BR9912395A - Preparação de formas de dosagem de solução clara aquosa com ácidos biliares - Google Patents
Preparação de formas de dosagem de solução clara aquosa com ácidos biliaresInfo
- Publication number
- BR9912395A BR9912395A BR9912395-9A BR9912395A BR9912395A BR 9912395 A BR9912395 A BR 9912395A BR 9912395 A BR9912395 A BR 9912395A BR 9912395 A BR9912395 A BR 9912395A
- Authority
- BR
- Brazil
- Prior art keywords
- bile acid
- values
- solution
- aqueous solution
- bile acids
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PREPARAçãO DE FORMAS DE DOSAGEM DE SOLUçãO CLARA AQUOSA COM áCIDOS BILIARES". Composições para usos farmacêuticos e para outros usos, para preparação de soluções aquosas claras contendo ácidos biliares, que não formam precipitados sobre faixas selecionadas de valores de pH da solução aquosa, e processos de preparação de tais soluções. As composições da invenção compreendem água, um ácido biliar na forma de um ácido biliar, sal de ácido biliar ou de um ácido biliar conjugado com uma amina por uma ligação amida, e um produto de conversão de amido solúvel aquoso de elevado peso molecular. A composição permanece em solução sem formar um precipitado sobre uma faixa de valores de pH e, de acordo com uma concretização, permanece em solução em todos os valores de pH obteníveis em um sistema aquoso. A composição, de acordo com algumas concretizações, pode conter adicionalmente um composto farmacêutico em uma quantidade farmaceuticamente eficaz.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9406998P | 1998-07-24 | 1998-07-24 | |
PCT/US1999/012840 WO2000004875A2 (en) | 1998-07-24 | 1999-07-20 | Preparation of aqueous clear solution dosage forms with bile acids |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9912395A true BR9912395A (pt) | 2001-10-16 |
Family
ID=22242686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9912395-9A BR9912395A (pt) | 1998-07-24 | 1999-07-20 | Preparação de formas de dosagem de solução clara aquosa com ácidos biliares |
Country Status (16)
Country | Link |
---|---|
US (1) | US6251428B1 (pt) |
EP (1) | EP1113785B1 (pt) |
JP (2) | JP4790123B2 (pt) |
KR (1) | KR100524358B1 (pt) |
CN (1) | CN1205922C (pt) |
AT (1) | ATE292956T1 (pt) |
AU (1) | AU758679B2 (pt) |
BR (1) | BR9912395A (pt) |
CA (1) | CA2338457C (pt) |
DE (1) | DE69924740T2 (pt) |
ES (1) | ES2238843T3 (pt) |
ID (1) | ID29632A (pt) |
IL (2) | IL140986A0 (pt) |
PT (1) | PT1113785E (pt) |
RU (1) | RU2224523C2 (pt) |
WO (1) | WO2000004875A2 (pt) |
Families Citing this family (59)
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KR100314496B1 (ko) | 1998-05-28 | 2001-11-22 | 윤동진 | 항혈전성이 있는 헤파린 유도체, 그의 제조방법 및 용도 |
US20070072828A1 (en) * | 1998-07-24 | 2007-03-29 | Yoo Seo H | Bile preparations for colorectal disorders |
US20050158408A1 (en) * | 1998-07-24 | 2005-07-21 | Yoo Seo H. | Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof |
US7303768B2 (en) | 1998-07-24 | 2007-12-04 | Seo Hong Yoo | Preparation of aqueous clear solution dosage forms with bile acids |
US7772220B2 (en) * | 2004-10-15 | 2010-08-10 | Seo Hong Yoo | Methods and compositions for reducing toxicity of a pharmaceutical compound |
DE19834814A1 (de) * | 1998-08-01 | 2000-02-03 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen mit einem wirksamen Gehalt an Gallensäuren, ihren Salzen und/oder ihren Derivaten |
US6417179B1 (en) * | 1998-10-13 | 2002-07-09 | Craig G. Burkhart | Ear wax solution |
GB2355009A (en) * | 1999-07-30 | 2001-04-11 | Univ Glasgow | Peptides conjugated to bile acids/salts |
AU2006203315B2 (en) * | 2000-02-04 | 2008-08-28 | Seo Hong Yoo | Preparation of aqueous clear solution dosage forms with bile acids |
RU2277913C2 (ru) * | 2000-02-04 | 2006-06-20 | Сео Хонг Ю | Получение водного прозрачного раствора лекарственных форм с желчными кислотами |
DE60028339T2 (de) * | 2000-04-20 | 2007-05-10 | Bioprogress S.P.A. | Verfahren zur Herstellung ursodeoxycholsäure enthaltender pharmazeutischer Zusammensetzungen in flüssiger Form |
FR2809310B1 (fr) * | 2000-05-26 | 2004-02-13 | Centre Nat Rech Scient | Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant |
KR100368936B1 (ko) * | 2000-10-04 | 2003-01-24 | 주식회사 대웅 | 우루소데옥시콜린산을 함유한 환경호르몬 독성의 예방 및치료제 |
GB0103046D0 (en) * | 2001-02-07 | 2001-03-21 | Novartis Ag | Organic Compounds |
AU2002313236B2 (en) * | 2001-06-14 | 2007-07-26 | Otsuka Pharmaceutical Co., Ltd. | Medicinal compositions |
US6702850B1 (en) | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
US20080026077A1 (en) * | 2002-11-12 | 2008-01-31 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
US7145125B2 (en) | 2003-06-23 | 2006-12-05 | Advanced Optical Technologies, Llc | Integrating chamber cone light using LED sources |
ES2660172T3 (es) * | 2004-05-19 | 2018-03-21 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Composición inyectable que comprende desoxicolato de sodio |
US7754230B2 (en) * | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
US7906137B2 (en) * | 2004-05-21 | 2011-03-15 | Mediplex Corporation, Korea | Delivery agents for enhancing mucosal absorption of therapeutic agents |
AU2005279961B2 (en) | 2004-08-30 | 2010-05-13 | Seo Hong Yoo | Neuroprotective effect of solubilized UDCA in focal ischemic model |
ATE506955T1 (de) * | 2004-10-15 | 2011-05-15 | Seo Hong Yoo | Zusammensetzungen zur verringerung der toxizität von cisplatin, carboplatin und oxaliplatin |
AU2005302452B2 (en) * | 2004-11-01 | 2010-12-09 | Seo Hong Yoo | Methods and compositions for reducing neurodegeneration in Amyotrophic Lateral Sclerosis |
ES2358089T3 (es) * | 2004-11-01 | 2011-05-05 | Seo Hong Yoo | Métodos y composiciones para reducir la neurodegeneración en esclerosis lateral amiotrófica. |
US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
JP4121537B2 (ja) | 2004-12-22 | 2008-07-23 | 日東電工株式会社 | 線維化抑制のための薬物担体および薬物担体キット |
US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
CN101023940A (zh) * | 2006-02-20 | 2007-08-29 | 郝守祝 | 一种紫杉烷类化合物的药用组合物、制备方法及用途 |
JP2010503667A (ja) * | 2006-09-15 | 2010-02-04 | ホン ユー,ソ | 大腸疾患用胆汁製剤 |
TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
ITMI20071573A1 (it) * | 2007-07-31 | 2009-02-01 | Acraf | Composizione farmaceutica liquida stabile a base di trazodone |
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US9295677B2 (en) | 2008-02-26 | 2016-03-29 | Qing Bile Therapeutics Inc. | Polyhydroxylated bile acids for treatment of biliary disorders |
US20100021538A1 (en) * | 2008-02-29 | 2010-01-28 | Youngro Byun | Pharmaceutical compositions containing heparin derivatives |
US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
JP5420946B2 (ja) * | 2009-03-23 | 2014-02-19 | 富士フイルム株式会社 | 胆汁酸を含むミノキシジル水性組成物 |
JP5909774B2 (ja) * | 2009-08-25 | 2016-04-27 | クィン ビル セラピューティクス インコーポレイテッド | 胆道疾患を治療するためのポリヒドロキシル化胆汁酸 |
MX363465B (es) | 2011-02-18 | 2019-03-25 | Kythera Biopharmaceuticals Inc | Tratamiento de la grasa submental. |
US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
IN2014CN02188A (pt) * | 2011-08-23 | 2015-05-29 | Kythera Biopharmaceuticals Inc | |
US9301911B2 (en) | 2012-01-06 | 2016-04-05 | Daewoong Pharmaceutical Co., Ltd. | Composition comprising tauroursodeoxycholic acid |
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WO2014195950A1 (en) | 2013-06-06 | 2014-12-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Bile acid-basic amino acid conjugates and uses thereof |
US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
MA40462A (fr) | 2014-08-13 | 2017-06-21 | Janssen Pharmaceutica Nv | Méthode de traitement de la dépression |
AU2015318123A1 (en) | 2014-09-15 | 2017-03-30 | Janssen Pharmaceutica Nv | Val66Met (SNP rs6265) genotype specific dosing regimens and methods for the treatment of depression |
US20160332962A1 (en) | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
WO2018062922A1 (ko) * | 2016-09-30 | 2018-04-05 | 주식회사 유스바이오팜 | 수가용화된 우르소데옥시콜산을 함유하는 염증성 피부질환 또는 중증 소양증 예방 또는 치료용 조성물 |
KR20180036580A (ko) * | 2016-09-30 | 2018-04-09 | 주식회사 유스바이오팜 | 수가용화(水加溶化)된 우르소데옥시콜산을 함유하는 염증성 피부질환 또는 중증 소양증 예방 또는 치료용 조성물 |
WO2018147685A1 (ko) * | 2017-02-09 | 2018-08-16 | 주식회사 유스바이오팜 | 우르소데옥시콜산을 함유하는 시각장애 예방 또는 치료용 조성물 |
KR102252450B1 (ko) * | 2017-02-09 | 2021-05-14 | 주식회사 아미코젠파마 | 우르소데옥시콜산을 함유하는 시각장애 예방 또는 치료용 조성물 |
US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
WO2019126108A1 (en) | 2017-12-22 | 2019-06-27 | Janssen Pharmaceutica Nv | Esketamine for the treatment of depression |
JP2019127471A (ja) * | 2018-01-26 | 2019-08-01 | 株式会社ヤマザキ | 美肌用組成物 |
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WO2023187398A1 (en) * | 2022-03-31 | 2023-10-05 | NZP UK Limited | 7-ketolithocholic acid for use in the treatment of gut dysbiosis and as a prebiotic |
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-
1999
- 1999-07-20 US US09/357,549 patent/US6251428B1/en not_active Expired - Fee Related
- 1999-07-20 BR BR9912395-9A patent/BR9912395A/pt not_active Application Discontinuation
- 1999-07-20 PT PT99935313T patent/PT1113785E/pt unknown
- 1999-07-20 ES ES99935313T patent/ES2238843T3/es not_active Expired - Lifetime
- 1999-07-20 AT AT99935313T patent/ATE292956T1/de active
- 1999-07-20 WO PCT/US1999/012840 patent/WO2000004875A2/en active IP Right Grant
- 1999-07-20 CN CNB998101478A patent/CN1205922C/zh not_active Expired - Fee Related
- 1999-07-20 AU AU50819/99A patent/AU758679B2/en not_active Ceased
- 1999-07-20 CA CA002338457A patent/CA2338457C/en not_active Expired - Fee Related
- 1999-07-20 JP JP2000560868A patent/JP4790123B2/ja not_active Expired - Fee Related
- 1999-07-20 KR KR10-2001-7001037A patent/KR100524358B1/ko not_active IP Right Cessation
- 1999-07-20 EP EP99935313A patent/EP1113785B1/en not_active Expired - Lifetime
- 1999-07-20 DE DE69924740T patent/DE69924740T2/de not_active Expired - Lifetime
- 1999-07-20 ID IDW20010199D patent/ID29632A/id unknown
- 1999-07-20 RU RU2001105906/15A patent/RU2224523C2/ru not_active IP Right Cessation
- 1999-07-20 IL IL14098699A patent/IL140986A0/xx active IP Right Grant
-
2001
- 2001-01-18 IL IL140986A patent/IL140986A/en not_active IP Right Cessation
-
2010
- 2010-10-18 JP JP2010233252A patent/JP2011021031A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DE69924740D1 (de) | 2005-05-19 |
PT1113785E (pt) | 2005-08-31 |
JP2011021031A (ja) | 2011-02-03 |
KR20010074748A (ko) | 2001-08-09 |
DE69924740T2 (de) | 2005-09-01 |
EP1113785A2 (en) | 2001-07-11 |
WO2000004875A3 (en) | 2001-05-03 |
ES2238843T3 (es) | 2005-09-01 |
CA2338457A1 (en) | 2000-02-03 |
RU2224523C2 (ru) | 2004-02-27 |
US6251428B1 (en) | 2001-06-26 |
IL140986A (en) | 2006-08-01 |
WO2000004875A2 (en) | 2000-02-03 |
EP1113785B1 (en) | 2005-04-13 |
CN1205922C (zh) | 2005-06-15 |
IL140986A0 (en) | 2002-02-10 |
KR100524358B1 (ko) | 2005-10-26 |
ATE292956T1 (de) | 2005-04-15 |
JP2002522357A (ja) | 2002-07-23 |
CN1348360A (zh) | 2002-05-08 |
AU5081999A (en) | 2000-02-14 |
AU758679B2 (en) | 2003-03-27 |
CA2338457C (en) | 2009-11-17 |
JP4790123B2 (ja) | 2011-10-12 |
ID29632A (id) | 2001-09-06 |
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