BR9911040A - 2-fenil-1-[4-(2-aminoetóxi)-benzil]-indol em combinação com estrogêneos - Google Patents

2-fenil-1-[4-(2-aminoetóxi)-benzil]-indol em combinação com estrogêneos

Info

Publication number
BR9911040A
BR9911040A BR9911040-7A BR9911040A BR9911040A BR 9911040 A BR9911040 A BR 9911040A BR 9911040 A BR9911040 A BR 9911040A BR 9911040 A BR9911040 A BR 9911040A
Authority
BR
Brazil
Prior art keywords
aminoethoxy
estrogens
benzyl
phenyl
combination
Prior art date
Application number
BR9911040-7A
Other languages
English (en)
Portuguese (pt)
Inventor
James Harrison Pickar
Barry Samuel Komm
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9911040(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9911040A publication Critical patent/BR9911040A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR9911040-7A 1998-05-15 1999-05-11 2-fenil-1-[4-(2-aminoetóxi)-benzil]-indol em combinação com estrogêneos BR9911040A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15
PCT/US1999/010217 WO1999059581A1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Publications (1)

Publication Number Publication Date
BR9911040A true BR9911040A (pt) 2001-02-13

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911040-7A BR9911040A (pt) 1998-05-15 1999-05-11 2-fenil-1-[4-(2-aminoetóxi)-benzil]-indol em combinação com estrogêneos

Country Status (41)

Country Link
EP (1) EP1076558B1 (en:Method)
JP (3) JP2002515431A (en:Method)
KR (1) KR100620772B1 (en:Method)
CN (1) CN1230163C (en:Method)
AP (1) AP1424A (en:Method)
AR (1) AR020074A1 (en:Method)
AT (1) ATE245026T1 (en:Method)
AU (1) AU760378B2 (en:Method)
BE (1) BE2015C026I2 (en:Method)
BG (1) BG64783B1 (en:Method)
BR (1) BR9911040A (en:Method)
CA (1) CA2329530A1 (en:Method)
CU (1) CU23241B7 (en:Method)
CY (1) CY2015020I1 (en:Method)
CZ (1) CZ299334B6 (en:Method)
DE (1) DE69909616T2 (en:Method)
DK (1) DK1076558T3 (en:Method)
EA (1) EA005932B1 (en:Method)
EE (1) EE04262B1 (en:Method)
ES (1) ES2203131T3 (en:Method)
FR (1) FR15C0035I2 (en:Method)
GE (1) GEP20033079B (en:Method)
HR (1) HRP20000778B1 (en:Method)
HU (2) HU226587B1 (en:Method)
ID (1) ID26890A (en:Method)
IL (1) IL139130A (en:Method)
IN (1) IN192220B (en:Method)
LT (1) LTC1076558I2 (en:Method)
LU (1) LU92699I2 (en:Method)
NO (2) NO328129B1 (en:Method)
NZ (1) NZ508200A (en:Method)
OA (1) OA11552A (en:Method)
PL (1) PL194750B1 (en:Method)
PT (1) PT1076558E (en:Method)
SI (1) SI1076558T1 (en:Method)
SK (1) SK284666B6 (en:Method)
TR (1) TR200003377T2 (en:Method)
TW (1) TW565554B (en:Method)
UA (1) UA66861C2 (en:Method)
WO (1) WO1999059581A1 (en:Method)
ZA (1) ZA200006959B (en:Method)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200003377T2 (tr) * 1998-05-15 2001-03-21 American Home Products Corporation Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
TR200403328T2 (tr) 1999-07-06 2005-03-21 Endorecherche, Inc. Kilo alımını tedavi ve/veya önleme metotları.
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
WO2002003989A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating sphincter incontinence
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
AU2001271785A1 (en) * 2000-07-06 2002-01-21 American Home Products Corporation Combinations of statins, estrogenic agents and optionally estrogens
CN1450913A (zh) * 2000-07-06 2003-10-22 惠氏公司 二膦酸酯、雌激素药物以及任选雌激素的联合应用
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
WO2003011282A1 (en) 2001-07-31 2003-02-13 Pfizer Products Inc. Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
CA2720215C (en) 2008-04-16 2018-02-27 Karo Bio Ab Estrogen receptor ligands
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
KR102781141B1 (ko) * 2017-12-15 2025-03-13 브리스톨-마이어스 스큅 컴퍼니 치환된 인돌 에테르 화합물
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
US20230158152A1 (en) * 2020-03-17 2023-05-25 Medshine Discovery Inc. Proteolysis regulator and method for using same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
AU665690B2 (en) * 1992-05-08 1996-01-11 Otsuka Pharmaceutical Factory, Inc. Indole derivative
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
EP0802183B1 (en) * 1996-04-19 2001-10-10 American Home Products Corporation Estrogenic agents
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
IL127668A0 (en) * 1996-07-09 1999-10-28 Smithkline Beecham Spa Indole derivatives for the treatment of osteoporosis
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
DE69837210T2 (de) * 1997-10-15 2007-12-27 Wyeth Neue aryloxy-alkyl-dialkylamine
JP2001520997A (ja) * 1997-10-28 2001-11-06 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin
TR200003377T2 (tr) * 1998-05-15 2001-03-21 American Home Products Corporation Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol

Also Published As

Publication number Publication date
NZ508200A (en) 2003-09-26
JP2009019042A (ja) 2009-01-29
AU760378B2 (en) 2003-05-15
EA005932B1 (ru) 2005-08-25
HUS1500023I1 (hu) 2017-03-28
NO328129B1 (no) 2009-12-14
HK1031691A1 (en) 2001-06-22
SK284666B6 (sk) 2005-08-04
JP2014159472A (ja) 2014-09-04
EP1076558B1 (en) 2003-07-16
IL139130A (en) 2005-11-20
LTC1076558I2 (lt) 2016-11-10
JP5607871B2 (ja) 2014-10-15
CN1326347A (zh) 2001-12-12
ID26890A (id) 2001-02-15
NO20005770D0 (no) 2000-11-14
WO1999059581A1 (en) 1999-11-25
DK1076558T3 (da) 2003-11-03
GEP20033079B (en) 2003-10-27
TW565554B (en) 2003-12-11
NO20005770L (no) 2001-01-12
HUP0103096A2 (hu) 2002-05-29
EE200000652A (et) 2002-04-15
ZA200006959B (en) 2001-11-27
AP2000001970A0 (en) 2000-12-31
AU3894499A (en) 1999-12-06
PT1076558E (pt) 2003-11-28
KR100620772B1 (ko) 2006-09-13
AP1424A (en) 2005-06-06
BG104930A (en) 2001-07-31
JP5872624B2 (ja) 2016-03-01
EP1076558A1 (en) 2001-02-21
BE2015C026I2 (en) 2018-08-24
CU23241B7 (es) 2007-10-17
EA200001193A1 (ru) 2001-12-24
NO2015015I1 (no) 2015-06-02
CZ20004254A3 (cs) 2001-12-12
PL194750B1 (pl) 2007-06-29
FR15C0035I1 (en:Method) 2015-06-26
SK17202000A3 (sk) 2001-07-10
HUP0103096A3 (en) 2002-11-28
FR15C0035I2 (fr) 2015-08-28
AR020074A1 (es) 2002-04-10
UA66861C2 (uk) 2004-06-15
ES2203131T3 (es) 2004-04-01
IN192220B (en:Method) 2004-03-20
ATE245026T1 (de) 2003-08-15
CN1230163C (zh) 2005-12-07
DE69909616T2 (de) 2004-06-17
LU92699I2 (fr) 2015-06-24
EE04262B1 (et) 2004-04-15
OA11552A (en) 2004-06-07
IL139130A0 (en) 2001-11-25
CY2015020I1 (el) 2020-05-29
BG64783B1 (bg) 2006-04-28
JP2002515431A (ja) 2002-05-28
HRP20000778A2 (en) 2001-06-30
CZ299334B6 (cs) 2008-06-25
SI1076558T1 (en) 2003-10-31
KR20010043641A (ko) 2001-05-25
CA2329530A1 (en) 1999-11-25
HRP20000778B1 (en) 2004-10-31
PL345268A1 (en) 2001-12-03
DE69909616D1 (de) 2003-08-21
HU226587B1 (en) 2009-04-28
TR200003377T2 (tr) 2001-03-21
NO2015015I2 (no) 2015-06-02

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO UMA VEZ QUE AS REIVINDICACOES NAO ATENDEM OA REQUISITO DE ATIVIDADE INVENTIVA ( ARTIGO 8O COMBINADO COM ARTIGO 13 DA LEI 9279 DE 14/05/1996 )

B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL: A61K 31/404, A61K 31/565, A61P 5/24, A61P 5/28, A61P 9/00, A61P 19/08

Ipc: A61K 31/404 (2009.01), A61K 31/565 (2009.01), A61P

B12B Appeal against refusal [chapter 12.2 patent gazette]