EE200000642A - Suurendatud saagisega FAPalfa-spetsiifilised antikehad - Google Patents

Suurendatud saagisega FAPalfa-spetsiifilised antikehad

Info

Publication number
EE200000642A
EE200000642A EEP200000642A EEP200000642A EE200000642A EE 200000642 A EE200000642 A EE 200000642A EE P200000642 A EEP200000642 A EE P200000642A EE P200000642 A EEP200000642 A EE P200000642A EE 200000642 A EE200000642 A EE 200000642A
Authority
EE
Estonia
Prior art keywords
fapalpha
specific antibodies
increased yield
yield
increased
Prior art date
Application number
EEP200000642A
Other languages
English (en)
Inventor
Edward Park John
Garin-Chesa Pilar
Bamberger Uwe
J. Rettig Wolfgang
Leger Olivier
Saldanha Jose
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of EE200000642A publication Critical patent/EE200000642A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EEP200000642A 1998-04-30 1999-04-22 Suurendatud saagisega FAPalfa-spetsiifilised antikehad EE200000642A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107925A EP0953639A1 (en) 1998-04-30 1998-04-30 FAPalpha-specific antibody with improved producibility
PCT/EP1999/002711 WO1999057151A2 (en) 1998-04-30 1999-04-22 FAP α-SPECIFIC ANTIBODY WITH IMPROVED PRODUCIBILITY

Publications (1)

Publication Number Publication Date
EE200000642A true EE200000642A (et) 2002-04-15

Family

ID=8231860

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000642A EE200000642A (et) 1998-04-30 1999-04-22 Suurendatud saagisega FAPalfa-spetsiifilised antikehad

Country Status (27)

Country Link
EP (2) EP0953639A1 (et)
JP (1) JP4421779B2 (et)
KR (1) KR100580936B1 (et)
CN (1) CN1303430A (et)
AR (1) AR016243A1 (et)
AT (1) ATE356873T1 (et)
AU (1) AU760305B2 (et)
BG (1) BG65034B1 (et)
BR (1) BR9910577A (et)
CA (1) CA2327586C (et)
CO (1) CO5050255A1 (et)
DE (1) DE69935516T2 (et)
EA (1) EA005401B1 (et)
EE (1) EE200000642A (et)
ES (1) ES2283114T3 (et)
HU (1) HUP0101501A3 (et)
ID (1) ID26555A (et)
IL (1) IL138701A0 (et)
NO (1) NO20005412L (et)
NZ (1) NZ508456A (et)
PL (1) PL358087A1 (et)
SK (1) SK16192000A3 (et)
TR (1) TR200003181T2 (et)
UA (1) UA73276C2 (et)
WO (1) WO1999057151A2 (et)
YU (1) YU66300A (et)
ZA (1) ZA200005506B (et)

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US8530627B2 (en) 2002-08-14 2013-09-10 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8193318B2 (en) 2002-08-14 2012-06-05 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8968730B2 (en) 2002-08-14 2015-03-03 Macrogenics Inc. FcγRIIB specific antibodies and methods of use thereof
US7425620B2 (en) 2002-08-14 2008-09-16 Scott Koenig FcγRIIB-specific antibodies and methods of use thereof
US8946387B2 (en) 2002-08-14 2015-02-03 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8044180B2 (en) 2002-08-14 2011-10-25 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8187593B2 (en) 2002-08-14 2012-05-29 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US7384744B2 (en) 2002-11-29 2008-06-10 Boehringer Ingelheim Pharma Gmbh & Co., Kg Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products
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WO2008140603A2 (en) 2006-12-08 2008-11-20 Macrogenics, Inc. METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
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CN103267852B (zh) * 2013-05-15 2015-03-25 中国医学科学院北京协和医院 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途
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CN113512116B (zh) * 2020-04-10 2022-09-20 苏州普乐康医药科技有限公司 一种抗igf-1r抗体及其应用
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CN115643797A (zh) * 2020-04-30 2023-01-24 天境生物科技(上海)有限公司 包含抗cd47抗体的药物组合物
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CN119604540A (zh) * 2022-08-03 2025-03-11 南京维立志博生物科技股份有限公司 靶向FAP和TGFβ的抗体融合蛋白及其用途
US20260053923A1 (en) 2022-10-07 2026-02-26 Genethon Immunotherapy of Skeletal Myopathies Using ANTI-FAP CAR-T Cells
CN116589566A (zh) * 2022-11-18 2023-08-15 昆明医科大学第一附属医院 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用
CN120309735A (zh) * 2024-01-15 2025-07-15 迈威(上海)生物科技股份有限公司 重组抗fap抗体及其应用
CN118496382B (zh) * 2024-05-22 2025-01-07 山东第一医科大学附属省立医院(山东省立医院) 一种靶向fap的嵌合抗原受体、car-t细胞及其在肝纤维化中的应用
CN118812715A (zh) * 2024-07-02 2024-10-22 国睿(广州)生物科技有限公司 一种靶向成纤维活化蛋白α的纳米抗体及其应用
CN119265201A (zh) * 2024-08-23 2025-01-07 中国人民解放军海军军医大学第一附属医院 编码基因、蛋白、表达il-15的nkg2dl-fap双靶点car-nk细胞及其构建方法和用途

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Also Published As

Publication number Publication date
JP4421779B2 (ja) 2010-02-24
EP1098979B1 (en) 2007-03-14
TR200003181T2 (tr) 2001-04-20
EA005401B1 (ru) 2005-02-24
CA2327586A1 (en) 1999-11-11
WO1999057151A3 (en) 2000-03-16
HUP0101501A2 (hu) 2001-08-28
IL138701A0 (en) 2001-10-31
NZ508456A (en) 2004-03-26
EP0953639A1 (en) 1999-11-03
WO1999057151A2 (en) 1999-11-11
CO5050255A1 (es) 2001-06-27
AU4032299A (en) 1999-11-23
HUP0101501A3 (en) 2004-01-28
YU66300A (sh) 2004-03-12
NO20005412D0 (no) 2000-10-27
ES2283114T3 (es) 2007-10-16
ID26555A (id) 2001-01-18
SK16192000A3 (sk) 2001-04-09
BG65034B1 (bg) 2006-12-29
EP1098979A2 (en) 2001-05-16
UA73276C2 (en) 2005-07-15
DE69935516T2 (de) 2008-01-31
BR9910577A (pt) 2001-09-11
DE69935516D1 (de) 2007-04-26
KR20010042826A (ko) 2001-05-25
JP2002513556A (ja) 2002-05-14
BG104828A (en) 2001-09-28
CN1303430A (zh) 2001-07-11
NO20005412L (no) 2000-12-06
KR100580936B1 (ko) 2006-05-17
CA2327586C (en) 2013-02-26
AU760305B2 (en) 2003-05-15
ATE356873T1 (de) 2007-04-15
AR016243A1 (es) 2001-06-20
PL358087A1 (en) 2004-08-09
ZA200005506B (en) 2002-05-14
EA200001023A1 (ru) 2001-06-25

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