PT1178833E - Composicoes topicas para administracao de prostaglandina e1 - Google Patents

Composicoes topicas para administracao de prostaglandina e1

Info

Publication number
PT1178833E
PT1178833E PT99923024T PT99923024T PT1178833E PT 1178833 E PT1178833 E PT 1178833E PT 99923024 T PT99923024 T PT 99923024T PT 99923024 T PT99923024 T PT 99923024T PT 1178833 E PT1178833 E PT 1178833E
Authority
PT
Portugal
Prior art keywords
composition
prostaglandine
administration
aliphatic
mixture
Prior art date
Application number
PT99923024T
Other languages
English (en)
Inventor
James L Yeager
Nadir Buyuktimkin
Servet Buyuktimkin
Original Assignee
Nexmed Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings Inc filed Critical Nexmed Holdings Inc
Publication of PT1178833E publication Critical patent/PT1178833E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT99923024T 1997-11-05 1999-05-13 Composicoes topicas para administracao de prostaglandina e1 PT1178833E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/964,509 US6046244A (en) 1997-11-05 1997-11-05 Topical compositions for prostaglandin E1 delivery
PCT/US1999/010596 WO2000069469A1 (en) 1997-11-05 1999-05-13 Topical compositions for prostaglandin e1 delivery

Publications (1)

Publication Number Publication Date
PT1178833E true PT1178833E (pt) 2004-11-30

Family

ID=25508632

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99923024T PT1178833E (pt) 1997-11-05 1999-05-13 Composicoes topicas para administracao de prostaglandina e1

Country Status (20)

Country Link
US (1) US6046244A (pt)
EP (2) EP1028708B1 (pt)
JP (2) JP4491560B2 (pt)
KR (2) KR100576986B1 (pt)
CN (2) CN1191060C (pt)
AT (2) ATE455535T1 (pt)
AU (1) AU757086B2 (pt)
BR (2) BR9813945A (pt)
CA (2) CA2309165A1 (pt)
DE (2) DE69841463D1 (pt)
DK (2) DK1028708T3 (pt)
ES (2) ES2338389T3 (pt)
HK (2) HK1034678A1 (pt)
HU (1) HU230300B1 (pt)
IL (3) IL135914A0 (pt)
MX (1) MXPA01011560A (pt)
PT (1) PT1178833E (pt)
TR (2) TR200002158T2 (pt)
TW (1) TW443933B (pt)
WO (2) WO1999022714A1 (pt)

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US7914814B2 (en) 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US7629384B2 (en) 1997-09-17 2009-12-08 Strategic Science & Technologies, Llc Topical delivery of L-arginine to cause beneficial effects
US6046244A (en) * 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
US6414028B1 (en) * 1997-11-05 2002-07-02 Nexmed Holdings, Inc. Topical compositions containing prostaglandin E1
GR1003199B (el) * 1998-08-14 1999-09-01 Χρηση της μισοπροστολης ή και της μισοπροστολης οξυ για την παρασκευη φαρμακευτικου προιοντος για τη θεραπευτικη αντιμετωπιση της σεξουαλικης δυσλειτουργιας στις γυναικες
US6486207B2 (en) * 1998-12-10 2002-11-26 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US20050004226A1 (en) * 1998-12-10 2005-01-06 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
EA008720B1 (ru) * 1998-12-10 2007-06-29 Нексмед (Холдингс), Инк. Применение композиции на основе простагландина для лечения расстройства сексуального возбуждения у женщин
US20070191320A1 (en) * 1998-12-10 2007-08-16 Nexmed Holdings, Inc. Methods of treatment for female sexual arousal disorder
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KR100373540B1 (ko) * 2000-09-20 2003-02-25 최한곤 프로스타글란딘 ｅ1용 요도좌제 조성물
KR100810404B1 (ko) * 2001-12-18 2008-03-04 환인제약 주식회사 알프로스타딜 알킬 에스테르를 함유하는 외용제 조성물
WO2003057162A2 (en) * 2002-01-04 2003-07-17 Combinatorx, Incorporated Combination for the treatment of immunoinflammatory disorders and proliferative skin diseases
BR0307345A (pt) * 2002-02-15 2004-12-14 Nexmed Holdings Inc Métodos para tratar disfunção erétil, para melhorar a microcirculação da glans penis e para produzir intumescência da glans penis em um paciente necessitando de tais tratamentos, artigo de manufatura, e, composição
WO2003092617A2 (en) * 2002-05-03 2003-11-13 Combinatorx, Incorporated Combinations for the treatment of inflammatory skin disorders
US7560001B2 (en) * 2002-07-17 2009-07-14 Liquidmetal Technologies, Inc. Method of making dense composites of bulk-solidifying amorphous alloys and articles thereof
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US20050181030A1 (en) * 2003-01-03 2005-08-18 Mo Y. J. Topical stabilized prostaglandin E compound dosage forms
US6841574B2 (en) * 2003-01-03 2005-01-11 Nexmed Holdings, Inc. Topical stabilized prostaglandin E compound dosage forms
PL2106805T3 (pl) * 2003-03-21 2011-10-31 Nexmed Holdings Inc Przeciwgrzybicza powłoka na paznokcie
MXPA05010068A (es) * 2003-03-21 2005-11-23 Nexmed Holdings Inc Promocion de la angiogenesis por composiciones de prostaglandina y metodos.
AU2004224413A1 (en) * 2003-03-21 2004-10-07 Nexmed (Holdings), Inc. Prostaglandin compositions for the treatment of erectile dysfunction
AU2004227853A1 (en) * 2003-04-02 2004-10-21 Nexmed (Holdings), Inc. Prostaglandin compositions and their use for the treatment of vasospasm
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Also Published As

Publication number Publication date
ES2338389T3 (es) 2010-05-06
HK1044289A1 (en) 2002-10-18
IL146470A0 (en) 2002-07-25
IL146470A (en) 2010-12-30
HU230300B1 (hu) 2015-12-28
ES2224661T3 (es) 2005-03-01
KR20010031836A (ko) 2001-04-16
AU3989199A (en) 2000-12-05
HK1034678A1 (en) 2001-11-02
TR200200146T2 (tr) 2002-06-21
IL135914A0 (en) 2001-05-20
KR100576986B1 (ko) 2006-05-10
CA2309165A1 (en) 1999-05-14
WO2000069469A1 (en) 2000-11-23
DE69919594T2 (de) 2005-09-15
KR100462442B1 (ko) 2004-12-17
BR9813945A (pt) 2002-01-22
US6046244A (en) 2000-04-04
CN1191060C (zh) 2005-03-02
CA2373821C (en) 2003-10-07
HUP0201145A3 (en) 2004-05-28
DE69841463D1 (de) 2010-03-11
EP1178833B1 (en) 2004-08-18
JP2001521886A (ja) 2001-11-13
KR20020012218A (ko) 2002-02-15
EP1178833A1 (en) 2002-02-13
CN1284862A (zh) 2001-02-21
EP1028708A1 (en) 2000-08-23
WO1999022714A1 (en) 1999-05-14
AU757086B2 (en) 2003-01-30
CN1354677A (zh) 2002-06-19
EP1028708B1 (en) 2010-01-20
BR9917299A (pt) 2002-07-09
CA2373821A1 (en) 2000-11-23
TW443933B (en) 2001-07-01
JP4491560B2 (ja) 2010-06-30
HUP0201145A2 (hu) 2002-12-28
DE69919594D1 (de) 2004-09-23
ATE455535T1 (de) 2010-02-15
DK1178833T3 (da) 2004-11-22
HK1044289B (zh) 2005-01-07
CN1195523C (zh) 2005-04-06
MXPA01011560A (es) 2002-06-04
ATE273714T1 (de) 2004-09-15
DK1028708T3 (da) 2010-05-03
TR200002158T2 (tr) 2000-11-21
JP2002544240A (ja) 2002-12-24
EP1028708A4 (en) 2006-01-18

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