AR003251A1 - Metodo de determinacion in vitro del grado de agregacion del peptido beta a4 y metodo para la determinacion del grado de inhibicion de la agregacion delpeptido beta a4 por un compuesto que inhibe la agregacion de dicho peptido. - Google Patents
Metodo de determinacion in vitro del grado de agregacion del peptido beta a4 y metodo para la determinacion del grado de inhibicion de la agregacion delpeptido beta a4 por un compuesto que inhibe la agregacion de dicho peptido.Info
- Publication number
- AR003251A1 AR003251A1 ARP960103964A AR10396496A AR003251A1 AR 003251 A1 AR003251 A1 AR 003251A1 AR P960103964 A ARP960103964 A AR P960103964A AR 10396496 A AR10396496 A AR 10396496A AR 003251 A1 AR003251 A1 AR 003251A1
- Authority
- AR
- Argentina
- Prior art keywords
- aggregation
- peptide
- degree
- determination
- beta
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Abstract
El método comprende las etapas de hacer reaccionar in vitro el péptido beta A4 con un reactivo de unión adecuado que es capaz de unirse a dichopéptido sólo en su estado no agregado, para formar una cantidad de reactivo de unión unido aproteína y una cantidad de reactivo de unión libre de proteína,y seguidamente medir dicha cantidad de reactivo unido a proteína. También se describe un método para la determinación del grado de inhibición de laagregación del péptido Beta A4 porun compues to candidato, que comprende la determinación del grado de agregación del citado péptido antes y después delagregado de dicho compuesto candidato. El péptido Beta A4 se encuentra en pacientes que presentan la enfermedad deAlzheimer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51560695A | 1995-08-16 | 1995-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003251A1 true AR003251A1 (es) | 1998-07-08 |
Family
ID=24052039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103964A AR003251A1 (es) | 1995-08-16 | 1996-08-12 | Metodo de determinacion in vitro del grado de agregacion del peptido beta a4 y metodo para la determinacion del grado de inhibicion de la agregacion delpeptido beta a4 por un compuesto que inhibe la agregacion de dicho peptido. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0846269B1 (es) |
| JP (1) | JP3042895B2 (es) |
| KR (1) | KR19990036439A (es) |
| CN (1) | CN1107230C (es) |
| AR (1) | AR003251A1 (es) |
| AT (1) | ATE250766T1 (es) |
| AU (1) | AU697842B2 (es) |
| CA (1) | CA2229187C (es) |
| DE (1) | DE69630131T2 (es) |
| DK (1) | DK0846269T3 (es) |
| ES (1) | ES2206586T3 (es) |
| HK (1) | HK1015030A1 (es) |
| IL (1) | IL122759A (es) |
| NO (1) | NO980623D0 (es) |
| NZ (1) | NZ313070A (es) |
| PT (1) | PT846269E (es) |
| TW (1) | TW574503B (es) |
| WO (1) | WO1997007403A1 (es) |
| ZA (1) | ZA966808B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60336848D1 (de) * | 2002-09-12 | 2011-06-01 | Univ California | Immunogene und entsprechende antikörper, die spezifisch sind für häufige hochmolekulare aggregations-zwischenprodukte von amyloiden aus proteinen unterschiedlicher sequenz |
| EP3540441A1 (en) * | 2014-05-22 | 2019-09-18 | Shimadzu Corporation | Surrogate biomarker for evaluating intracerebral amyloid ss peptide accumulation and method for analysis thereof |
| CN104729946A (zh) * | 2014-12-18 | 2015-06-24 | 江苏大学 | 一种检测淀粉样多肽聚集及其聚集抑制剂评估的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816416A (en) * | 1986-08-27 | 1989-03-28 | Paul Averback | Microspheric bodies for use in screening therapies for Azheimer's disease and related conditions |
| WO1995005604A2 (en) * | 1993-08-13 | 1995-02-23 | Molecular Geriatrics Corporation | Methods for the diagnosis of alzheimer's disease |
| US5744368A (en) * | 1993-11-04 | 1998-04-28 | Research Foundation Of State University Of New York | Methods for the detection of soluble amyloid β-protein (βAP) or soluble transthyretin (TTR) |
-
1996
- 1996-07-23 IL IL12275996A patent/IL122759A/xx not_active IP Right Cessation
- 1996-07-23 ES ES96924657T patent/ES2206586T3/es not_active Expired - Lifetime
- 1996-07-23 AU AU65052/96A patent/AU697842B2/en not_active Ceased
- 1996-07-23 KR KR1019980701109A patent/KR19990036439A/ko not_active Application Discontinuation
- 1996-07-23 NZ NZ313070A patent/NZ313070A/xx unknown
- 1996-07-23 DE DE69630131T patent/DE69630131T2/de not_active Expired - Fee Related
- 1996-07-23 JP JP9509288A patent/JP3042895B2/ja not_active Expired - Lifetime
- 1996-07-23 CA CA002229187A patent/CA2229187C/en not_active Expired - Fee Related
- 1996-07-23 CN CN96196312A patent/CN1107230C/zh not_active Expired - Fee Related
- 1996-07-23 DK DK96924657T patent/DK0846269T3/da active
- 1996-07-23 WO PCT/US1996/012034 patent/WO1997007403A1/en not_active Application Discontinuation
- 1996-07-23 PT PT96924657T patent/PT846269E/pt unknown
- 1996-07-23 EP EP96924657A patent/EP0846269B1/en not_active Expired - Lifetime
- 1996-07-23 AT AT96924657T patent/ATE250766T1/de not_active IP Right Cessation
- 1996-08-12 AR ARP960103964A patent/AR003251A1/es unknown
- 1996-08-12 ZA ZA9606808A patent/ZA966808B/xx unknown
- 1996-08-13 TW TW85109828A patent/TW574503B/zh not_active IP Right Cessation
-
1998
- 1998-02-13 NO NO980623A patent/NO980623D0/no not_active Application Discontinuation
-
1999
- 1999-01-14 HK HK99100195A patent/HK1015030A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1107230C (zh) | 2003-04-30 |
| IL122759A (en) | 2003-05-29 |
| DK0846269T3 (da) | 2003-12-01 |
| JPH11501398A (ja) | 1999-02-02 |
| AU697842B2 (en) | 1998-10-15 |
| MX9801255A (es) | 1998-05-31 |
| NO980623L (no) | 1998-02-13 |
| EP0846269A1 (en) | 1998-06-10 |
| AU6505296A (en) | 1997-03-12 |
| ZA966808B (en) | 1997-02-19 |
| CN1193385A (zh) | 1998-09-16 |
| ATE250766T1 (de) | 2003-10-15 |
| JP3042895B2 (ja) | 2000-05-22 |
| CA2229187C (en) | 2003-03-18 |
| NO980623D0 (no) | 1998-02-13 |
| IL122759A0 (en) | 1998-08-16 |
| KR19990036439A (ko) | 1999-05-25 |
| TW574503B (en) | 2004-02-01 |
| CA2229187A1 (en) | 1997-02-27 |
| ES2206586T3 (es) | 2004-05-16 |
| EP0846269B1 (en) | 2003-09-24 |
| WO1997007403A1 (en) | 1997-02-27 |
| DE69630131T2 (de) | 2004-07-08 |
| NZ313070A (en) | 1999-01-28 |
| HK1015030A1 (en) | 1999-10-08 |
| DE69630131D1 (de) | 2003-10-30 |
| PT846269E (pt) | 2004-01-30 |
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