EA200000772A1 - Фармацевтические композиции и способы их приготовления - Google Patents

Фармацевтические композиции и способы их приготовления

Info

Publication number
EA200000772A1
EA200000772A1 EA200000772A EA200000772A EA200000772A1 EA 200000772 A1 EA200000772 A1 EA 200000772A1 EA 200000772 A EA200000772 A EA 200000772A EA 200000772 A EA200000772 A EA 200000772A EA 200000772 A1 EA200000772 A1 EA 200000772A1
Authority
EA
Eurasian Patent Office
Prior art keywords
composition
pharmaceutically acceptable
preparation
compound
value corresponding
Prior art date
Application number
EA200000772A
Other languages
English (en)
Inventor
Шериф И. Бейдейви
Донна Л. Джилберт
Original Assignee
Дюпон Фармасьютикалз Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дюпон Фармасьютикалз Компани filed Critical Дюпон Фармасьютикалз Компани
Publication of EA200000772A1 publication Critical patent/EA200000772A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

Предложена фармацевтическая композиция, включающая таблетку или капсулу, содержащая фармакологически эффективное количество фармацевтического соединения или его фармацевтически приемлемой соли, имеющего амидиновую группу и необязательно сложноэфирную группу, фармацевтически приемлемый твердый носитель и фармацевтически приемлемую кислоту в количестве, позволяющем изменять pH композиции до значения, соответствующего наибольшей стабильности данного соединения. Такую композицию готовят путем добавления воды в процессе приготовления композиции и проведения реакции данного соединения в процессе приготовления композиции с фармацевтически приемлемой кислотой, обладающей в насыщенном водном растворе значением pH, соответствующим наибольшей стабильности данного соединения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000772A 1998-01-16 1999-01-14 Фармацевтические композиции и способы их приготовления EA200000772A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7171298P 1998-01-16 1998-01-16
PCT/US1999/000748 WO1999036096A1 (en) 1998-01-16 1999-01-14 Pharmaceutical formulations and processes for their preparation

Publications (1)

Publication Number Publication Date
EA200000772A1 true EA200000772A1 (ru) 2000-12-25

Family

ID=22103090

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000772A EA200000772A1 (ru) 1998-01-16 1999-01-14 Фармацевтические композиции и способы их приготовления

Country Status (16)

Country Link
US (1) US6136833A (ru)
EP (1) EP1042002A1 (ru)
JP (1) JP2002509120A (ru)
KR (1) KR20010024855A (ru)
CN (1) CN1288385A (ru)
AR (1) AR016017A1 (ru)
AU (1) AU746284C (ru)
BR (1) BR9907166A (ru)
CA (1) CA2314148A1 (ru)
EA (1) EA200000772A1 (ru)
HR (1) HRP990014A2 (ru)
IL (1) IL136635A0 (ru)
NZ (1) NZ505080A (ru)
PL (1) PL342011A1 (ru)
WO (1) WO1999036096A1 (ru)
ZA (1) ZA99168B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465009B1 (en) * 1998-03-18 2002-10-15 Yamanouchi Pharmaceutical Co., Ltd. Water soluble polymer-based rapidly dissolving tablets and production processes thereof
US20020160441A1 (en) * 1998-06-02 2002-10-31 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
JP2002326925A (ja) * 2001-04-27 2002-11-15 Asahi Breweries Ltd 造粒物および錠剤の製造方法
US20050187249A1 (en) * 2002-05-13 2005-08-25 Daiichi Pharmaceutical Co., Ltd. Lypohilization product
US7273627B2 (en) * 2004-07-20 2007-09-25 Sukanya Nimmannit Botanical compositions having hypoglycemic, hypolipidemic and antimicrobial activities for maintaining good health in normal person and diabetic patient

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1287674A (en) * 1969-07-21 1972-09-06 Ici Australia Ltd Injectable compositions
BR9408137A (pt) * 1993-11-24 1997-08-12 Du Pont Merck Pharma Composto éster de prodroga método de tratamento composição farmacêutica e método de inibição
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists

Also Published As

Publication number Publication date
HRP990014A2 (en) 1999-10-31
JP2002509120A (ja) 2002-03-26
IL136635A0 (en) 2001-06-14
NZ505080A (en) 2002-09-27
AU746284C (en) 2003-01-16
PL342011A1 (en) 2001-05-07
US6136833A (en) 2000-10-24
KR20010024855A (ko) 2001-03-26
CN1288385A (zh) 2001-03-21
AU2115699A (en) 1999-08-02
AR016017A1 (es) 2001-05-30
WO1999036096A1 (en) 1999-07-22
ZA99168B (en) 2000-07-11
EP1042002A1 (en) 2000-10-11
AU746284B2 (en) 2002-04-18
BR9907166A (pt) 2000-10-24
CA2314148A1 (en) 1999-07-22

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