AU760305B2 - FAP alpha-specific antibody with improved producibility - Google Patents

FAP alpha-specific antibody with improved producibility Download PDF

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Publication number
AU760305B2
AU760305B2 AU40322/99A AU4032299A AU760305B2 AU 760305 B2 AU760305 B2 AU 760305B2 AU 40322/99 A AU40322/99 A AU 40322/99A AU 4032299 A AU4032299 A AU 4032299A AU 760305 B2 AU760305 B2 AU 760305B2
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AU
Australia
Prior art keywords
ser
thr
leu
val
antibody
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU40322/99A
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English (en)
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AU4032299A (en
Inventor
Uwe Bamberger
Pilar Garin-Chesa
Olivier Leger
John Edward Park
Wolfgang J Rettig
Jose Saldanha
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Publication of AU4032299A publication Critical patent/AU4032299A/en
Application granted granted Critical
Publication of AU760305B2 publication Critical patent/AU760305B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AU40322/99A 1998-04-30 1999-04-22 FAP alpha-specific antibody with improved producibility Ceased AU760305B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98107925 1998-04-30
EP98107925A EP0953639A1 (en) 1998-04-30 1998-04-30 FAPalpha-specific antibody with improved producibility
PCT/EP1999/002711 WO1999057151A2 (en) 1998-04-30 1999-04-22 FAP α-SPECIFIC ANTIBODY WITH IMPROVED PRODUCIBILITY

Publications (2)

Publication Number Publication Date
AU4032299A AU4032299A (en) 1999-11-23
AU760305B2 true AU760305B2 (en) 2003-05-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU40322/99A Ceased AU760305B2 (en) 1998-04-30 1999-04-22 FAP alpha-specific antibody with improved producibility

Country Status (27)

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EP (2) EP0953639A1 (enExample)
JP (1) JP4421779B2 (enExample)
KR (1) KR100580936B1 (enExample)
CN (1) CN1303430A (enExample)
AR (1) AR016243A1 (enExample)
AT (1) ATE356873T1 (enExample)
AU (1) AU760305B2 (enExample)
BG (1) BG65034B1 (enExample)
BR (1) BR9910577A (enExample)
CA (1) CA2327586C (enExample)
CO (1) CO5050255A1 (enExample)
DE (1) DE69935516T2 (enExample)
EA (1) EA005401B1 (enExample)
EE (1) EE200000642A (enExample)
ES (1) ES2283114T3 (enExample)
HU (1) HUP0101501A3 (enExample)
ID (1) ID26555A (enExample)
IL (1) IL138701A0 (enExample)
NO (1) NO20005412L (enExample)
NZ (1) NZ508456A (enExample)
PL (1) PL358087A1 (enExample)
SK (1) SK16192000A3 (enExample)
TR (1) TR200003181T2 (enExample)
UA (1) UA73276C2 (enExample)
WO (1) WO1999057151A2 (enExample)
YU (1) YU66300A (enExample)
ZA (1) ZA200005506B (enExample)

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TR201804897T4 (tr) 2009-10-07 2018-06-21 Macrogenics Inc Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler
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KR102799318B1 (ko) * 2020-08-11 2025-04-23 주식회사 카나프테라퓨틱스 Il-12 및 항-fap 항체를 포함하는 융합단백질 및 이의 용도
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JP2025503533A (ja) * 2021-12-30 2025-02-04 コンセプト トゥー メディシン バイオテック カンパニー， リミテッド Ｆａｐ－アルファに対するヒト抗体
CN119604540A (zh) * 2022-08-03 2025-03-11 南京维立志博生物科技股份有限公司 靶向FAP和TGFβ的抗体融合蛋白及其用途
CN120112308A (zh) 2022-10-07 2025-06-06 吉尼松公司 使用抗fap car-t细胞免疫治疗骨骼肌病
CN116589566A (zh) * 2022-11-18 2023-08-15 昆明医科大学第一附属医院 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用
CN120309735A (zh) * 2024-01-15 2025-07-15 迈威(上海)生物科技股份有限公司 重组抗fap抗体及其应用
CN118496382B (zh) * 2024-05-22 2025-01-07 山东第一医科大学附属省立医院(山东省立医院) 一种靶向fap的嵌合抗原受体、car-t细胞及其在肝纤维化中的应用
CN119265201A (zh) * 2024-08-23 2025-01-07 中国人民解放军海军军医大学第一附属医院 编码基因、蛋白、表达il-15的nkg2dl-fap双靶点car-nk细胞及其构建方法和用途

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Also Published As

Publication number Publication date
SK16192000A3 (sk) 2001-04-09
EP1098979A2 (en) 2001-05-16
JP4421779B2 (ja) 2010-02-24
CA2327586C (en) 2013-02-26
WO1999057151A2 (en) 1999-11-11
YU66300A (sh) 2004-03-12
KR100580936B1 (ko) 2006-05-17
ID26555A (id) 2001-01-18
CA2327586A1 (en) 1999-11-11
DE69935516D1 (de) 2007-04-26
ZA200005506B (en) 2002-05-14
EP1098979B1 (en) 2007-03-14
IL138701A0 (en) 2001-10-31
ES2283114T3 (es) 2007-10-16
HUP0101501A3 (en) 2004-01-28
NZ508456A (en) 2004-03-26
AU4032299A (en) 1999-11-23
AR016243A1 (es) 2001-06-20
UA73276C2 (en) 2005-07-15
BG104828A (en) 2001-09-28
KR20010042826A (ko) 2001-05-25
EE200000642A (et) 2002-04-15
EA005401B1 (ru) 2005-02-24
DE69935516T2 (de) 2008-01-31
EA200001023A1 (ru) 2001-06-25
WO1999057151A3 (en) 2000-03-16
HUP0101501A2 (hu) 2001-08-28
CO5050255A1 (es) 2001-06-27
BG65034B1 (bg) 2006-12-29
NO20005412L (no) 2000-12-06
BR9910577A (pt) 2001-09-11
EP0953639A1 (en) 1999-11-03
CN1303430A (zh) 2001-07-11
NO20005412D0 (no) 2000-10-27
TR200003181T2 (tr) 2001-04-20
ATE356873T1 (de) 2007-04-15
PL358087A1 (en) 2004-08-09
JP2002513556A (ja) 2002-05-14

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