipetidylpeptidasehemmer zur Regulierung des Glukosemetabolismus |
| EP1062222A1 (de) | 1998-03-09 | 2000-12-27 | Fondatech Benelux N.V. | Serin-peptidase modulatoren |
| DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
| DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
| DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US6083969A (en) | 1999-10-20 | 2000-07-04 | Ortho-Mcneil Pharaceutical, Inc. | 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents |
| US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| EP1427707A1 (de) | 2001-09-19 | 2004-06-16 | Pharmacia Corporation | Substituierte indazol verbindungen zur behandlung von entzündungen |
| JP4745609B2 (ja) | 2002-01-22 | 2011-08-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | グルココルチコイドレセプターのための非ステロイド性リガンド、その組成物および使用 |
| ATE496620T1 (de) | 2002-04-11 | 2011-02-15 | Merck Sharp & Dohme | 1h-benzo(f)indazol-5-yl-derivate als selektive glucocorticoid-rezeptor-modulatoren |
| AU2003251970A1 (en) | 2002-07-18 | 2004-02-09 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| EP1599201B1 (de) | 2003-02-25 | 2010-04-14 | Merck Sharp & Dohme Corp. | Selektive nichtsteroidale glucocorticoid-rezeptor- modulatoren |
| US20050090529A1 (en) | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| CA2561305C (en) * | 2004-03-24 | 2013-07-30 | Bharat Lagu | Tetrahydro-indazole cannabinoid modulators |
-
2006
- 2006-06-13 US US11/451,660 patent/US7888381B2/en active Active
- 2006-06-14 JP JP2008517065A patent/JP2008546702A/ja not_active Ceased
- 2006-06-14 WO PCT/US2006/023164 patent/WO2006138373A2/en not_active Ceased
- 2006-06-14 EP EP06773159A patent/EP1896424B1/de not_active Not-in-force
- 2006-06-14 AT AT06773159T patent/ATE525359T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006138373A3 (en) | 2007-05-10 |
| EP1896424B1 (de) | 2011-09-21 |
| US7888381B2 (en) | 2011-02-15 |
| WO2006138373A2 (en) | 2006-12-28 |
| JP2008546702A (ja) | 2008-12-25 |
| US20070129400A1 (en) | 2007-06-07 |
| EP1896424A2 (de) | 2008-03-12 |
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