BR9917299A - Composição tópica e uso de uma composição tópica - Google Patents

Composição tópica e uso de uma composição tópica

Info

Publication number
BR9917299A
BR9917299A BR9917299-2A BR9917299A BR9917299A BR 9917299 A BR9917299 A BR 9917299A BR 9917299 A BR9917299 A BR 9917299A BR 9917299 A BR9917299 A BR 9917299A
Authority
BR
Brazil
Prior art keywords
composition
topical composition
topical
manufacture
mixture
Prior art date
Application number
BR9917299-2A
Other languages
English (en)
Inventor
Nadir Buyuktimkin
Servet Buyuktimkin
James L Yeager
Original Assignee
Nexmed Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings Inc filed Critical Nexmed Holdings Inc
Publication of BR9917299A publication Critical patent/BR9917299A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçãO TóPICA E USO DE UMA COMPOSIçãO TóPICA". é fornecida uma composição com uma consistência semi-sólida para uso na fabricação de um medicamento tópico para a aplicação transdernal de prostaglandina E~ 1~. A composição compreende prostaglandina E~ 1~, um melhorador de penetração, uma goma de polissacarídeo, um composto lipofílico e um sistema tamponador ácido. O melhorador de penetração é um éster alcanoato de alquila 2-(amino N,N-dissubstituído), um alcanoato de alcanol (N,N-dissubstituído) ou uma mistura dos mesmos. O composto lipofílico pode ser um álcool C~ 1~ a C~ 8~ alifático, um éster C~ 8~ a C~ 30~ alifático ou uma mistura dos mesmos. A composição inclui um sistema tamponador capaz de fornecer um valor de pH tamponado para a dita composição na faixa de desde cerca de 3 até cerca de 7,4. A composição é útil na fabricação de medicamentos para o tratamento de disfunção erétil, disfunção sexual feminina e de doença vascular periférica.
BR9917299-2A 1997-11-05 1999-05-13 Composição tópica e uso de uma composição tópica BR9917299A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/964,509 US6046244A (en) 1997-11-05 1997-11-05 Topical compositions for prostaglandin E1 delivery
PCT/US1999/010596 WO2000069469A1 (en) 1997-11-05 1999-05-13 Topical compositions for prostaglandin e1 delivery

Publications (1)

Publication Number Publication Date
BR9917299A true BR9917299A (pt) 2002-07-09

Family

ID=25508632

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9813945-2A BR9813945A (pt) 1997-11-05 1998-11-05 Composições tópicas para distribuição de prostaglandina e1
BR9917299-2A BR9917299A (pt) 1997-11-05 1999-05-13 Composição tópica e uso de uma composição tópica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR9813945-2A BR9813945A (pt) 1997-11-05 1998-11-05 Composições tópicas para distribuição de prostaglandina e1

Country Status (20)

Country Link
US (1) US6046244A (pt)
EP (2) EP1028708B1 (pt)
JP (2) JP4491560B2 (pt)
KR (2) KR100576986B1 (pt)
CN (2) CN1191060C (pt)
AT (2) ATE455535T1 (pt)
AU (1) AU757086B2 (pt)
BR (2) BR9813945A (pt)
CA (2) CA2309165A1 (pt)
DE (2) DE69841463D1 (pt)
DK (2) DK1028708T3 (pt)
ES (2) ES2338389T3 (pt)
HK (2) HK1034678A1 (pt)
HU (1) HU230300B1 (pt)
IL (3) IL135914A0 (pt)
MX (1) MXPA01011560A (pt)
PT (1) PT1178833E (pt)
TR (2) TR200002158T2 (pt)
TW (1) TW443933B (pt)
WO (2) WO1999022714A1 (pt)

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US20070191320A1 (en) * 1998-12-10 2007-08-16 Nexmed Holdings, Inc. Methods of treatment for female sexual arousal disorder
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Also Published As

Publication number Publication date
CA2309165A1 (en) 1999-05-14
DE69919594D1 (de) 2004-09-23
KR20010031836A (ko) 2001-04-16
EP1178833B1 (en) 2004-08-18
DE69919594T2 (de) 2005-09-15
WO1999022714A1 (en) 1999-05-14
ATE273714T1 (de) 2004-09-15
WO2000069469A1 (en) 2000-11-23
AU3989199A (en) 2000-12-05
EP1028708A1 (en) 2000-08-23
TW443933B (en) 2001-07-01
DK1178833T3 (da) 2004-11-22
DK1028708T3 (da) 2010-05-03
IL146470A0 (en) 2002-07-25
HUP0201145A3 (en) 2004-05-28
KR100462442B1 (ko) 2004-12-17
CA2373821C (en) 2003-10-07
EP1178833A1 (en) 2002-02-13
TR200200146T2 (tr) 2002-06-21
HK1044289A1 (en) 2002-10-18
TR200002158T2 (tr) 2000-11-21
JP4491560B2 (ja) 2010-06-30
IL135914A0 (en) 2001-05-20
ATE455535T1 (de) 2010-02-15
BR9813945A (pt) 2002-01-22
PT1178833E (pt) 2004-11-30
AU757086B2 (en) 2003-01-30
HUP0201145A2 (hu) 2002-12-28
CN1191060C (zh) 2005-03-02
JP2001521886A (ja) 2001-11-13
EP1028708B1 (en) 2010-01-20
US6046244A (en) 2000-04-04
JP2002544240A (ja) 2002-12-24
CN1284862A (zh) 2001-02-21
CN1195523C (zh) 2005-04-06
EP1028708A4 (en) 2006-01-18
MXPA01011560A (es) 2002-06-04
IL146470A (en) 2010-12-30
ES2338389T3 (es) 2010-05-06
DE69841463D1 (de) 2010-03-11
HU230300B1 (hu) 2015-12-28
HK1044289B (zh) 2005-01-07
ES2224661T3 (es) 2005-03-01
HK1034678A1 (en) 2001-11-02
KR100576986B1 (ko) 2006-05-10
KR20020012218A (ko) 2002-02-15
CA2373821A1 (en) 2000-11-23
CN1354677A (zh) 2002-06-19

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