BR9910577A - Anticorpo alfa-especìfico de fap com produtibilidade aperfeiçoada - Google Patents

Anticorpo alfa-especìfico de fap com produtibilidade aperfeiçoada

Info

Publication number
BR9910577A
BR9910577A BR9910577-2A BR9910577A BR9910577A BR 9910577 A BR9910577 A BR 9910577A BR 9910577 A BR9910577 A BR 9910577A BR 9910577 A BR9910577 A BR 9910577A
Authority
BR
Brazil
Prior art keywords
alpha
improved productivity
fap antibody
specific fap
antibodies
Prior art date
Application number
BR9910577-2A
Other languages
English (en)
Portuguese (pt)
Inventor
John Edward Park
Pilar Garin-Chesa
Uwe Bamberger
Wolfgang J Rettig
Olivier Leger
Jose William Saldanha
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR9910577A publication Critical patent/BR9910577A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
BR9910577-2A 1998-04-30 1999-04-22 Anticorpo alfa-especìfico de fap com produtibilidade aperfeiçoada BR9910577A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107925A EP0953639A1 (en) 1998-04-30 1998-04-30 FAPalpha-specific antibody with improved producibility
PCT/EP1999/002711 WO1999057151A2 (en) 1998-04-30 1999-04-22 FAP α-SPECIFIC ANTIBODY WITH IMPROVED PRODUCIBILITY

Publications (1)

Publication Number Publication Date
BR9910577A true BR9910577A (pt) 2001-09-11

Family

ID=8231860

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910577-2A BR9910577A (pt) 1998-04-30 1999-04-22 Anticorpo alfa-especìfico de fap com produtibilidade aperfeiçoada

Country Status (27)

Country Link
EP (2) EP0953639A1 (enExample)
JP (1) JP4421779B2 (enExample)
KR (1) KR100580936B1 (enExample)
CN (1) CN1303430A (enExample)
AR (1) AR016243A1 (enExample)
AT (1) ATE356873T1 (enExample)
AU (1) AU760305B2 (enExample)
BG (1) BG65034B1 (enExample)
BR (1) BR9910577A (enExample)
CA (1) CA2327586C (enExample)
CO (1) CO5050255A1 (enExample)
DE (1) DE69935516T2 (enExample)
EA (1) EA005401B1 (enExample)
EE (1) EE200000642A (enExample)
ES (1) ES2283114T3 (enExample)
HU (1) HUP0101501A3 (enExample)
ID (1) ID26555A (enExample)
IL (1) IL138701A0 (enExample)
NO (1) NO20005412L (enExample)
NZ (1) NZ508456A (enExample)
PL (1) PL358087A1 (enExample)
SK (1) SK16192000A3 (enExample)
TR (1) TR200003181T2 (enExample)
UA (1) UA73276C2 (enExample)
WO (1) WO1999057151A2 (enExample)
YU (1) YU66300A (enExample)
ZA (1) ZA200005506B (enExample)

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EP2365004B1 (en) * 2002-06-21 2016-01-06 Johns Hopkins University School of Medicine Membrane associated tumor endothelium markers
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US8193318B2 (en) 2002-08-14 2012-06-05 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
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CN103267852B (zh) * 2013-05-15 2015-03-25 中国医学科学院北京协和医院 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途
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JP2025503533A (ja) * 2021-12-30 2025-02-04 コンセプト トゥー メディシン バイオテック カンパニー， リミテッド Ｆａｐ－アルファに対するヒト抗体
CN119604540A (zh) 2022-08-03 2025-03-11 南京维立志博生物科技股份有限公司 靶向FAP和TGFβ的抗体融合蛋白及其用途
EP4598566A1 (en) 2022-10-07 2025-08-13 Genethon Immunotherapy of skeletal myopathies using anti-fap car-t cells
CN116589566A (zh) * 2022-11-18 2023-08-15 昆明医科大学第一附属医院 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用
WO2025152756A1 (zh) * 2024-01-15 2025-07-24 迈威(上海)生物科技股份有限公司 重组抗fap抗体及其应用
CN118496382B (zh) * 2024-05-22 2025-01-07 山东第一医科大学附属省立医院(山东省立医院) 一种靶向fap的嵌合抗原受体、car-t细胞及其在肝纤维化中的应用
CN119265201A (zh) * 2024-08-23 2025-01-07 中国人民解放军海军军医大学第一附属医院 编码基因、蛋白、表达il-15的nkg2dl-fap双靶点car-nk细胞及其构建方法和用途

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Also Published As

Publication number Publication date
NO20005412L (no) 2000-12-06
SK16192000A3 (sk) 2001-04-09
BG104828A (en) 2001-09-28
ES2283114T3 (es) 2007-10-16
YU66300A (sh) 2004-03-12
EP0953639A1 (en) 1999-11-03
JP4421779B2 (ja) 2010-02-24
WO1999057151A2 (en) 1999-11-11
EA200001023A1 (ru) 2001-06-25
ATE356873T1 (de) 2007-04-15
KR100580936B1 (ko) 2006-05-17
AR016243A1 (es) 2001-06-20
ZA200005506B (en) 2002-05-14
NO20005412D0 (no) 2000-10-27
CA2327586A1 (en) 1999-11-11
CN1303430A (zh) 2001-07-11
EP1098979B1 (en) 2007-03-14
EE200000642A (et) 2002-04-15
HUP0101501A3 (en) 2004-01-28
ID26555A (id) 2001-01-18
KR20010042826A (ko) 2001-05-25
NZ508456A (en) 2004-03-26
CA2327586C (en) 2013-02-26
EP1098979A2 (en) 2001-05-16
AU4032299A (en) 1999-11-23
UA73276C2 (en) 2005-07-15
DE69935516T2 (de) 2008-01-31
IL138701A0 (en) 2001-10-31
CO5050255A1 (es) 2001-06-27
HUP0101501A2 (hu) 2001-08-28
AU760305B2 (en) 2003-05-15
JP2002513556A (ja) 2002-05-14
BG65034B1 (bg) 2006-12-29
PL358087A1 (en) 2004-08-09
EA005401B1 (ru) 2005-02-24
TR200003181T2 (tr) 2001-04-20
WO1999057151A3 (en) 2000-03-16
DE69935516D1 (de) 2007-04-26

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